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Homocysteine lowering interventions for preventing cardiovascular events
Open accessAbstract
BACKGROUND: Cardiovascular disease such as coronary artery disease, stroke and congestive heart failure, is a leading cause of death worldwide. A postulated risk factor is elevated circulating total homocysteine (tHcy) levels which is influenced mainly by blood levels of cyanocobalamin (vitamin B12), folic acid (vitamin B9) and pyridoxine (vitamin B6). There is uncertainty regarding the strength of association between tHcy and the risk of cardiovascular disease. OBJECTIVES: To assess the clinical effectiveness of homocysteine-lowering interventions (HLI) in people with or without pre-existing cardiovascular disease. SEARCH STRATEGY: We searched The Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library (issue 3 2008), MEDLINE (1950 to August 2008), EMBASE (1988 to August 2008), and LILACS (1982 to September 2, 2008). We also searched in Allied and Complementary Medicine (AMED; 1985 to August 2008), ISI Web of Science (1993 to August 2008), and the Cochrane Stroke Group Specialised Register (April 2007). We hand searched pertinent journals and the reference lists of included papers. We also contacted researchers in the field. There was no language restriction in the search. SELECTION CRITERIA: We included randomised clinical trials (RCTs) assessing the effects of HLI for preventing cardiovascular events with a follow-up period of 1 year or longer. We considered myocardial infarction and stroke as the primary outcomes. We excluded studies in patients with end-stage renal disease. DATA COLLECTION AND ANALYSIS: We independently performed study selection, risk of bias assessment and data extraction. We estimated relative risks (RR) for dichotomous outcomes. We measured statistical heterogeneity using I(2). We used a random-effects model to synthesise the findings. MAIN RESULTS: We included eight RCTs involving 24,210 participants with a low risk of bias in general terms. HLI did not reduce the risk of non-fatal or fatal myocardial infarction, stroke, or death by any cause (pooled RR 1.03, 95% CI 0.94 to 1.13, I(2) = 0%; pooled RR 0.89, 95% CI 0.73 to 1.08, I(2) = 15%); and pooled RR 1.00 (95% CI 0.92 to 1.09, I(2): 0%), respectively. AUTHORS' CONCLUSIONS: Results from available published trials suggest that there is no evidence to support the use of HLI to prevent cardiovascular events.
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“The Cochrane Collaboration concluded in a recent meta-analysis of eight RCTs that homocysteine-lowering interventions did not reduce the risk of fatal/non-fatal myocardial infarction (RR 1.03, 95% CI 0.94-1.13),stroke (RR 0.89, 95% CI 0.73 -1.08), or death by any cause (RR 1.00, 95% CI 0.92-1.09).290”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [290]
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Items 201–311 of 311
Homocysteine and vitamin therapy in stroke prevention and treatment: a review.
Manolescu, B. N., Oprea, E., FARCASANU, I. C., Berteanu, M., & Cercasov, C. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2432 · Cited by 71
Homocysteine, a risk factor for cardiovascular disease
Prasad, K. (2005) · International Journal of Angiology · doi:10.1007/bf01616850 · Cited by 70
The controversial role of B-vitamins in cardiovascular risk: An update
Ntaios, G., Savopoulos, C. G., Grekas, D. M., & Hatzitolios, A. I. (2009) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2009.07.002 · Cited by 69
Potter, K., Hankey, G. J., GREEN, D. J., Eikelboom, J. W., Jamrozik, K. D., & Arnolda, L. (2008) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-8-24 · Cited by 68
Qin, X., Li, J., Spence, J. D., Zhang, Y., Li, Y., Wang, X., Wang, B., Sun, N., Chen, F., Guo, J., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.014578 · Cited by 65
Zappacosta, B., Mastroiacovo, P., Persichilli, S., Pounis, G., Ruggeri, S., Minucci, A., Carnovale, E., Andria, G., Ricci, R., Scala, I., et al. (2013) · Nutrients · doi:10.3390/nu5051531 · Cited by 64
Secondary prevention with folic acid: results of the Goes extension study: Figure 1
Liem, A. H., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., & van Veldhuisen, D. J. (2005) · Heart · doi:10.1136/hrt.2004.035030 · Cited by 64
Su, S.-J., Huang, L., Pai, L.-S., Liu, H., & Chang, K. (2005) · Nutrition · doi:10.1016/j.nut.2005.01.011 · Cited by 63
Jamison, D. T. T., Breman, J. G., Measham, A. R., Alleyne, G. A. O., Claeson, M., EVANS, D. B., Jha, P., MILLS, A. J., & Musgrove, P. (2006) · Cited by 62
Bahmani, F., Karamali, M., Shakeri, H., & Asemi, Z. (2014) · Clinical Endocrinology · doi:10.1111/cen.12451 · Cited by 62
Effect of Homocysteine-Induced Oxidative Stress on Endothelial Function in Coronary Slow-Flow
Tanriverdi, H. I., Evrengül, H., Enli, Y., et al. (2007) · Cardiology · doi:10.1159/000099068 · Cited by 59
Tighe, P., Ward, M., McNulty, H., Finnegan, O., Dunne, A., Strain, J., Molloy, A. M., Duffy, M. E., Pentieva, K. D., & Scott, J. M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29427 · Cited by 59
Lonn, E. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70238-0 · Cited by 59
Homocysteine lowering and cardiovascular disease risk: Lost in translation
Marcus, J. S., Sarnak, M. J., Menon, V., & Verma, S. (2007) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(07)70814-0 · Cited by 57
Protein homocysteinylation: a new mechanism of atherogenesis?
