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Cooling for newborns with hypoxic ischaemic encephalopathy
Open accessAbstract
BACKGROUND: Newborn animal studies and pilot studies in humans suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae without adverse effects. OBJECTIVES: To determine the effect of therapeutic hypothermia in encephalopathic asphyxiated newborn infants on mortality, long-term neurodevelopmental disability and clinically important side effects. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal Review Group as outlined in The Cochrane Library (Issue 2, 2007). Randomised controlled trials evaluating therapeutic hypothermia in term and late preterm newborns with hypoxic ischaemic encephalopathy were identified by searching the Oxford Database of Perinatal Trials, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, 2007, Issue 2), MEDLINE (1966 to June 2007), previous reviews including cross-references, abstracts, conferences, symposia proceedings, expert informants and journal handsearching. We updated this search in May 2012. SELECTION CRITERIA: We included randomised controlled trials comparing the use of therapeutic hypothermia with standard care in encephalopathic term or late preterm infants with evidence of peripartum asphyxia and without recognisable major congenital anomalies. The primary outcome measure was death or long-term major neurodevelopmental disability. Other outcomes included adverse effects of cooling and 'early' indicators of neurodevelopmental outcome. DATA COLLECTION AND ANALYSIS: Four review authors independently selected, assessed the quality of and extracted data from the included studies. Study authors were contacted for further information. Meta-analyses were performed using risk ratios (RR) and risk differences (RD) for dichotomous data, and weighted mean difference for continuous data with 95% confidence intervals (CI). MAIN RESULTS: We included 11 randomised controlled trials in this updated review, comprising 1505 term and late preterm infants with moderate/severe encephalopathy and evidence of intrapartum asphyxia. Therapeutic hypothermia resulted in a statistically significant and clinically important reduction in the combined outcome of mortality or major neurodevelopmental disability to 18 months of age (typical RR 0.75 (95% CI 0.68 to 0.83); typical RD -0.15, 95% CI -0.20 to -0.10); number needed to treat for an additional beneficial outcome (NNTB) 7 (95% CI 5 to 10) (8 studies, 1344 infants). Cooling also resulted in statistically significant reductions in mortality (typical RR 0.75 (95% CI 0.64 to 0.88), typical RD -0.09 (95% CI -0.13 to -0.04); NNTB 11 (95% CI 8 to 25) (11 studies, 1468 infants) and in neurodevelopmental disability in survivors (typical RR 0.77 (95% CI 0.63 to 0.94), typical RD -0.13 (95% CI -0.19 to -0.07); NNTB 8 (95% CI 5 to 14) (8 studies, 917 infants). Some adverse effects of hypothermia included an increase sinus bradycardia and a significant increase in thrombocytopenia. AUTHORS' CONCLUSIONS: There is evidence from the 11 randomised controlled trials included in this systematic review (N = 1505 infants) that therapeutic hypothermia is beneficial in term and late preterm newborns with hypoxic ischaemic encephalopathy. Cooling reduces mortality without increasing major disability in survivors. The benefits of cooling on survival and neurodevelopment outweigh the short-term adverse effects. Hypothermia should be instituted in term and late preterm infants with moderate-to-severe hypoxic ischaemic encephalopathy if identified before six hours of age. Further trials to determine the appropriate techniques of cooling, including refinement of patient selection, duration of cooling and method of providing therapeutic hypothermia, will refine our understanding of this intervention.
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“Despite TH, some infants with HIE will exhibit poor long-term neurologic outcomes across a spectrum of severity including neurodevelopmental impairment (NDI) (3–6).”
