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Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents
Open accessAbstract
BACKGROUND: Depressive disorders are common in young people and are associated with significant negative impacts. Selective serotonin reuptake inhibitors (SSRIs) are often used, however, evidence of their effectiveness in children and adolescents is not clear. Furthermore, there have been warnings against their use in this population due to concerns about increased risk of suicidal ideation and behaviour. OBJECTIVES: To determine the efficacy and adverse outcomes, including definitive suicidal behaviour and suicidal ideation, of SSRIs compared to placebo in the treatment of depressive disorders in children and adolescents. SEARCH STRATEGY: We searched the CCDAN Trials Register, MEDLINE, PSYCHINFO and CENTRAL. Reference lists were checked, letters were sent to key researchers and internet databases searched. SELECTION CRITERIA: We included published and unpublished randomised controlled trials. DATA COLLECTION AND ANALYSIS: Two or three review authors selected the trials, assessed the quality and extracted trial and outcome data. We used a fixed-effect meta-analysis. The relative risk was used to summarise dichotomous outcomes and the mean difference to summarise continuous measures. MAIN RESULTS: Twelve trials were eligible for inclusion, with ten providing usable data. At 8-12 weeks, there was evidence that children and adolescents 'responded' to treatment with SSRIs (RR 1.28, 95% CI 1.17 to 1.41). There was also evidence of an increased risk of suicidal ideation and behaviour for those prescribed SSRIs (RR 1.80, 95% CI 1.19 to 2.72). Fluoxetine was the only SSRI where there was consistent evidence from three trials that it was effective in reducing depression symptoms in both children and adolescents (CDRS-R treatment effect -5.63, 95% CI -7.38 to -3.88), and 'response' to treatment (RR 1.86, 95% CI 1.49 to 2.32). Where rates of adverse events were reported, this was higher for those prescribed SSRIs. AUTHORS' CONCLUSIONS: Caution is required to interpret the results. First, there were methodological issues, including high attrition, issues regarding measurement instruments and clinical usefulness of outcomes, often variously defined across trials. Second, patients seen in clinical practice are likely to be more unwell, and at greater risk of suicide, compared to those in the trials, and it is unclear how this group would respond to SSRIs. This needs to be considered, along with the evidence of an increased risk of suicide related outcomes in those treated with SSRIs. It is unclear what the effect of SSRIs is on suicide completion. While untreated depression is associated with the risk of completed suicide and impacts on functioning, it is unclear whether SSRIs would modify this risk in a clinically meaningful way.
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“due to the concern that taking antidepressant medications may potentially result in suicidal behaviour”
From Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents (2012) · cites this paper as Hetrick 2007
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“Recent reviews highlight uncertainty about the risk-benefit ratio of selective serotonin reuptake inhibitors (SSRIs) (Bridge 2007; Hetrick 2007)”
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Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
Morbidity and Mortality Weekly Report
Hiv/aids, N. B. (2011) · Wilderness and Environmental Medicine · doi:10.1016/j.wem.2010.11.007 · Cited by 3,431
What is meant by intention to treat analysis? Survey of published randomised controlled trials
Hollis, S., & Campbell, F. (1999) · BMJ · doi:10.1136/bmj.319.7211.670 · Cited by 2,160
Childhood and adolescent depression: a review of the past 10 years, Part I
BIRMAHER, B., RYAN, N. D., WILLIAMSON, D. E., BRENT, D. A., KAUFMAN, J., DAHL, R. E., PEREL, J., & NELSON, B. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199611000-00011 · Cited by 2,076
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.56 · Cited by 1,753
Psychiatric Diagnosis in Child and Adolescent Suicide
Shaffer, D. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830040075012 · Cited by 1,250
Major depressive disorder in older adolescents
Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (1998) · Clinical Psychology Review · doi:10.1016/s0272-7358(98)00010-5 · Cited by 1,078
Flagged first, then by citations
2 of the 114 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
- Mandoki, 1997, Vanlafaxine in the treatment of children and adolescents with major depression, Psychopharmacology Bulletin, 33, 149
