Cited by 783Blood Pressure and Hypertension StudiesSodium Intake and HealthCardiovascular Health and Disease Prevention

The DOI matches its Crossref record, with a small difference in title or year; 32 of the 33 references it cites were found in a registry or an index.

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis

Open access

Bundy, Joshua D., Li, Changwei, Stuchlik, Patrick, Bu, Xiaoqing, Kelly, Tanika N., Mills, Katherine T., He, Hua, Chen, Jing, Whelton, Paul K., He, Jiang·2017·JAMA Cardiology

DOI 10.1001/jamacardio.2017.1421PMC PMC5710614

Open this paper in CoChat — free account Open PDF

Abstract

Importance: Clinical trials have documented that lowering blood pressure reduces cardiovascular disease and premature deaths. However, the optimal target for reduction of systolic blood pressure (SBP) is uncertain. Objective: To assess the association of mean achieved SBP levels with the risk of cardiovascular disease and all-cause mortality in adults with hypertension treated with antihypertensive therapy. Data Sources: MEDLINE and EMBASE were searched from inception to December 15, 2015, supplemented by manual searches of the bibliographies of retrieved articles. Study Selection: Studies included were clinical trials with random allocation to an antihypertensive medication, control, or treatment target. Studies had to have reported a difference in mean achieved SBP of 5 mm Hg or more between comparison groups. Data Extraction and Synthesis: Data were extracted from each study independently and in duplicate by at least 2 investigators according to a standardized protocol. Network meta-analysis was used to obtain pooled randomized results comparing the association of each 5-mm Hg SBP category with clinical outcomes after adjusting for baseline risk. Main Outcomes and Measures: Cardiovascular disease and all-cause mortality. Results: Forty-two trials, including 144 220 patients, met the eligibility criteria. In general, there were linear associations between mean achieved SBP and risk of cardiovascular disease and mortality, with the lowest risk at 120 to 124 mm Hg. Randomized groups with a mean achieved SBP of 120 to 124 mm Hg had a hazard ratio (HR) for major cardiovascular disease of 0.71 (95% CI, 0.60-0.83) compared with randomized groups with a mean achieved SBP of 130 to 134 mm Hg, an HR of 0.58 (95% CI, 0.48-0.72) compared with those with a mean achieved SBP of 140 to 144 mm Hg, an HR of 0.46 (95% CI, 0.34-0.63) compared with those with a mean achieved SBP of 150 to 154 mm Hg, and an HR of 0.36 (95% CI, 0.26-0.51) compared with those with a mean achieved SBP of 160 mm Hg or more. Likewise, randomized groups with a mean achieved SBP of 120 to 124 mm Hg had an HR for all-cause mortality of 0.73 (95% CI, 0.58-0.93) compared with randomized groups with a mean achieved SBP of 130 to 134 mm Hg, an HR of 0.59 (95% CI, 0.45-0.77) compared with those with a mean achieved SBP of 140 to 144 mm Hg, an HR of 0.51 (95% CI, 0.36-0.71) compared with those with a mean achieved SBP of 150 to 154 mm Hg, and an HR of 0.47 (95% CI, 0.32-0.67) compared with those with a mean achieved SBP of 160 mm Hg or more. Conclusions and Relevance: This study suggests that reducing SBP to levels below currently recommended targets significantly reduces the risk of cardiovascular disease and all-cause mortality. These findings support more intensive control of SBP among adults with hypertension.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamacardio.2017.1421

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
(2002) · The Lancet · doi:10.1016/s0140-6736(02)11911-8 · Cited by 10,266
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,698
Self-citation
2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
(2015) · The Lancet · doi:10.1016/s0140-6736(14)61682-2 · Cited by 7,439
A Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Ettehad, D., Emdin, C. A., Kiran, A., Anderson, S. G., Callender, T., Emberson, J., Chalmers, J., Rodgers, A., & Rahimi, K. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01225-8 · Cited by 3,755

Show all 33 references

Research works printed but not linked: 1

[17]17. Jones DW, Weatherly L, Hall JE. SPRINT: what remains unanswered and where do we go from here? Hypertension. 2016;67(2):261-262.