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Cites
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Pharmacological interventions for somatoform disorders in adults
Kleinstäuber, M., Witthöft, M., Steffanowski, A., van Marwijk, H., Hiller, W., & Lambert, M. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010628.pub2 · Cited by 11,369
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862
Neonatal Encephalopathy Following Fetal Distress
Sarnat, H. B. (1976) · Archives of Neurology · doi:10.1001/archneur.1976.00500100030012 · Cited by 2,691
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
Azzopardi, D., Strohm, B., Edwards, A. D., Dyet, L. E., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M. I., Marlow, N., Porter, E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900854 · Cited by 1,715
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Marion, D. W., Penrod, L. E., Kelsey, S. F., Obrist, W. D., Kochanek, P. M., Palmer, A. M., Wisniewski, S. R., & DeKosky, S. T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360803 · Cited by 1,287
Edwards, A. D., Brocklehurst, P., Gunn, A. J., Halliday, H. L., Juszczak, E., Levene, M. I., Strohm, B., Thoresen, M., Whitelaw, A., & Azzopardi, D. (2010) · BMJ · doi:10.1136/bmj.c363 · Cited by 944
Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study
Badawi, N. A., Kurinczuk, J. J., Keogh, J., Alessandri, L. M., O'Sullivan, F., Burton, P. R., Pemberton, P. J., & Stanley, F. J. (1998) · BMJ · doi:10.1136/bmj.317.7172.1549 · Cited by 891
Childhood Outcomes after Hypothermia for Neonatal Encephalopathy
Shankaran, S., Pappas, A., McDonald, S. A., Vohr, B. R., Hintz, S. R., Yolton, K. A., Gustafson, K. E., Leach, T. M., Green, C., Bara, R., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112066 · Cited by 738
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1 of the 150 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Thayyil S Ayer M Guhan B Marlow N Jacobs I Costello A Whole body cooling using phase changing material in neonatal encephalopathy: a pilot randomised control trial. Proceedings of the Neonatal Society Autumn Conference; 2009 Nov 29; London London Neonatal Society 2009
- Filippi, Safety and efficacy of oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a pilot study of the Neonatal Neuroprotection of Asphyxiated Tuscan Infants (NeoNATI) Network, clinicaltrials.gov/show/NCT01241019
- Gunn, 2001, Is cerebral hypothermia a possible neuroprotective strategy after asphyxia in the premature fetus?, Pediatric Research, 49, 435A
- Pfister R Bingham P Carpenter J Horbar J Kenny M Inder T Hypothermia in practice, initial observations from the Vermont Oxford Network. Proceeding of the Pediatric Academic Society Conference. 2010 May 2; Vancouver E-PAS2010:26.32.5 2010
- The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2011
Cited by
Sorted by citations
Items 101–200 of 1,006
Moore, E., Nichol, A., Bernard, S. A., & Bellomo, R. (2011) · Injury · doi:10.1016/j.injury.2011.03.027 · Cited by 126
Chandrasekaran, M., Chaban, B., Montaldo, P., & Thayyil, S. (2017) · Journal of Perinatology · doi:10.1038/jp.2017.14 · Cited by 130
Physiologic and pharmacologic considerations for hypothermia therapy in neonates
Zanelli, S. A., Buck, M. L., & Fairchild, K. D. (2010) · Journal of Perinatology · doi:10.1038/jp.2010.146 · Cited by 125
Basu, S. K., Kaiser, J. R., Guffey, D., Minard, C. G., Guillet, R., & Gunn, A. J. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2015-308733 · Cited by 124
Massaro, A. N., Murthy, K., Zaniletti, I., Cook, N., DiGeronimo, R., Dizon, M. L. V., Hamrick, S. E. G., McKay, V. J., Natarajan, G., Rao, R., et al. (2014) · Journal of Perinatology · doi:10.1038/jp.2014.190 · Cited by 122
Park, W. S., Sung, S. I., Ahn, S. Y., Yoo, H. S., Sung, D. K., Im, G. H., Choi, S. J., & Chang, Y. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120893 · Cited by 122
Hoehn, T., Hansmann, G., Bührer, C., Simbruner, G., Gunn, A. J., Yager, J. Y., Levene, M. I., Hamrick, S. E. G., Shankaran, S., & Thoresen, M. (2008) · Resuscitation · doi:10.1016/j.resuscitation.2008.04.027 · Cited by 121
Hypothermia therapy for newborns with hypoxic ischemic encephalopathy
Silveira, R. C., & Procianoy, R. S. (2015) · Jornal de Pediatria · doi:10.1016/j.jped.2015.07.004 · Cited by 120
Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key