Bełtowski, J. (2005) · PubMed · Cited by 56
Mei, W., Rong, Y., Jinming, L., Li, Y., & Hu, Z. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02207.x · Cited by 56
Molecular targeting by homocysteine: a mechanism for vascular pathogenesis
Jacobsen, D. W., Cătănescu, O., DiBello, P. M., & Barbato, J. C. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.188 · Cited by 56
Folate Nutrition and Older Adults: Challenges and Opportunities
Koehler, K. M., Pareo-Tubbeh, S. L., Romero, L. J., Baumgartner, R., & Garry, P. J. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00044-8 · Cited by 55
Bleie, Ø., Semb, A. G., Grundt, H., Nordrehaug, J. E., Vollset, S. E., Ueland, P. M., Nilsen, D. W. T., Bakken, A. M., Refsum, H., & Nygard, O. K. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01810.x · Cited by 55
Deshmukh, U., Joglekar, C. V., Lubree, H., Ramdas, L. V., Bhat, D., Naik, S. S., Hardikar, P. S., RAUT, D. A., Konde, T. B., Wills, A. K., et al. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.15 · Cited by 53
Winkels, R. M., Brouwer, I. A., Clarke, R., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.348 · Cited by 52
Sofi, F., Marcucci, R., Bolli, P., Giambene, B., Sodi, A., Fedi, S., Menchini, U., Gensini, G. F., Abbate, R., & Prisco, D. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.09.009 · Cited by 51
Qin, X., Li, Y., Sun, N., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308515 · Cited by 51
Acute Hyperhomocysteinemia Induces Microvascular and Macrovascular Endothelial Dysfunction
Abahji, T. N., Nill, L., Ide, N., et al. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.01.004 · Cited by 50
Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women
Rautiainen, S., Åkesson, A., Levitan, E. B., Morgenstern, R., Mittleman, M. A., & Wolk, A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29371 · Cited by 49
Green, T., Skeaff, C. M., McMahon, J. A., Venn, B. J., Williams, S., Devlin, A. M., & Innis, S. M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993552 · Cited by 49
Løland, K. H., Bleie, Ø., Blix, A. J., Strand, E., Ueland, P. M., Refsum, H., Ebbing, M., Nordrehaug, J. E., & Nygard, O. K. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.01.019 · Cited by 48
Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use
Yetley, E. A. D., & Johnson, C. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013300 · Cited by 48
Galan, P., de Bree, A., Mennen, L. I., de Courcy, G. P., Preziozi, P., Bertrais, S., Castetbon, K., & Herçberg, S. (2003) · PubMed · Cited by 48
Genetic Aspects of Folate Metabolism
Molloy, A. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_7 · Cited by 47
Ntaios, G., Savopoulos, C. G., Karamitsos, D. T., Economou, I., Destanis, E., Chryssogonidis, I., Pidonia, I., Zebekakis, P. E., Polatides, C., Sion, M. L., et al. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.01.023 · Cited by 47
Liu, Y., Tian, T., Zhang, H., Gao, L., & Zhou, X. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.03.032 · Cited by 47
Undas, A., Stïpień, E., Głowacki, R., Tisończyk, J., Tracz, W., & Jakubowski, H. (2006) · Thrombosis and Haemostasis · doi:10.1160/th06-04-0228 · Cited by 46
Folate and risk of coronary heart disease: A meta-analysis of prospective studies
Wang, Z.-M., Zhou, B., Nie, Z., Gao, W. Q., Wang, Y.-C., Zhao, H., Zhu, J., Yan, J., Yang, Z., & Wang, L.-S. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.011 · Cited by 45
van Dijk, S. C., Enneman, A. W., Swart, K. M. A., van Wijngaarden, J. P., Ham, A. C., Brouwer-Brolsma, E. M., van der Zwaluw, N. L., Blom, H. J., Feskens, E. J. M., Geleijnse, J. M., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000647 · Cited by 45
