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Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies
Open accessAbstract
IMPORTANCE: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are independent, or are interrelated. OBJECTIVE: To examine whether the accelerated cognitive decline observed after delirium is independent of the pathologic processes of classic dementia. DESIGN, SETTING, AND PARTICIPANTS: Harmonized data from 987 individual brain donors from 3 observational cohort studies with population-based sampling (Vantaa 85+, Cambridge City Over-75s Cohort, Cognitive Function and Ageing Study) performed from January 1, 1985, through December 31, 2011, with a median follow-up of 5.2 years until death, were used in this study. Neuropathologic assessments were performed with investigators masked to clinical data. Data analysis was performed from January 1, 2012, through December 31, 2013. Clinical characteristics of brain donors were not different from the rest of the cohort. Outcome ascertainment was complete given that the participants were brain donors. EXPOSURES: Delirium (never vs ever) and pathologic burden of neurofibrillary tangles, amyloid plaques, vascular lesions, and Lewy bodies. Effects modeled using random-effects linear regression and interactions between delirium and pathologic burden were assessed. OUTCOMES: Change in Mini-Mental State Examination (MMSE) scores during the 6 years before death. RESULTS: There were 987 participants (290 from Vantaa 85+, 241 from the Cambridge City Over-75s Cohort, and 456 from the Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4) years, including 682 women (69%). The mean MMSE score 6 years before death was 24.7 points. The 279 individuals with delirium (75% women) had worse initial scores (-2.8 points; 95% CI, -4.5 to -1.0; P < .001). Cognitive decline attributable to delirium was -0.37 MMSE points per year (95% CI, -0.60 to -0.13; P < .001). Decline attributable to the pathologic processes of dementia was -0.39 MMSE points per year (95% CI, -0.57 to -0.22; P < .001). However, the combination of delirium and the pathologic processes of dementia resulted in the greatest decline, in which the interaction contributed an additional -0.16 MMSE points per year (95% CI, -0.29 to -0.03; P = .01). The multiplicative nature of these variables resulted in individuals with delirium and the pathologic processes of dementia declining 0.72 MMSE points per year faster than age-, sex-, and educational level-matched controls. CONCLUSIONS AND RELEVANCE: Delirium in the presence of the pathologic processes of dementia is associated with accelerated cognitive decline beyond that expected for delirium or the pathologic process itself. These findings suggest that additional unmeasured pathologic processes specifically relate to delirium. Age-related cognitive decline has many contributors, and these findings at the population level support a role for delirium acting independently and multiplicatively to the pathologic processes of classic dementia.
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“However, no intervention has successfully reduced number of hospital admissions of community-dwelling people with dementia,276 although education, exercise, rehabilitation, and telemedicine have reduced admissions for older people without dementia.277”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [277]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye, S. K., Bogardus, S. T., Charpentier, P. A., Leo-Summers, L. S., Acampora, D., Holford, T. R., & Cooney, L. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400901 · Cited by 2,904
Long-term cognitive impairment after critical illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842
Self-citationInouye, S. K. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052321 · Cited by 2,091
Witlox, J., Eurelings, L. S. M., de Jonghe, J. F. M., Kalisvaart, K. J., Eikelenboom, P., & van Gool, W. A. (2010) · JAMA · doi:10.1001/jama.2010.1013 · Cited by 1,972
Cited by
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Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430
Self-citationRetractedAssociation of Delirium With Long-term Cognitive Decline: A Meta-analysis
Goldberg, T. E., Chen, C., Wang, Y., Jung, E., Swanson, A., Ing, C., Garcia, P. S., Whittington, R. A., & Moitra, V. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2273 · Cited by 606
