Molecular mechanisms of dietary restriction promoting health and longevity

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mTOR at the nexus of nutrition, growth, ageing and disease

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Mechanisms, regulation and functions of the unfolded protein response

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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FGF-21 as a novel metabolic regulator

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Sirtuins as regulators of metabolism and healthspan

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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

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mTOR is a key modulator of ageing and age-related disease

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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NAD+ metabolism and its roles in cellular processes during ageing

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Antioxidants prevent health-promoting effects of physical exercise in humans

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Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes

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NAD+ and sirtuins in aging and disease

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

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Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Impact of intermittent fasting on health and disease processes

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SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

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Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

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Dwarf mice and the ageing process

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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

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The sirtuin SIRT6 regulates lifespan in male mice

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Caloric restriction improves health and survival of rhesus monkeys

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Regulation of Immune Responses by mTOR

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Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

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How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

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Caloric restriction

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Autophagy as a promoter of longevity: insights from model organisms

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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

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Caloric Intake and Aging

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

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Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

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