The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Time to Publication Among Completed Clinical Trials
Open accessAbstract
Prior studies have shown that 25% to 50% of clinical trials are never published.[1][2][3][4] However, among those published, we know little about the length of time required for publication in the peer-reviewed biomedical literature after study completion.Ioannidis previously demonstrated that a sample of randomized phase 2 and 3 trials conducted between 1986 and 1996 required nearly 2.5 years for publication, 5 while our more recent study of National Institutes of Health (NIH)-funded trials found that average time to publication was almost two years.4 We sought to determine time to publication for a recent and representative sample of trials published in 2009. METHODSWe examined clinical trials published during the 2009 calendar year that were indexed via MEDLINE and linked to a ClinicalTrials.govidentifier (NCT Number).6 We excluded articles that were not the first publication reporting on the clinical trial by reviewing article text for citations to and searching MEDLINE for earlier trial publications.We imputed completion dates based on the subject enrollment dates and the longest period of follow-up required for any outcome measure reported in the article.For trials without enrollment dates, we used the completion date provided on ClinicalTrials.gov;
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“Clinical trial registries are an important source of information for tracking clinical trials from their inception through to their reporting, and have been used to measure publication bias and outcome reporting bias.”
From Systematic review protocol assessing the processes for linking clinical trial registries and their published results (2016) · cites this paper as [13]
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“our estimated time to publication of covid-19 preprints is different from estimates made from before covid-19.”
From Consistency of covid-19 trial preprints with published reports and impact for decision making: retrospective review (2022) · cites this paper as [48]
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Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias
Dwan, K., Altman, D. G., Arnaiz, J. A., Bloom, J., Chan, A.-W., Cronin, E., Decullier, E., Easterbrook, P. J., Von Elm, E., Gamble, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003081 · Cited by 1,546
The ClinicalTrials.gov Results Database — Update and Key Issues
Zarin, D. A., Tse, T., Williams, R. J., Califf, R. M., & Ide, N. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmsa1012065 · Cited by 838
Self-citationIoannidis, J. P. A. (1998) · JAMA · doi:10.1001/jama.279.4.281 · Cited by 632
DeAngelis, C. D., Drazen, J. M., Frizelle, F., Haug, C. J., Hoey, J., Horton, R. C., Kotzin, S., Laine, C. M., Marušić, A., Overbeke, A. J. P. M., et al. (2004) · JAMA · doi:10.1001/jama.292.11.1363 · Cited by 579
Clinical trial registration: a statement from the International Committee of Medical Journal Editors
De Angelis, C., Drazen, J. M., Frizelle, F. A., Haug, C., Hoey, J., Horton, R., Kotzin, S., Laine, C., Marusic, A., Overbeke, A. J. P., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17034-7 · Cited by 408
Trial Publication after Registration in ClinicalTrials.Gov: A Cross-Sectional Analysis
Ross, J. S., Mulvey, G. K., Hines, E. M., Nissen, S. E., & Krumholz, H. M. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000144 · Cited by 401
Self-citationPublication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis
Ross, J. S., Tse, T., Zarin, D. A., Xu, H., Zhou, L., & Krumholz, H. M. (2012) · BMJ · doi:10.1136/bmj.d7292 · Cited by 371
Self-citationPublication of Clinical Trials Supporting Successful New Drug Applications: A Literature Analysis
Lee, K., Bacchetti, P., & Sim, I. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050191 · Cited by 215
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Chen, R., Desai, N. R., Ross, J. S., Zhang, W., Chau, K. H., Wayda, B., Murugiah, K., Lu, D. Y., Mittal, A., & Krumholz, H. M. (2016) · BMJ · doi:10.1136/bmj.i637 · Cited by 227
Self-citationGresham, G. K., Meinert, J. L., Gresham, A. G., & Meinert, C. L. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.14682 · Cited by 86
Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review
Sierocinski, E., Holzinger, F., & Chenot, J. (2021) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-021-03090-4 · Cited by 69
Patient‐specific instruments: industry’s innovation with a surgeon’s interest
Thienpont, E., Bellemans, J., Delport, H., Overschelde, P. V., Stuyts, B., Brabants, K., & Victor, J. M. K. (2013) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-013-2626-5 · Cited by 54
Outcome reporting bias in randomized-controlled trials investigating antipsychotic drugs
Lancee, M., Lemmens, C. M. C., Kahn, R. S., Vinkers, C. H., & Luykx, J. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.203 · Cited by 53
Metadata
- Authors
- Ross, J. S., Mocanu, M., Lampropulos, J. F., Tse, T., & Krumholz, H. M.
- Affiliations
- Yale New Haven Hospital (US)
- Mayo Clinic (US)
- National Institutes of Health (US)
- Corresponding author
- Ross, Joseph S.
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2013-05-13
- Volume
- 173
- Issue
- 9
- Pages
- 825
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC3691813
- OpenAlex
- W1995839006
- Cited by
- 114
- References
- 8
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 2 · 2013: 5
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services (K08 AG032886)
- National Institutes of Health
- U.S. Public Health Service (HHSN276201000788P)
- National Institute on Aging (K08AG032886)
- National Heart, Lung, and Blood Institute (U01HL105270)
- U.S. National Library of Medicine
- Topics
- Social Sciences › Library and Information Sciences › Academic Publishing and Open Access
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Nursing › Issues, ethics and legal aspects › Pharmaceutical industry and healthcare
- Keywords
- time to publication, clinical trials, trial completion, randomized controlled trials, ClinicalTrials.gov, biomedical literature
- MeSH terms
- Clinical Trials as Topic, Humans, Periodicals as Topic, Publishing, Time Factors, Research Report
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