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Pharmacological interventions for non-ulcer dyspepsia

Moayyedi, Paul, Shelly, Soo, Deeks, Jonathan J, Delaney, Brendan, Innes, Michael, Forman, David·2006·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd001960.pub3
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Abstract

Background The commonest cause of upper gastrointestinal symptoms is non-ulcer dyspepsia (NUD) and yet the pathophysiology of this condition has been poorly characterised and the optimum treatment is uncertain. It is estimated that pound450 million is spent on dyspepsia drugs in the UK each year. Objectives This review aims to determine the effectiveness of six classes of drugs (antacids, histamine H(2) antagonists, proton pump inhibitors, prokinetics, mucosal protecting agents and antimuscarinics) in the improvement of either the individual or global dyspepsia symptom scores and also quality of life scores patients with non-ulcer dyspepsia. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2005), MEDLINE (1966 to January 2006), EMBASE (1988 to January 2006), CINAHL (1982 to January 2006), SIGLE, and reference lists of articles. We also contacted experts in the field and pharmaceutical companies. Trials were located through electronic searches of the Cochrane Controlled Trials Register (CCTR), MEDLINE, EMBASE, CINAHL and SIGLE, using appropriate subject headings and text words, searching bibliographies of retrieved articles, and through contacts with experts in the fields of dyspepsia and pharmaceutical companies. Selection criteria All randomised controlled trials (RCTs) comparing drugs of any of the six groups with each other or with placebo for non-ulcer dyspepsia (NUD). Data collection and analysis Two…

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  • PPIs do not improve quality of life compared with placebo in functional dyspepsia (no evidence of a difference).

    “We have confirmed the findings from Moayyedi 2006 on the lack of a positive effect of PPIs over placebo on improving QoL.”

    From Proton pump inhibitors for functional dyspepsia (2017) · cites this paper as Moayyedi 2006

  • There is substantial heterogeneity and methodological differences between the two studies comparing PPIs and H2RAs that may explain inconsistent results.

    “As previously reported by Moayyedi 2006, we found substantial heterogeneity and methodological differences between the two studies that may explain the inconsistent results.”

    From Proton pump inhibitors for functional dyspepsia (2017) · cites this paper as Moayyedi 2006

  • The results from this review were similar to the findings of previous systematic reviews (Moayyedi 2006; Wang 2007), supporting the beneficial effect of PPIs in functional dyspepsia.

    “The fact that the results from our review were similar to the findings of previous systematic reviews (Moayyedi 2006; Wang 2007) support the beneficial effect of PPIs in FD”

    From Proton pump inhibitors for functional dyspepsia (2017) · cites this paper as Moayyedi 2006

  • The review confirmed the findings from Moayyedi 2006 on the lack of a positive effect of PPIs over placebo on improving quality of life.

    “We have confirmed the findings from Moayyedi 2006 on the lack of a positive effect of PPIs over placebo on improving QoL.”

    From Proton pump inhibitors for functional dyspepsia (2017) · cites this paper as Moayyedi 2006

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Metadata

Authors
Moayyedi, P., Shelly, S., Deeks, J. J., Delaney, B., Innes, M., & Forman, D.
Venue
Cochrane Database of Systematic Reviews
Publisher
John Wiley & Sons, Ltd
Published
2006-10-18
DOI
10.1002/14651858.cd001960.pub3
Cited by
99
References
1
Language
en
Status
Retracted
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