Sorted by citations

Items 701–783 of 783

Effectiveness of a BCW-based interactive pictorial health education program among patients with hypertension in the urban-rural fringe area in China
Zhang, Q., Gan, W., Pei, R., Bao, X., Shimpuku, Y., Chen, S., Song, L., Yin, J., Wang, Y., & Zheng, Y. (2025) · Patient Education and Counseling · doi:10.1016/j.pec.2025.108782
A Cross-sectional Study on Endothelial Function and Subclinical Cardiovascular Risk Markers in Various Obesity Phenotypes in Tertiary Care Hospitals in Central India
Daiya, V., Archarya, S., Shukla, S., Kumar, S., Manuja, N., Jaiswal, S., Pradeep, U., Hamdulay, K., Kumar, J., & Padwal, A. (2025) · Journal of the Practice of Cardiovascular Sciences · doi:10.4103/jpcs.jpcs_51_24
Blood Pressure Outcomes Following a Home Blood Pressure Monitoring Program in a Large Integrated us Health System
Harrison, T. N., Juan, R. A., An, J., Zhou, H., Marquez, J. M., Ong‐Su, A. L., Brettler, J. W., & Reynolds, K. (2025) · American Journal of Hypertension · doi:10.1093/ajh/hpaf082 · Cited by 1
Multicomponent Blood Pressure Control Program in Medicare Beneficiaries with Hypertension Primarily of Hispanic Origin in a Large Health System in South FloridaPreprint
Chaves, P. H. M., Desoria, M., Roque, L., & Mas, R. (2025) · medRxiv · doi:10.1101/2025.05.29.25328595
“Despite the fact that efficacious intervention approaches for blood pressure (BP) control in adults with hypertension exist 4–8 , BP control rates in large populations remain disappointingly low 9–11 .”
The Impact of Smart Management Model on Blood Pressure Control Rate in Elderly Hypertensive Patients
孙, 浩. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1551670
Utilization Trends and Outcomes of Alteplase in Acute Cerebral Ischemia among Patients with Hypertension or Diabetes: A Tertiary Care Experience from Southern Punjab
Mukhtar, M. A., Tariq, N., Mukhtar, A., Khalid, A., Mukhtar, A., & Mukhtar, R. (2025) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/011871529x381588250612061045
Impact of Aerobic, Resistance, and Combined Training on Blood Pressure in Patients with Chronic Diseases: A Narrative Review
Alkhamees, N. H., AL-Mhanna, S. B., Grivas, G. V., Astuti, Y., Omar, N., Afolabi, H. A., Abubakar, B. D., Mohamed, K., & Batrakoulis, A. (2025) · Annals of Applied Sport Science · doi:10.61186/aassjournal.1447
“Clinical research consistently shows that reducing BP can lower cardiovascular mortality (9).”
COMPARATIVE EVALUATION OF SPORT-BASED EXERCISE MODALITIES FOR REDUCING ARTERIAL HYPERTENSION: A LITERATURE REVIEW
Boczek, S., Herba, M., Kost, K., Smyła-Gruca, W., & Gruca, M. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3717
Racial and Disaggregated Ethnic Disparities of Blood Pressure Control in Community Health Centers
Boston, D., Hwang, J.-S., Lucas, J. A., Marino, M., Larson, Z., Sun, E., Giebultowicz, S., Quiñones, A. R., Crookes, D. M., Rodríguez, C., et al. (2025) · Journal of general internal medicine · doi:10.1007/s11606-025-09735-9
Prevalence and associated factors of hypertension in women of reproductive age in Bangladesh based on JNC-8 & AHA-2017 guidelines: Evidence from Bangladesh Demographic & Health Survey 2022Preprint
Ahmed, T., Monju, I. H., Akib, A. H., Khulal, R., Das, C., & Hashan, M. R. (2025) · medRxiv · doi:10.1101/2025.09.16.25335939
Encouraged by the 2025 US Guidelines to Lower Systolic Blood Pressure Below 120 mm Hg: From Guidelines to Clinical Practice
Verdecchia, P., Angeli, F., & Reboldi, G. (2025) · Hypertension · doi:10.1161/hypertensionaha.125.25902
Policosanol (sugarcane wax alcohols) 20 mg/day in Cuban Patients With Grade I Hypertension: A Randomized, Double‐Blind, Multicenter Study
Agüero, M. R., Chiquet, A. J., González, Y. V., Travieso, J. C. F., Nuñez, Y. R., Domínguez, Y. F., Pla, E. G., Castaño, S. M., Guerra, Y. P., Caballero, M. D. P., et al. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70126
“…cardiovascular risk, a large-scale analysis of randomized trials proved that just a simple SBP reduction of 5 mmHg lowered the risk of major cardiovascular events by about 10%, irrespective of previous diagnoses of cardiovascular disease and even at normal or high-normal blood pressure values [64].”
