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Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial
Open accessAbstract
Importance: Alternate-day fasting has become increasingly popular, yet, to date, no long-term randomized clinical trials have evaluated its efficacy. Objective: To compare the effects of alternate-day fasting vs daily calorie restriction on weight loss, weight maintenance, and risk indicators for cardiovascular disease. Design, Setting, and Participants: A single-center randomized clinical trial of obese adults (18 to 64 years of age; mean body mass index, 34) was conducted between October 1, 2011, and January 15, 2015, at an academic institution in Chicago, Illinois. Interventions: Participants were randomized to 1 of 3 groups for 1 year: alternate-day fasting (25% of energy needs on fast days; 125% of energy needs on alternating "feast days"), calorie restriction (75% of energy needs every day), or a no-intervention control. The trial involved a 6-month weight-loss phase followed by a 6-month weight-maintenance phase. Main Outcomes and Measures: The primary outcome was change in body weight. Secondary outcomes were adherence to the dietary intervention and risk indicators for cardiovascular disease. Results: Among the 100 participants (86 women and 14 men; mean [SD] age, 44 [11] years), the dropout rate was highest in the alternate-day fasting group (13 of 34 [38%]), vs the daily calorie restriction group (10 of 35 [29%]) and control group (8 of 31 [26%]). Mean weight loss was similar for participants in the alternate-day fasting group and those in the daily calorie restriction group at month 6 (-6.8% [95% CI, -9.1% to -4.5%] vs -6.8% [95% CI, -9.1% to -4.6%]) and month 12 (-6.0% [95% CI, -8.5% to -3.6%] vs -5.3% [95% CI, -7.6% to -3.0%]) relative to those in the control group. Participants in the alternate-day fasting group ate more than prescribed on fast days, and less than prescribed on feast days, while those in the daily calorie restriction group generally met their prescribed energy goals. There were no significant differences between the intervention groups in blood pressure, heart rate, triglycerides, fasting glucose, fasting insulin, insulin resistance, C-reactive protein, or homocysteine concentrations at month 6 or 12. Mean high-density lipoprotein cholesterol levels at month 6 significantly increased among the participants in the alternate-day fasting group (6.2 mg/dL [95% CI, 0.1-12.4 mg/dL]), but not at month 12 (1.0 mg/dL [95% CI, -5.9 to 7.8 mg/dL]), relative to those in the daily calorie restriction group. Mean low-density lipoprotein cholesterol levels were significantly elevated by month 12 among the participants in the alternate-day fasting group (11.5 mg/dL [95% CI, 1.9-21.1 mg/dL]) compared with those in the daily calorie restriction group. Conclusions and Relevance: Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction. Trial Registration: clinicaltrials.gov Identifier: NCT00960505.
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“There were no statistically significant differences between the alternate-day fasting group and the daily calorie restriction group for fat mass, lean mass, or visceral fat mass at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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“There were also no statistically significant differences in heart rate between the alternate-day fasting group and the daily calorie restriction group at month 6 or month 12 (Table 2).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Blood Pressure and Heart Rate
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“Blood pressure was not significantly different between the intervention groups, or relative to controls, at month 6 or month 12 (Table 2).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Blood Pressure and Heart Rate
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“Total cholesterol levels were not significantly different between the intervention groups, or relative to controls, at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Plasma Lipids
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In the paper
“Moreover, weight regain from months 6 to 12 was not significantly different between the alternate-day fasting group and controls (0.8%; 95% CI, −1.8% to 3.3%)”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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In the paper
“There were also no significant differences in fasting insulin or the homeostasis model assessment of insulin resistance between the intervention groups at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
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In the paper
“On the fast day (Figure 2A), participants in the alternate-day fasting group exceeded their prescribed energy goal at months 3 and 6.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Prescribed vs Actual Energy Intake Determined via Food Records
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In the paper
“or the daily calorie restriction group and controls (1.5%; 95% CI, −0.8% to 3.9%).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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In the paper
“High-sensitivity C-reactive protein and homocysteine levels did not differ significantly between the intervention groups, or relative to controls, at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
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In the paper
“At month 12, low-density lipoprotein cholesterol levels significantly increased in the alternate-day fasting group (11.5 mg/dL [95% CI, 1.9–21.1 mg/ dL]) (to convert to millimoles per liter, multiply by 0.0259) relative to the daily calorie restriction group.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Plasma Lipids
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In the paper
“Triglyceride levels did not differ significantly between the intervention groups at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Plasma Lipids
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In the paper
“At the end of the study, total weight loss was −6.0% (95% CI, −8.5% to −3.6%) for the alternate-day fasting group and −5.3% (95% CI, −7.6% to −3.0%) for the daily calorie restriction group, relative to controls, with no significant difference between the intervention groups.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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In the paper
“There were also no significant differences in fasting insulin or the homeostasis model assessment of insulin resistance between the intervention groups at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“There were no statistically significant differences between the alternate-day fasting group and the daily calorie restriction group for fat mass, lean mass, or visceral fat mass at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“Weight regain from months 6 to 12 (−0.8%; 95% CI, −3.2% to 1.7%) was not significantly different between the alternate-day fasting group and the daily calorie restriction group.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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In the paper
“Weight loss was not significantly different between the alternate-day fasting group and the daily calorie restriction group at month 6.”
