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Time to Publication Among Completed Clinical Trials

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Ross, Joseph S., Mocanu, Marian, Lampropulos, Julianna F., Tse, Tony, Krumholz, Harlan M.·2013·JAMA Internal Medicine

DOI 10.1001/jamainternmed.2013.136PMC PMC3691813

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Abstract

Prior studies have shown that 25% to 50% of clinical trials are never published.[1][2][3][4] However, among those published, we know little about the length of time required for publication in the peer-reviewed biomedical literature after study completion.Ioannidis previously demonstrated that a sample of randomized phase 2 and 3 trials conducted between 1986 and 1996 required nearly 2.5 years for publication, 5 while our more recent study of National Institutes of Health (NIH)-funded trials found that average time to publication was almost two years.4 We sought to determine time to publication for a recent and representative sample of trials published in 2009. METHODSWe examined clinical trials published during the 2009 calendar year that were indexed via MEDLINE and linked to a ClinicalTrials.govidentifier (NCT Number).6 We excluded articles that were not the first publication reporting on the clinical trial by reviewing article text for citations to and searching MEDLINE for earlier trial publications.We imputed completion dates based on the subject enrollment dates and the longest period of follow-up required for any outcome measure reported in the article.For trials without enrollment dates, we used the completion date provided on ClinicalTrials.gov;

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Authors: Ross, J. S., Mocanu, M., Lampropulos, J. F., Tse, T., & Krumholz, H. M.
Affiliations: Yale New Haven Hospital (US)
Mayo Clinic (US)
National Institutes of Health (US)
Corresponding author: Ross, Joseph S.
ORCID: Ross, Joseph S.
Tse, Tony
Krumholz, Harlan M.
Venue: JAMA Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2013-05-13
Volume: 173
Issue: 9
Pages: 825
ISSN: 2168-6106 (ISSN-L)
DOI: 10.1001/jamainternmed.2013.136
PMC: PMC3691813
OpenAlex: W1995839006
Cited by: 114
References: 8
Citations by year: 2026: 7 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 2 · 2013: 5
FWCI: 16.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services (K08 AG032886)
National Institutes of Health
U.S. Public Health Service (HHSN276201000788P)
National Institute on Aging (K08AG032886)
National Heart, Lung, and Blood Institute (U01HL105270)
U.S. National Library of Medicine
Topics: Social Sciences › Library and Information Sciences › Academic Publishing and Open Access
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Health Sciences › Nursing › Issues, ethics and legal aspects › Pharmaceutical industry and healthcare
Keywords: time to publication, clinical trials, trial completion, randomized controlled trials, ClinicalTrials.gov, biomedical literature
MeSH terms: Clinical Trials as Topic, Humans, Periodicals as Topic, Publishing, Time Factors, Research Report

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