The inter-relationship between delirium and dementia: the importance of delirium prevention
Fong, T. G., & Inouye, S. K. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00698-7 · Cited by 404
Sasannejad, C., Ely, E. W., & Lahiri, S. (2019) · Critical Care · doi:10.1186/s13054-019-2626-z · Cited by 326
Self-citationPostoperative Delirium and Postoperative Cognitive Dysfunction
Daiello, L. A., Racine, A. M., Gou, R. Y., Marcantonio, E. R., Xie, Z., Kunze, L. J., Vlassakov, K. V., Inouye, S. K., Jones, R. N., & for the SAGES Study Group (2019) · Anesthesiology · doi:10.1097/aln.0000000000002729 · Cited by 310
Lopez‐Rodriguez, A. B., Hennessy, E., Murray, C. L., Nazmi, A., Delaney, H. J., Healy, D., Fagan, S. G., Rooney, M., Stewart, E., Lewis, A., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12341 · Cited by 293
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Yang, T., Velagapudi, R., & Terrando, N. (2020) · Nature Immunology · doi:10.1038/s41590-020-00812-1 · Cited by 288
Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis
Peters, R., Booth, A., Rockwood, K., Peters, J., D’Este, C., & Anstey, K. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-022846 · Cited by 255
“Given, however, the recent report from two prospective, community-based autopsy studies, showing that in one-quarter of patients with a history of delirium, accelerated cognitive decline was not related to classical neuropathology suggests that there is much to learn about how late-life dementia is related to overall…”
ResultShenkin, S. D., Fox, C., Godfrey, M., Siddiqi, N., Goodacre, S. W., Young, J. B., Anand, A., Gray, A. J., Hanley, J., MacRaild, A., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1367-9 · Cited by 203
Self-citationWalle‐Hansen, M. M., Ranhoff, A. H., Mellingsæter, M. R., Wang-Hansen, M. S., & Myrstad, M. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02140-x · Cited by 187
Wang, Y., Yue, J., Xie, D., Carter, P. A., Li, Q., Gartaganis, S. L., Chen, J., & Inouye, S. K. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.4446 · Cited by 198
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Mcloughlin, B. C., Miles, A., Webb, T. E., Knopp, P., Eyres, C., Fabbri, A., Humphries, F., & Davis, D. H. J. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00353-8 · Cited by 178
Self-citationCollaborative, G. M. R. (2019) · BMC Medicine · doi:10.1186/s12916-019-1458-7 · Cited by 184
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Tisher, A., & Salardini, A. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1683408 · Cited by 186
Greaves, D., Psaltis, P. J., Ross, T. J., Davis, D. H. J., Smith, A. E., Boord, M. S., & Keage, H. A. D. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.04.065 · Cited by 172
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Bush, S. H., Tierney, S., & Lawlor, P. G. (2017) · Drugs · doi:10.1007/s40265-017-0804-3 · Cited by 161
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Baker, H. A., Safavynia, S. A., & Evered, L. A. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.09.045 · Cited by 130
The economic cost of delirium: A systematic review and quality assessment
Kinchin, I., Mitchell, E., Agar, M. R., & Trépel, D. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12262 · Cited by 123
Invited Review: From nose to gut – the role of the microbiome in neurological disease
Bell, J. S., Spencer, J. I., Yates, R. L., Yee, S. A., Jacobs, B. M., & DeLuca, G. C. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12520 · Cited by 111
Skelly, D., Griffin, É. W., Murray, C., Harney, S. C., O’Boyle, C., Hennessy, E., Dansereau, M., Nazmi, A., Tortorelli, L. S., Rawlins, J. N. P., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0075-8 · Cited by 114
Self-citationGodfrey, M., Green, J., Smith, J., Cheater, F., Inouye, S. K., Hurst, K., & Young, J. B. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1374-x · Cited by 105
Morandi, A., Santo, S. G. D., Zambon, A., Mazzone, A., Cherubini, A., Mossello, E., Bo, M., Marengoni, A., Bianchetti, A., Cappa, S. F., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly154 · Cited by 100
Challenges and opportunities in understanding dementia and delirium in the acute hospital
Jackson, T. A., Gladman, J. R. F., Harwood, R. H., MacLullich, A. M. J., Sampson, E. L., Sheehan, B., & Davis, D. H. J. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002247 · Cited by 99
