Cited by 252Dementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive DisordersAlcoholism and Thiamine Deficiency

The DOI matches its Crossref record, with a small difference in title or year; 51 of the 51 references it cites were found in a registry or an index.

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

Open access

Davis, Daniel H. J., Muniz-Terrera, Graciela, Keage, Hannah A. D., Stephan, Blossom C. M., Fleming, Jane, Ince, Paul G., Matthews, Fiona E., Cunningham, Colm, Ely, E. Wesley, MacLullich, Alasdair M. J., Brayne, Carol, for the Epidemiological Clinicopathological Studies in Europe (EClipSE) Collaborative Members·2017·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2016.3423PMC PMC6037291

Open this paper in CoChat — free account Open PDF

Abstract

IMPORTANCE: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, or are interrelated. OBJECTIVE: To examine whether the accelerated cognitive decline observed after delirium is independent of the pathologic processes of classic dementia. DESIGN, SETTING, AND PARTICIPANTS: Harmonized data from 987 individual brain donors from 3 observational cohort studies with population-based sampling (Vantaa 85+, Cambridge City Over-75s Cohort, Cognitive Function and Ageing Study) performed from January 1, 1985, through December 31, 2011, with a median follow-up of 5.2 years until death, were used in this study. Neuropathologic assessments were performed with investigators masked to clinical data. Data analysis was performed from January 1, 2012, through December 31, 2013. Clinical characteristics of brain donors were not different from the rest of the cohort. Outcome ascertainment was complete given that the participants were brain donors. EXPOSURES: Delirium (never vs ever) and pathologic burden of neurofibrillary tangles, amyloid plaques, vascular lesions, and Lewy bodies. Effects modeled using random-effects linear regression and interactions between delirium and pathologic burden were assessed. OUTCOMES: Change in Mini-Mental State Examination (MMSE) scores during the 6 years before death. RESULTS: There were 987 participants (290 from Vantaa 85+, 241 from the Cambridge City Over-75s Cohort, and 456 from the Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4) years, including 682 women (69%). The mean MMSE score 6 years before death was 24.7 points. The 279 individuals with delirium (75% women) had worse initial scores (-2.8 points; 95% CI, -4.5 to -1.0; P < .001). Cognitive decline attributable to delirium was -0.37 MMSE points per year (95% CI, -0.60 to -0.13; P < .001). Decline attributable to the pathologic processes of dementia was -0.39 MMSE points per year (95% CI, -0.57 to -0.22; P < .001). However, the combination of delirium and the pathologic processes of dementia resulted in the greatest decline, in which the interaction contributed an additional -0.16 MMSE points per year (95% CI, -0.29 to -0.03; P = .01). The multiplicative nature of these variables resulted in individuals with delirium and the pathologic processes of dementia declining 0.72 MMSE points per year faster than age-, sex-, and educational level-matched controls. CONCLUSIONS AND RELEVANCE: Delirium in the presence of the pathologic processes of dementia is associated with accelerated cognitive decline beyond that expected for delirium or the pathologic process itself. These findings suggest that additional unmeasured pathologic processes specifically relate to delirium. Age-related cognitive decline has many contributors, and these findings at the population level support a role for delirium acting independently and multiplicatively to the pathologic processes of classic dementia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamapsychiatry.2016.3423

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye, S. K., Bogardus, S. T., Charpentier, P. A., Leo-Summers, L. S., Acampora, D., Holford, T. R., & Cooney, L. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400901 · Cited by 2,904
Long-term cognitive impairment after critical illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842
