The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Abnormal Rich Club Organization and Functional Brain Dynamics in Schizophrenia
Open accessAbstract
IMPORTANCE: The human brain forms a large-scale structural network of regions and interregional pathways. Recent studies have reported the existence of a selective set of highly central and interconnected hub regions that may play a crucial role in the brain's integrative processes, together forming a central backbone for global brain communication. Abnormal brain connectivity may have a key role in the pathophysiology of schizophrenia. OBJECTIVE: To examine the structure of the rich club in schizophrenia and its role in global functional brain dynamics. DESIGN: Structural diffusion tensor imaging and resting-state functional magnetic resonance imaging were performed in patients with schizophrenia and matched healthy controls. SETTING: Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands. PARTICIPANTS: Forty-eight patients and 45 healthy controls participated in the study. An independent replication data set of 41 patients and 51 healthy controls was included to replicate and validate significant findings. MAIN OUTCOME(S) AND MEASURES: Measures of rich club organization, connectivity density of rich club connections and connections linking peripheral regions to brain hubs, measures of global brain network efficiency, and measures of coupling between brain structure and functional dynamics. RESULTS: Rich club organization between high-degree hub nodes was significantly affected in patients, together with a reduced density of rich club connections predominantly comprising the white matter pathways that link the midline frontal, parietal, and insular hub regions. This reduction in rich club density was found to be associated with lower levels of global communication capacity, a relationship that was absent for other white matter pathways. In addition, patients had an increase in the strength of structural connectivity-functional connectivity coupling. CONCLUSIONS: Our findings provide novel biological evidence that schizophrenia is characterized by a selective disruption of brain connectivity among central hub regions of the brain, potentially leading to reduced communication capacity and altered functional brain dynamics.
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Cites
Modularity and community structure in networks
Newman, M. E. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601602103 · Cited by 12,256
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173
Self-citationThe Human Connectome: A Structural Description of the Human Brain
Sporns, O., Tononi, G., & Kötter, R. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010042 · Cited by 3,260
Self-citationThe global signal and observed anticorrelated resting state brain networks
Fox, M. D., Zhang, D., Snyder, A. Z., & Raichle, M. E. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90777.2008 · Cited by 1,877
Default-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675
Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809141106 · Cited by 1,435
Efficiency of Functional Brain Networks and Intellectual Performance
van den Heuvel, M. P., Stam, C. J., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-09.2009 · Cited by 1,078
Self-citationDetecting rich-club ordering in complex networks
Colizza, V., Flammini, A., Serrano, M. A., & Vespignani, A. (2006) · Nature Physics · doi:10.1038/nphys209 · Cited by 1,001
van den Heuvel, M. P., Mandl, R. C. W., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Human Brain Mapping · doi:10.1002/hbm.20737 · Cited by 987
Self-citationSaad, Z. S., Gotts, S. J., Murphy, K., Chen, G., Jo, H. J., Martin, A., & Cox, R. W. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0080 · Cited by 859
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Network hubs in the human brain
van den Heuvel, M. P., & Sporns, O. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.012 · Cited by 2,123
Self-citationStructural and Functional Brain Networks: From Connections to Cognition
Park, H.-J., & Friston, K. (2013) · Science · doi:10.1126/science.1238411 · Cited by 2,106
Social cognition in schizophrenia
Green, M. F., Horan, W. P., & Lee, J. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4005 · Cited by 1,159
Building better biomarkers: brain models in translational neuroimaging
Woo, C.-W., Chang, L. J., Lindquist, M. A., & Wager, T. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4478 · Cited by 1,056
Controllability of structural brain networks
Gu, S., Pasqualetti, F., Cieslak, M., Telesford, Q. K., Yu, A. B., Kahn, A. E., Medaglia, J. D., Vettel, J. M., Miller, M. B., Grafton, S. T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9414 · Cited by 912
Metadata
- Authors
- van den Heuvel, M. P., Sporns, O., Collin, G., Scheewe, T., Mandl, R. C. W., Cahn, W., Goñi, J., Hulshoff Pol, H. E., & Kahn, R. S.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2013-08-01
- Volume
- 70
- Issue
- 8
- Pages
- 783
- ISSN
- 2168-622X (ISSN-L)
- OpenAlex
- W2162551380
- Cited by
- 645
- References
- 16
- FWCI
- 30.13
- Type
- journal article
- Language
- en
- Open access
- green
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