- Dubitsky GM Review and Evaluation of Clinical Data: Placebo-Controlled Antidepressant Studies In Pediatric Patients Medicines and Healthcare Products Regulatory Agency
- Essau, 1999, In FPCA Essau (Ed). Depressive Disorders in Children and Adolescents: Epidemiology, Risk Factors and Treatment (p 326)
- Jureidini J Tonkin A Paroxetine in major depression Journal of the American Academy of Child and Adolescent Psychiatry 2003 514 · DOI
- Moncrieff, 2005, Active placebo versus antidepressants for depression, Cochrane Database of Systematic Reviews
- Murray, 1996, The Global Burden of Disease. A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020
- 1997, Depression in young people: Clinical Practice Guidelines
- 2005, Depression in Children and Young People: Identification and management in primary, community and secondary care
- Petti, 1985, Scales of potential use in the psychopharmacological treatment of depressed children and adolescents, Psychopharmacology Bulletin, 21, 951
- The Nortic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2003
Cited by
Sorted by citations
Items 101–180 of 180
Imaging genetics: implications for research on variable antidepressant drug response
Rabl, U., Scharinger, C., Müller, M., & Pezawas, L. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.35 · Cited by 15
Zhang, Y., Gao, Y., Li, X., Zou, Y., Ye, Y., & Zou, Z. (2025) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-025-02688-8 · Cited by 20
El suicidio y algunos de sus correlatos neurobiológicos. Segunda parte
Gutiérrez‐García, A. G., & Contreras, C. M. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 13
Strategies for the Prescription of Psychotropic Drugs with Black Box Warnings
Stevens, J. R., Jarrahzadeh, T., Brendel, R. W., & Stern, T. A. (2013) · Psychosomatics · doi:10.1016/j.psym.2013.08.009 · Cited by 13
Mishara, B. L., & Chagnon, F. (2011) · Wiley eBooks · doi:10.1002/9781119998556.ch35 · Cited by 13
Yin, X., Xu, J., Dong, B., Ma, J., Chen, Z., Yin, P., Wu, J., Zhu, B.-C., Cao, Y., Zheng, H., et al. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/1069597 · Cited by 12
Tkachev, A., Stekolshchikova, E., Bobrovskiy, D. M., Anikanov, N. A., Ogurtsova, P., Park, D. I., Horn, A. K. E., Petrova, D., Khrameeva, E. E., Golub, M. S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158089 · Cited by 12
Advances in the prevalence and treatment of depression for adolescents: a review
Yin, C., Xu, M., & Zong, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1574574 · Cited by 13
Antidepressant use in children and adolescents: Practice touch points to guide paediatricians
Oberlander, T. F., & Miller, A. R. (2011) · Paediatrics & Child Health · doi:10.1093/pch/16.9.549 · Cited by 11
Klomp, A., Hamelink, R., Feenstra, M. G. P., Denys, D. A. J. P., & Reneman, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099873 · Cited by 11
Saastamoinen, L., Wallin, M., Lavikainen, P., Airaksinen, M., Sourander, A., & Bell, J. S. (2012) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1233-6 · Cited by 10
Su, S.-Y., Hogrefe, C. E., Asara, J. M., Turck, C. W., & Golub, M. S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.017 · Cited by 10
Similia similibus curentur: o princípio de cura homeopático fundamentado na farmacologia moderna
Teixeira, M. Z. (2013) · Revista de Medicina · doi:10.11606/issn.1679-9836.v92i3p183-203 · Cited by 13
A guide to what works for depression in young people
Purcell, R., Ryan, S., Scanlan, F., Morgan, A. J., Callahan, P. M., Allen, N., & Jorm, A. F. (2010) · Swinburne figshare (Swinburne University of Technology) · Cited by 9
Overweight of Adolescent Girls Is Associated with Self-Mutilative Behavior
Riala, K., Juutinen, J., Hakko, H. H., Räsänen, P. K., & workgroup, A. T. S.-7. (2011) · Psychopathology · doi:10.1159/000322085 · Cited by 8
Antidepressant‐like effects and basal immobility depend on age and serotonin transporter genotype
Mitchell, N. C., Koek, W., & Daws, L. C. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12238 · Cited by 8
Mosheva, M., Mekori‐Domachevsky, E., Kantor, S., Berg, Y., Weizman, A., & Gothelf, D. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0229 · Cited by 8
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Delicou, S., & Maragkos, K. (2013) · EMJ Hematology · doi:10.33590/emjhematol/10310931 · Cited by 8
Regulation of emotional response in juvenile monkeys treated with fluoxetine: MAOA interactions
Golub, M. S., Hogrefe, C. E., & Bulleri, A. M. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.10.010 · Cited by 7
Health care consequences of black-box warnings for antidepressants in the United States and Canada
Nagar, S. P., Mehta, S., Bhatara, V. S., & Aparasu, R. R. (2009) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2009.02.005 · Cited by 7
