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A Prospective Study of Chronic Obstructive Pulmonary Disease and the Risk for Mild Cognitive Impairment
Open accessAbstract
IMPORTANCE: Previous studies suggest cross-sectional associations between a diagnosis of chronic obstructive pulmonary disease (COPD) and mild cognitive impairment (MCI). However, few studies have assessed whether COPD, a potentially modifiable factor, is associated with an increased risk for MCI and whether the relation is specific to the type of MCI. OBJECTIVE: To investigate whether a diagnosis of COPD and duration of COPD are associated with an increased risk for incident MCI and MCI subtypes (amnestic MCI [A-MCI] and nonamnestic MCI [NA-MCI]). DESIGN, SETTING, AND PARTICIPANTS: A prospective population-based cohort from the Mayo Clinic Study on Aging. We included 1425 cognitively normal individuals aged 70 to 89 years who were randomly selected from Olmsted County, Minnesota, on October 1, 2004, using the medical records linkage system. At baseline and every 15 months thereafter, participants underwent assessment with a nurse interview, neurologic examination, and neuropsychological testing. A diagnosis of COPD was confirmed via medical record review. A baseline diagnosis of COPD and duration of COPD were examined as risk factors for MCI and MCI subtypes using Cox proportional hazards models and adjusting for demographic variables and medical comorbidities, with age as the time scale. EXPOSURE: A baseline diagnosis of COPD and duration of COPD. MAIN OUTCOMES AND MEASURES: Incident MCI, A-MCI, and NA-MCI. RESULTS: Of the 1425 participants with normal cognition at baseline, 370 developed incident MCI. The median duration of follow-up was 5.1 years (interquartile range, 3.8-5.4 years). A diagnosis of COPD significantly increased the risk for NA-MCI by 83% (hazard ratio, 1.83 [95% CI, 1.04-3.23]), but not of any MCI or A-MCI in multivariate analyses. We found a dose-response relationship such that individuals with COPD duration of longer than 5 years at baseline had the greatest risk for any MCI (hazard ratio, 1.58 [95% CI, 1.04-2.40]) and NA-MCI (2.58 [1.32-5.06]). CONCLUSIONS AND RELEVANCE: A diagnosis of COPD is associated with an increased risk for MCI, particularly NA-MCI. We have found a dose-response relationship between COPD duration and risk for MCI. These findings highlight the importance of COPD as a risk factor for MCI and may provide a substrate for early intervention to prevent or delay the onset and progression of MCI, particularly NA-MCI.
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“Moreover, COPD is associated with a significant risk of developing mild cognitive impairment, especially in patients older than 70 years [18].”
From A psychological intervention to promote acceptance and adherence to non-invasive ventilation in people with chronic obstructive pulmonary disease: study protocol of a randomised controlled trial. (2017) · cites this paper as [18]
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Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965
Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Unified Parkinson's Disease Rating Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_184495 · Cited by 3,071
Chronic Obstructive Pulmonary Disease
Flavin, K., Morkane, C. M., & Marsh, S. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108233712.025 · Cited by 2,687
Rabe, K. F. (2007) · American Journal of Respiratory and Critical Care Medicine · Cited by 2,567
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306
Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale
Fahn, S. (1987) · Medical Entomology and Zoology · Cited by 2,163
History of the Rochester Epidemiology Project
Melton, L. J. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.3.266 · Cited by 1,443
Keatings, V. M., COLLINS, P. D., Scott, D. M., & Barnes, P. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564092 · Cited by 1,359
Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430407 · Cited by 1,078
Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Pankratz, V. S., Boeve, B. F., Ivnik, R. J., Tangalos, E. G., Petersen, R. C., & Rocca, W. A. (2008) · Neuroepidemiology · doi:10.1159/000115751 · Cited by 797
Self-citationPrevalence of mild cognitive impairment is higher in men
