The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Streptozotocin‐Induced Diabetic Models in Mice and Rats
Abstract
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. © 2015 by John Wiley & Sons, Inc.
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Cites
Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus
Like, A. A., & Rossini, A. A. (1976) · Science · doi:10.1126/science.180605 · Cited by 979
Diabetogenic action of streptozotocin: relationship of dose to metabolic response
Junod, A., Lambert, A. E., Stauffacher, W., & Renold, A. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106180 · Cited by 930
A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
Reed, M. J., Meszaros, K., Entes, L. J., Claypool, M. D., Pinkett, J. G., Gadbois, T. M., & Reaven, G. M. (2000) · Metabolism · doi:10.1053/meta.2000.17721 · Cited by 848
Studies on the diabetogenic action of streptozotocin
Rakieten, N. (1963) · Medical Entomology and Zoology · Cited by 820
Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., & Ribes, G. (1998) · Diabetes · doi:10.2337/diab.47.2.224 · Cited by 781
Zhang, M., Lv, X.-Y., Li, J., Xu, Z.-G., & Chen, L. (2008) · Journal of Diabetes Research · doi:10.1155/2008/704045 · Cited by 667
Deeds, M. C., Anderson, J. M., Armstrong, A. S., Gastineau, D. A., Hiddinga, H. J., Jahangir, A., Eberhardt, N. L., & Kudva, Y. C. (2011) · Laboratory Animals · doi:10.1258/la.2010.010090 · Cited by 605
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
Skovsø, S. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12235 · Cited by 596
Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes
Wang, B., Chandrasekera, P., & Pippin, J. (2014) · Current Diabetes Reviews · doi:10.2174/1573399810666140508121012 · Cited by 506
Studies of the Diabetogenic Action of Streptozotocin.
Junod, A., Lambert, A. E., Orci, L., Pictet, R., Gonet, A. E., & Renold, A. E. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-126-32401 · Cited by 491
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Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes
Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O’Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135236 · Cited by 130
Geng, J., Wang, L., Zhang, L., Qin, C., Song, Y., Ma, Y., Chen, Y., Chen, S., Wang, Y., Zhang, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00129 · Cited by 123
Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes
Simas, J. N., Mendes, T. B., Fischer, L. W., Vendramini, V., & Miraglia, S. M. (2021) · Andrology · doi:10.1111/andr.12891 · Cited by 39
Anti-cataract effects of coconut water in vivo and in vitro
Zhang, X., Peng, L., Dai, Y., Xie, Q., Wu, P., Chen, M., & Liu, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112032 · Cited by 16
Metadata
- Authors
- Furman, B. L.
- Venue
- Current Protocols in Pharmacology
- Publisher
- Wiley
- Published
- 2015-09
- Volume
- 70
- Issue
- 1
- Pages
- 5.47.1-5.47.20
- ISSN
- 1934-8282 (ISSN-L)
- 1934-8290
- OpenAlex
- W2119304571
- Cited by
- 1,232
- References
- 36
- FWCI
- 32.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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