- Also stated in: § RESULTS · plain
“Mean weight loss was similar for participants in the alternate-day fasting group and those in the daily calorie restriction group at month 6 (−6.8% [95% CI, −9.1% to −4.5%] vs −6.8% [95% CI, −9.1% to −4.6%])”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
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- Also stated in: § RESULTS · plain
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In the paper
“At month 6, high-density lipoprotein cholesterol levels were significantly elevated in the alternate-day fasting group by 6.2 mg/dL (95% CI, 0.1–12.4 mg/ dL) (to convert to millimoles per liter, multiply by 0.0259) vs the daily calorie restriction group, but this effect was no longer observed by month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Plasma Lipids
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At month 6, high-density lipoprotein cholesterol levels were significantly elevated in the alternate-day fasting group by 6.2 mg/dL (95% CI, 0.1–12.4 mg/ dL) (to convert to millimoles per liter, multiply by 0.0259) vs the daily calorie restriction group, but this effect was no longer observed by month 12.”
- Also stated in: § RESULTS · plain
“Mean high-density lipoprotein cholesterol levels at month 6 significantly increased among the participants in the alternate-day fasting group (6.2 mg/dL [95% CI, 0.1–12.4 mg/dL]), but not at month 12 (1.0 mg/dL [95% CI, −5.9 to 7.8 mg/dL]), relative to those in the daily calorie restriction group.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Plasma Lipids
Strength:plain· not yet calibratedn = 100Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
- Also stated in: § RESULTS · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no statistically significant differences between the alternate-day fasting group and the daily calorie restriction group for fat mass, lean mass, or visceral fat mass at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Weight Loss and Weight Maintenance
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“High-sensitivity C-reactive protein and homocysteine levels did not differ significantly between the intervention groups, or relative to controls, at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“A higher proportion of participants in the daily calorie restriction group were adherent to their energy goals at months 3, 6, 9, and 12 relative to those in the alternate-day fasting group.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Prescribed vs Actual Energy Intake Determined via Food Records
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“On the feast day (Figure 2B), participants in the alternate-day fasting group ate less than their prescribed goal at months 3, 6, 9, and 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Prescribed vs Actual Energy Intake Determined via Food Records
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
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In the paper
“Fasting plasma glucose did not differ significantly between the intervention groups, or relative to controls, at month 6 or month 12.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
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In the paper
“From baseline to month 6, the alternate-day fasting group achieved a mean (SD) percentage energy restriction of 21% (16%), and the daily calorie restriction group achieved a mean (SD) percentage energy restriction of 24% (16%), with no significant difference between the intervention groups or compared with the control group (eFigure 2 in Supplement 2).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Percentage Energy Restriction Determined via Doubly Labeled Water
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In the paper
“Physical activity, measured as steps per day, did not change during the course of the trial in any group (eTable 2 in Supplement 2).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Physical Activity and Dietary Intake
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In the paper
“Contrary to our original hypotheses, the participants in the alternate-day fasting group did not experience more pronounced improvements in risk indicators for cardiovascular disease compared with the participants in the daily calorie restriction group.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
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In the paper
“Percentage of energy intake from fat, carbohydrates, and protein did not differ significantly over time in any of the groups.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Physical Activity and Dietary Intake
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The dropout rate was highest in the alternate-day fasting group (13 of 34 [38%]), relative to the daily calorie restriction group (10 of 35 [29%]) and control group (8 of 31 [26%]).”