Self-citationSilva, L. O. J. E., Berning, M. J., Stanich, J. A., Gerberi, D., Murad, M. H., Han, J. H., & Bellolio, F. (2021) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2021.03.005 · Cited by 94
Fostering healthy aging: The interdependency of infections, immunity and frailty
Vetrano, D. L., Triolo, F., Maggi, S., Malley, R., Jackson, T., Poscia, A., Bernabei, R., Ferrucci, L., & Fratiglioni, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101351 · Cited by 97
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Dani, M., Owen, L. H., Jackson, T., Rockwood, K. J., Sampson, E. L., & Davis, D. H. J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx214 · Cited by 89
Self-citationMorandi, A., Pozzi, C., Milisen, K., Hobbelen, H. J. S. M., Bottomley, J. M., Lanzoni, A., Tatzer, V. C., Carpena-Niño, M. G., Cherubini, A., Ranhoff, A. H., et al. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1264-2 · Cited by 83
Self-citationInvestigating how electroencephalogram measures associate with delirium: A systematic review
Boord, M. S., Moezzi, B., Davis, D. H. J., Ross, T. J., Coussens, S. W., Psaltis, P. J., Bourke, A., & Keage, H. A. D. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.09.009 · Cited by 79
Self-citationPostoperative neurocognitive disorders
Olotu, C. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000812 · Cited by 79
Tsui, A., Searle, S. D., Bowden, H., Hoffmann, K., Hornby, J., Goslett, A., Weston-Clarke, M., Hamill Howes, L., Street, R., Perera, R., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00013-7 · Cited by 73
Self-citationPasina, L., Colzani, L., Cortesi, L., Tettamanti, M., Zambon, A., Nobili, A., Mazzone, A., Mazzola, P., Annoni, G., & Bellelli, G. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0612-9 · Cited by 73
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Williams, S. T., Dhesi, J. K., & Partridge, J. S. L. (2019) · European Geriatric Medicine · doi:10.1007/s41999-019-00276-z · Cited by 79
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Hall, R. J., Watne, L. O., Cunningham, E. L., Zetterberg, H., Shenkin, S. D., Wyller, T. B., & MacLullich, A. M. J. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4720 · Cited by 70
Self-citationSetters, B., & Solberg, L. M. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.04.010 · Cited by 77
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Koirala, B., Hansen, B. R., Hosie, A., Budhathoki, C. B., Seal, S. M., Beaman, A., & Davidson, P. M. (2020) · Journal of Clinical Nursing · doi:10.1111/jocn.15219 · Cited by 72
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Corradi, J., Thompson, S., Mather, J. F., Waszynski, C. M., & Dicks, R. S. (2018) · Journal of Medical Systems · doi:10.1007/s10916-018-1109-0 · Cited by 66
Gual, N., Morandi, A., Pérez, L. M., Brítez, L., Burbano, P., Man, F., & Inzitari, M. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000485794 · Cited by 64
Anand, A., Cheng, M., Ibitoye, T., MacLullich, A. M. J., & Vardy, E. R. L. C. (2022) · Age and Ageing · doi:10.1093/ageing/afac051 · Cited by 63
Self-citationPostoperative Delirium in Older Adults Undergoing Noncardiac Surgery
Lander, H. L., Dick, A. W., Maddox, K. E. J., Oldham, C. M., Fleisher, L. A., Mazzeffi, M. A., Lustik, S. J., Shang, J., Stone, P. W., Gloff, M. S., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.19467 · Cited by 65
Gao, F., Zhang, Q., Li, Y., Tai, Y., Xin, X., Wang, X., & Wang, Q. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s183698 · Cited by 62
Oldham, C. M., & Holloway, R. G. (2020) · Neurology · doi:10.1212/wnl.0000000000009949 · Cited by 62
Racine, A. M., Tommet, D., D’Aquila, M., Fong, T. G., Gou, Y., Tabloski, P. A., Metzger, E. D., Hshieh, T. T., Schmitt, E. M., Vasunilashorn, S. M., et al. (2020) · Journal of General Internal Medicine · doi:10.1007/s11606-020-06238-7 · Cited by 64
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Bugiani, O. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05339-3 · Cited by 68
Gordon, M. N., Heneka, M. T., Page, L. M. L., Limberger, C., Morgan, D., Tenner, A. J., Terrando, N., Willette, A. A., & Willette, S. A. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12488 · Cited by 59
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Bellelli, G., Triolo, F., Ferrara, M. C., Deiner, S. G., Morandi, A., Cesari, M., Davis, D. H. J., Marengoni, A., Inzitari, M., Watne, L. O., et al. (2024) · Journal of Internal Medicine · doi:10.1111/joim.20014 · Cited by 65