Ophelders, D. R. M. G., Gussenhoven, R., Klein, L., Jellema, R. K., Westerlaken, R. J. J., Hütten, M. C., Vermeulen, R. J., Wassink, G., Gunn, A. J., & Wolfs, T. G. A. M. (2020) · Cells · doi:10.3390/cells9081871 · Cited by 124
Brain Perfusion in Asphyxiated Newborns Treated with Therapeutic Hypothermia
Wintermark, P., Hansen, A. R., Gregas, M. C., Soul, J. S., LaBrecque, M. A., Robertson, R. L., & Warfield, S. K. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2708 · Cited by 119
van Handel, M., Swaab, H., de Vries, L. S., & Jongmans, M. J. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp049 · Cited by 117
Wintermark, P., Hansen, A. R., Warfield, S. K., Dukhovny, D., & Soul, J. S. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.072 · Cited by 115
Practical approaches to sedation and analgesia in the newborn
McPherson, C. C., Ortinau, C. M., & Vesoulis, Z. A. (2020) · Journal of Perinatology · doi:10.1038/s41372-020-00878-7 · Cited by 115
A tertiary care centerʼs experience with therapeutic hypothermia after pediatric cardiac arrest*
Fink, E. L., Clark, R. S. B., Kochanek, P. M., Bell, M. J., & Watson, R. S. (2009) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181c58237 · Cited by 114
Wood, T. R., Osredkar, D., Puchades, M. A., Maes, E., Falck, M., Flatebø, T., Walløe, L., Sabir, H., & Thoresen, M. (2016) · Scientific Reports · doi:10.1038/srep23430 · Cited by 114
Shepherd, E. S., Salam, R. A., Middleton, P., Makrides, M., McIntyre, S. J., Badawi, N. A., & Crowther, C. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012077.pub2 · Cited by 113
collaborators, T. E., Andrews, P., Sinclair, H. L., Battison, C. G., Polderman, K. H., Citerio, G., Mascia, L., Harris, B. A., Murray, G. D., Stocchetti, N., et al. (2011) · Trials · doi:10.1186/1745-6215-12-8 · Cited by 111
Perinatal asphyxia in the term newborn
Antonucci, R., Porcella, A., & Pilloni, M. D. (2014) · Journal of pediatric and neonatal individualized medicine · doi:10.7363/030269 · Cited by 118
Perinatal Events and Early Magnetic Resonance Imaging in Therapeutic Hypothermia
Bonifacio, S. L., Glass, H. C., VanderPluym, J. H., Agrawal, A. T., Xu, D., Barkovich, A. J., & Ferriero, D. M. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.09.003 · Cited by 110
Xenon Ventilation During Therapeutic Hypothermia in Neonatal Encephalopathy: A Feasibility Study
Dingley, J., Tooley, J., Liu, X., Scull-Brown, E., Elstad, M., Chakkarapani, E., Sabir, H., & Thoresen, M. (2014) · PEDIATRICS · doi:10.1542/peds.2013-0787 · Cited by 110
Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches
Arteaga, O., Alvarez, A. A., Revuelta, M., Santaolalla, F., Urtasun, A., & Hilario, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020265 · Cited by 110
Neonatal Encephalopathy: Beyond Hypoxic-Ischemic Encephalopathy
Russ, J. B., Simmons, R. L., & Glass, H. C. (2021) · NeoReviews · doi:10.1542/neo.22-3-e148 · Cited by 110
Perinatal brain damage: The term infant
Hagberg, H., Edwards, A. D., & Groenendaal, F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.09.011 · Cited by 115
Schreglmann, M., Ground, A., Vollmer, B., & Johnson, M. J. (2019) · Acta Paediatrica · doi:10.1111/apa.14821 · Cited by 109
Brief Update on Animal Models of Hypoxic-Ischemic Encephalopathy and Neonatal Stroke
Northington, F. J. (2006) · ILAR Journal · doi:10.1093/ilar.47.1.32 · Cited by 107
Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews
Shepherd, E. S., Salam, R. A., Middleton, P., Han, S., Makrides, M., McIntyre, S. J., Badawi, N. A., & Crowther, C. A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012409.pub2 · Cited by 108
Promoting Early Child Development With Interventions in Health and Nutrition: A Systematic Review
Vaivada, T., Gaffey, M. F., & Bhutta, Z. A. (2017) · PEDIATRICS · doi:10.1542/peds.2016-4308 · Cited by 107
Current thinking in the health care management of children with cerebral palsy
Graham, D., Paget, S., & Wimalasundera, N. (2019) · The Medical Journal of Australia · doi:10.5694/mja2.12106 · Cited by 108
Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis
Ouwehand, S., Smidt, L. C. A., Dudink, J., Benders, M. J. N. L., de Vries, L. S., Groenendaal, F., & van der Aa, N. E. (2020) · Neonatology · doi:10.1159/000505519 · Cited by 108
Neuroimaging in the term newborn with neonatal encephalopathy
Wisnowski, J. L., Wintermark, P., Bonifacio, S. L., Smyser, C. D., Barkovich, A. J., Edwards, A. D., de Vries, L. S., Inder, T. E., & Chau, V. (2021) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2021.101304 · Cited by 112
