Dietary Manipulation of Mouse Metabolism
Open accessAbstract
The maintenance of metabolic homeostasis relies on the balanced intake of nutrients from food. Consequently, diet composition strongly impacts whole-body physiology. Dietary formulations with strong nutrient imbalances can lead to metabolic disorders, with lipids and simple sugars playing a prominent role. This unit describes how diet formulation can be modified to generate mouse models of human metabolic pathologies, and it details methodological procedures linked to dietary manipulations, including caloric restriction and introduction of a test compound.
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Ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol induce mitochondrial biogenesis in humans and other organisms.
“ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol also induce mitochondrial biogenesis in humans and other organisms (Baur et al., 2010; Feige et al., 2008; Rodriguez-Bies et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Feige et al., 2008
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- Authors
- Feige, J. N., Lagouge, M., & Auwerx, J.
- Affiliations
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Venue
- Current Protocols in Molecular Biology
- Publisher
- Wiley
- Published
- 2008-10
- Volume
- 84
- Issue
- 1
- Pages
- Unit 29B.5-Unit 29B.5
- ISSN
- 1934-3639 (ISSN-L)
- 1934-3647
- OpenAlex
- W1537445906
- Cited by
- 18
- References
- 29
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2013: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Current Protocols in Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dietary intervention, mouse model, metabolic homeostasis, caloric restriction, diet formulation, nutrient imbalance, metabolic disorders, lipid-rich diet, high-sugar diet
- MeSH terms
- Animals, Animal Feed, Diet, Disease Models, Animal, Humans, Metabolic Diseases, Molecular Biology, Caloric Restriction, Mice
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