Combination of treatment intensity score and interankle diastolic blood pressure is associated with cardiovascular prognosis among adults with controlled hypertension who have pre-existing cardiovascular disease
Zhang, Z., Fan, Z., & Han, L. (2025) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000775
“Our multivariable analysis confirmed TIS’s independence from traditional risk factors (adjusted hazard ratio: 1.92, P = 0.027), suggesting its unique role in risk stratification beyond traditional factors [14,15].”
Influential
From Healthcare to Higher Ed: A Five-Level Framework for Fostering Academic Integrity
Kalra, J. (2025) · Ethics and integrity in educational contexts · doi:10.1007/978-3-031-98157-9_4
Optimal blood pressure (≤120/70 mmHg) as a marker for antihypertensive discontinuation
Boivin, J., Ferreira, J. P., & Girerd, N. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf675
Importance of Secondary Prevention in Coronary Heart Disease
Moșteoru, S., Kundnani, N. R., Rus, A.-A., Ilin, S., Ciocan, V., Albulescu, N., Nicula, M., Gaiţă, L., & Gaiță, D. I. (2025) · Medicina · doi:10.3390/medicina61112011
“A comprehensive meta-analysis has demonstrated that an incremental increase in systolic blood pressure is associated with a proportional rise in cardiovascular mortality, underscoring the importance of achieving optimal blood pressure control [26].”
Mediating Role of Leisure-Time Physical Activity on the Association Between Public Open Spaces and Hypertension in Adults: A Prospective Study
Miranda, A. M., Onita, B. M., Hallal, P. C., & Florindo, A. A. (2025) · Journal of Physical Activity and Health · doi:10.1123/jpah.2025-0344
Additional file 1 of Efficacy of mHealth and education-led peer counseling for patients with hypertension and coronary artery disease in Pakistan: study protocol for a double-blinded pragmatic randomized-controlled trial with factorial design
Arshed, M., Zakar, R., Umer, M. F., Kiran, M., Ullah, N., Iftikhar, G., & Fischer, F. (2023) · Figshare · doi:10.6084/m9.figshare.23651413
Additional file 2 of The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients
Liu, S., Li, F., Zhang, C., Wei, B., Wan, J., & Shao, H. (2023) · Figshare · doi:10.6084/m9.figshare.23733135
Additional file 1 of Efficacy of antihyperglycemic therapies on cardiovascular and heart failure outcomes: an updated meta-analysis and meta-regression analysis of 35 randomized cardiovascular outcome trials
Hasebe, M., Yoshiji, S., Keidai, Y., Minamino, H., Murakami, T., Tanaka, D., Fujita, Y., Harada, N., Hamasaki, A., & Inagaki, N. (2024) · Figshare · doi:10.6084/m9.figshare.26575994
Additional file 1 of Risk factors of undiagnosed and uncontrolled hypertension in primary care patients with hypertension: a cross-sectional study
Adediran, E., Owens, R. E., Gardner, E., Curtin, A. D., Stuligross, J., Forbes, D., Wang, J., & Ose, D. J. (2024) · Figshare · doi:10.6084/m9.figshare.26798763
Additional file 1 of The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients
Liu, S., Li, F., Zhang, C., Wei, B., Wan, J., & Shao, H. (2023) · Figshare · doi:10.6084/m9.figshare.23733132
Additional file 2 of Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007–18
Gupta, R. D., Akonde, M., Sajal, I. H., & Al Kibria, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14129412
Additional file 1 of Clinical impact of guideline-based practice and patients’ adherence in uncontrolled hypertension
Sohn, I. S., Kim, C. J., Yoo, B.-S., Kim, B. J., Choi, J. W., Kim, D.-I., Lee, S.-H., Song, W.-H., Jeon, D. W., Cha, T. J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17210571
Additional file 3 of Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007–18
Gupta, R. D., Akonde, M., Sajal, I. H., & Al Kibria, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14129415
Additional file 2 of Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
Delaney, J. A. C., Olson, N. C., Sitlani, C. M., Fohner, A. E., Huber, S. A., LANDAY, A. L., Heckbert, S. R., Tracy, R. P., Psaty, B. M., Feinstein, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13633010
Additional file 1 of Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care
Martín-Fernández, J., Alonso‐Safont, T., Polentinos-Castro, E., Esteban-Vasallo, M. D., Ariza-Cardiel, G., González-Anglada, M. I., Perruca, L. S., Rodríguez-Martínez, G., del Campo, R. R., & Bilbao-González, A. (2023) · Figshare · doi:10.6084/m9.figshare.22623391