- Also stated in: § RESULTS · plain
“Among the 100 participants (86 women and 14 men; mean [SD] age, 44 [11] years), the dropout rate was highest in the alternate-day fasting group (13 of 34 [38%]), vs the daily calorie restriction group (10 of 35 [29%]) and control group (8 of 31 [26%]).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Participant Characteristics and Attrition
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- Also stated in: § RESULTS · plain
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In the paper
“More participants in the alternate-day fasting group than in the daily calorie restriction group with-drew owing to difficulties adhering with the diet.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Participant Characteristics and Attrition
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction.”
- Also stated in: § Discussion · boosted
“The results of this randomized clinical trial demonstrated that alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or improvement in risk indicators for cardiovascular disease compared with daily calorie restriction.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > CONCLUSIONS AND RELEVANCE
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
- Also stated in: § Discussion · boosted
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction.”
- Also stated in: § Discussion · boosted
“The results of this randomized clinical trial demonstrated that alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or improvement in risk indicators for cardiovascular disease compared with daily calorie restriction.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > CONCLUSIONS AND RELEVANCE
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
- Also stated in: § Discussion · boosted
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction.”
- Also stated in: § Discussion · boosted
“The results of this randomized clinical trial demonstrated that alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or improvement in risk indicators for cardiovascular disease compared with daily calorie restriction.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > CONCLUSIONS AND RELEVANCE
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
- Also stated in: § Discussion · boosted
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All baseline characteristics had comparable distributions between the alternate-day fasting group, the daily calorie restriction group, and the control group (Table 1).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Participant Characteristics and Attrition
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
None of the sources cited for this claim have been checked yet.
In the paper
“Finally, we enrolled predominantly metabolically healthy obese individuals, which may have hindered the abilities of the interventions to produce greater improvements in our measured cardiovascular disease risk indicators.28,29 The generalizability of our findings is also limited by the enrollment.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
What the sources say
- Not checked yetcites [28] Janiszewski PM Ross R Effects of weight loss among metabolically healthy obese men and women Diabetes Care 2010 33 9 1957 1959 20573755 PMC2928342
- Not checked yetcites [29] Kantartzis K Machann J Schick F Effects of a lifestyle intervention in metabolically benign and malign obesity Diabetologia 2011 54 4 864 868 21174075
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Rather, it appears as though many participants in the alternate-day fasting group converted their diet into de facto calorie restriction as the trial progressed.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“The higher dropout rate in the alternate-day fasting group may have also introduced a possible selection bias between groups.27”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
What the sources say
- Not checked yetcites [27] Hernán MA Hernández-Díaz S Robins JM A structural approach to selection bias Epidemiology 2004 15 5 615 625 15308962
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“We chose this design because weight loss typically peaks at 6 months during a lifestyle intervention.16”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Randomization and Intervention Groups
What the sources say
- Not checked yetcites [16] Gardner CD Kiazand A Alhassan S Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial JAMA 2007 297 9 969 977 17341711
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“However, many patients find it difficult to adhere to a conventional weight-loss diet because food intake must be limited every day.2”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > TRIAL REGISTRATION
What the sources say
- Not checked yetcites [2] Moreira EA Most M Howard J Ravussin E Dietary adherence to long-term controlled feeding in a calorie-restriction study in overweight men and women Nutr Clin Pract 2011 26 3 309 315 21586416 PMC4830337
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“As such, adherence to daily calorie restriction decreases after 1 month and continues to decline thereafter.3–5”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > TRIAL REGISTRATION
What the sources say
- Not checked yetcites [3] Dansinger ML Gleason JA Griffith JL Selker HP Schaefer EJ Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial JAMA 2005 293 1 43 53 15632335
- Not checked yetcites [4] Das SK Gilhooly CH Golden JK Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial Am J Clin Nutr 2007 85 4 1023 1030 17413101
- Not checked yetcites [5] Sacks FM Bray GA Carey VJ Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates N Engl J Med 2009 360 9 859 873 19246357 PMC2763382
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“Most of these past studies provided food on the fast day,7,8,10,11 so the provision of food is not a confounder when comparing past findings with present findings.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
What the sources say
- Not checked yetcites [7] Bhutani S Klempel MC Kroeger CM Trepanowski JF Varady KA Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans Obesity (Silver Spring) 2013 21 7 1370 1379 23408502
- Not checked yetcites [8] Hoddy KK Kroeger CM Trepanowski JF Barnosky A Bhutani S Varady KA Meal timing during alternate day fasting: impact on body weight and cardiovascular disease risk in obese adults Obesity (Silver Spring) 2014 22 12 2524 2531 25251676
- Not checked yetcites [10] Klempel MC Kroeger CM Varady KA Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet Metabolism 2013 62 1 137 143 22889512
- Not checked yetcites [11] Varady KA Bhutani S Church EC Klempel MC Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults Am J Clin Nutr 2009 90 5 1138 1143 19793855
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesWhat the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Third, since the dropout rate was higher than anticipated, our power to detect the hypothesized difference of 5% weight loss between the intervention groups at month 6 decreased from 80% to 60%.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction.”