Self-citation
Delirium in Older Persons
Inouye, S. K. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052321 · Cited by 2,091
Delirium in Elderly Patients and the Risk of Postdischarge Mortality, Institutionalization, and Dementia
Witlox, J., Eurelings, L. S. M., de Jonghe, J. F. M., Kalisvaart, K. J., Eikelenboom, P., & van Gool, W. A. (2010) · JAMA · doi:10.1001/jama.2010.1013 · Cited by 1,972

Flagged first, then by citations

Show all 51 references

Sorted by citations

Items 101–200 of 252

Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
Morandi, A., Zambon, A., Santo, S. G. D., Mazzone, A., Cherubini, A., Mossello, E., Bo, M., Marengoni, A., Bellelli, G., Rispoli, V., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.02.013 · Cited by 17
Neuropsychological disorders after COVID-19. Urgent need for research and clinical practice
Łojek, E., Egbert, A. R., Gambin, M., Gawron, N., Gorgol, J., Hansen, K., Holas, P., Hyniewska, S., Malinowska, E., Pluta, A., et al. (2021) · Postępy Psychiatrii i Neurologii · doi:10.5114/ppn.2021.108474 · Cited by 17
Biomarkers of neurodegeneration and neural injury as potential predictors for delirium
Fong, T. G., Vasunilashorn, S. M., Kivisäkk, P., Metzger, E. D., Schmitt, E. M., Marcantonio, E. R., Jones, R. N., Shanes, H., Arnold, S. E., Inouye, S. K., et al. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.6044 · Cited by 16
Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people—results from a nested, longitudinal cohort study
Richardson, S. J., Lawson, R. A., Davis, D. H. J., Stephan, B. C. M., Robinson, L. A., Matthews, F. E., Brayne, C., Barnes, L., Taylor, J., Parker, S. G., et al. (2021) · Age and Ageing · doi:10.1093/ageing/afab068 · Cited by 16
Self-citation
Anticholinergic load and delirium in end-of-life patients
Pasina, L., Rizzi, B., Nobili, A., & Recchia, A. (2021) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-021-03125-w · Cited by 15
Challenges in Predicting Cognitive Decline in Dementia with Lewy Bodies
Tsamakis, K., & Mueller, C. (2021) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000515008 · Cited by 15
The Clinician's Interview‐Based Impression of Change (Plus caregiver input) and goal attainment in two dementia drug trials: Clinical meaningfulness and the initial treatment response
Stanley, J., Howlett, S. E., Dunn, T., & Rockwood, K. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12242 · Cited by 17
From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium
Monge, K. M., Shapiro, A. L. B., Coughlan, C. M., Mungo, B., Schulick, R. D., Pratap, A., Kovacs, E. J., & Idrovo, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14238418 · Cited by 19
Genetic assessment of the causal effect of plasma metabolites and metabolic pathways on delirium
He, X., Shi, X., Wang, Y., Han, S., Liu, J., Yang, F., Ma, K., & Li, B. (2024) · Anesthesiology and Perioperative Science · doi:10.1007/s44254-024-00064-4 · Cited by 14
Long-Term Cognitive Impairment Associated With Delirium in Acute Neurological Injury
Meeks, J. R., Bambhroliya, A. B., Sheth, S. A., Khan, B. A., Slooter, A. J. C., Ely, E. W., Miller, C. C., Tyson, J. E., McCullough, L. D., Savitz, S. I., et al. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000130 · Cited by 14
Self-citation
Delirium Post-Stroke—Influence on Post-Stroke Dementia (Research Study—Part of the PROPOLIS Study)
Droś, J., Kowalska, K., Pasińska, P., Szyper-Maciejowska, A., Gorzkowska, A., & Klimkowicz‐Mrowiec, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072165 · Cited by 15
Association Between Common Infections and Incident Post-Stroke Dementia: A Cohort Study Using the Clinical Practice Research Datalink
Morton, C. E., Forbes, H. J., Pearce, N. E., Smeeth, L. L., & Warren‐Gash, C. (2020) · Clinical Epidemiology · doi:10.2147/clep.s260243 · Cited by 14
Discharge Destinations of Delirious Patients: Findings From a Prospective Cohort Study of 27,026 Patients From a Large Health Care System
Zipser, C. M., Spiller, T. R., Hildenbrand, F. F., Seiler, A., Ernst, J., von Känel, R., Inouye, S. K., & Böettger, S. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.01.051 · Cited by 14
Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition
Han, J. H., Hayhurst, C. J., Chandrasekhar, R., Hughes, C. G., Vasilevskis, E. E., Wilson, J. E., Schnelle, J. F., Dittus, R. S., & Ely, E. W. (2018) · Psychosomatics · doi:10.1016/j.psym.2018.05.003 · Cited by 14
Self-citation
Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium
Racine, A. M., Gou, Y., Fong, T. G., Marcantonio, E. R., Schmitt, E. M., Travison, T. G., Inouye, S. K., & Jones, R. N. (2018) · BMC Medical Research Methodology · doi:10.1186/s12874-018-0530-x · Cited by 14
Long-Term Impact of Delirium on the Risk of Dementia in Hospitalized Older Patients: A Real-World Multicenter Study
Hwang, G., Park, C., Son, S. J., Roh, H. W., Hwang, J. Y., Jang, J., Jo, Y. T., Byeon, G., Youn, H., & Park, R. W. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.08.004 · Cited by 13
Management of Delirium in the Intensive Care Unit
Huang, D.-D., & Fischer, P. E. (2021) · Surgical Clinics of North America · doi:10.1016/j.suc.2021.09.006 · Cited by 13
Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a controlled clinical trial design
Weldingh, N., Mellingsæter, M., Hegna, B. W., Benth, J. Š., Einvik, G., Juliebø, V., Thommessen, B., & Kirkevold, M. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02949-0 · Cited by 13
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature
Ang, H. P., Makpol, S., Nasaruddin, M. L., Zaidi, W. A. W., Ahmad, N. S., & Embong, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065580 · Cited by 12
Clock‐Drawing Test as a Bedside Assessment of Post‐operative Delirium Risk in Elderly Patients with Accidental Hip Fracture
Vasilian, C. C., Tamasan, S. C., Lungeanu, D., & Poenaru, D. V. (2017) · World Journal of Surgery · doi:10.1007/s00268-017-4294-y · Cited by 12
Brain MRI after critical care admission: A longitudinal imaging study
Šprung, J., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., et al. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.11.024 · Cited by 13
Network for Investigation of Delirium across the U.S.: Advancing the Field of Delirium with a New Interdisciplinary Research Network
Fick, D. M., Auerbach, A. D., Avidan, M. S., Busby‐Whitehead, J., Ely, E. W., Jones, R. N., Marcantonio, E. R., Needham, D. M., Pandharipande, P. P., Robinson, T. N., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14942 · Cited by 13
Self-citation
Evaluation and Management of Delirium
Ryan, S. L., & Kimchi, E. Y. (2021) · Seminars in Neurology · doi:10.1055/s-0041-1733791 · Cited by 15
Risk factors for delirium in advanced cancer patients: A systematic review and meta-analysis
Guo, Y., Mu, Y., Wu, T., Xu, Q., & Lin, X. (2023) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2023.102267 · Cited by 12
The quality of life of patients developed delirium after coronary artery bypass grafting is determined by cognitive function after discharge: A cross‐sectional study
Chen, Y., Ding, S., Tao, X., Feng, X., Lu, L., Yu-zhi, S., Wu, Y. X., & An, X. (2017) · International Journal of Nursing Practice · doi:10.1111/ijn.12563 · Cited by 12
COMO AVALIAR O RISCO DE QUEDA EM IDOSOS INSTITUCIONALIZADOS?
Baixinho, C. L., Bernardes, R. A., & Henriques, M. A. (2020) · Revista Baiana de Enfermagem‏ · doi:10.18471/rbe.v34.34861 · Cited by 12
Delirium and Clusters of Older Patients Affected by Multimorbidity in Acute Hospitals
Monacelli, F., Signori, A., Marengoni, A., Santo, S. G. D., Rossi, E., Valsecchi, M. G., Morandi, A., & Bellelli, G. (2021) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2021.10.004 · Cited by 12
Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial
Neerland, B. E., Busund, R., Haaverstad, R., Helbostad, J. L., Landsverk, S. A., Martinaityte, I., Norum, H. M., Raeder, J. C., Selbæk, G., Simpson, M. R., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057460 · Cited by 12
Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study
Tsui, A., Kuh, D. J., Richards, M., & Davis, D. H. J. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.08.018 · Cited by 12
Self-citation