Additional file 5 of Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007–18
Gupta, R. D., Akonde, M., Sajal, I. H., & Al Kibria, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14129421
Additional file 2 of Risk factors of undiagnosed and uncontrolled hypertension in primary care patients with hypertension: a cross-sectional study
Adediran, E., Owens, R. E., Gardner, E., Curtin, A. D., Stuligross, J., Forbes, D., Wang, J., & Ose, D. J. (2024) · Figshare · doi:10.6084/m9.figshare.26798766
Additional file 1 of Quality of care in patients with hypertension: a retrospective cohort study of primary care routine data in Germany
Strumann, C., Engler, N., von Meißner, W., Blickle, P.-G., & Steinhäuser, J. (2024) · Figshare · doi:10.6084/m9.figshare.25203607
Additional file 3 of Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
Delaney, J. A. C., Olson, N. C., Sitlani, C. M., Fohner, A. E., Huber, S. A., LANDAY, A. L., Heckbert, S. R., Tracy, R. P., Psaty, B. M., Feinstein, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13633013
Additional file 4 of The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients
Liu, S., Li, F., Zhang, C., Wei, B., Wan, J., & Shao, H. (2023) · Figshare · doi:10.6084/m9.figshare.23733141
Additional file 4 of Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007–18
Gupta, R. D., Akonde, M., Sajal, I. H., & Al Kibria, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14129418
Additional file 3 of The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients
Liu, S., Li, F., Zhang, C., Wei, B., Wan, J., & Shao, H. (2023) · Figshare · doi:10.6084/m9.figshare.23733138
Additional file 1 of Financial incentives for hypertension control: rationale and study design
Zheng, L., Wang, Y., Liu, S., Zheng, R., Pei, D., Sun, Y., & Sun, Z. (2020) · Figshare · doi:10.6084/m9.figshare.11966973
Additional file 1 of Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA)
Delaney, J. A. C., Olson, N. C., Sitlani, C. M., Fohner, A. E., Huber, S. A., LANDAY, A. L., Heckbert, S. R., Tracy, R. P., Psaty, B. M., Feinstein, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13633007
Additional file 1 of Association between height and hypertension among US adults: analyses of National Health and Nutrition Examination Survey 2007–18
Gupta, R. D., Akonde, M., Sajal, I. H., & Al Kibria, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14129409
Additional file 1 of Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies
Gan, L., Zhao, B., Inoue-Choi, M., Liao, L. M., Graubard, B. I., Weinstein, S. J., Albanes, D., & Huang, J. (2024) · Figshare · doi:10.6084/m9.figshare.25464873
Non-achievement of therapeutic range of antihypertensive drug concentration in a triple combination as a cause of ineffective control of primary arterial hypertension: ambiguous results of a cross-sectional clinical trial in routine clinical practice
Селезнев, С. В., Shchulkin, A. V., Yakusheva, E. N., Yakushin, S. S., Mylnikov, P. Y., Nikulina, N., Abalenikhina, Y. V., & MZHAVANADZE, N. D. (2025) · I P Pavlov Russian Medical Biological Herald · doi:10.17816/pavlovj693157
FROM CIGARETTES TO THE FUTURE: ALTERNATIVE WAYS TO ADMINISTER NICOTINE
Sikora, M., Drabik, M., Nowak, J. M., Platschek, M., Dybalska, K., Kosmulska, J., Kęska, M., Tuleja, A. B., Kolano, S. W., & Szkarłat, K. J. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4252
Hypertension and diabetes
Niakan, A., Cushman, W. C., & Kotsis, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00369-1
The association between cardiometabolic index and hypertension-diabetes comorbidity among adults aged 45 and older: evidence from two national databases
Yang, D., Huang, J., Duan, L., Chen, Z., & Feng, Y. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-026-02177-2
Long-term memory effects of an incremental blood pressure intervention in a mortal cohort
Josefsson, M., Karalija, N., & Daniels, M. J. (2026) · Biometrics · doi:10.1093/biomtc/ujaf176
“That is, what we call a survivors average intervention effect : Note, previous studies have shown a the link between reduced sBP and reduced all-cause mortality (Bundy et al., 2017 ).”
TREAT: A Multicentre Cross‐sectional TReatment Evaluation of Apparent Resistant hyperTension in Belgium
