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Association Between Maternal Perinatal Depression and Anxiety and Child and Adolescent Development: A Meta-analysis
Open accessAbstract
Importance: There is widespread interest in associations between maternal perinatal depression and anxiety and offspring development; however, to date, there has been no systematic, meta-analytic review on the long-term developmental outcomes spanning infancy through adolescence. Objective: To provide a comprehensive systematic review and meta-analysis of the extant literature on associations between maternal perinatal depression and anxiety and social-emotional, cognitive, language, motor, and adaptability outcomes in offspring during the first 18 years of life. Data Sources: Six databases were searched (CINAHL Complete, Cochrane Library, Embase, Informit, MEDLINE Complete, and PsycInfo) for all extant studies reporting associations between perinatal maternal mental health problems and offspring development to March 1, 2020. Study Selection: Studies were included if they were published in English; had a human sample, quantitative data, a longitudinal design, and measures of perinatal depression and/or anxiety and social-emotional, cognitive, language, motor, and/or adaptability development in offspring; and investigated an association between perinatal depression or anxiety and childhood development. Data Extraction and Synthesis: Of 27 212 articles identified, 191 were eligible for meta-analysis. Data were extracted by multiple independent observers and pooled using a fixed- or a random-effects model. A series of meta-regressions were also conducted. Data were analyzed from January 1, 2019, to March 15, 2020. Main Outcomes and Measures: Primary outcomes included social-emotional, cognitive, language, motor, and adaptability development in offspring during the first 18 years of life. Results: After screening, 191 unique studies were eligible for meta-analysis, with a combined sample of 195 751 unique mother-child dyads. Maternal perinatal depression and anxiety were associated with poorer offspring social-emotional (antenatal period, r = 0.21 [95% CI, 0.16-0.27]; postnatal period, r = 0.24 [95% CI, 0.19-0.28]), cognitive (antenatal period, r = -0.12 [95% CI, -0.19 to -0.05]; postnatal period, r = -0.25 [95% CI, -0.39 to -0.09]), language (antenatal period, r = -0.11 [95% CI, -0.20 to 0.02]; postnatal period, r = -0.22 [95% CI, -0.40 to 0.03]), motor (antenatal period, r = -0.07 [95% CI, -0.18 to 0.03]; postnatal period, r = -0.07 [95% CI, -0.16 to 0.03]), and adaptive behavior (antenatal period, r = -0.26 [95% CI, -0.39 to -0.12]) development. Findings extended beyond infancy, into childhood and adolescence. Meta-regressions confirmed the robustness of the results. Conclusions and Relevance: Evidence suggests that perinatal depression and anxiety in mothers are adversely associated with offspring development and therefore are important targets for prevention and early intervention to support mothers transitioning into parenthood and the health and well-being of next-generation offspring.
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“Correspondingly, perinatal depression and anxiety are associated with poorer offspring outcomes spanning from infancy through to adolescence, across mental health (Srinivasan et al., 2020), cognitive, language, motor, and adaptive behaviour domains (Rogers et al., 2020).”
From Associations between maternal psychological distress and mother-infant bonding: a systematic review and meta-analysis (2023) · cites this paper as Rogers et al., 2020
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Depression and anxiety in pregnancy during COVID-19: A rapid review and meta-analysis
Tomfohr‐Madsen, L. M., Racine, N. M., Giesbrecht, G. F., Lebel, C. A., & Madigan, S. L. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113912 · Cited by 248
O’Dea, G. A., Youssef, G. J., Hagg, L. J., Francis, L. M., Spry, E. A., Rossen, L., Smith, I., Teague, S. J., Mansour, K., Booth, A., et al. (2023) · Archives of Women's Mental Health · doi:10.1007/s00737-023-01332-1 · Cited by 213
Self-citationRacine, N. M., Eirich, R., Cooke, J. E., Zhu, J., Pador, P., Dunnewold, N., & Madigan, S. L. (2021) · Infant Mental Health Journal · doi:10.1002/imhj.21959 · Cited by 136
Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy
Sha, Q., Madaj, Z. B., Keaton, S. A., Galvis, M. L. E., Smart, L., Krzyżanowski, S., Fazleabas, A. T., Leach, R. E., Postolache, T. T., Achtyes, E. D., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01801-8 · Cited by 101
Metadata
- Authors
- Rogers, A., Obst, S., Teague, S. J., Rossen, L., Spry, E. A., Macdonald, J. A., Sunderland, M., Olsson, C. A., Youssef, G., & Hutchinson, D.
- Affiliations
- Deakin University (AU)
- University of British Columbia (CA)
- Royal Children's Hospital (AU)
- The University of Sydney (AU)
- Corresponding author
- Hutchinson, Delyse
- ORCID
- Venue
- JAMA Pediatrics
- Publisher
- American Medical Association (AMA)
- Published
- 2020-11-01
- Volume
- 174
- Issue
- 11
- Pages
- 1082
- ISSN
- 1072-4710 (ISSN-L)
- 2168-6203
- PMC
- PMC7490743
- OpenAlex
- W3086442239
- Cited by
- 620
- References
- 77
- Citations by year
- 2026: 144 · 2025: 157 · 2024: 123 · 2023: 97 · 2022: 54 · 2021: 42 · 2020: 2
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- perinatal depression, offspring development, child development, adolescent development, social-emotional development, cognitive development, language development, motor development, adaptability, antenatal depression, postpartum depression, maternal mental health, mother-child dyads
- MeSH terms
- Correlation of Data, Adolescent, Anxiety, Child, Child Development, Child, Preschool, Depression, Female, Humans, Infant, Male, Pregnancy
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