Neuropsychiatric symptoms as predictors of clinical course in neurodegeneration. A longitudinal study
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Background: To study the extent that neuropsychiatric symptoms (NPS) influence the cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer’s disease (AD). Methods: We assessed the progression of NPS and their influence on cognitive and functional progression in a group of FTD [n=36] and AD patients [n=47] at two different stages of the disease (2.5 years). A standardized scale was used to assess NPS - Columbia University Scale for Psychopathology in Alzheimer’s Disease (CUSPAD), which tracks different symptoms including depression, psychotic symptoms, as well as sleep, and conduct problems. In addition, in a subsample of patients (AD n=14 and FTD n= 14), we analyzed another group of NPS by using the Neuropsychiatric Inventory (NPI). Cognitive declines were tracked by using the Montreal Cognitive Assessment (MoCA), the Mini-mental state examination (MMSE); and functionality was tracked by using the Lawton scale and the Barthel Index. Results: The presence of NPS impacts cognitive and functional decline in both groups of patients 2.5 years after disease onset. However, we observed a dissociable profile of the affectation of NPS in each group. In the AD group, results indicate that the progression of depressive symptoms and sleep problems predict cognitive and functional decline. In contrast, the progression of a mixed group of NPS including conduct problems and delusions predict cognitive and functional decline in FTD. Conclusion: The presence of NPS have a critical impact on the prediction of cognitive decline in FTD and AD patients after 2.5 years of disease progression. Our results demonstrate the importance of assessing different types of NPS in neurodegenerative disorders which in turn, predict disease progression. Future studies should assess the role of NPS in predicting different neurocognitive pathways and in neurodegeneration. Keywords: Frontotemporal dementia, Alzheimer’s disease, behavioral disturbances, depression, cohort studies, assessment of cognitive disorders/dementia.
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Parts of AD-oriented neuropsychiatric scales, such as the NPI and CUSPAD, predicted cognitive and functional decline in FTD (2.5 years).
“While parts of AD-oriented neuropsychiatric scales, such as the NPI and the Columbia University Scale for Psychopathology in Alzheimer’s Disease (CUSPAD), predicted cognitive and functional decline in FTD (2.5 years) (Santacruz Escudero et al., 2019), associations with disease severity were inconsistent (Josephs et al., 2011; Kazui et al., 2016; Ranasinghe et al., 2016) and the evidence as bvFTD-s”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Santacruz Escudero et al., 2019
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Dhikav, V., Sethi, M., & Anand, K. S. (2014) · British Journal of Radiology · doi:10.1259/bjr.20140150 · Cited by 40 · see citing works
Ismail, Z., Emeremni, C. A., Houck, P. R., Mazumdar, S., Rosen, J., Rajji, T. K., Pollock, B. G., & Mulsant, B. H. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.013 · Cited by 40 · see citing works
Hallikainen, I. T., Hongisto, K., Välimäki, T. H., Hänninen, T., Martikainen, J. A., & Koivisto, A. M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170697 · Cited by 38 · see citing works
Psychosis in behavioral variant frontotemporal dementia
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First Symptoms and Neurocognitive Correlates of Behavioral Variant Frontotemporal Dementia
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Self-citationIs early‐onset clinically different from late‐onset frontotemporal dementia?
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The Measurement of Psychosis in Dementia
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Type 2 Diabetes Aggravates Alzheimer's Disease-Associated Vascular Alterations of the Aorta in Mice
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(1965) · PubMed
Flagged first, then by citations
Cited by
Sorted by citations
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
- Authors
- Santacruz Escudero, J. M., Beltrán, J., Palacios, Á., Chimbí, C. M., Matallana, D., Reyes, P., Perez-Sola, V., & Santamaría-García, H.
- Affiliations
- Pontificia Universidad Javeriana (CO)
- Hospital Universitario San Ignacio (CO)
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-07-24
- Volume
- 11
- Pages
- 176-176
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC6668630
- OpenAlex
- W2962854462
- Cited by
- 41
- References
- 92
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 2
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- neuropsychiatric symptoms, frontotemporal dementia, Alzheimer's disease, cognitive decline, functional decline, behavioral problems, depression, sleep disorders, conduct problems, delusions, disease progression, Neuropsychiatric Inventory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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