Brouwers, S., Justine, H., Chabot, M., Nieuwenhuyse, B. V., Bacquer, D. D., & Daniel, M. (2026) · Journal of Clinical Hypertension · doi:10.1111/jch.70230
Association of systolic blood pressure time in target range and all-cause mortality in patients with atherosclerotic cardiovascular disease: an analysis of a prospective cohort study
Zhao, J., Zhang, X., Zhang, L., Wu, S., Chen, S., Zhao, L., Chen, B., & Li, W. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-110956
Applying the Behavior Change Wheel to develop strategies to integrate hypertension and HIV care in South African urban primary care clinics
Johnson, L. C. M., Galaviz, K. I., Ordóñez, C. E., Nyatela, A., Siedner, M. J., Heine, M., Klipstein‐Grobusch, K., Ali, M. K., Venter, F., Marconi, V. C., et al. (2026) · Translational Behavioral Medicine · doi:10.1093/tbm/ibag008
Effects of a combination of olive leaf extract and potassium on blood pressure in participants with mild to moderate hypertension: A double blind, randomized, placebo-controlled trial
Fladerer-Grollitsch, J.-P., Bučar, F., Klein, T., Kompek, A., Menzel, D., & Schön, C. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158138
Estimation de la pression aortique à l'aide de l'imagerie par résonance magnétique : développement d'un modèle biomécanique d'écoulement
Rachid, K. (2018) · theses.fr (ABES) · doi:10.70675/0a477bbezde0ez4db6zb52az410c780898e1
Challenges in personalized evidence-based medicine, applications in type 2 diabetes
Grenet, G. (2019) · theses.fr (ABES) · doi:10.70675/3c0d95afza6c0z4a90zb34az472f1eccb72a
Trends in Blood Pressure Control During the COVID‐19 Pandemic: A Study of 17 US Health Systems in the National Patient‐Centered Clinical Research Network Blood Pressure Control Laboratory
Chamberlain, A. M., Cooper‐DeHoff, R. M., Fontil, V., Park, S., Shaw, K. M., Smith, M. C., Carton, T. W., O'Brien, E. C., Modrow, M. F., Wozniak, G. D., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.045694
Home blood pressure monitoring and the risk of falls in older adults with hypertension: The AMBROSIA-HOME study
Poudel, B., Wang, Z., Shimbo, D., Schwartz, J. E., Reynolds, K., Harrison, T. N., Cannavale, K. L., Wei, R., Muntner, P., Bowling, C. B., et al. (2026) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2026.100791
Trial of an individualised Intervention for the prevention of Stroke (TIIPS): Protocol and statistical analysis plan for a randomized controlled trialPreprint
Feigin, V. L., Krishnamurthi, R., DeSilva, D., Yee, L., Dyer, J., Nair, B., Ao, B. T., Bennett, D., Arroll, B., Choy, L., et al. (2026) · medRxiv · doi:10.64898/2026.05.07.26352701
DETECTION OF DRUG-DRUG INTERACTIONS CAUSED BY ANTI-HYPERTENSIVES: AN OBSERVATIONAL STUDY
Tanırcan, B., & Arslan, M. (2026) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1766785
Circadian profile of 24-hour ambulatory blood pressure monitoring in healthy young adults
GOEL, A., Goyal, M., Mahadule, A. A., Verma, N., & Tiwari, S. (2026) · The National Medical Journal of India · doi:10.25259/nmji_617_2023
The comparative effectiveness of different exercise training modes on ambulatory blood pressure: a systematic review and network meta-analysis of randomized controlled trials
Anderson, V. A., Kambo, K., Bruce‐Low, S., Galbraith, A., O’Driscoll, J. M., & Edwards, J. J. (2026) · Journal of Hypertension · doi:10.1097/hjh.0000000000004320
Nutritional and Health Aspects of Oat Proteins
Hu, X., Rafique, H., & Ren, T. (2026) · doi:10.1002/9781394369522.ch08
Incorporating geospatial environmental exposure indicators in individual hypertension risk prediction: a multi-stage machine learning pipeline
Hu, Y., Jamal, H., Deng, X., Lawrence, K. G., Werder, E. J., Launer, L. J., & Sandler, D. P. (2026) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-026-00915-1
Association between blood pressure levels and risk of stroke in patients with atrial fibrillation: results from a prospective registry in Xinjiang, China
Che, B., Yeerken, M., Luo, K. W., Peng, W., Wei, M., Yang, X., Lu, Y.-R., Zhou, X., Wang, H., Ma, F., et al. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1759080
“It was also indicative that progressively lower BP lower stroke risk in these patients, which corroborated previous ﬁndings in a network meta-analysis of the relationship between SBP and stroke risk among hypertensive subjects (22).”