Comorbidity: Coexisting substance use and mental disorders in young people
Howard, J., Stubbs, M., & Arcuri, A. (2007) · Clinical Psychologist · doi:10.1080/13284200701871853 · Cited by 6
Childhood maltreatment and its impact on the mental health
Sivolap, Y. P., & Portnova, A. A. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201611671108-112 · Cited by 6
Yan, Y., Zhao, Y., Lu, Y., Acharya, A. P., Wang, W., Zhan, C., Ye, J., Du, F., Zhu, X., & Xu, Y. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad020 · Cited by 6
Serotonin Dysfunction in Autism
Blue, M. E., Johnston, M. V., Moloney, C. B., & Höhmann, C. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-489-0_5 · Cited by 6
The use of cognitive behavioral therapy in the treatment of resistant depression in adolescents
Skoch, S. H., Skoch, S. H., & Hicks, X. P. (2012) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s13781 · Cited by 6
Potential Risks for the Off-Label Use of SSRIs in Premature Ejaculation (CME)
Jc, L. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01945.x · Cited by 5
Callahan, P., Hetrick, S. E., Churchill, R. C., Hunot, V., Merry, S., & Parker, A. G. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008324 · Cited by 5
Self-citationThe provision of cognitive behavioral therapy in Japan: an analysis using insurance claims data
Mukai, K., Hosoi, Y., Yamanishi, K., Sakurai, M., Ogino, S., Hayashida, K., & Matsunaga, H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07316-y · Cited by 5
A survey-wide association study to identify youth-specific correlates of major depressive episodes
Dhodapkar, R. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232373 · Cited by 5
Biomarkers associated with treatment outcome in young people with depression: A systematic review
Zierotin, A., Mondelli, V., & Zajkowska, Z. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104082 · Cited by 4
Wang, D., Wang, J., Yan, D., Wang, M., Yang, L., Demin, K. A., de Abreu, M. S., & Kalueff, A. V. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149209 · Cited by 4
Managing high‐acuity‐depressed adults in primary care
Sobczak, J. A. (2009) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2009.00422.x · Cited by 4
Treatment decision making for young people diagnosed with major depressive disorders
Simmons, M. B. (2011) · Minerva Access (University of Melbourne) · Cited by 4
Koç, D., Ince, E., San, T., Akan, P., Paketçi, A., Böber, E., Direk, N., İnal, N., & Akay, A. P. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114676 · Cited by 3
Treating dexamethasone‐induced mood disorders in children with leukemia
Joshi, D. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21518 · Cited by 3
Delaney, M. (2009) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x09990031 · Cited by 3
Carey, T. A., & Oxman, L. N. (2007) · Clinical Psychologist · doi:10.1080/13284200701870962 · Cited by 3
A narrative review of major depressive disorder in children and adolescents
Gehlawat, P., & Kumar, G. V. (2020) · Archives of Depression and Anxiety · doi:10.17352/2455-5460.000046 · Cited by 2
Antidepressants and Black Box Warning: Duty to Inform or Unintended Consequence of Cautious Response
Naveed, S., Urrutia, V., Zeshan, M., Akal, H., Backman, A. E., & Malik, S. (2021) · Psychiatric Annals · doi:10.3928/00485713-20210916-01 · Cited by 2
Clinical inquiries. Which drugs are safest for moderate to severe depression in adolescents?
Guirguis‐Blake, J., Wright, A., Rich, J., & Crawford, J. (2008) · PubMed · Cited by 2
[Do antidepressive agents work against depression?].
Næss, M. S. (2017) · Tidsskrift for Den Norske Laegeforening · doi:10.4045/tidsskr.17.0263 · Cited by 1
An Overview of Depressive Disorder in Chinese Adolescents
Bu, Y., & Chen, Y. (2022) · Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research · doi:10.2991/assehr.k.220504.408 · Cited by 2
Gordon, M., & Melvin, G. A. (2014) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12517 · Cited by 2
Kratochvil, C. J., Kutcher, S., Murphy, A. L., & Gardner, D. M. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181825ae1 · Cited by 2
Zinck, S., Bagnell, A. L., Bond, K., & Newton, A. S. (2009) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.439 · Cited by 2
Escitalopram in the Treatment of Major Depressive Disorder in Adolescent Patients†
Yang, L. P. H., & Scott, L. J. (2010) · CNS Drugs · doi:10.2165/11204690-000000000-00000 · Cited by 2
Pharmacological treatment of depression and bipolar disorder in children and adolescents
Dubicka, B., Wilkinson, P. O., Kelvin, R. G., & Goodyer, I. M. (2010) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.108.005553 · Cited by 2
Antidepressants for functional gastrointestinal disorders in children.
