Mouse phenogenomics: the fast track to “systems metabolism

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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

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Noise in Gene Expression: Origins, Consequences, and Control

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Genetics of gene expression surveyed in maize, mouse and man

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Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

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Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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Genetic Dissection of Transcriptional Regulation in Budding Yeast

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Killing the messenger: short RNAs that silence gene expression

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A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

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Regulation of Muscle Fiber Type and Running Endurance by PPARδ

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An integrative genomics approach to infer causal associations between gene expression and disease

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Genetical genomics: the added value from segregation

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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Talking about a Revolution

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ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

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Variation in susceptibility to atherosclerosis among inbred strains of mice

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The knockout mouse project

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Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

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Redundant Pathways for Negative Feedback Regulation of Bile Acid Production

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Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

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Site- and Time-Specific Gene Targeting in the Mouse

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Systems Biology: Its Practice and Challenges

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SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues

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Systematic interpretation of genetic interactions using protein networks

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An Aneuploid Mouse Strain Carrying Human Chromosome 21 with down Syndrome Phenotypes.

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Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse

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The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis

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Cyberinfrastructure for e-Science

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Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

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Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice

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Genetic analysis of the mouse brain proteome

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Mouse models of insulin resistance

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Mouse Models of Insulin Resistance

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Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression.

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Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

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Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

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The Small Heterodimer Partner Interacts with the Liver X Receptor α and Represses Its Transcriptional Activity

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The European dimension for the mouse genome mutagenesis program

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Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiaeinteraction network

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Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice

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Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ

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To knockout in 129 or in C57BL/6: that is the question

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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells

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Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.

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Genetic Correlates of Gene Expression in Recombinant Inbred Strains: A Relational Model System to Explore Neurobehavioral Phenotypes

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Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen

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Mouse functional genomics requires standardization of mouse handling and housing conditions

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Combining Data From Multiple Inbred Line Crosses Improves the Power and Resolution of Quantitative Trait Loci Mapping

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One Hundred Years of Mouse Genetics: An Intellectual History. II. The Molecular Revolution (1981-2002)

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Deconstructing and Reconstructing Obesity-Induced Diabetes (Diabesity) in Mice

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DISEASE GENE DISCOVERY THROUGH INTEGRATIVE GENOMICS

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Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene

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A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program

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Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

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EMPReSS: European Mouse Phenotyping Resource for Standardized Screens

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Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice

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A New Mouse Model of Type 2 Diabetes, Produced by N-Ethyl-Nitrosourea Mutagenesis, Is the Result of a Missense Mutation in the Glucokinase Gene

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Genetic analysis of intestinal cholesterol absorption in inbred mice

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Moving forward with chemical mutagenesis in the mouse

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Marker-assisted congenic screening ( MACS ): A database tool for the efficient production and characterization of congenic lines

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Two ways to trap a gene in mice

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Metabolic fuel selection: the importance of being flexible

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Untangling the web of functional and physical interactions in yeast.

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Mitonuclear protein imbalance as a conserved longevity mechanism

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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

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The implications of human metabolic network topology for disease comorbidity

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Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

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Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles

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Nano zinc, an alternative to conventional zinc as animal feed supplement: A review

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NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

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Metabolic Characterization of a Sirt5 deficient mouse model

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Genetic background determines metabolic phenotypes in the mouse

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The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male micePreprint

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A Next Generation Multiscale View of Inborn Errors of Metabolism

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Systems Biology: The Next Frontier for Bioinformatics

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Genome-wide association studies and genetic risk assessment of liver diseases

Krawczyk, M. J., Müllenbach, R., Weber, S. N., Zimmer, V., & Lammert, F. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.170 · Cited by 73 · see citing works

The mitochondrial unfolded protein response in mammalian physiology

Mottis, A., Jovaisaite, V., & Auwerx, J. H. (2014) · Mammalian Genome · doi:10.1007/s00335-014-9525-z · Cited by 68 · see citing works

Targeted Disruption of the Murine Retinal Dehydrogenase Gene Rdh12 Does Not Limit Visual Cycle Function

Kurth, I., Thompson, D. A., Rüther, K., Feathers, K. L., Chrispell, J. D., Schroth, J., McHenry, C. L., Schweizer, M., Skosyrski, S., Gal, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01486-06 · Cited by 67 · see citing works