Prevalence and factors associated with uncontrolled systolic blood pressure among treated older adults in Sri Lanka: a nationwide multicenter cross-sectional study
Zoysa, P. D., Weerarathna, T., Darshana, I., Egodage, U., Rathnayake, R., Jayasekara, M. M. P. T., Sujanitha, V., Matthias, A., Ratnayake, B., Mayurathan, P., et al. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-06062-7
“Evidence from multiple studies indicates a consistent, linear relationship between achieved systolic blood pressure (SBP) and the risk of cardiovascular events and death [4].”
Hypertension management: is lower always better?
Shamsulddin, A. B. (2026) · Minerva Medica · doi:10.23736/s0026-4806.26.09891-5
Trends in Ischemic Heart Disease Burden in China From 1992 to 2021: Prevalence, Mortality Rates, and Attributable Risks From Four Key Factors
Yu, D., Yu, Y., Zhang, T., Huang, W., Liang, X., & Ruan, Z. (2026) · International Journal of Clinical Practice · doi:10.1155/ijcp/6665417
Blood Levels of Angiotensinogen and Risk of Ischemic Stroke: The Multi‐Ethnic Study of Atherosclerosis
Masrouri, S., Trainor, P. J., Chevli, P. A., Lima, J. A. C., Tsimikas, S., DeFilippis, A. P., & Shapiro, M. D. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.047698
Cardiometabolic Effects of Semaglutide in Individuals with Type 2 Diabetes in the United Arab Emirates: Real-World 12-Month Outcomes and Predictors of Response
Mian, M. H. S., Janahi, K. A. H. A., Tayeb, A., Musaffar, F. M. M., Khalil, N., Toubah, S. H. A., Karim, A. M. A., Almarzooqi, A. M., Sayfoo, F. M., Hamadeh, A., et al. (2026) · Diabetes Therapy · doi:10.1007/s13300-026-01888-y
Retrospective cohort study assessing cardiovascular risk reduction through intensive blood pressure management in high-risk patients
Tang, B., & Gu, W. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1711504
“A recent study by (18) further strengthened the evidence base, demonstrating that intensive systolic BP lowering consistently reduced cardiovascular events across multiple populations, with relative risk reductions ranging from 20% to 25%.”
Hypertension in women
Huang, A. L., & Vongpatanasin, W. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00059-7
Prevalence of adherence to antihypertensive treatment: a comparison of drug biochemical analysis and the self-report scale
Guimarães, M. C. D. L. P., Coelho, J. C., dos Santos, J., Meira, K. C., Vattimo, M. D. F. F., Costa, E., da Silva, G. V., Drager, L. F., & Pierin, Â. M. G. (2026) · Clinical Hypertension · doi:10.5646/ch.2026.32.e37
Global, Regional, and National Burden of Stroke Attributable to High Systolic Blood Pressure in Adults Aged 45 Years and Above From 1990 to 2021, with Projections to 2045: A Systematic and Comprehensive Analysis of the Global Burden of Disease Study 2021
Yu, Q., Tian, Y., Shen, S., Yan, Y., Liu, X., & Liu, Z. (2026) · Archives of Iranian Medicine · doi:10.34172/aim.34957
The effect of a family-centered empowerment model with traditional Chinese medicine health education on self-management in community-dwelling older adult hypertensive patients with a chance health locus of control
Li, F., Li, M., Guo, S., Cao, Y., Zhang, Q., Cheng, T., & Li, Y. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1743254
“A review found that each 10 mmHg decrease in SBP (mean SBP of 120–124 mmHg) was associated with a 29 % reduction in cardiovascular disease and 27 % reduction in all-cause mortality compared with a mean SBP of 130–134 mmHg (20).”
Hypertension Control Rates Before and After Implementation of a Multicomponent Quality Improvement Program in Medicare Beneficiaries Primarily of Hispanic Origin in a Large Health System in South Florida, 2011–2018
Chaves, P. H. M., Desoria, M., Roque, L., & Mas, R. J. (2026) · Journal of Clinical Hypertension · doi:10.1111/jch.70297
Association of urinary sodium and potassium excretion with outcomes of neuroendocrine cancer
Sun, Q., Aji, M., Yan, X., Zhang, Y., Nan, F., Wang, Y., & Li, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1866503
“Prior research has linked elevated STP ratios to hypertension and cardiovascular mortality (10, 19, 20), suggesting that it may also serve as a prognostic marker in cancer patients with renal metabolic disturbances.”
