Cited by 167Coagulation, Bradykinin, Polyphosphates, and AngioedemaRenin-Angiotensin System StudiesComplement system in diseases

Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

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Bekassy, Zivile, Lopatko Fagerström, Ingrid, Bader, Michael, Karpman, Diana·2022·Nature reviews. Immunology

Abstract

During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin-angiotensin system, the complement system, and the closely linked kallikrein-kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.

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Authors
Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D.
Affiliations
Lund University (SE)
Corresponding author
Karpman, Diana
Venue
Nature reviews. Immunology
Published
2021-11-10
Volume
22
Issue
7
Pages
411-428
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W3211940634
Cited by
167
References
290
Citations by year
2026: 25 · 2025: 34 · 2024: 46 · 2023: 42 · 2022: 20
FWCI
3.85
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB1365)
  • Crafoordska Stiftelsen
  • Knut och Alice Wallenbergs Stiftelse (Wallenberg Clinical Scholar 2015.0320, 2015.0320)
  • Vetenskapsrådet (2017-01920)
Topics
  • Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Keywords
renin-angiotensin system, complement system, kallikrein-kinin system, contact system, inflammation, hereditary angioedema, vasculitis, glomerular disease, COVID-19 pandemic, vascular tone, vascular leakage, thrombosis, chemotaxis, cell proliferation, cardiovascular disease, kidney disease, therapeutic target
MeSH terms
COVID-19, Complement System Proteins, Humans, Inflammation, Renin-Angiotensin System, Thrombosis, Kallikrein-Kinin System

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