Delirium is associated with higher mortality in transcatheter aortic valve replacement: systemic review and meta-analysis
Prasitlumkum, N., Mekritthikrai, R., Kewcharoen, J., Kanitsoraphan, C., Mao, M. A., & Cheungpasitporn, W. (2019) · Cardiovascular Intervention and Therapeutics · doi:10.1007/s12928-019-00592-y · Cited by 12
Cognition and Health Ageing
Briggs, R., Kennelly, S., & O’Neill, D. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-06200-2_15 · Cited by 12
Artificial intelligence in drug development for delirium and Alzheimer’s disease
Ai, R., Xiao, X., Deng, S., Yang, N., Xing, X., Watne, L. O., Selbæk, G., Wedatilake, Y., Xie, C., Rubinsztein, D. C., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.026 · Cited by 11
Prevalence of Delirium in End-of-Life Palliative Care Patients: An Observational Study
Recchia, A., Rizzi, B., Favero, A., Nobili, A., & Pasina, L. (2022) · Medical Principles and Practice · doi:10.1159/000521994 · Cited by 10
Causal relationship between dementia and delirium: Insights from a bidirectional two-sample Mendelian randomization analysis
Cai, Y., Wang, J., Wang, X., Yuan, Q., Xu, Y., & Xu, P. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.064 · Cited by 10
Anoxia-Hypoxia in Forensic Neuropsychological Assessment: Cognitive Impact of Pulmonary Injuries, Respiratory Distress, Cerebral Blood Hypoperfusion, and Major Surgeries
Schultz, I. Z., Sepehry, A. A., & Greer, S. C. (2018) · Psychological Injury and Law · doi:10.1007/s12207-018-9319-9 · Cited by 10
Former smoking, but not active smoking, is associated with delirium in postoperative ICU patients: a matched case-control study
Komninou, M. A., Egli, S., Rossi, A., Ernst, J., Krauthammer, M. O., Schuepbach, R. A., Delgado, M., & Bartussek, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1347071 · Cited by 9
The Relationship between Delirium and Dementia
Umoh, M. E., Fitzgerald, D., Vasunilashorn, S. M., Oh, E. S., & Fong, T. G. (2024) · Seminars in Neurology · doi:10.1055/s-0044-1791543 · Cited by 9
Perioperative blood loss is a risk factor for postoperative delirium in geriatric hip fracture patients: a retrospective study
Deng, Y., Zhang, T., Xie, H., & Zeng, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1617891 · Cited by 9
Population-Based Studies in Dementia and Ageing Research: A Local and National Experience in Cambridgeshire and the UK
Brayne, C., & Wu, Y. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221104347 · Cited by 9
Self-citation
e‐Screening revolution: A novel approach to developing a delirium screening tool in the intensive care unit
Eeles, E. M., Gunn, H., Sutt, A., Pinsker, D. M., Flaws, D., Jarrett, P., Lye, I., & Fraser, J. F. (2018) · Australian Journal on Ageing · doi:10.1111/ajag.12525 · Cited by 9
Identifying hormones and other perioperative risk factors for postoperative delirium after endoscope‐assisted transsphenoidal pituitary adenoma resection: A retrospective, matched cohort study
Liu, J., Qian, J., Wang, X., Lin, J., Yang, S., Hu, R., Xian, J., Feng, H., Chen, Y., & Tan, B. (2023) · Brain and Behavior · doi:10.1002/brb3.3041 · Cited by 8
Causal relationships between delirium and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study
Zheng, J., Du, X., Liu, Y., & Fu, H. C. (2023) · European journal of medical research · doi:10.1186/s40001-023-01245-w · Cited by 9
Gait Ability and Muscle Strength in Institutionalized Older Persons with and without Cognitive Decline and Association with Falls
Dixe, M. D. A., Madeira, C., Alves, S., Henriques, M. A., & Baixinho, C. L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111543 · Cited by 8
Performance on bedside tests of attention and organized thinking in patients with dementia free from delirium
Oudewortel, L., Joling, K. J., Hertogh, C. M. P. M., Wijnen, V. J. M., van der Brug, A. A. M., & van Gool, W. A. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218000522 · Cited by 8
Genetic predisposition and modifiable risks for late-life dementia
Rockwood, K. J., Wallace, L. M. K., & Davis, D. H. J. (2019) · Nature Medicine · doi:10.1038/s41591-019-0575-3 · Cited by 8
