Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19
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This case-control study examines the association between receipt of the bradykinin 2 (B2) receptor antagonist icatibant and improved oxygenation in patients with coronavirus disease 2019 (COVID-19).
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Icatibant for the kallikrein-kinin system and anti-C5a/C3a antibodies for coagulation have been proposed to ease symptoms and lower death rates.
“Along these lines, therapies targeting the kallikrein-kinin system with icatibant (van de Veerdonk et al., 2020), or the coagulation system with antibodies against C5a and C3a (Mastellos et al., 2020), have been introduced as additional options to ameliorate clinical symptoms and reduce mortality rates.”
From COVID-19 and the human innate immune system (2021) · cites this paper as van de Veerdonk et al., 2020
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- Authors
- van de Veerdonk, F. L., Kouijzer, I. J. E., de Nooijer, A. H., van der Hoeven, H. G., Maas, C., Netea, M. G., & Brüggemann, R. J. M.
- Affiliations
- Radboudumc Institute for Molecular Life Sciences, Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands
- Radboud University Medical Center (NL)
- Department of Intensive Care Medicine, Radboudumc, Nijmegen, the Netherlands
- University Medical Center Utrecht (NL)
- University of Bonn (DE)
- Venue
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Published
- 2020-08-13
- Volume
- 3
- Issue
- 8
- Pages
- e2017708
- ISSN
- 2574-3805 (ISSN-L)
- PMC
- PMC7426743
- OpenAlex
- W3048929918
- Cited by
- 65
- References
- 3
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 17 · 2021: 22 · 2020: 8
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JAMA Network Open (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- COVID-19 pandemic, icatibant, bradykinin B2 receptor antagonist, oxygenation, hypoxemia, treatment outcomes
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Adult, Aged, Bradykinin, Female, Humans, Male, Middle Aged, Oxygen, Pneumonia, Viral, Coronavirus Infections, Receptor, Bradykinin B2, Pandemics, Bradykinin B2 Receptor Antagonists
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