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Cited by 143Dementia and Cognitive Impairment ResearchChronic Obstructive Pulmonary Disease (COPD) ResearchCancer-related cognitive impairment studies

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

A Prospective Study of Chronic Obstructive Pulmonary Disease and the Risk for Mild Cognitive Impairment

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Singh, Balwinder, Mielke, Michelle M., Parsaik, Ajay K., Cha, Ruth H., Roberts, Rosebud O., Scanlon, Paul D., Geda, Yonas E., Christianson, Teresa J., Pankratz, V. Shane, Petersen, Ronald C.·2014·JAMA Neurology
DOI 10.1001/jamaneurol.2014.94PMC PMC4020948
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Abstract

IMPORTANCE: Previous studies suggest cross-sectional associations between a diagnosis of chronic obstructive pulmonary disease (COPD) and mild cognitive impairment (MCI). However, few studies have assessed whether COPD, a potentially modifiable factor, is associated with an increased risk for MCI and whether the relation is specific to the type of MCI. OBJECTIVE: To investigate whether a diagnosis of COPD and duration of COPD are associated with an increased risk for incident MCI and MCI subtypes (amnestic MCI [A-MCI] and nonamnestic MCI [NA-MCI]). DESIGN, SETTING, AND PARTICIPANTS: A prospective population-based cohort from the Mayo Clinic Study on Aging. We included 1425 cognitively normal individuals aged 70 to 89 years who were randomly selected from Olmsted County, Minnesota, on October 1, 2004, using the medical records linkage system. At baseline and every 15 months thereafter, participants underwent assessment with a nurse interview, neurologic examination, and neuropsychological testing. A diagnosis of COPD was confirmed via medical record review. A baseline diagnosis of COPD and duration of COPD were examined as risk factors for MCI and MCI subtypes using Cox proportional hazards models and adjusting for demographic variables and medical comorbidities, with age as the time scale. EXPOSURE: A baseline diagnosis of COPD and duration of COPD. MAIN OUTCOMES AND MEASURES: Incident MCI, A-MCI, and NA-MCI. RESULTS: Of the 1425 participants with normal cognition at baseline, 370 developed incident MCI. The median duration of follow-up was 5.1 years (interquartile range, 3.8-5.4 years). A diagnosis of COPD significantly increased the risk for NA-MCI by 83% (hazard ratio, 1.83 [95% CI, 1.04-3.23]), but not of any MCI or A-MCI in multivariate analyses. We found a dose-response relationship such that individuals with COPD duration of longer than 5 years at baseline had the greatest risk for any MCI (hazard ratio, 1.58 [95% CI, 1.04-2.40]) and NA-MCI (2.58 [1.32-5.06]). CONCLUSIONS AND RELEVANCE: A diagnosis of COPD is associated with an increased risk for MCI, particularly NA-MCI. We have found a dose-response relationship between COPD duration and risk for MCI. These findings highlight the importance of COPD as a risk factor for MCI and may provide a substrate for early intervention to prevent or delay the onset and progression of MCI, particularly NA-MCI.

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Authors
Singh, B., Mielke, M. M., Parsaik, A. K., Cha, R. H., Roberts, R. O., Scanlon, P. D., Geda, Y. E., Christianson, T. J., Pankratz, V. S., & Petersen, R. C.
Affiliations
Mayo Clinic (US)
Corresponding author
Mielke, Michelle M.
ORCID
Venue
JAMA Neurology
Publisher
American Medical Association (AMA)
Published
2014-05-01
Volume
71
Issue
5
Pages
581
ISSN
2168-6149 (ISSN-L)
DOI
10.1001/jamaneurol.2014.94
PMC
PMC4020948
OpenAlex
W2061580724
Cited by
143
References
46
Citations by year
2026: 7 · 2025: 13 · 2024: 6 · 2023: 16 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 11 · 2018: 16 · 2017: 13 · 2016: 7 · 2015: 16 · 2014: 6
FWCI
10.69
Type
journal article
Language
en
Open access
Locations
  • JAMA Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000135)
  • National Institute on Aging (R01AG034676, U01AG006786, K01AG028573, P50AG016574)
  • National Institute of Mental Health (K01MH068351)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
chronic obstructive pulmonary disease, mild cognitive impairment, non-amnestic mild cognitive impairment, amnestic mild cognitive impairment, cognitive decline risk, older adults, dose-response relationship, modifiable risk factors
MeSH terms
Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Male, Population Surveillance, Prospective Studies, Risk Factors, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Cognitive Dysfunction

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