Sick individuals and sick populations
Abstract
Rose G (Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK). Sick individuals and sick populations. International Journal of Epidemiology 1985;14:32--38. Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding strategies in control are the 'high-risk' approach, which seeks to protect susceptible individuals, and the population approach, which seeks to control the causes of incidence. The two approaches are not usually in competition, but the prior concern should always be to discover and control the causes of incidence.
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Even small reductions of population exposure to large risks will yield substantial health gains.
“Even small reductions of population exposure to large risks will yield substantial health gains.194”
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Hobin, E. P., Leatherdale, S. T., Manske, S., Dubin, J. A., Elliott, S., & Veugelers, P. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-74 · Cited by 54 · see citing works
Maternal breastfeeding and children’s cognitive development
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Utility of genetic determinants of lipids and cardiovascular events in assessing risk
Holmes, M. V., Harrison, S., Talmud, P. J., Hingorani, A. D., & Humphries, S. E. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.6 · Cited by 44 · see citing works
Zotcheva, E., Håberg, A. K., Wisløff, U., Salvesen, Ø., Selbæk, G., Stensvold, D., & Ernstsen, L. (2022) · Sports Medicine · doi:10.1007/s40279-021-01608-5 · Cited by 43 · see citing works
- Authors
- Rose, G.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Rose, Geoffrey
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06
- Volume
- 30
- Issue
- 3
- Pages
- 427-432
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W1907953089
- Cited by
- 3,736
- References
- 7
- Citations by year
- 2026: 84 · 2025: 108 · 2024: 113 · 2023: 157 · 2022: 137 · 2021: 184 · 2020: 168 · 2019: 182 · 2018: 162 · 2017: 153 · 2016: 154 · 2015: 192 · 2014: 184 · 2013: 174 · 2012: 177
- FWCI
- 374.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Topics
- Social Sciences › Sociology and Political Science › Historical and modern epidemiology studies
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- etiology, incidence rates, case-control study, cohort studies, susceptibility markers, high-risk approach, population approach, disease control
- MeSH terms
- Cardiovascular Diseases, Disease Susceptibility, Epidemiologic Methods, Humans, Population Surveillance, Risk, Causality, Incidence
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