Self-citationWatne, L. O., Pollmann, C. T., Neerland, B. E., Quist‐Paulsen, E., Halaas, N. B., Idland, A., Hassel, B., Henjum, K., Knapskog, A., Frihagen, F., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci163472 · Cited by 59
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Gao, L., Li, P., Gaykova, N., Zheng, X., Gao, C., Lane, J. M., Saxena, R., Scheer, F. A. J. L., Rutter, M. K., Akeju, O., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26617 · Cited by 57
CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
Henjum, K., Quist‐Paulsen, E., Zetterberg, H., Blennow, K., Nilsson, L. N. G., & Watne, L. O. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1331-1 · Cited by 56
Machine Learning–Based Prediction Models for Delirium: A Systematic Review and Meta-Analysis
Xie, Q., Wang, X., Pei, J., Wu, Y., Guo, Q., Su, Y., Yan, H., Nan, R., Chen, H., & Dou, X. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.06.020 · Cited by 54
Morandi, A., Inzitari, M., Udina, C., Gual, N., Mota, M., Tassistro, E., Andreano, A., Cherubini, A., Gentile, S., Mossello, E., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.09.032 · Cited by 49
Delirium superimposed on dementia
Morandi, A., & Bellelli, G. (2019) · European Geriatric Medicine · doi:10.1007/s41999-019-00261-6 · Cited by 49
Diwell, R. A., Davis, D. H. J., Vickerstaff, V., & Sampson, E. L. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0719-1 · Cited by 46
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Self-citationNitchingham, A., Pereira, J. V., Wegner, E. A., Oxenham, V., Close, J., & Caplan, G. A. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12604 · Cited by 44
Prampart, S., Gentil, S. L., Bureau, M. L., Macchi, C., Leroux, C., Chapelet, G., de Decker, L., Rouaud, A., & Boureau, A. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03197-y · Cited by 43
Richardson, S. J., Davis, D. H. J., Bellelli, G., Hasemann, W., Meagher, D. J., Kreisel, S. H., MacLullich, A. M. J., Cerejeira, J., & Morandi, A. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000916 · Cited by 44
Self-citationOldham, C. M., Flaherty, J. H., & Maldonado, J. R. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.04.002 · Cited by 44
Vasunilashorn, S. M., Ngo, L. H., Inouye, S. K., Fong, T. G., Jones, R. N., Dillon, S. T., Libermann, T. A., O’Connor, M. G., Arnold, S. E., Xie, Z., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.09.080 · Cited by 44
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Marra, A., Kotfis, K., Hosie, A., MacLullich, A. M. J., Pandharipande, P. P., Ely, E. W., & Pun, B. T. (2019) · American Journal of Critical Care · doi:10.4037/ajcc2019874 · Cited by 43
Self-citationCerebrospinal Fluid S100B and Alzheimer’s Disease Biomarkers in Hip Fracture Patients with Delirium
Hov, K. R., Bolstad, N., Idland, A., Zetterberg, H., Blennow, K., Chaudhry, F. A., Frihagen, F., Raeder, J. C., Wyller, T. B., & Watne, L. O. (2017) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000481853 · Cited by 41
Racine, A. M., Fong, T. G., Travison, T. G., Jones, R. N., Gou, Y., Vasunilashorn, S. M., Marcantonio, E. R., Alsop, D. C., Inouye, S. K., & Dickerson, B. C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.07.010 · Cited by 40
Penfold, R., Squires, C., Angus, A., Shenkin, S. D., Ibitoye, T., Tieges, Z., Neufeld, K. J., Avelino‐Silva, T. J., Davis, D. H. J., Anand, A., et al. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18751 · Cited by 39
Self-citationSystems Delivery Innovation for Alzheimer Disease
Bott, N. T., Sheckter, C. C., Yang, D. S., Peters, S. R., Brady, B. M., Plowman, R. S., Soo Borson, B., Leff, B. A., Kaplan, R. M., Platchek, T. S., et al. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.09.015 · Cited by 40
Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis
Golubovic, J., Neerland, B. E., Aune, D., & Baker, F. A. (2022) · Brain Sciences · doi:10.3390/brainsci12050568 · Cited by 38
Lahiri, S., Regis, G. C., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Kim, E. H., Mastali, M., Eyk, J. E. V., Rajput, P. S., Lyden, P. D., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2356-2 · Cited by 38
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James, B. D., Wilson, R. S., Capuano, A. W., Boyle, P. A., Shah, R. C., Lamar, M., Ely, E. W., Bennett, D. A., & Schneider, J. A. (2019) · Neurology · doi:10.1212/wnl.0000000000006918 · Cited by 36
Self-citationHarrison, R. A., Sharafeldin, N., Rexer, J. L., Streck, B. P., Petersen, M. E., Henneghan, A. M., & Kesler, S. R. (2021) · The Oncologist · doi:10.1002/onco.13867 · Cited by 38
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
Sajjad, M. U., Blennow, K., Knapskog, A. B., Idland, A.-V., Chaudhry, F. A., Wyller, T. B., Zetterberg, H., & Watne, L. O. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190941 · Cited by 34
Hasemann, W., Tolson, D., Godwin, J., Spirig, R., Frei, I. A., & Kressig, R. W. (2018) · Journal of Gerontological Nursing · doi:10.3928/00989134-20181018-02 · Cited by 34
Causes and outcomes of hospitalization in Lewy body dementia: A retrospective cohort study
Spears, C. C., Besharat, A., Hastings, E., Martínez-Ramírez, D., Almeida, L., & Armstrong, M. J. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.03.014 · Cited by 33
O’Connell, K. M., Patel, K. V., Powelson, E. B., Robinson, B. R. H., Boyle, K., Peschman, J. R., Blocher-Smith, E. C., Jacobson, L. E., Leavitt, J., McCrum, M. L., et al. (2021) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000003258 · Cited by 31
Cirbus, J., MacLullich, A. M. J., Noel, C., Ely, E. W., Chandrasekhar, R., & Han, J. H. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218000777 · Cited by 30
Self-citationAssociation Between Sepsis and Microvascular Brain Injury*
Ehlenbach, W. J., Sonnen, J. A., Montine, T. J., & Larson, E. B. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003924 · Cited by 31
Time course of dementia following sepsis in German health claims data
Fritze, T., Doblhammer, G., Widmann, C. N., & Heneka, M. T. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000911 · Cited by 29
The frail patient undergoing cardiac surgery: lessons learned and future perspectives
Pozzi, M., Mariani, S., Scanziani, M., Passolunghi, D., Bruni, A. A., Finazzi, A., Lettino, M., Foti, G., Bellelli, G., & Marchetto, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1295108 · Cited by 32
Maciel, M. D. L., Benedet, S. R., Lunardelli, E. B., Delziovo, H. A., Domingues, R. L., Vuolo, F. S., Tomasi, C. D., Walz, R., Ritter, C., & Dal‐Pizzol, F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1166-x · Cited by 28
Post-traumatic stress disorder (PTSD) related symptoms following an experience of delirium
Grover, S., Sahoo, S., Chakrabarti, S., & Avasthi, A. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.05.003 · Cited by 30
Heiberg, K. E., Heggestad, A. K. T., Jøranson, N., Lausund, H., Breievne, G., Myrstad, M., Ranhoff, A. H., Walle‐Hansen, M. M., & Bruun‐Olsen, V. (2022) · European Geriatric Medicine · doi:10.1007/s41999-022-00630-8 · Cited by 27
Antipsychotics for the Prevention and Treatment of Delirium
Neufeld, K. J., Needham, D. M., Oh, E. S., Wilson, L. M., Nikooie, R., Zhang, A. W., Koneru, M., Balagani, A., Singu, S., Aldabain, L., et al. (2019) · doi:10.23970/ahrqepccer219 · Cited by 27
Racine, A. M., for the SAGES study group, Touroutoglou, A., Abrantes, T. F., Wong, B., Fong, T. G., Cavallari, M., Travison, T. G., Gou, Y., Marcantonio, E. R., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190380 · Cited by 26
A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA‐AA Research Framework
Wang, S., Lindroth, H. L., Chan, C. K., Greene, R., Andrews, P., Khan, S., Rios, G. R., Jabbari, S., Lim, J., Saykin, A. J., et al. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16836 · Cited by 27
Lieberman, O. J., Lee, S., & Zabinski, J. S. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12807 · Cited by 26
Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium
Leung, J. M., Rojas, J. C., Tang, C., Chan, B., Lario‐Lago, A., Boxer, A. L., Do, Q., Kramer, J. H., Du, Z., Du, P., et al. (2023) · Anesthesiology · doi:10.1097/aln.0000000000004666 · Cited by 26
Rolandi, E., Cavedo, E., Pievani, M., Galluzzi, S., Ribaldi, F., Buckley, C. J., Cunningham, C. M., Guerra, U. P., Musarra, M., Morzenti, S., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.020 · Cited by 26
Self-citationDisparities in 30‐day readmission rates among Medicare enrollees with dementia
Gilmore‐Bykovskyi, A., Zuelsdorff, M., Block, L., Golden, B., Kaiksow, F., Sheehy, A. M., Bartels, C. M., Kind, A. J. H., & Powell, W. R. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18311 · Cited by 25
Insights into the pathological basis of dementia from population‐based neuropathology studies
Wharton, S. B., Simpson, J. E., Ince, P. G., Richardson, C. D., Merrick, R. L., Matthews, F. E., Brayne, C., & CFAS (2023) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12923 · Cited by 27
Self-citationRole of glia in delirium: proposed mechanisms and translational implications
Heffernan, Á. B., Steinruecke, M., Dempsey, G., Chandran, S., Selvaraj, B. T., Jiwaji, Z., & Stavrou, M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02801-4 · Cited by 26
Hospitalization, Alzheimer's Disease and Related Neuropathologies, and Cognitive Decline
James, B. D., Wilson, R. S., Capuano, A. W., Boyle, P. A., Shah, R. C., Lamar, M., Ely, E. W., Bennett, D. A., & Schneider, J. A. (2019) · Annals of Neurology · doi:10.1002/ana.25621 · Cited by 25
Self-citationTeale, E. A., Munyombwe, T., Schuurmans, M. J., Siddiqi, N., & Young, J. B. (2017) · Age and Ageing · doi:10.1093/ageing/afx155 · Cited by 24
Morandi, A., Mazzone, A., Bernardini, B., Suardi, T., Prina, R., Pozzi, C., Gentile, S., Trabucchi, M., & Bellelli, G. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13628 · Cited by 24
Chen, K., Hu, Q., Xie, Z., & Yang, G. (2022) · Advanced Science · doi:10.1002/advs.202104106 · Cited by 24
MacLullich, A. M. J., Hosie, A., Tieges, Z., & Davis, D. H. J. (2022) · Age and Ageing · doi:10.1093/ageing/afac271 · Cited by 23
Self-citationDavis, D. H. J., Richardson, S. J., Hornby, J., Bowden, H., Hoffmann, K., Weston-Clarke, M., Green, F., Chaturvedi, N., Hughes, A. D., Kuh, D. J., et al. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0742-2 · Cited by 21
Self-citationChen, K., Hu, Q., Gupta, R., Stephens, J., Xie, Z., & Yang, G. (2022) · Aging Cell · doi:10.1111/acel.13592 · Cited by 22
Pendlebury, S. T., Luengo-Fernández, R., Seeley, A. E., Downer, M. B., McColl, A. J., & Rothwell, P. M. (2024) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(23)00266-0 · Cited by 21
Interventions to support recovery following an episode of delirium: A realist synthesis
O’Rourke, G., Parker, D., Anderson, R., Morgan‐Trimmer, S., & Allan, L. M. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1793902 · Cited by 19
Wang, Q., 四川大学华西医院国家老年医学临床研究中心老年医学科, 生., Zhang, X., Guo, Y.-J., Pang, Y., Li, J., Zhao, Y., Wei, J.-F., Zhu, B.-T., Tang, J.-X., et al. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.473 · Cited by 23
Verholt, A. B., Gregersen, M., Bofill, N. G., Hansen, T. K., Ebdrup, L., Foss, C. H., & Lietzen, L. W. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00522-3 · Cited by 17
Metadata
- Authors
- Davis, D. H. J., Muniz-Terrera, G., Keage, H. A. D., Stephan, B. C. M., Fleming, J., Ince, P. G., Matthews, F. E., Cunningham, C., Ely, E. W., MacLullich, A. M. J., Brayne, C., & Members, F. T. E. C. S. I. E. (. C.
- Affiliations
- University of Cambridge (GB)
- Centre for Dementia Prevention, University of Edinburgh, Edinburgh, Scotland
- University of South Australia (AU)
- Newcastle University (GB)
- University of Sheffield (GB)
- Trinity College Dublin (IE)
- VA Tennessee Valley Healthcare System (US)
- University of Edinburgh (GB)
- Corresponding author
- Davis, Daniel H. J.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2017-03-01
- Volume
- 74
- Issue
- 3
- Pages
- 244
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6037291
- OpenAlex
- W2580337369
- Cited by
- 252
- References
- 51
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 27 · 2023: 21 · 2022: 30 · 2021: 31 · 2020: 27 · 2019: 29 · 2018: 30 · 2017: 20
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UEF eRepo (University of Eastern Finland) (submittedVersion)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (107467/Z/15/Z)
- National Institute for Health and Care Research (NF-SI-0611-10084)
- European Commission
- Medical Research Council (MR/K026992/1)
- NIHR Cambridge Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- delirium, cognitive decline, old age, dementia, neuropathology, neurofibrillary tangles, amyloid plaques, Lewy bodies, vascular lesions, brain donors, Mini-Mental State Examination, cognitive aging, postmortem brain, older adults, sex differences
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebrovascular Circulation, Delirium, Female, Humans, Male, Mental Status Schedule, Cohort Studies, Lewy Bodies, Neurofibrillary Tangles, Disease Progression, Plaque, Amyloid, Cognitive Dysfunction
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