Comparing moral judgments of patients with frontotemporal dementia and frontal stroke
Open accessAbstract
IMPORTANCE: Several clinical reports have stated that patients with prefrontal lesions or patients with the behavioral variant of frontotemporal dementia share social cognition impairments. Moral reasoning is impaired in both conditions but there have been few investigations that directly compare this domain in the 2 groups. OBSERVATIONS: This work compared the moral judgments of these patient groups using a task designed to disentangle the contributions of intentions and outcomes in moral judgment. For both disorders, patients judged scenarios where the protagonists believed that they would cause harm but did not as being more permissible than the control group. Moreover, patients with frontotemporal dementia judged harmful outcomes in the absence of harmful intentions as less permissible than the control participants. There were no differences between the 2 conditions. CONCLUSIONS AND RELEVANCE: Both disorders involved impairments in integrating intention and outcome information for moral judgment. This study was the first, to our knowledge, to directly compare a social cognition domain in 2 frontal pathologies with different etiology. Our results highlighted the importance of comparing patients with vascular lesions and patients with neurodegenerative diseases.
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Changes in processing of moral dimensions in bvFTD have been documented using verbal or pictorial scenarios describing moral situations followed by a moral judgement query.
“Changes in processing of moral dimensions in bvFTD have been documented using verbal or pictorial scenarios describing moral situations followed by a moral judgement query (Mendez et al. , 2005; Baez et al. , 2014).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Baez et al. , 2014
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- Authors
- Baez, S., Couto, B., Torralva, T., Sposato, L. A., Huepe, D., Montañes, P., Reyes, P., Matallana, D., Vigliecca, N. S., Slachevsky, A., Manes, F., & Ibanez, A.
- Affiliations
- Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina2UDP-INECO Foundation Core on Neuroscience, Diego Portales University, Santiago, Chile3National Scientific and Technical Research Council, Buenos
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Favaloro University (AR)
- Western University (CA)
- Universidad Diego Portales (CL)
- Universidad Javeriana, Facultad de Medicina, Instituto de Envejecimiento, Departamento de Psiquiatría y Salud Mental, Centro de Memoria y Cognición, Hospital San Ignacio, Bogota, Colombia8Universidad Nacional de Colombia, Bogota, Colombia
- Pontificia Universidad Javeriana (CO)
- Hospital del Salvador (CL)
- Australian Research Council (AU)
- ORCID
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2014-09-01
- Volume
- 71
- Issue
- 9
- Pages
- 1172
- ISSN
- 2168-6149 (ISSN-L)
- OpenAlex
- W2078651530
- Cited by
- 93
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 3 · 2014: 4
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Institucional (Pontificia Universidad Javeriana) (submittedVersion, cc-by-nc)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Scholarship@Western (Western University) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Psychology of Moral and Emotional Judgment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- moral judgment, frontotemporal dementia, behavioral variant frontotemporal dementia, social cognition, prefrontal lesions, vascular lesions, neurodegenerative diseases, moral reasoning
- MeSH terms
- Adult, Cerebrovascular Disorders, Humans, Judgment, Magnetic Resonance Imaging, Male, Middle Aged, Morals, Social Perception, Prefrontal Cortex, Stroke, Frontotemporal Dementia
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