Self-citation
Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non‐pharmacological delirium prevention program
Garrido, M. A., Álvarez, E., Ponce, D. P., Salech, F., Tobar, D., & Tobar, E. A. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5425 · Cited by 7
Effect of Cognitive Status on the Receipt of Procedures Requiring Anesthesia and Critical Care Admissions in Older Adults
Schulte, P. J., Martin, D. P., Deljou, A., Sabov, M., Roberts, R. O., Knopman, D. S., Petersen, R. C., Weingarten, T. N., Hanson, A. C., Schroeder, D. R., et al. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.06.021 · Cited by 7
Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study
Sidoli, C., Zambon, A., Tassistro, E., Rossi, E., Mossello, E., Inzitari, M., Cherubini, A., Marengoni, A., Morandi, A., Bellelli, G., et al. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02099-8 · Cited by 7
Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium
Ran, W., Liang, N., Yuan, R., Wang, Z., & Gao, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.836534 · Cited by 7
Caregivers’ experience with Tele-Savvy Caregiver Program post-hospitalization
Kovaleva, M. A., Kleinpell, R., Dietrich, M. S., Jones, A. C., Boon, J. T., Duggan, M. C., Dennis, B. M., Lauderdale, J., & Maxwell, C. A. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.03.002 · Cited by 6
Is Electroencephalographic Burst-Suppression Good, Bad, or Indifferent for Brain Health? Context Matters
Jegarl, A. M., Walline, M. C., Goldstein, P. A., & Safavynia, S. A. (2025) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007739 · Cited by 6
Cognitive Outcomes After Hip Fracture Surgery: The Association of Postoperative Delirium on Previously Cognitively Normal Older Adults
Umoh, M. E., Sharma, A., Leoutsakos, J., Lyketsos, C. G., Inouye, S. K., Marcantonio, E. R., Rosenberg, P. B., Neufeld, K. J., Sieber, F. E., & Oh, E. S. (2025) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2025.10.002 · Cited by 6
Assessing patterns of delirium symptoms reveals a novel subtype among elective surgical patients with postoperative delirium
Yang, L., Do, Q., Zhu, X., Leung, J. M., & Sands, L. P. (2024) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.6049 · Cited by 6
The perceptions of European geriatricians on the co-occurrence and links between dementia, delirium and frailty
Faherty, M., Curtin, C., Bellelli, G., Brunetti, E., Bo, M., Morandi, A., Cherubini, A., Fedecostante, M., Ferrara, M. C., Coin, A., et al. (2025) · European Geriatric Medicine · doi:10.1007/s41999-025-01173-4 · Cited by 6
Evaluation of Bedside Tests of Attention and Arousal Assessing Delirium in Parkinson’s Disease, Dementia, and Older Adults
Lawson, R. A., Richardson, S. J., Kershaw, D., Davis, D. H. J., Stephan, B. C. M., Robinson, L., Brayne, C., Barnes, L., Burn, D. J., Yarnall, A. J., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212849 · Cited by 6
Self-citation
The long-COVID-19 in older adults: facts and conjectures
Poloni, T. E., Medici, V., Zito, A., & Carlos, A. F. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339483 · Cited by 6
Delirium and Dementia in the Elderly: Sometimes Associated or Always Together?
Bugiani, O. (2023) · European Neurology · doi:10.1159/000530226 · Cited by 6
Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients
Geßele, C., Saller, T., Smolka, V., Dimitriadis, K. A., Amann, U., & Strobach, D. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05005-1 · Cited by 7
Dementia Research: Populations, Progress, Problems, and Predictions
Hunter, S., Smailagic, N., & Brayne, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179927 · Cited by 6
Self-citation
The intersection of delirium and long-term cognition in older adults: the critical role of delirium prevention
Lu, Z., Wang, X., Wang, J., Zhao, L., Wu, Y., Sun, M., & Zhang, J. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13104-1 · Cited by 5
Risk factors associated with postoperative intensive care unit delirium in patients undergoing invasive mechanical ventilation following acute exacerbation of chronic obstructive pulmonary disease