- Also stated in: § Discussion · boosted
“The results of this randomized clinical trial demonstrated that alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or improvement in risk indicators for cardiovascular disease compared with daily calorie restriction.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > CONCLUSIONS AND RELEVANCE
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- The authors state this as an assumption: The missing data mechanism is missing at random.
- Also stated in: § Discussion · boosted
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, these findings suggest that alternate-day fasting may be less sustainable in the long term, compared with daily calorie restriction, for most obese individuals.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- Probably not a substantial claim. 17
- It may state two separate claims as one. 8
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants in the daily calorie restriction group (Figure 2C) met their prescribed energy goals at months 3, 6, and 12 but ate less than their prescribed goal at month 9.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Prescribed vs Actual Energy Intake Determined via Food Records
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- The authors state this as an assumption: The missing data mechanism is missing at random.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“who had previously been sedentary (<60 minutes per week of light activity for the 3 months prior to the study)”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Participants
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All participants were instructed not to change their physical activity habits throughout the trial (eg, not to join a gym) to avoid potential confounding.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Randomization and Intervention Groups
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Tests for normality were included in the model, and all data were found to be normally distributed.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Statistical Analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- The authors state this as an assumption: The missing data mechanism is missing at random.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We calculated that 26 participants per group would provide 80% power to detect a significant difference of 5% in body weight between the alternate-day fasting group and the daily calorie restriction group at month 6, using a 2-tailed independent-samples t test with α = .05.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Statistical Analysis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The participants were primarily metabolically healthy obese women.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Participant Characteristics and Attrition
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“images were analyzed using validated software.20”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Outcome Measures
What the sources say
- Not checked yetcites [20] Demerath EW Ritter KJ Couch WA Validity of a new automated software program for visceral adipose tissue estimation Int J Obes (Lond) 2007 31 2 285 291 16770332 PMC1783906
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We also performed a sensitivity analysis, in which sex and race/ethnicity were included as adjustment covariates in the intention-to-treat mixed model. The inclusion of sex and race/ethnicity did not affect any of the estimated treatment effects reported in Table 2.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Results > Glucoregulatory and Inflammatory Factors
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- The authors state this as an assumption: The missing data mechanism is missing at random.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“mean body mass index, 34”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > DESIGN, SETTING, AND PARTICIPANTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The first-line therapy prescribed to obese patients for weight loss is daily calorie restriction.1”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > TRIAL REGISTRATION
What the sources say
- Not checked yetcites [1] Jensen MD Ryan DH Apovian CM American College of Cardiology/American Heart Association, Task Force on Practice Guidelines; Obesity Society 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society Circulation 2014 129 25(suppl 2) S102 S138 24222017 PMC5819889
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Second, the control group was imperfect, in that they received no food, no counseling, and less attention from study personnel, relative to the intervention groups, which may have confounded our findings.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since many of the participants had normal cholesterol levels and normal blood pressure at baseline, it is not surprising that most risk indicators for cardiovascular disease did not change in response to diet.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The protocol was approved by the Office for the Protection of Research Subjects at the University of Illinois at Chicago, and written informed consent was obtained from all participants.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Participants