Self-citationNeonatal Encephalopathy: Treatment with Hypothermia
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Wood, T. R., & Thoresen, M. (2014) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2014.10.005 · Cited by 111
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Hypothermia for hypoxic–ischemic encephalopathy
Cotten, C. M., & Shankaran, S. (2010) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.10.7 · Cited by 106
Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU
Fairchild, K. D., Sokora, D., Scott, J. N., & Zanelli, S. A. (2009) · Journal of Perinatology · doi:10.1038/jp.2009.168 · Cited by 105
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Walsh, B. H., Neil, J. J., Morey, J., Yang, E., Silvera, M. V., Inder, T. E., & Ortinau, C. M. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.03.065 · Cited by 104
Self-citationTherapeutic hypothermia following perinatal asphyxia
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Inflammation‐induced sensitization of the brain in term infants
Fleiss, B., Tann, C. J., Degos, V., Sigaut, S., Steenwinckel, J. V., Schang, A., Kichev, A., Robertson, N. J., Mallard, C. E., Hagberg, H., et al. (2015) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12723 · Cited by 106
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Melatonin Promotes Myelination by Decreasing White Matter Inflammation After Neonatal Stroke
Villapol, S., Fau, S., Renolleau, S., Biran, V., Charriaut‐Marlangue, C., & Baud, O. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181fcb40b · Cited by 103
Preventing Brain Injury in the Preterm Infant—Current Controversies and Potential Therapies
Yates, N. J., Gunn, A. J., Bennet, L., Dhillon, S. K., & Davidson, J. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041671 · Cited by 101
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Eid, T., Gruenbaum, S. E., Dhaher, R., Lee, T.-S. W., Zhou, Y., & Danbolt, N. C. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_14 · Cited by 99
Lee‐Kelland, R., Jary, S., Tonks, J., Cowan, F. M., Thoresen, M., & Chakkarapani, E. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316509 · Cited by 100
Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis
Mathew, J. L., Kaur, N., & Dsouza, J. M. (2022) · Journal of Global Health · doi:10.7189/jogh.12.04030 · Cited by 99
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Glass, H. C., Bonifacio, S. L., Peloquin, S., Shimotake, T. K., Sehring, S. A., Sun, Y., Sullivan, J. E., Rogers, E. E., Barkovich, A. J., Rowitch, D. H., et al. (2010) · Neurocritical Care · doi:10.1007/s12028-009-9324-7 · Cited by 98
Brain Resuscitation in the Drowning Victim
Topjian, A., Berg, R. A., Bierens, J. J. L. M., Branche, C. M., Clark, R. S. B., Friberg, H., Hoedemaekers, C., Holzer, M. S., Katz, L. M., Knape, J. T. A., et al. (2012) · Neurocritical Care · doi:10.1007/s12028-012-9747-4 · Cited by 97
Shipley, L., Gale, C., & Sharkey, D. (2021) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2020-320902 · Cited by 97
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia
Solevåg, A. L., Schmölzer, G. M., & Cheung, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.028 · Cited by 95
Neuroprotective therapies in the NICU in term infants: present and future
Molloy, E. J., El‐Dib, M., Juul, S. E., Benders, M. J. N. L., Gonzalez, F. F., Bearer, C. F., Wu, Y. W., Robertson, N. J., Hurley, T., Branagan, A., et al. (2022) · Pediatric Research · doi:10.1038/s41390-022-02295-2 · Cited by 95
Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Munter, S. D., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-13 · Cited by 97
Chaudhari, T., & McGuire, W. L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006817.pub2 · Cited by 94
Birth Asphyxia and Hypoxic-Ischemic Brain Injury in the Preterm Infant
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Hypoxic-Ischemic encephalopathy and therapeutic hypothermia: the hemodynamic perspective
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Kessler, S. K., Topjian, A., Gutierrez‐Colina, A. M., Ichord, R., Donnelly, M., Nadkarni, V., Berg, R. A., Dlugos, D., Clancy, R. R., & Abend, N. S. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9450-2 · Cited by 92
