The DOI matches its Crossref record; 63 of the 66 references it cites were found in a registry or an index, and 1 are not checked yet.
Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression
Open accessAbstract
Importance: The value of early intervention in psychosis and allocation of public resources has long been debated because outcomes in people with schizophrenia spectrum disorders have remained suboptimal. Objective: To compare early intervention services (EIS) with treatment as usual (TAU) for early-phase psychosis. Data Sources: Systematic literature search of PubMed, PsycINFO, EMBASE, and ClinicalTrials.gov without language restrictions through June 6, 2017. Study Selection: Randomized trials comparing EIS vs TAU in first-episode psychosis or early-phase schizophrenia spectrum disorders. Data Extraction and Synthesis: This systematic review was conducted according to PRISMA guidelines. Three independent investigators extracted data for a random-effects meta-analysis and prespecified subgroup and meta-regression analyses. Main Outcomes and Measures: The coprimary outcomes were all-cause treatment discontinuation and at least 1 psychiatric hospitalization during the treatment period. Results: Across 10 randomized clinical trials (mean [SD] trial duration, 16.2 [7.4] months; range, 9-24 months) among 2176 patients (mean [SD] age, 27.5 [4.6] years; 1355 [62.3%] male), EIS was associated with better outcomes than TAU at the end of treatment for all 13 meta-analyzable outcomes. These outcomes included the following: all-cause treatment discontinuation (risk ratio [RR], 0.70; 95% CI, 0.61-0.80; P < .001), at least 1 psychiatric hospitalization (RR, 0.74; 95% CI, 0.61-0.90; P = .003), involvement in school or work (RR, 1.13; 95% CI, 1.03-1.24; P = .01), total symptom severity (standardized mean difference [SMD], -0.32; 95% CI, -0.47 to -0.17; P < .001), positive symptom severity (SMD, -0.22; 95% CI, -0.32 to -0.11; P < .001), and negative symptom severity (SMD, -0.28; 95% CI, -0.42 to -0.14; P < .001). Superiority of EIS regarding all outcomes was evident at 6, 9 to 12, and 18 to 24 months of treatment (except for general symptom severity and depressive symptom severity at 18-24 months). Conclusions and Relevance: In early-phase psychosis, EIS are superior to TAU across all meta-analyzable outcomes. These results support the need for funding and use of EIS in patients with early-phase psychosis.
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“It incorporates several components of multimodal early intervention programs with empirical support, such as psychoeducation for patients and for their families, medication review, vocational and educational counselling, crisis management and relapse prevention [13].”
From Mindfulness-based social cognition training (SocialMIND) versus psychoeducational multicomponent intervention for people with a first episode of psychosis: A study protocol for a randomised controlled trial (2019) · cites this paper as [13]
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“Moreover, there is evidence from indicated prevention in FEP-populations [97], suggesting that specialized psycho-social and pharmacological interventions can improve clinical outcomes compared to standard care [97].”
From Towards a youth mental health paradigm: a perspective and roadmap (2023) · cites this paper as [97]
In the citing paper
“The available evidence that early intervention is effective in psychosis [97, 134] as well as in other syndromes [8]”
From Towards a youth mental health paradigm: a perspective and roadmap (2023) · cites this paper as [97]
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,762
Research works printed but not linked: 2
- Birchwood, 2014, The UK national evaluation of the development and impact of Early Intervention Services (the National EDEN studies): study rationale, design and baseline characteristics., Early Interv Psychiatry, 8, 59, 10.1111/eip.2014.8.issue-1 · DOI
- Hui, 2015, Clinical and social correlates of duration of untreated psychosis among adult-onset psychosis in Hong Kong Chinese: the JCEP study., Early Interv Psychiatry, 9, 118, 10.1111/eip.2015.9.issue-2 · DOI
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Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies
Solmi, M., Radua, J., Olivola, M., Croce, E., Soardo, L., Salazar de Pablo, G., Il Shin, J., Kirkbride, J. B., Jones, P., Kim, J. H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01161-7 · Cited by 3,835
Self-citationJauhar, S., Johnstone, M., & McKenna, P. J. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01730-x · Cited by 1,116
The Lancet Psychiatry Commission on youth mental health
McGorry, P. D., Mei, C., Dalal, N., Alvarez-Jimenez, M., Blakemore, S.-J., Browne, V., Dooley, B., Hickie, I. B., Jones, P. B., McDaid, D., et al. (2024) · The Lancet Psychiatry · doi:10.1016/s2215-0366(24)00163-9 · Cited by 663
Self-citationDesigning and scaling up integrated youth mental health care
McGorry, P. D., Mei, C., Chanen, A., Hodges, C., Alvarez‐Jimenez, M., & Killackey, E. (2022) · World Psychiatry · doi:10.1002/wps.20938 · Cited by 546
Preventive psychiatry: a blueprint for improving the mental health of young people
Fusar‐Poli, P., Correll, C. U., Arango, C., Berk, M., Patel, V., & Ioannidis, J. P. A. (2021) · World Psychiatry · doi:10.1002/wps.20869 · Cited by 497
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Metadata
- Authors
- Correll, C. U., Galling, B., Pawar, A., Krivko, A., Bonetto, C., Ruggeri, M., Craig, T. J., Nordentoft, M., Srihari, V. H., Guloksuz, S., Hui, C. L. M., Chen, E. Y. H., Valencia, M., Juarez, F., Robinson, D. G., Schooler, N. R., Brunette, M. F., Mueser, K. T., Rosenheck, R. A., Marcy, P., Addington, J., Estroff, S. E., Robinson, J., Penn, D., Severe, J. B., & Kane, J. M.
- Affiliations
- Northwell Health (US)
- University of Verona (IT)
- Institute of Psychiatry, King’s College London, London, England
- Copenhagen University Hospital (DK)
- Yale University (US)
- Department of Psychiatry, Yale University, New Haven, Connecticut
- University of Hong Kong (HK)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Division of Epidemiological and Psychosocial Research, National Institute of Psychiatry, Mexico City, Mexico
- Dartmouth College (US)
- Boston University (US)
- University of Calgary (CA)
- University of North Carolina at Chapel Hill (US)
- Nathan Kline Institute for Psychiatric Research (US)
- National Institute of Mental Health (US)
- Corresponding author
- Correll, Christoph U.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2018-06-01
- Volume
- 75
- Issue
- 6
- Pages
- 555
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC6137532
- OpenAlex
- W2799778639
- Cited by
- 826
- References
- 66
- Citations by year
- 2026: 106 · 2025: 110 · 2024: 115 · 2023: 96 · 2022: 118 · 2021: 105 · 2020: 95 · 2019: 68 · 2018: 13
- FWCI
- 55.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Patrick and Catherine Weldon Donaghue Medical Research Foundation
- Bristol-Myers Squibb
- Eli Lilly and Company
- Sanofi
- American Academy of Child and Adolescent Psychiatry
- Sunovion
- Wellcome Trust
- National Institute for Health and Care Research
- Lundbeckfonden (R155-2014-1724, R248‐2017‐2003)
- Novo Nordisk
- Allergan
- National Institute of Mental Health (RC1MH088971, P30MH090590)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- early intervention services, first-episode psychosis, schizophrenia spectrum disorders, usual care, treatment discontinuation, psychiatric hospitalization, symptom severity, social functioning, public resource allocation, mental health services, randomized trial comparison, treatment duration
- MeSH terms
- Education, Employment, Hospitalization, Humans, Psychotic Disorders, Regression Analysis, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index, Randomized Controlled Trials as Topic, Early Medical Intervention
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