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We also failed to include the control group in our initial power calculation.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“To our knowledge, the present study is the longest and largest trial of alternate-day fasting to date.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion
What the sources say
- Not checked yetcites [7] Bhutani S Klempel MC Kroeger CM Trepanowski JF Varady KA Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans Obesity (Silver Spring) 2013 21 7 1370 1379 23408502
- Not checked yetcites [8] Hoddy KK Kroeger CM Trepanowski JF Barnosky A Bhutani S Varady KA Meal timing during alternate day fasting: impact on body weight and cardiovascular disease risk in obese adults Obesity (Silver Spring) 2014 22 12 2524 2531 25251676
- Not checked yetcites [9] Johnson JB Summer W Cutler RG Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma [published correction appears in Free Radic Biol Med. 2007;43(9):1348] Free Radic Biol Med 2007 42 5 665 674 17291990 PMC1859864
- Not checked yetcites [10] Klempel MC Kroeger CM Varady KA Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet Metabolism 2013 62 1 137 143 22889512
- Not checked yetcites [11] Varady KA Bhutani S Church EC Klempel MC Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults Am J Clin Nutr 2009 90 5 1138 1143 19793855
- Not checked yetcites [12] Catenacci VA Pan Z Ostendorf D A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity Obesity (Silver Spring) 2016 24 9 1874 1883 27569118 PMC5042570
- Not checked yetcites [13] Alhamdan BA Garcia-Alvarez A Alzahrnai AH Alternate-day versus daily energy restriction diets: which is more effective for weight loss? a systematic review and meta-analysis Obes Sci Pract 2016 2 3 293 302 27708846 PMC5043510
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear? Based: unclearIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We conducted an intention-to-treat analysis, which included data from all 100 participants who underwent randomization.”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Statistical Analysis
Strength:plain· not yet calibratedn = 100Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- The authors state this as an assumption: The missing data mechanism is missing at random.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“clinicaltrials.gov Identifier: NCT00960505”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > TRIAL REGISTRATION
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants were randomized in a 1:1:1 ratio to an alternate-day fasting group, daily calorie restriction group, or no-intervention control group. Randomization was performed by a stratified random sampling procedure by sex, age (18–42 years and 43–65 years), and body mass index (25.0–32.5 and 32.6–39.9).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Methods > Randomization and Intervention Groups
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“obese adults (18 to 64 years of age; mean body mass index, 34)”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > DESIGN, SETTING, AND PARTICIPANTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“First, the duration of the maintenance phase was short (6 months).”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Discussion > Limitations
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Findings from short-term studies indicate that participants lose 3% to 7% of body weight after 2 to 3 months of alternate-day fasting and experience improvements in lipid profiles, blood pressure, and insulin sensitivity.7–13”
§ Effect of Alternate-Day Fasting onWeight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults > Abstract > TRIAL REGISTRATION
What the sources say
- Not checked yetcites [7] Bhutani S Klempel MC Kroeger CM Trepanowski JF Varady KA Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans Obesity (Silver Spring) 2013 21 7 1370 1379 23408502
- Not checked yetcites [8] Hoddy KK Kroeger CM Trepanowski JF Barnosky A Bhutani S Varady KA Meal timing during alternate day fasting: impact on body weight and cardiovascular disease risk in obese adults Obesity (Silver Spring) 2014 22 12 2524 2531 25251676
- Not checked yetcites [9] Johnson JB Summer W Cutler RG Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma [published correction appears in Free Radic Biol Med. 2007;43(9):1348] Free Radic Biol Med 2007 42 5 665 674 17291990 PMC1859864
- Not checked yetcites [10] Klempel MC Kroeger CM Varady KA Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet Metabolism 2013 62 1 137 143 22889512
- Not checked yetcites [11] Varady KA Bhutani S Church EC Klempel MC Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults Am J Clin Nutr 2009 90 5 1138 1143 19793855
- Not checked yetcites [12] Catenacci VA Pan Z Ostendorf D A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity Obesity (Silver Spring) 2016 24 9 1874 1883 27569118 PMC5042570
- Not checked yetcites [13] Alhamdan BA Garcia-Alvarez A Alzahrnai AH Alternate-day versus daily energy restriction diets: which is more effective for weight loss? a systematic review and meta-analysis Obes Sci Pract 2016 2 3 293 302 27708846 PMC5043510
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The authors state this as an assumption.
The missing data mechanism is missing at random.