Goeral, K., Urlesberger, B., Giordano, V., Kasprian, G. J., Wagner, M., Schmidt, L. M., Berger, A., Klebermaß-Schrehof, K., & Olischar, M. (2017) · Neonatology · doi:10.1159/000468976 · Cited by 92
Fang, A. Y., Gonzalez, F. F., Sheldon, R. A., & Ferriero, D. M. (2012) · Pediatric Research · doi:10.1038/pr.2012.138 · Cited by 91
Lawn, J. E., Bhutta, Z. A., Ezeaka, C., & Saugstad, O. D. (2023) · Neonatology · doi:10.1159/000530496 · Cited by 91
Hallberg, B., Olson, L., Bartocci, M., Edqvist, I., & Blennow, M. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2009.01303.x · Cited by 91
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Groenendaal, F., Casaer, A., Dijkman, K. P., Gavilanes, A. W. D., de Haan, T. R., ter Horst, H. J., Laroche, S. M., Naulaers, G., Rijken, M., Straaten, H. L. M. V., et al. (2013) · Neonatology · doi:10.1159/000348823 · Cited by 91
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Self-citationVaivada, T., Lassi, Z. S., Irfan, O., Salam, R. A., Das, J. K., Oh, C., Carducci, B., Jain, R. P., Als, D., Sharma, N., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02725-2 · Cited by 89
Walsh, B. H., Murray, D. M., & Boylan, G. B. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.03.032 · Cited by 88
Hypothermia Therapy for Neonatal Hypoxic Ischemic Encephalopathy in the State of California
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Towards evidence-based resuscitation of the newborn infant
Manley, B. J., Owen, L. S., Hooper, S. B., Jacobs, S. E., Cheong, J. L. Y., Doyle, L. W., & Davis, P. G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30547-0 · Cited by 86
Self-citationMagnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy
Parmentier, C. E. J., de Vries, L. S., & Groenendaal, F. (2022) · Diagnostics · doi:10.3390/diagnostics12030645 · Cited by 86
Greif, R., Bray, J., Djärv, T., Drennan, I. R., Liley, H. G., Ng, K.-C., Cheng, A., Douma, M. J., Scholefield, B. R., Smyth, M., et al. (2024) · Resuscitation · doi:10.1016/j.resuscitation.2024.110414 · Cited by 94
Self-citationLakshminrusimha, S., Shankaran, S., Laptook, A. R., McDonald, S. A., Keszler, M., Meurs, K. P. V., Guillet, R., Chawla, S., Sood, B. G., Bonifacio, S. L., et al. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.12.055 · Cited by 85
Akula, V. P., Joe, P., Thusu, K., Davis, A. S., Tamaresis, J. S., Kim, S., Shimotake, T. K., Butler, S., Honold, J., Kuzniewicz, M. W., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.12.061 · Cited by 84
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Oliveira, V., Singhvi, D. P., Montaldo, P., Lally, P., Mendoza, J., Manerkar, S., Shankaran, S., & Thayyil, S. (2017) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2017-313320 · Cited by 84
Kaandorp, J. J., van Bel, F., Veen, S., Derks, J. B., Groenendaal, F., Rijken, M., Roze, E., Venema, M. U., Rademaker, C. M. A., Bos, A. F., et al. (2011) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2011-300356 · Cited by 84
Sisa, C., Kholia, S., Naylor, J., Sanchez, M. B. H., Bruno, S., Deregibus, M. C., Camussi, G., Inal, J. M., Lange, S., & Hristova, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00282 · Cited by 85
Mitra, S., Kendall, G. S., Bainbridge, A. P., Sokolska, M., Dinan, M., Uria-Avellanal, C., Price, D., Mckinnon, K., Gunny, R. S., Huertas‐Ceballos, A., et al. (2018) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-315478 · Cited by 82
Oorschot, D. E., Sizemore, R. J., & Amer, A. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041487 · Cited by 82
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Xiong, T., Qu, Y., Mu, D., & Ferriero, D. M. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.12.007 · Cited by 81
Pinchefsky, E. F., Hahn, C. D., Kamino, D., Chau, V., Brant, R., Moore, A. M., & Tam, E. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.02.027 · Cited by 80
Thrombocytopenia in the newborn
Roberts, I. A. G., & Murray, N. A. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200302000-00004 · Cited by 80
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Bonifacio, S. L., deVries, L. S., & Groenendaal, F. (2015) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2014.12.011 · Cited by 80
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Wassink, G., Davidson, J. O., Lear, C. A., Juul, S. E., Northington, F. J., Bennet, L., & Gunn, A. J. (2018) · The Journal of Physiology · doi:10.1113/jp274928 · Cited by 80