Tan, E., Smith, C. H., & Goldman, R. D. (2013) · Europe PMC (PubMed Central) · Cited by 2
Safety of Psychotropic Drugs in Children and Adolescents
Kaguelidou, F., & Acquaviva, É. (2015) · Springer eBooks · doi:10.1007/978-3-319-24741-0_13 · Cited by 2
Rang, H. P., Dale, M. M., Ritter, J. M., Flower, R. J., & Henderson, G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-7020-3471-8.00046-9 · Cited by 2
Evaluation and treatment of male pelvic pain syndromes and sexual dysfunction
Paduch, D. A. (2008) · Current Prostate Reports · doi:10.1007/s11918-008-0020-4 · Cited by 2
Entwicklungspsychiatrische Aspekte depressiver Störungen
Mehler‐Wex, C. (2012) · Nervenheilkunde · doi:10.1055/s-0038-1628164 · Cited by 1
Getting the Bug: Exploring Running Group Therapy for Youth with Affective Disorders
Bell, J. (2009) · Scholars Commons (Wilfrid Laurier University) · Cited by 1
The Treatment of Preschool Mood Disorders
DeFilippis, M., & Wagner, K. D. (2015) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-015-0036-7 · Cited by 1
Idiosyncratic Adverse Reactions to Psychotropic Medications
Stevens, J. R., Rodgers, J. J., & Stern, T. A. (2016) · Psychiatric Annals · doi:10.3928/00485713-20160622-01 · Cited by 1
A Narrative Review: Serotonin Reuptake Inhibitors and the Risk of Suicidal Ideation in Adolescents
Gage, D. S., Priefer, V. E., & Priefer, R. (2025) · Adolescents · doi:10.3390/adolescents5010005 · Cited by 1
Depression in Children and Adolescents
Hirota, T., Milavić, G., McNicholas, F., Frodl, T., & Skokauskas, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802456-0.00010-8 · Cited by 2
Hinojosa, A. B., Gassó, P., Rodríguez, N., Boloc, D., Torres, T., Mas, S., Lafuente, A., & Lázaro, L. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.523 · Cited by 1
Depression Treatment Evidence and Application to Individuals with Intellectual Disability
Kemp, G. N., Curren, L. C., O’Connor, E., Kritikos, T. K., & Tompson, M. C. (2020) · Autism and child psychopathology series · doi:10.1007/978-3-030-46835-4_28 · Cited by 1
Cardiovascular Effects of Antidepressants and Mood Stabilizers
Maleki, J., & Akhondzadeh, S. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Sociodemographic correlates of antidepressant utilisation in Australia
Simmons, M. B., Willet, M. R., & Hetrick, S. E. (2009) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2009.tb02895.x · Cited by 1
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Abel, U., & Hautzinger, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-29791-5_3
Cognitive-Behavioural Therapy Combined with Antidepressants for Major Depressive Disorder
Maneeton, N. (2012) · InTech eBooks · doi:10.5772/30340
Sport und psychische Gesundheit
Hartmann, T., & Pühse, U. (2009) · Springer eBooks · doi:10.1007/978-3-540-79545-2_51
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Kolshus, E. M., Kolshus, E. H., Gavin, B. E., Cullen, W., & McNicholas, F. (2015) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2015.52
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Loyola, G. (2010) · UA Campus Repository (The University of Arizona)
Medicamentos y conducta suicida: un estudio de casos y controles
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Abidi, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-58027-2_20
Why do we need to publish paediatric data?
Auby, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-100616-0.00013-7
Brook, L. A. (2010) · Pediatric Hematology and Oncology · doi:10.1002/9781444315134.ch23
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Bauer, K. H. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-827 · Cited by 3
Steinhausen, H. (2019) · Elsevier eBooks · doi:10.1016/b978-3-437-21083-9.00014-3
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Ren, J., Yu, Y., Zhu, Y., Zhou, Y., Wang, K., Zhang, Y., Duan, S., Xuan, F., Ma, Y., Li, N., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107533
Metadata
- Authors
- Hetrick, S. E., Merry, S. N., McKenzie, J., Sindahl, P., & Proctor, M.
- Affiliations
- The University of Melbourne (AU)
- University of Auckland (NZ)
- Monash University (AU)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2007-07-18
- Issue
- 3
- Pages
- CD004851-CD004851
- ISSN
- 1361-6137 (ISSN-L)
- OpenAlex
- W1935785240
- Cited by
- 180
- References
- 114
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 14 · 2015: 5 · 2014: 11 · 2013: 15 · 2012: 27
- Type
- reference entry
- Language
- en
- Update notices
- new_version (2012-11-14)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- selective serotonin reuptake inhibitors, childhood depression, adolescent depression, suicidal ideation, suicidal behavior, fluoxetine, antidepressant efficacy, adverse drug reactions, treatment response, placebo comparison, antidepressant-induced mania
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Depressive Disorder, Fluoxetine, Humans, Suicide, Citalopram, Randomized Controlled Trials as Topic, Selective Serotonin Reuptake Inhibitors, Paroxetine, Sertraline
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