Additional blood-pressure-lowering effect of exercise in adults on stable antihypertensive medication: a systematic review and meta-analysis of randomised controlled trials
Etayo-Urtasun, P., de Asteasu, M. L. S., & Izquierdo, M. (2026) · Hypertension Research · doi:10.1038/s41440-026-02784-5
Efficacy of Mediterranean diet interventions on children and adolescents affected by overweight or obesity: a systematic review and meta-analysis
Rapti, I., Markozannes, G., Papathanasiou, O. E., Veroni, A., Zachariades, C., Tseretopoulou, X., Kotanidou, E. P., Serbis, A., Koutras, V., Rizos, E. C., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1749319
“As long as elevated SBP is a risk factor for cardiovascular disease, a decrease of SBP during childhood and adolescence could also lead to a reduction of cardiovascular risk during adulthood (65).”
Long-Term Effectiveness of Intensive Blood Pressure Management Led by Nonphysician Community Healthcare Providers on Cardiovascular Events: 7-Year Follow-Up of a Cluster Randomized Trial
Sun, G., Guo, X., Zhao, C., Ouyang, N., Li, G., Wang, C., Ren, Y., Xing, L., Sun, Z., Qiao, L., et al. (2026) · Circulation · doi:10.1161/circulationaha.126.082511
Self-citation
Achieved systolic blood pressure and cardiovascular outcomes in advanced chronic kidney disease
Al‐Sodany, E., Szummer, K. E., Österman, J., Dietrich, C. E., Carrero, J. J., Heimbürger, O., Barany, P. F., & Evans, M. (2026) · Clinical Kidney Journal · doi:10.1093/ckj/sfag296
“BP values were obtained as attended clinic readings rather than with SPRINT’s largely unattended protocol, which has been difficult to compare with other trials [ 3 8 ].”
Influential
Innovative pharmacist-led hypertension management in urgent care: Bridging the gaps in cardiovascular disease
Lee, J. J., Zunti, J., Song, G., Low, R., Zhang, J. J., Pollock, J., & Koro, M. (2026) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.3138/cpj-26-0006
Bergamot ( Citrus bergamia ) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta‐Analysis
Chambari, M., Mardani, H., Roshandel, M., Rafiei, H., Linsenmeyer, W. R., Jafari, M., Ulaganathan, V., & Jafari, A. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72357
“While the absolute change in SBP may appear modest at the individual level, even small reductions in SBP have been shown to yield meaningful reductions in cardio-vascular morbidity and mortality across populations (Bundy et al. 2017).”
Efficacy and safety of intensive vs. standard blood pressure control: a systematic review and meta-analysis
Yang, H., Li, Y., Xiang, G., Pei, S., Wang, M., Xu, L., Zhu, B., Liu, Y., & Yang, X. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1929546
“Despite decades of evidence demonstrating that antihypertensive therapy effectively reduces cardiovascular risk (30, 31), the optimal blood pressure treatment target remains a subject of significant debate.”
Primary medical prevention of chronic non-infectious diseases: World practice and evidence base (review)
Ulbasheva, Z. (2026) · Saratov Journal of Medical Scientific Research · doi:10.15275/ssmj2201084
Is it always necessary to reduce elevated blood pressure in elderly and senile patients, and to what values?
Pisaruk, A. (2026) · Problems of ageing and longevity (Ukraine) · doi:10.71012/pro-ageing-2026-3-08
From bench to formulary: a pharmacological appraisal of aldosterone synthase inhibitors for uncontrolled and resistant hypertension
Baker, W. L. (2026) · American Journal of Hypertension · doi:10.1093/ajh/hpag077
Triệt đốt thần kinh giao cảm thận: Triển vọng mới từ những dữ liệu gần đây
Hiếu, T. B., Quang, N. N., Phong, P. Đ., & Hùng, P. M. (2026) · Tạp chí Tim Mạch Học Việt Nam · doi:10.58354/jvc.103.2022.1373
Effect of Family Medical History of Hypertension and Its Interaction with Diabetes on an Additive Scale on the Diagnosis of Hypertension Among Middle-Aged and Older Adults in India: Longitudinal Ageing Study in India
Jowf, G. I. A., & Ahmed, W. (2026) · Healthcare · doi:10.3390/healthcare14203538
“High blood pressure is a leading risk factor for coronary heart disease, heart failure, and stroke [17–19].”
2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the Management of Hypertension.
(2022) · PubMed Central · doi:10.6515/acs.202205_38(3).20220321a · Cited by 117