Serdar, M., Kempe, K., Rizazad, M., Herz, J., Bendix, I., Felderhoff‐Müser, U., & Sabir, H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00237 · Cited by 79
Aridas, J. D. S., McDonald, C. A., Paton, M. C. B., Yawno, T., Sutherland, A. E., Nitsos, I., Pham, Y., Ditchfield, M. R., Fahey, M. C., Wong, F. Y., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271104 · Cited by 79
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Basu, A. P. (2014) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12407 · Cited by 79
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Balduini, W., Carloni, S., Perrone, S., Bertrando, S., Tataranno, M. L., Negro, S., Proietti, F., Longini, M., & Buonocore, G. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.663232 · Cited by 79
Shi, X.-D., Xu, L., Doycheva, D., Tang, J.-P., Yan, M., & Zhang, J. H. (2017) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x16656201 · Cited by 72
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Alderliesten, T., de Vries, L. S., Staats, L. C., van Haastert, I. C., Weeke, L. C., Benders, M. J. N. L., Koopman-Esseboom, C., & Groenendaal, F. (2016) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2016-310514 · Cited by 79
Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies
Glass, H. C. (2018) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000557 · Cited by 78
Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database
Kirkley, M. J., Boohaker, L. J., Griffin, R. L., Soranno, D. E., Gien, J., Askenazi, D. J., Gist, K. M., & (NKC), O. B. O. T. N. K. C. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-4068-2 · Cited by 79
Gagné-Loranger, M., Sheppard, M., Ali, N., Saint‐Martin, C., & Wintermark, P. (2015) · American Journal of Perinatology · doi:10.1055/s-0035-1563712 · Cited by 78
Perinatal risk factors for neonatal encephalopathy: an unmatched case-control study
Tann, C. J., Nakakeeto, M., Willey, B., Sewegaba, M., Webb, E. L., Oke, I., Mutuuza, E. D., Peebles, D., Musoke, M., Harris, K., et al. (2017) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2017-312744 · Cited by 78
Cardiovascular dysfunction in infants with neonatal encephalopathy: Table 1
Armstrong, K., Franklin, O., Sweetman, D., & Molloy, E. J. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2011.214205 · Cited by 77
Metabolic Alterations in Developing Brain After Injury: Knowns and Unknowns
McKenna, M. C., Scafidi, S., & Robertson, C. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1600-7 · Cited by 77
Jackson, T. C., & Kochanek, P. M. (2019) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2019.0001 · Cited by 77
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Wilkinson, D. J. C. (2011) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2011.4 · Cited by 76
Joseph, A., Wood, T. R., Chen, C., Corry, K. A., Snyder, J. M., Juul, S. E., Parikh, P., & Nance, E. A. (2018) · Nano Research · doi:10.1007/s12274-018-2104-y · Cited by 79
Early versus late MRI in asphyxiated newborns treated with hypothermia
Wintermark, P., Hansen, A. R., Soul, J. S., LaBrecque, M. A., Robertson, R. L., & Warfield, S. K. (2010) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2010.184291 · Cited by 76
Metadata
- Authors
- Jacobs, S. E., Berg, M., Hunt, R., Tarnow-Mordi, W. O., Inder, T. E., & Davis, P. G.
- Affiliations
- Royal Women's Hospital (AU)
- University of Vermont Medical Center (US)
- Royal Children's Hospital (AU)
- Westmead Hospital (AU)
- St. Louis Children's Hospital (US)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2013-01-31
- Volume
- 2013
- Issue
- 3
- Pages
- CD003311-CD003311
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC7003568
- OpenAlex
- W1830337612
- Cited by
- 2,328
- References
- 150
- Citations by year
- 2026: 44 · 2025: 142 · 2024: 190 · 2023: 179 · 2022: 191 · 2021: 231 · 2020: 157 · 2019: 132 · 2018: 162 · 2017: 155 · 2016: 138 · 2015: 142 · 2014: 107 · 2013: 65
- FWCI
- 21.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- therapeutic hypothermia, hypoxic-ischemic encephalopathy, neonates, intrapartum asphyxia, neurodevelopmental disorders, neonatal mortality, term infants, late preterm infants, neuroprotection, neonatal resuscitation, hypothermia duration
- MeSH terms
- Asphyxia Neonatorum, Developmental Disabilities, Humans, Hypothermia, Induced, Infant, Infant, Newborn, Infant, Premature, Randomized Controlled Trials as Topic, Hypoxia-Ischemia, Brain, Term Birth
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