Tian, H., Chen, M., Yu, W., Ma, Q., Lu, P., Zhang, J., Jin, Y., & Wang, M. (2020) · Journal of International Medical Research · doi:10.1177/0300060520946516 · Cited by 5
Delirium-Onset of Prodromal Dementia With Lewy Bodies—Putative Brainstem-Related Pathomechanism and Clinical Relevance
Hansen, N., Timäus, C., Bouter, C., Lange, C., & Packroß, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.829098 · Cited by 5
Delirium Leads to Poor In‐Hospital and 90‐Day Outcomes Among Patients With Acute Ischemic Stroke With and Without Intravenous Thrombolysis or Intraarterial Therapy
Pan, A. P., Agarwal, K. L., Taffet, G. E., Jones, S. L., Potter, T. B. H., Bako, A. T., Tannous, J. D., MCCANE, C. D., Ahmed, W. O., Garg, T., et al. (2022) · Stroke Vascular and Interventional Neurology · doi:10.1161/svin.122.000338 · Cited by 5
Risk factors for dementia in older intensive care unit (ICU) survivors
Wang, S., Perkins, A. J., Chi, R., Yates, B. A., Khan, S., Gao, S., Boustani, M. A., & Khan, B. A. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13423 · Cited by 7
Requesting That Delirium Achieve Parity With Acute Encephalopathy in the MS-DRG System
Oldham, C. M., Heinrich, T. W., & Luccarelli, J. (2024) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.jaclp.2024.02.004 · Cited by 5
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Idland, A., Wyller, T. B., Støen, R., Dahl, G. T., Frihagen, F., Brækhus, A., Hassel, B., & Watne, L. O. (2017) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000478723 · Cited by 5
Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort
Tsui, A., Richards, M., & Davis, D. H. J. (2018) · Aging Medicine · doi:10.1002/agm2.12044 · Cited by 5
Self-citation
Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances
Ceolin, C., Papa, M. V., Simonato, C., Cazzavillan, S., Vergadoro, M., Trapella, G. S., Sermasi, R., RUI, M. D., Noale, M., Zanforlini, B. M., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05334-1 · Cited by 4
Validation of the 4AT for assessing recovery from delirium in older hospital patients
McCartney, H., Noble, E., Thompson, K., Fomina, K., Guevara, L. M., Davis, D. H. J., Evans, J. J., Shenkin, S. D., Terrera, G. M., Sandeman, D., et al. (2025) · Age and Ageing · doi:10.1093/ageing/afaf166 · Cited by 4
Self-citation
Impact of delirium in cardiosurgical patients on short- and long-term mortality
Mohammad, B., Nydahl, P., Gravert, H., Grothusen, C., Huenges, K., Friedrich, C., Sommer, W., Haneya, A., Warnecke, G., & Panholzer, B. (2025) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2025.104252 · Cited by 4
The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer’s disease
Chouhan, J. K., Fowler, S. A., Webster, C. I., & Teeling, J. L. (2017) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2018.10.004 · Cited by 4
The evidence for introducing case-finding for delirium and dementia in older medical inpatients in a New Zealand hospital
Cullum, S. J., Kubba, Y., Varghese, C., Coomarasamy, C., & Hopkins, J. (2022) · Australasian Psychiatry · doi:10.1177/10398562211062465 · Cited by 4
Plasma SOMAmer proteomics of postoperative delirium
Leung, J. M., Rojas, J. C., Sands, L. P., Chan, B., Rajbanshi, B., Du, Z., & Du, P. (2024) · Brain and Behavior · doi:10.1002/brb3.3422 · Cited by 4
The brain–heart-immune axis: a vago-centric framework for predicting and enhancing resilient recovery in older surgery patients
Acker, L., Xu, K., & Ginsberg, J. P. (2024) · Bioelectronic Medicine · doi:10.1186/s42234-024-00155-4 · Cited by 5
A two-year multicenter point prevalence study of older patients with hip fractures admitted to rehabilitation units in Italy
Guerzoni, V., Lanzoni, A., Pozzi, C., Paci, M., Gatti, R., Benedetti, M. G., Gentile, S., Trabucchi, M., Bellelli, G., & Morandi, A. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00363-6 · Cited by 4
Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients
Chalmers, L. A., Searle, S. D., Whitby, J., Tsui, A., & Davis, D. H. J. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00474-8 · Cited by 4
Self-citation
Cognitive Trajectories Following Acute Infection in Older Patients With and Without Cognitive Impairment: An 1-Year Follow-Up Study
Silva, A. R., Regueira, P., Cardoso, A. L., Baldeiras, I., Santana, I. J., & Cerejeira, J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.754489 · Cited by 4
Systemic inflammation, delirium and clinical progression in mild-moderate Alzheimer disease
Dyer, A. H., Dolphin, H., Morrison, L., Kenny, T., Fallon, P. G., Cunningham, C. M., O’Connor, A., LAWLOR, B. A., O’Farrelly, C., Bourke, N. M., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106159 · Cited by 3
Self-citation
Role of Education and Physical Activity in Executive Function Performance of Adult Population
Sharma, N., & Shenoy, S. (2023) · Current Aging Science · doi:10.2174/1874609816666230214100557 · Cited by 4
Delirium in older hospitalized patients—A prospective analysis of the detailed course of delirium in geriatric inpatients
Wilke, S., Steiger, E., Bärwolff, T. L., Kleine, J. F., Müller‐Werdan, U., & Rosada, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0279763 · Cited by 3
Delirium assessment, management and barriers to effective care across Scotland: A secondary analysis of survey data from World Delirium Awareness Day 2023
Naeem, F., Penfold, R., Soiza, R. L., von Haken, R., Lindroth, H. L., Liu, K., Nydhal, P., & Quinn, T. (2024) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.1177/14782715241301486 · Cited by 3
Evidence from a Mendelian randomization study: Delirium’s noncausal role in dementia onset
Lu, Z., Wang, X., Mao, T., Liu, L., & Zhang, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.025 · Cited by 3
Delirium detection in hospitalized adults: the performance of the 4 'A's Test and the modified Confusion Assessment Method for the Emergency Department. A comparison study
Muser, O., Seiler, K. R., Bachnick, S., Gehri, B., Zúñiga, F., & Hasemann, W. (2022) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-022-00863-4 · Cited by 3
Delirium Superimposed on Dementia
Işık, A. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-65239-9_4 · Cited by 3
Inflammatory and blood gas markers of COVID-19 delirium compared to non-COVID-19 delirium: a cross-sectional study
Saini, A., Oh, T. H., Ghanem, D. A., Castro, M., Butler, M., Lam, C. C. S. F., Posporelis, S., Lewis, G., David, A. S., & Rogers, J. P. (2021) · Aging & Mental Health · doi:10.1080/13607863.2021.1989375 · Cited by 3
Systematisches Erkennen von Delirien – Empfehlungen der Sektion Delir-Detektion des Delir-Netzwerks e. V.
Monke, S., Bello, M. A., Ernst, J., Kaltwasser, A., Melms, T., Neunhoeffer, F., & Hasemann, W. (2022) · intensiv · doi:10.1055/a-1721-8276 · Cited by 3
Proposing a Scientific and Technological Approach to the Summaries of Clinical Issues of Inpatient Elderly with Delirium: A Viewpoint
Frisardi, V., Nicolini, M., Cautero, N., Ghirardelli, R., Davolio, F., Haouili, M., & Barani, M. (2022) · Healthcare · doi:10.3390/healthcare10081534 · Cited by 3
APOEε4, in-hospital delirium and long-term cognitive impairment: A longitudinal memory clinic study
Kim, C., Lee, H. J., Kim, H. S., Lee, J. H., & Kim, J. H. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105204 · Cited by 2
Impact of CNS medication burden and drug interactions on delirium in patients with advanced cancer: a multicenter prospective observational study
Geum, M. J., Yoo, S. H., Lee, S. W., Hong, M., Jung, E. H., Kim, Y. J., & Kang, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-23079-8 · Cited by 3
Cerebral metabolic covariance in delirium: pattern response to symptomatic changes
Colloby, S. J., Nitchingham, A., Richardson, S. J., Lawson, R. A., O'Brien, J. T., Wegner, E. A., Welschinger, R., Caplan, G. A., & Taylor, J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70993 · Cited by 2
Delirium superimposed on dementia (DSD)—a practical approach
Timmons, S., Bellelli, G., Morandi, A., & Harwood, R. (2025) · Age and Ageing · doi:10.1093/ageing/afaf367 · Cited by 2
Delirium in Hospitalized Older Adults: A Narrative Review