Authors: Bundy, J. D., Li, C., Stuchlik, P., Bu, X., Kelly, T. N., Mills, K. T., He, H., Chen, J., Whelton, P. K., & He, J.
Affiliations: Tulane University (US)
Corresponding author: He, Jiang
ORCID: Bundy, Joshua D.
Li, Changwei
Bu, Xiaoqing
Kelly, Tanika N.
Mills, Katherine T.
He, Hua
Chen, Jing
Whelton, Paul K.
He, Jiang
Venue: JAMA Cardiology
Publisher: American Medical Association (AMA)
Published: 2017-07-01
Volume: 2
Issue: 7
Pages: 775
ISSN: 2380-6583 (ISSN-L)
DOI: 10.1001/jamacardio.2017.1421
PMC: PMC5710614
OpenAlex: W2618382346
Cited by: 783
References: 33
Citations by year: 2026: 59 · 2025: 102 · 2024: 96 · 2023: 99 · 2022: 65 · 2021: 95 · 2020: 80 · 2019: 78 · 2018: 73 · 2017: 35
FWCI: 56.22
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA Cardiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (P20GM109036)
Fogarty International Center (D43TW009107)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: systolic blood pressure, blood pressure targets, hypertension, antihypertensive therapy, cardiovascular disease, all-cause mortality, blood pressure reduction, linear dose-response relationship, cardiovascular risk reduction, cardiovascular disease prevention, cardiovascular disease prevention and treatment
MeSH terms: Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Humans, Hypertension, Mortality, Patient Care Planning, Systole

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks