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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease

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Regional Development of the Brain in Early Life

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Apolipoprotein E: Far More Than a Lipid Transport Protein

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Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects

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ApoE4-Mediated Blood Brain Barrier Damage in Alzheimer's Disease: Progress and Prospects

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Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy

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Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review

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More than just risk for Alzheimer’s disease: APOE ε4's impact on the aging brain

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Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline

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Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle‐Aged Adults

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Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status

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Evolving brain structural changes in PSEN1 mutation carriers

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Alzheimer's disease and other dementias: advances in 2013

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Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science

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Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling

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Towards Personalized Intervention for Alzheimer’s Disease

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Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele

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Apolipoprotein E Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells

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Longitudinal change in working memory as a function of APOE genotype in midlife and old age

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Adverse Effects of the Apolipoprotein E ε4 Allele on Episodic Memory, Task Switching and Gray Matter Volume in Healthy Young Adults

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Dementia prevention and reserve against neurodegenerative disease

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A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment

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Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

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Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

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TMEM106B Influences Volume of Left-Sided Temporal Lobe and Interhemispheric Structures in the General Population

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Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects

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APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM2.5 Polluted Cities

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A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank

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Associations Between ApoEε4 Carrier Status and Serum BDNF Levels—New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer’s Disease

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APOE effects on cognition from childhood to adolescence

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White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

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The APOE ε4 variant and hippocampal atrophy in Alzheimer’s disease and Lewy body dementia: a systematic review of magnetic resonance imaging studies and therapeutic relevance

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Healthy Food Pyramid as Well as Physical and Mental Activity in the Prevention of Alzheimer’s Disease

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Effects of polyphenols and their metabolites on age-related diseases

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Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

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Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4

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Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes

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Childhood Learning Disabilities and Atypical Dementia: A Retrospective Chart Review

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Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4

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Cingulate-centered large-scale networks: Normal functions, aging, and neurodegenerative disease

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Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns

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White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease

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Association between polygenic risk for Alzheimer’s disease and brain structure in children and adults

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The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer’s Disease

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Use of the NESMA Filter to Improve Myelin Water Fraction Mapping with Brain MRI

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Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4

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Pathway-specific polygenic scores for Alzheimer’s disease are associated with changes in brain structure in younger and older adults

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Interplay Between Aging and Tau Pathology in Alzheimer’s Disease: Mechanisms and Translational Perspectives

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Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults

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Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging

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Vascular Dysfunction Is Central to Alzheimer’s Disease Pathogenesis in APOE e4 Carriers

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Advanced neuroimaging to quantify myelin in vivo: Application to mild TBI

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Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations

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APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

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Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia

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Let Food Be Thy Medicine: Diet, Nutrition, and Biomarkers’ Risk of Alzheimer’s Disease

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Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task

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Predictors That a Diagnosis of Mild Cognitive Impairment Will Remain Stable 3 Years Later

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Alzheimer’s Disease, Drosophila melanogaster and Polyphenols

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APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

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Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

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Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents

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Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

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Low household income and neurodevelopment from infancy through adolescence

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Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease

Duarte-Abritta, B., Villarreal, M. F., Abulafia, C., Loewenstein, D., Curiel, R. E., Castro, M. N., Surace, E. I., Sánchez, S. M., Vigo, D. E., Vázquez, S., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.10.008 · Cited by 17

Exploring the ATN classification system using brain morphology

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Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents

Dell’Acqua, F., Khan, W., Gottlieb, N., Giampietro, V., Ginestet, C. E., Bouls, D., Newhouse, S., Dobson, R., Banaschewski, T., Barker, G. J., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-140519 · Cited by 14

Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults

Yokoyama, J. S., Lee, A. K. L., Takada, L. T., Busovaca, E., Bonham, L. W., Chao, S. Z., Tse, M., He, J., Schwarz, C. G., Carmichael, O. T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118338 · Cited by 16

APOEandKIBRAInteractions on Brain Functional Connectivity in Healthy Young Adults

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Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture

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Dementia risk in women higher in same‐sex than opposite‐sex twins

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Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome

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Midlife Consequences of Cumulative Blood Pressure Exposure

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Neuroimaging genetic risk for Alzheimer’s disease in preclinical individuals: from candidate genes to polygenic approaches

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Normal Aging and Dementia

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Vascular Risk Factors and Midlife Cognition

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Exploring potential developmental origins of common neurodegenerative disorders

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Alzheimer's disease

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Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesPreprint

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Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer’s disease and/or major depressive disorder

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Is Apolipoprotein E Required for Cognitive Function in Humans?

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Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer’s disease-like pathologies in male mouse model

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Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene

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The puzzle of preserved cognition in the oldest old

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A profile of brain reserve in adults at genetic risk of Alzheimer's disease

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Alzheimer’s risk variant APOE4 linked to myelin-assembly malfunction

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Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

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Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype

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Burden of psychiatric disease inversely correlates with Alzheimer's age at onset

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What can pediatricians learn from adult inherited metabolic diseases?

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Highlights

(2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4126

Alzheimer Gene Linked to Brain Development

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Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele

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P1‐199: ApoE‐e4 is associated with altered myelin content in preclinical ad

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