The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

van Ommen, B., Keijer, J., Kleemann, R., Elliott, R. M., Drevon, C. A., McArdle, H. J., Gibney, M. J., & Müller, M. M. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0084-3 · Cited by 60 · see citing works

Rdh12 activity and effects on retinoid processing in the murine retina

Chrispell, J. D., Feathers, K. L., Kane, M. A., Kim, C. Y., Brooks, M., Khanna, R., Kurth, I., Hübner, C. A., Gal, A., Mears, A. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020966 · Cited by 56 · see citing works

Current and future approaches using genetically modified mice in endocrine research

Davey, R. A., & MacLean, H. E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00124.2006 · Cited by 53 · see citing works

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

Andreux, P. A., Mouchiroud, L., Wang, X., Jovaisaite, V., Mottis, A., Bichet, S., Moullan, N., Houtkooper, R. H., & Auwerx, J. H. (2014) · Scientific Reports · doi:10.1038/srep05285 · Cited by 44 · see citing works

PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia

Jiang, M., Strand, D. W., Franco, O. E., Clark, P. E., & Hayward, S. W. (2011) · Differentiation · doi:10.1016/j.diff.2011.05.008 · Cited by 44 · see citing works

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

Rabhi, N., Denechaud, P., Gromada, X., Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E., Sand, O., Bonnefond, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.079 · Cited by 40 · see citing works

Zinc oxide nanoparticle induced age dependent immunotoxicity in BALB/c mice

Senapati, V. A., Gupta, G. S., Pandey, A. K., Shanker, R., Dhawan, A., & Kumar, A. (2017) · Toxicology Research · doi:10.1039/c6tx00439c · Cited by 30 · see citing works

Mutagenicity and genotoxicity of isatin in mammalian cells in vivo

Cândido-Bacani, P. D. M., dos Reis, M. B., Serpeloni, J. M., Calvo, T. R., Vilegas, W., Varanda, E. A., & Cólus, I. M. D. S. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.11.006 · Cited by 28 · see citing works

Mouse phenogenomics, toolbox for functional annotation of human genome

Kim, I.-Y., Shin, J. H., & Seong, J. K. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.2.079 · Cited by 23 · see citing works

Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase

Gaspar, R. S., Katashima, C. K., Crisol, B., Carneiro, F. S., Sampaio, I. H., Silveira, L. R., da Silva, A. S. R., Cintra, D. E., Pauli, J. R., & Ropelle, E. R. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101816 · Cited by 20 · see citing works

Characterization and Validation of Cre‐Driver Mouse Lines

Gofflot, F., Wendling, O., Chartoire, N., Birling, M., Warot, X., & Auwerx, J. H. (2011) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo100103 · Cited by 16 · see citing works

Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice

Zheng, J., Parfett, C. L. J., Williams, A., Yagminas, A. P., Zhou, G., Douglas, G. R., & Yauk, C. L. (2011) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2011.02.006 · Cited by 16 · see citing works

Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy

Sokolović, A., Montenegro-Miranda, P. S., de Waart, D. R., Cappai, R. M. N., Duijst, S., Sokolović, M., & Bosma, P. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.022 · Cited by 14 · see citing works

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R., & Williamson, G. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00565.2005 · Cited by 14 · see citing works

Mild inborn errors of metabolism in commonly used inbred mouse strains

Leandro, J., Violante, S. N., Argmann, C., Hagen, J., Dodatko, T., Bender, A. S., Zhang, W., Williams, E. G., Bachmann, A., Auwerx, J. H., et al. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.01.021 · Cited by 12 · see citing works

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

English, J., Orofino, J., Cederquist, C., Paul, I., Li, H., Auwerx, J. H., Emili, A., Belkina, A. C., Cardamone, M. D., & Perissi, V. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101682 · Cited by 11 · see citing works

The translational network for metabolic disease – from protein interaction to disease co-occurrence

Nam, Y., Lee, D. A., Bang, S., Kim, J. H., Kim, J., & Shin, H. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-3106-9 · Cited by 10 · see citing works

Disease embryo development network reveals the relationship between disease genes and embryo development genes

Gong, B., Liu, T., Zhang, X., Chen, X., Li, J., Lv, H., Zou, Y., Li, X., & Rao, S. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.07.018 · Cited by 10 · see citing works

Essential steps in super user education for ambulatory clinic nurses.

McIntire, S., & Clark, T. M. (2009) · PubMed · Cited by 9 · see citing works

Uses of Forward and Reverse Genetics in Mice to Study Gene Function

Argmann, C., Dierich, A., & Auwerx, J. H. (2006) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb29a01s73 · Cited by 8 · see citing works

Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats

Salinas‐Rubio, D., Tovar, A. R., Torre-Villalvazo, I., Granados‐Portillo, O., Torres, N., Pedraza‐Chaverrí, J., & Noriega, L. G. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.05.011 · Cited by 7 · see citing works

Antidiabetic Activity

Vogel, H. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-70995-4_12 · Cited by 6 · see citing works

Génomique fonctionnelle de la souris : la dynamique européenne

Masson, R., Sorg, T., & Warot, X. (2007) · médecine/sciences · doi:10.1051/medsci/20072310877 · Cited by 3 · see citing works

Protective effects of Vitamin E against Zinc Oxide nanoparticle--induced Oxidative stress, genotoxicity, and histotoxicity of hepatic and testicular tissues in male albino rats

Hosney, A., Khamis, H., Ali, H., & Kheirallah, N. (2026) · Biobacta Journal of Biochemistry and Molecular Biology · doi:10.71428/bjbmb.2026.0301 · Cited by 1 · see citing works

Die eukaryotische Zelle und Modellorganismen

Graw, J. (2020) · Springer eBooks · doi:10.1007/978-3-662-60909-5_5 · Cited by 1 · see citing works

Punching Above Their Weight: The Compact Genomes of Pufferfishes

Cusack, B. P., & Crollius, H. R. (2012) · Springer eBooks · doi:10.1007/978-3-642-31316-5_5 · Cited by 1 · see citing works

Characterization of RPE65 and RDH12, two enzymes associated with retinal dystrophy and retinoid processing

Chrispell, J. D. (2010) · Deep Blue (University of Michigan)

Gene Inactivation and Tissue‐specific Metabolism

Flowers, M. T., & Ntambi, J. M. (2008) · Wiley eBooks · doi:10.1002/9780470015902.a0021020

Die eukaryotische Zelle und Modellorganismen

Graw, J. (2015) · Springer eBooks · doi:10.1007/978-3-662-44817-5_5

Genetically Diabetic Animals

Müller, G. A. (2015) · Springer eBooks · doi:10.1007/978-3-642-27728-3_64-1

PTEN Loss and Reactive Microenvironments in Prostate Cancer Progression

Strand, D. W. (2011) · Defense Technical Information Center (DTIC) · doi:10.21236/ada550912

Mouse Genome Mapping and Genomics

Denny, P. (2012) · Springer eBooks · doi:10.1007/978-3-642-31316-5_8

Genetically Diabetic Animals

Müller, G. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-05392-9_64

Die eukaryotische Zelle und Modellorganismen

Ehrenhofer‐Murray, A. E. (2025) · Springer eBooks · doi:10.1007/978-3-662-70328-1_5

New Animal Models for Study of Metabolism Minireview Series

Hanson, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300016200

Identification of new targets playing a role in metabolic diseases by systemic phenotypic analysis of mouse mutant lines in the German Mouse Clinic

Rozman, J. (2013) · 한국실험동물학회 학술발표대회 논문집

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Rozman, J., Rathkolb, B., Oestereicher, M. A., Schütt, C., Ravindranath, A. C., Leuchtenberger, S., Sharma, S., Kistler, M., Willershäuser, M., Brommage, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-01995-2 · Cited by 70 · see citing works

Understanding mouse models of disease through metabolomics

Griffin, J. L. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.06.027 · Cited by 84 · see citing works

Genome-scale modeling and in silico analysis of mouse cell metabolic network

Selvarasu, S., Karimi, I. A., Ghim, G.-H., & Lee, D. (2009) · Molecular BioSystems · doi:10.1039/b912865d · Cited by 75 · see citing works