Jeyakanthan, J., Corso, G., Woldetsadik, B., Kotilo, S., & Esan, O. (2026) · Cureus · doi:10.7759/cureus.109991 · Cited by 2
Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline
Dutta, S., Dutta, T. K., Nanda, P. K., Dhar, P., Das, A. K., & Bhunia, A. K. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11136-1 · Cited by 2
Short‐term outcomes of prehospital opioid pain management for older adults with fall‐related injury
Jarman, M. P., Jin, G., Chen, A., Losina, E., Weissman, J. S., Berry, S. D., & Salim, A. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18830 · Cited by 2
CSF sodium at toxic levels precedes delirium in hip fracture patients
Hassel, B., Mariussen, E., Idland, A., Dahl, G. T., Raeder, J. C., Frihagen, F., Berg, J. P., Chaudhry, F. A., Wyller, T. B., & Watne, L. O. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.08.010 · Cited by 2
Prognostic Impact of Delirium in Older People With/Without Dementia: A Retrospective Cohort Study in Taiwan
Liang, C., Chuang, H.-Y., Hsiao, F., Chou, M.-Y., Liu, T., Yang, C., & Chen, L. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1459-4 · Cited by 2
POSTOPED: improving surveillance of postoperative delirium in a Scottish tertiary hospital
Brown, K. A., & McCulloch, A. (2023) · BMJ Open Quality · doi:10.1136/bmjoq-2022-002161 · Cited by 2
Neurocognitive Dysfunction and Geriatric Neurocritical Care
McGrane, T. J., Pandharipande, P. P., & Hughes, C. G. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316676325.006 · Cited by 2
Network for Investigation of Delirium Across the U.S. (NIDUS): Advancing the Field of Delirium with a New Interdisciplinary Research Network
Fick, D. M., Auerbach, A. D., Avidan, M. S., Busby‐Whitehead, J., Ely, E. W., Jones, R. N., Marcantonio, E. R., Needham, D. M., Pandharipande, P. P., Robinson, T. N., et al. (2017) · Journal of Gerontological Nursing · doi:10.3928/00989134-20170411-01 · Cited by 2
Self-citation
Delirium superimposed on dementia
Alessandro, M., Pozzi, C., Grossi, E., & Bellelli, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00036-0 · Cited by 1

Authors: Davis, D. H. J., Muniz-Terrera, G., Keage, H. A. D., Stephan, B. C. M., Fleming, J., Ince, P. G., Matthews, F. E., Cunningham, C., Ely, E. W., MacLullich, A. M. J., Brayne, C., & Members, F. T. E. C. S. I. E. (. C.
Affiliations: University of Cambridge (GB)
Centre for Dementia Prevention, University of Edinburgh, Edinburgh, Scotland
University of South Australia (AU)
Newcastle University (GB)
University of Sheffield (GB)
Trinity College Dublin (IE)
VA Tennessee Valley Healthcare System (US)
University of Edinburgh (GB)
Corresponding author: Davis, Daniel H. J.
ORCID: Davis, Daniel H. J.
Keage, Hannah A. D.
Stephan, Blossom C. M.
Fleming, Jane
Ince, Paul G.
Matthews, Fiona E.
Cunningham, Colm
Ely, E. Wesley
MacLullich, Alasdair M. J.
Brayne, Carol
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2017-03-01
Volume: 74
Issue: 3
Pages: 244
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2016.3423
PMC: PMC6037291
OpenAlex: W2580337369
Cited by: 252
References: 51
Citations by year: 2026: 14 · 2025: 23 · 2024: 27 · 2023: 21 · 2022: 30 · 2021: 31 · 2020: 27 · 2019: 29 · 2018: 30 · 2017: 20
FWCI: 23.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
UEF eRepo (University of Eastern Finland) (submittedVersion)
Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust (107467/Z/15/Z)
National Institute for Health and Care Research (NF-SI-0611-10084)
European Commission
Medical Research Council (MR/K026992/1)
NIHR Cambridge Biomedical Research Centre
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: delirium, cognitive decline, old age, dementia, neuropathology, neurofibrillary tangles, amyloid plaques, Lewy bodies, vascular lesions, brain donors, Mini-Mental State Examination, cognitive aging, postmortem brain, older adults, sex differences
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebrovascular Circulation, Delirium, Female, Humans, Male, Mental Status Schedule, Cohort Studies, Lewy Bodies, Neurofibrillary Tangles, Disease Progression, Plaque, Amyloid, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks