Negative Psychosis Prevention Trials
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The current absence of evidence supporting specific preventive treatments is consistent with the fact that the three largest interventional studies in this field all produced negative findings.
“The current lack of evidence to support specific preventive treatments is also consistent with the fact that the three largest interventional studies in this field have all produced negative findings 95 .”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [95]
Unstructured recruitment processes and risk enrichment procedures in samples undergoing clinical high-risk for psychosis assessment substantially determine the actual level of psychosis risk in these individuals, leading to underpowered and non-significant trials.
“For example, it is apparent that unstructured recruitment processes and risk enrichment procedures in samples undergoing CHR-P assessment have a substantial role in determining the actual level of risk for psychosis in these individuals 107-109 , leading to underpowered and non-significant trials 95 .”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [95]
Cites
Morrison, A. P., French, P., Stewart, S. L. K., Birchwood, M., Fowler, D., Gumley, A. I., Jones, P. B., Bentall, R. P., Lewis, S. W., Murray, G. K., et al. (2012) · BMJ · doi:10.1136/bmj.e2233 · Cited by 332 · see citing works
McGorry, P. D., Nelson, B., Markulev, C., Yuen, H. P., Schäfer, M. R., Mossaheb, N., Schlögelhofer, M., Smesny, S., Hickie, I. B., Berger, G. E., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2902 · Cited by 262 · see citing works
Fusar-Poli, P., Schultze-Lutter, F., Cappucciati, M., Rutigliano, G., Bonoldi, I., Stahl, D., Borgwardt, S., Riecher-Rössler, A., Addington, J., Perkins, D. O., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv162 · Cited by 219 · see citing works
Self-citationFusar-Poli, P., Rutigliano, G., Stahl, D., Schmidt, A., Ramella-Cravaro, V., Hitesh, S., & McGuire, P. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2707 · Cited by 121 · see citing works
Self-citationMcFarlane, W. R., Levin, B. L., Travis, L., Lucas, F. L., Lynch, S., Verdi, M., Williams, D. L., Adelsheim, S. N., Calkins, R., Carter, C. S., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu108 · Cited by 117 · see citing works
Ballenger, J. C. (2012) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2012.06.037 · Cited by 34 · see citing works
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Prevention of Psychosis: Advances in Detection, Prognosis, and Intervention
Fusar-Poli, P., Salazar de Pablo, G., Correll, C. U., Meyer-Lindenberg, A., Millan, M. J., Borgwardt, S., Galderisi, S., Bechdolf, A., Pfennig, A., Kessing, L. V., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4779 · Cited by 476 · see citing works
Self-citationLack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis
Davies, C., Cipriani, A., Ioannidis, J. P. A., Radua, J., Stahl, D., Provenzani, U., McGuire, P., & Fusar‐Poli, P. (2018) · World Psychiatry · doi:10.1002/wps.20526 · Cited by 229 · see citing works
Self-citationMei, C., van der Gaag, M., Nelson, B., Smit, F., Yuen, H. P., Berger, M., Krcmar, M., French, P., Amminger, G. P., Bechdolf, A., et al. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102005 · Cited by 143 · see citing works
Preventive Treatments for Psychosis: Umbrella Review (Just the Evidence)
Fusar-Poli, P., Davies, C., Solmi, M., Brondino, N., De Micheli, A., Kotlicka-Antczak, M., Shin, J. I., & Radua, J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00764 · Cited by 108 · see citing works
Self-citationDavies, C., Radua, J., Cipriani, A., Stahl, D., Provenzani, U., McGuire, P., & Fusar-Poli, P. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00187 · Cited by 107 · see citing works
Self-citationOliver, D., Raduà, J., Reichenberg, A., Uher, R., & Fusar‐Poli, P. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00174 · Cited by 69 · see citing works
Self-citationExtending the Benefits of Indicated Prevention to Improve Outcomes of First-Episode Psychosis
Fusar‐Poli, P. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.1009 · Cited by 52 · see citing works
Self-citationFusar‐Poli, P., Palombini, E., Davies, C., Oliver, D., Bonoldi, I., Ramella‐Cravaro, V., & McGuire, P. K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.015 · Cited by 48 · see citing works
Self-citationFusar‐Poli, P., Davies, C., Rutigliano, G., Stahl, D. R., Bonoldi, I., & McGuire, P. K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00313 · Cited by 19 · see citing works
Self-citationEarly interventions for psychosis
Goldman, M. B. (2021) · Current Psychiatry · doi:10.12788/cp.0176 · Cited by 3 · see citing works
- Authors
- Fusar-Poli, P.
- Affiliations
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, England
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2017-06-01
- Volume
- 74
- Issue
- 6
- Pages
- 651
- ISSN
- 2168-622X (ISSN-L)
- OpenAlex
- W2595508788
- Cited by
- 10
- References
- 6
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- other-oa
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- psychosis prevention, negative symptoms, schizophrenia
- MeSH terms
- Adolescent, Humans, Psychotic Disorders, Antipsychotic Agents, Fatty Acids, Omega-3
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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