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Cited by 171Poisoning and overdose treatmentsDrug-Induced Hepatotoxicity and ProtectionParaquat toxicity studies and treatments

The DOI matches its Crossref record; 131 of the 133 references it cites were found in a registry or an index.

Interventions for paracetamol (acetaminophen) overdose

Open access
Chiew, Angela L, Gluud, Christian, Brok, Jesper, Buckley, Nick A·2018·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd003328.pub3
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Abstract

BackgroundParacetamol (acetaminophen) is the most widely used non-prescription analgesic in the world.Paracetamol is commonly taken in overdose either deliberately or unintentionally.In high-income countries, paracetamol toxicity is a common cause of acute liver injury.There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person.These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites. ObjectivesTo assess the benefits and harms of interventions for paracetamol overdosage irrespective of the cause of the overdose. Search methodsWe searched The Cochrane Hepato-Biliary Group Controlled Trials Register (January 2017), CENTRAL (2016, Issue 11),

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2 of the 133 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. Bastaki, 2006, Drugs update, Emirates Medical Journal, 24, 245
  2. Douglas, 1976, Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning, Lancet, 1, 111, 10.1016/S0140-6736(76)93154-8 · DOI
  3. Hamlyn, 1980, Prevention of hepatic necrosis in severe paracetamol (acetaminophen) poisoning: prospective controlled trial of early treatment with cysteamine or methionine [abstract], Gut, 21, A448
  4. Keays, 1989, Use of late N-acetyl cysteine in severe paracetamol overdose [abstract], Gut, 30, A1512
  5. Gluud C Nikolova D Klingenberg SL Cochrane Hepato-Biliary Group About Cochrane (Cochrane Review Groups (CRGs)) 2017, Issue 5. Art. No.: LIVER
  6. Higgins JPT Altman DG Sterne JAC Chapter 8: Assessing risk of bias in included studies In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011
  7. The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014
  8. Skoog, 2015, Transparency and Registration in Clinical Research in the Nordic Countries

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Metadata

Authors
Chiew, A. L., Gluud, C., Brok, J., & Buckley, N. A.
Affiliations
  • The University of Sydney (AU)
  • Copenhagen University Hospital (DK)
  • Rigshospitalet (DK)
  • University of Sydney; Department of Pharmacology; Camperdown NSW Australia
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2018-02-23
Volume
2018
Issue
2
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd003328.pub3
OpenAlex
W3183688590
Cited by
170
References
133
Citations by year
2026: 14 · 2025: 22 · 2024: 18 · 2023: 27 · 2022: 32 · 2021: 24 · 2020: 15 · 2019: 14 · 2018: 4
FWCI
3.52
Type
journal article
Language
en
Open access
Locations
Cochrane Database of Systematic Reviews (publishedVersion)
Topics
  • Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
Keywords
acetaminophen overdose, acetaminophen toxicity, acute liver injury, decontamination, paracetamol removal, analgesic overdose, therapeutic interventions

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