Petersen, R. C., Roberts, R. O., Knopman, D. S., Geda, Y. E., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., & Rocca, W. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f11d85 · Cited by 771
Self-citationChronic obstructive pulmonary disease
Barnes, P. J., Burney, P., Silverman, E. K., Celli, B. R., Vestbo, J., Wedzicha, J. A., & Wouters, E. F. �. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.76 · Cited by 761
Inflammatory markers and cognition in well-functioning African-American and white elders
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706
Sauver, J. L. S., Grossardt, B. R., Leibson, C. L., Yawn, B. P., Melton, L. J., & Rocca, W. A. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2011.11.009 · Cited by 652
Mayo's older americans normative studies: WAIS-R norms for ages 56 to 97
Ivnik, R. J., Malec, J. F., Smith, G. E., Tangalos, E. G., Petersen, R. C., Kokmen, E., & Kurland, L. T. (1992) · The Clinical Neuropsychologist · doi:10.1080/13854049208401877 · Cited by 446
Self-citationDodd, J. W., Getov, S. V., & Jones, P. W. (2010) · European Respiratory Journal · doi:10.1183/09031936.00125109 · Cited by 426
Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease
Grant, I. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340210062015 · Cited by 416
Cardiovascular Comorbidity in COPD
Müllerová, H., Agustí, A. G. N., Erqou, S. A., & Mapel, D. W. (2013) · CHEST Journal · doi:10.1378/chest.12-2847 · Cited by 360
Prevalence, severity and underdiagnosis of COPD in the primary care setting
Bednarek, M., Maciejewski, J., Wozniak, M., Kuca, P., & Zielinski, J. (2008) · Thorax · doi:10.1136/thx.2007.085456 · Cited by 358
The Short Test of Mental Status
Kokmen, E. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530190071018 · Cited by 338
COPD Surveillance—United States, 1999-2011
Ford, E. S., Croft, J. B., Mannino, D. M., Wheaton, A. G., Zhang, X., & Giles, W. H. (2013) · CHEST Journal · doi:10.1378/chest.13-0809 · Cited by 304
The incidence of MCI differs by subtype and is higher in men
Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., Rocca, W. A., & Petersen, R. C. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452862 · Cited by 290
Self-citationThe Interrelationship of Sputum Inflammatory Markers in Patients with Chronic Bronchitis
HILL, A. T., Bayley, D., & STOCKLEY, R. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9901091 · Cited by 230
Plasma clusterin and the risk of Alzheimer disease
Schrijvers, E. M. C. (2011) · JAMA · doi:10.1001/jama.2011.381 · Cited by 220
Singh, B., Singh, A., Ahmed, A., Wilson, G. A., Pickering, B. W., Herasevich, V., Gajic, O., & Li, G. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.04.015 · Cited by 209
Self-citationChronic Obstructive Pulmonary Disease: An Original Model of Cognitive Decline
Incalzi, R. A., Gemma, A., Marra, C., Muzzolon, R., Capparella, O., & Carbonin, P. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.2.418 · Cited by 198
Mild Cognitive Impairment in Moderate to Severe COPD
Villeneuve, S., Pepin, V., Rahayel, S., Bertrand, J., de Lorimier, M., Rizk, A., Desjardins, C., Parenteau, S., Beaucage, F., Joncas, S., et al. (2012) · CHEST Journal · doi:10.1378/chest.11-3035 · Cited by 186
Cognitive impairment in chronic obstructive pulmonary disease
Antonelli Incalzi, R., Marra, C., Giordano, A., Calcagni, M. L., Cappa, A., Basso, S., Pagliari, G., & Fuso, L. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1005-4 · Cited by 172
Ortapamuk, H., & Naldöken, S. (2006) · Annals of Nuclear Medicine · doi:10.1007/bf02985621 · Cited by 156
Cooke, C. R., Joo, M. J., Anderson, S. M., Lee, T. A., Udris, E. M., Johnson, E., & Au, D. H. (2011) · BMC Health Services Research · doi:10.1186/1472-6963-11-37 · Cited by 149
Association of C‐reactive protein with mild cognitive impairment
Roberts, R. O., Geda, Y. E., Knopman, D. S., Boeve, B. F., Christianson, T. J. H., Pankratz, V. S., Kullo, I. J., Tangalos, E. G., Ivnik, R. J., & Petersen, R. C. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.025 · Cited by 136
Self-citationCognitive dysfunction in patients with chronic obstructive pulmonary disease – A systematic review
Schou, L., Østergaard, B., Rasmussen, L. S., Rydahl-Hansen, S., & Phanareth, K. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.03.013 · Cited by 131
Critical threshold cerebral hypoperfusion causes Alzheimer's disease?