“This model provides unbiased estimates of time and treatment effects under a missing-at-random assumption.”
The paper relies on this without support.
No long-term randomized clinical trials have evaluated the efficacy of alternate-day fasting or compared it with a conventional weight-loss diet.
“Despite the growing popularity of alternate-day fasting, to our knowledge, no long-term randomized clinical trials have evaluated its efficacy or compared this regimen with a conventional weight-loss diet.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The superior weight loss in the INT group in the present study is in contrast with the majority of studies that have reported no advantage of intermittent over continuous ER.”
From Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study (2018) · cites this paper as [42]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This trend is consistent with Trepanowski et al.'s findings [74], which also observed improvements in plasma lipids with ADF at 6 months.”
From Comparing caloric restriction regimens for effective weight management in adults: a systematic review and network meta-analysis (2024) · cites this paper as [74]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A recent 12-month clinical trial42 and several recent reviews9,43, 44 have concluded that existing models of intermittent ER (largely versions of intermittent fasting), could be considered equivalent, but not superior, alternatives for weight loss.”
From Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study (2018) · cites this paper as [42]
In the citing paper
“It was demonstrated that although the two intervention groups lost weight, insulin sensitivity, blood lipid levels and blood glucose were not improved.”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [350]
In the citing paper
“A few studies have extended up to 52 weeks and show similar findings (152-155).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [153]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Trial phases total 13 months, not one year
MinorThe stated baseline, weight-loss, and maintenance phases add up to 13 months, although the active trial duration is described as one year (12 months).
Reported 12 · recomputed 13
“The active trial duration was 1 year and consisted of a baseline phase (1 month), a weight-loss phase (6 months), and a weight-maintenance phase (6 months)”
Citations
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A structural approach to selection bias
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Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437739.71477.ee · Cited by 2,735
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Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804748 · Cited by 1,966
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Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.005 · Cited by 604
Flagged first, then by citations
Research works printed but not linked: 1
- [15]The 5:2 Fast Diet For Beginners Berkeley, CA Rockridge Press 2013
Cited by
Sorted by citations
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605
Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.010 · Cited by 1,531
Self-citationTargeting inflammation in atherosclerosis — from experimental insights to the clinic
Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,085
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting
Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 822
“Table 3 presents findings from clinical trials that examined ADMF and ADF regimens (12,54,119,131-135).”
BackgroundMolecular mechanisms of dietary restriction promoting health and longevity
Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714
Metadata
- Authors
- Trepanowski, J. F., Kroeger, C. M., Barnosky, A., Klempel, M. C., Bhutani, S., Hoddy, K. K., Gabel, K., Freels, S., Rigdon, J., Rood, J., Ravussin, E., & Varady, K. A.
- Affiliations
- University of Illinois Chicago (US)
- University of Alabama at Birmingham (US)
- Stanford University (US)
- Pennington Biomedical Research Center (US)
- Nutrition Obesity Research Center, Pennington Biomedical Research Center, Baton Rouge, Louisiana
- Corresponding author
- Varady, Krista A.
- ORCID
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2017-07-01
- Volume
- 177
- Issue
- 7
- Pages
- 930
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC5680777
- OpenAlex
- W2611504779
- Semantic Scholar
- 90534c8b9843eb662b022d9e79d5b5143434d1c6
- Cited by
- 645
- References
- 32
- Citations by year
- 2026: 45 · 2025: 71 · 2024: 76 · 2023: 95 · 2022: 103 · 2021: 90 · 2020: 81 · 2019: 35 · 2018: 38 · 2017: 10
- FWCI
- 33.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL106228)
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK107157, P30DK072476)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Keywords
- alternate-day fasting, caloric restriction, weight loss, weight maintenance, metabolically healthy obesity, cardiovascular risk factors, cardioprotection, dietary adherence, blood pressure, insulin resistance, fasting blood glucose, triglycerides, long-term weight management, heart rate, blood pressure variability, heart rate variability
- MeSH terms
- Adult, Blood Glucose, Cardiovascular Diseases, Diet Therapy, Fasting, Feeding Behavior, Female, Humans, Insulin, Male, Middle Aged, Obesity, Outcome and Process Assessment, Health Care, Patient Compliance, Risk Factors, Weight Loss, Caloric Restriction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-05, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-05 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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