de la Torre, J. C. (1999) · Acta Neuropathologica · doi:10.1007/s004010051044 · Cited by 124
Rusanen, M., Ngandu, T., Laatikainen, T. K., Tuomilehto, J., Soininen, H. S., & Kivipelto, M. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310050011 · Cited by 113
Stuss, D. T., Peterkin, I. R., Guzman, D., Guzmán, C. A., & Troyer, A. K. (1997) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639708403741 · Cited by 112
Case Definitions for Chronic Obstructive Pulmonary Disease
Hnizdo, E., Glindmeyer, H. W., Petsonk, E. L., Enright, P., & Buist, A. S. (2006) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550600651552 · Cited by 105
Metabolic Syndrome, Inflammation, and Nonamnestic Mild Cognitive Impairment in Older Persons
Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Boeve, B. F., Ivnik, R. J., Pankratz, V. S., Tangalos, E. G., & Petersen, R. C. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181a4485c · Cited by 85
Self-citationAlsara, A., Warner, D. O., Li, G., Herasevich, V., Gajic, O., & Kor, D. J. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0802 · Cited by 84
Hypertension is Associated With Cognitive Decline in Elderly People at High Risk for Dementia
Wysocki, M., Luo, X., Schmeidler, J., Dahlman, K. L., Lesser, G. T., Grossman, H. T., Haroutunian, V. H., & Beeri, M. S. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820ee833 · Cited by 78
Cardiac Disease Associated With Increased Risk of Nonamnestic Cognitive Impairment
Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., Ivnik, R. J., Mielke, M. M., & Petersen, R. C. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.607 · Cited by 67
Self-citationSingh, B., Parsaik, A. K., Mielke, M. M., Roberts, R. O., Scanlon, P. D., Geda, Y. E., Pankratz, V. S., Christianson, T. J. H., Yawn, B. P., & Petersen, R. C. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.08.012 · Cited by 66
Self-citationLi, J., Huang, Y., & Fei, G. (2012) · Respiration · doi:10.1159/000342970 · Cited by 50
Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI)
Ettorre, E., Cerra, E., Marigliano, B., Vigliotta, M. T., Vulcano, A., FOSSATI, C., Benedetto, G. D., Servello, A., Andreozzi, P., & Marigliano, V. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.04.025 · Cited by 36
Prieto-Centurion, V., Huang, F. F.-Y., Naureckas, E. T., Camargo, C. A., Charbeneau, J., Joo, M. J., Press, V. G., & Krishnan, J. A. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-73 · Cited by 32
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Morley, J. E., Morris, J. C., Berg‐Weger, M., Soo Borson, B., Carpenter, B. D., del Campo, N., Dubois, B., Fargo, K. N., Fitten, L. J., Flaherty, J. H., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.06.017 · Cited by 341
Self-citationLiu, Y.-H., Chen, Y., Wang, Q.-H., Wang, L.-R., Jiang, L., Yang, Y., Chen, X., Li, Y., Cen, Y., Xu, C., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0461 · Cited by 225
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Vassilaki, M. E., Aakre, J. A., Cha, R. H., Kremers, W. K., Sauver, J. L. S., Mielke, M. M., Geda, Y. E., Machulda, M. M., Knopman, D. S., Petersen, R. C., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13612 · Cited by 238
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Metadata
- Authors
- Singh, B., Mielke, M. M., Parsaik, A. K., Cha, R. H., Roberts, R. O., Scanlon, P. D., Geda, Y. E., Christianson, T. J., Pankratz, V. S., & Petersen, R. C.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Mielke, Michelle M.
- ORCID
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2014-05-01
- Volume
- 71
- Issue
- 5
- Pages
- 581
- ISSN
- 2168-6149 (ISSN-L)
- PMC
- PMC4020948
- OpenAlex
- W2061580724
- Cited by
- 143
- References
- 46
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 6 · 2023: 16 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 11 · 2018: 16 · 2017: 13 · 2016: 7 · 2015: 16 · 2014: 6
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000135)
- National Institute on Aging (R01AG034676, U01AG006786, K01AG028573, P50AG016574)
- National Institute of Mental Health (K01MH068351)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- chronic obstructive pulmonary disease, mild cognitive impairment, non-amnestic mild cognitive impairment, amnestic mild cognitive impairment, cognitive decline risk, older adults, dose-response relationship, modifiable risk factors
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Male, Population Surveillance, Prospective Studies, Risk Factors, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Cognitive Dysfunction
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