Pan, Y., Guo, L., Cai, L. L., Zhu, X. J., Shu, J. L., Liu, X. L., & Jin, H. M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007033 · Cited by 42
Cardiovascular effects of B-vitamins and/or N-3 fatty acids: The Su.Fol.Om3 trial
Blacher, J., Czernichow, S., Paillard, F., Ducimetière, P., Herçberg, S., & Galan, P. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.060 · Cited by 42
Vitamin B6 and Cardiovascular Disease
Friso, S., Lotto, V., Corrocher, R., & Choi, S. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-2199-9_14 · Cited by 41
Zhang, C., Wang, Z., Qin, Y., Yu, F., & Zhou, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107060 · Cited by 41
Galan, P., Briançon, S., Blacher, J., Czernichow, S., & Herçberg, S. (2008) · Trials · doi:10.1186/1745-6215-9-35 · Cited by 41
Effect of folic acid fortification of food on homocysteine-related mortality
Anderson, J. L., Jensen, K. R., Carlquist, J. F., Bair, T. L., Horne, B. D., & Muhlestein, J. B. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.10.024 · Cited by 40
Andreeva (2012) · doi:10.1001/archinternmed.2011.1450 · Cited by 40
Enneman, A. W., Swart, K. M. A., van Wijngaarden, J. P., van Dijk, S. C., Ham, A. C., Brouwer-Brolsma, E. M., van der Zwaluw, N. L., Dhonukshe-Rutten, R. A. M., van der Velde, N., de Groot, C. P. G. M., et al. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9968-6 · Cited by 40
Park, J., Saposnik, G., Ovbiagele, B., Markovic, D., & Towfighi, A. (2016) · International Journal of Stroke · doi:10.1177/1747493015616512 · Cited by 40
The growing burden of risk from high blood pressure, cholesterol, and bodyweight.
Rodgers, A., Lawes, C. M. M., Gaziano, T. A., & Vos, T. (2006) · Cited by 39
Durga, J., Bots, M. L., Schouten, E. G., Grobbee, D. E., Kok, F. J., & Verhoef, P. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006429 · Cited by 39
The VITATOPS Trial Study Group (2007) · International Journal of Stroke · doi:10.1111/j.1747-4949.2007.00111.x · Cited by 39
Potter, K., Lenzo, N. P., Eikelboom, J. W., Arnolda, L., Etherton‐Beer, C., & Hankey, G. J. (2009) · Cerebrovascular Diseases · doi:10.1159/000199463 · Cited by 37
Ueland, P. M., & Clarke, R. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.085480 · Cited by 37
Riksen, N. P., Rongen, G. A. P. J. M., Boers, G. H. J., Blom, H. J., van den Broek, P. H. H., & Smits, P. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000150651.85907.69 · Cited by 37
Bailey, R. L., Fakhouri, T. H. I., Park, Y., Dwyer, J. T., Thomas, P. R., Gahche, J. J., Miller, P. E., Dodd, K. W., Sempos, C. T., & Murray, D. M. (2015) · Journal of Nutrition · doi:10.3945/jn.114.204743 · Cited by 36
Qin, X., Shen, L., Zhang, R., Li, Y., Wang, X., Wang, B., Jiang, X., Jiang, H., Yu, L., Hou, F. F., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30094 · Cited by 36
Nowak-Wegrzyn, A. H., & Groetch, M. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.09.008 · Cited by 35
Huang, T., Li, K., Asimi, S., Chen, Q., & Li, D. (2015) · PubMed · doi:10.6133/apjcn.2015.24.3.19 · Cited by 35
Association between homocysteine, vitamin B6 concentrations and inflammation
Gori, A. M., Sofi, F., Marcucci, R., Giusti, B., Gensini, G. F., & Abbate, R. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.347 · Cited by 34
Dong, H., Pi, F., Ding, Z., Chen, W., Pang, S., Dong, W., & Zhang, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137533 · Cited by 33
Wu, Y., Huang, Y., Hu, Y., Zhong, J., He, Z., Li, W., Yang, Y., Xu, D., & Wu, S. (2013) · Herz · doi:10.1007/s00059-013-3761-y · Cited by 31
Yi, X., Zhou, Y., Jiang, D., et al. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1553 · Cited by 31
Plasma total homocysteine: instigator or indicator of cardiovascular disease?
Moat, S. J. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008053 · Cited by 31
Mechanisms in homocysteine-induced vascular disease
Wang, H., Tan, H., & Yang, F. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.05.029 · Cited by 31
Neal, B. C., MacMahon, S. W., Ohkubo, T., Tonkin, A. M., & Wilcken, D. E. L. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3161 · Cited by 31
Folic Acid-Based Intervention in Non-ST Elevation Acute Coronary Syndromes
Imasa, M. S. B., Gomez, N. T., & Nevado, J. B. (2009) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/0218492309102494 · Cited by 30
Roshanov, P. S., Dennis, B. B., Pasic, N., Garg, A. X., & Walsh, M. W. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw219 · Cited by 29
Technical Aspects of Food Fortification
Wirakartakusumah, M. A., & Hariyadi, P. (1998) · Food and Nutrition Bulletin · doi:10.1177/156482659801900203 · Cited by 28
The Role of Vitamin B in Stroke Prevention
Saposnik, G. (2011) · Stroke · doi:10.1161/strokeaha.110.608356 · Cited by 28
Lonn, E. (2007) · Current Opinion in Internal Medicine · doi:10.1097/moh.0b013e3282c48bd8 · Cited by 27
Wang, L., Li, H., Zhou, Y., Jin, L., & Liu, J. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0729-5 · Cited by 27
Xu, B. P., Kong, X., Xu, R., et al. (2017) · Medicine · doi:10.1097/md.0000000000005862 · Cited by 27
Mager, A., Orvin, K., Koren‐Morag, N., Lev, I. E., Assali, A. R., Kornowski, R., Shohat, M., Battler, A., & Hasdai, D. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.05.011 · Cited by 25
Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD
de Edelenyi, F. S., Vergnaud, A., Ahluwalia, N., Julia, C., Herçberg, S., Blacher, J., & Galan, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003692 · Cited by 25
Shidfar, F., Homayounfar, R., Fereshtehnejad, S., & Kalani, A. (2009) · Archives of Medical Research · doi:10.1016/j.arcmed.2009.06.004 · Cited by 24
Effect of B-vitamin Supplementation on Stroke: a Meta-Analysis of Randomized Controlled Trials
Zhang, C., Chi, F.-L., Xie, T., & Zhou, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081577 · Cited by 23
The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers
Peeters, A. C. T. M., van Aken, B. E., Blom, H. J., Reitsma, P. H., & den Heijer, M. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.021 · Cited by 23
Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.641613 · Cited by 23
Maron, B. A., & Loscalzo, J. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.06.008 · Cited by 23
L’hyperhomocystéinémie : facteur de risque cardiovasculaire ou simple marqueur ?
Guilland, J.-C., Favier, A. E., de Courcy, G. P., et al. (2003) · Pathologie Biologie · doi:10.1016/s0369-8114(03)00105-6 · Cited by 22
Andreeva, V. A., Latarche, C., Herçberg, S., Briançon, S., Galan, P., & Kesse‐Guyot, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084844 · Cited by 21
Gs, B. (1974) · PubMed · Cited by 21
Homocysteine — is it still an important risk factor for cardiovascular disease?
Cybulska, B., & Kłosiewicz−Latoszek, L. (2015) · Kardiologia Polska · doi:10.5603/kp.2015.0229 · Cited by 20
Bleie, Ø., Strand, E., Ueland, P. M., Vollset, S. E., Refsum, H., Igland, J., Nordrehaug, J. E., & Nygard, O. K. (2011) · Coronary Artery Disease · doi:10.1097/mca.0b013e328344fff4 · Cited by 19
Meta-analysis reveals protective effects of vitamin B on stroke patients
Wang, L., Cui, W., Nan, G., et al. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0014 · Cited by 17
Urquhart, B. L., Freeman, D. J., Spence, J. D., & House, A. A. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007303767 · Cited by 16
Liu, X., Shi, M., Feng, X., Han, J., Liu, Z.-R., Wang, B., Yang, F., Li, L., Wu, S., Wang, L., et al. (2013) · International Journal of Stroke · doi:10.1111/ijs.12017 · Cited by 14
Homocysteine, vitamin B12 and folate levels in Iranian patients with ischemic stroke
Moghaddasi, M., Mamarabadi, M., Mirzadeh, S., Freydoonnejad, A. A., & Razjouyan, H. (2010) · Neurological Research · doi:10.1179/016164110x12644252260475 · Cited by 14
Li, J., Li, B., Qi, J., & Shen, B. (2015) · PubMed · Cited by 14
Homocysteine targeting of plasma proteins in hemodialysis patients
Jacobsen, D. W. (2006) · Kidney International · doi:10.1038/sj.ki.5000235 · Cited by 13
Li, H., Qin, X., Xie, D., Tang, G., Zhang, Y., Li, J., Hou, F. F., Wang, X., Huo, Y., & Xu, X. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.2931 · Cited by 13
Ding, Y., Pedersen, E. K. R., Johansson, S., Gregory, J. F., Ueland, P. M., Svingen, G. F. T., Helgeland, Ø., Meyer, K., Fredriksen, A., & Nygard, O. K. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.12.009 · Cited by 13
Qin, X., Fan, F., Cui, Y., Chen, F., Chen, Y., Cheng, X., Li, Y., Wang, B., Xu, X. P., Xu, X., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.01.006 · Cited by 12
Vesin, C., Galan, P., Gautier, B., Czernichow, S., Herçberg, S., & Blacher, J. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3283383f47 · Cited by 12
Baszczuk, A., Kopczyński, Z., Kopczyński, J., et al. (2015) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1148336 · Cited by 11
Earnest, C. P., Kupper, S., Thompson, M., Guo, W., & Church, S. (2012) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000093 · Cited by 10
Homocysteine as a new risk factor for cardiovascular events in heart failure
Kardeşoğlu, E., Uz, Ö., Işılak, Z., & Cebeci, B. S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.005 · Cited by 10
Jamison, D. T. T. (2006) · World Bank, Washington, DC eBooks · doi:10.1596/978-0-8213-6260-0 · Cited by 10
Dell’Edera, D., Tinelli, A., MILAZZO, G. N., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1563 · Cited by 9
Unraveling the Complexities of Statistical Presentation
Fuster, V. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.11.011 · Cited by 9
González, J. M., Millán, E. R., Julve, J., & Blanco‐Vaca, F. (2010) · Revista de Neurología · doi:10.33588/rn.5004.2009081 · Cited by 8
Homocysteine and cardiovascular disease: should we treat?
Potter, K. (2008) · PubMed Central · Cited by 7
Sharifi, F., Fakhrzadeh, H., Mirarefin, M., Pourebrahim, R., Masoomeh, N., Hossein, F. M., Ghotbi, S., Ghaderpanahi, M., & Larijani, B. A. (2010) · Journal of Diabetes & Metabolic Disorders · Cited by 7
Li, W., Zhang, D., Xia, J.-T., Wen, S.-F., Guo, J., & Li, Z. (2014) · Europe PMC (PubMed Central) · Cited by 6
Huang, T., & Li, D. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.01.002 · Cited by 4
Steps to control the burden of cardiovascular disease in the Indian Subcontinent.
Math, M. V., & Balasubramaniam, P. (2007) · PubMed · Cited by 4
Dondorp, A. M., Fanello, C. A., Hendriksen, I. C. E., et al. (2011) · The Lancet · Cited by 4
Efficacy of folic acid in primary prevention of stroke among patients with hypertension in China
Goel, S., & Messerli, F. H. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.08.007 · Cited by 3
Folic acid significantly reduces risk of first stroke, large Chinese study finds
Wise, J. (2015) · BMJ · doi:10.1136/bmj.h1461 · Cited by 3
Durga, J., & Verhoef, P. (2005) · Current Nutrition & Food Science · doi:10.2174/1573401052953221 · Cited by 3
Mirarefin, M., Aminpour, A., Fakhrzadeh, H., et al. (2007) · Iranian Journal of Diabetes and Metabolism · Cited by 2
Mishchenko, O. Y., Яковлєва, Л. В., Kyrychenko, O., et al. (2015) · Value in Health · doi:10.1016/j.jval.2015.09.942 · Cited by 2
Huang, X. B., Wang, H., Qin, X., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(17)35159-8 · Cited by 2
Interventions for lowering plasma homocysteine levels in dialysis patients
Nigwekar, S. U., Cass, A., Gallagher, M., et al. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004683.pub3 · Cited by 2
Efficacité de l’acide folique dans la prévention cérébrovasculaire
Vesin, C., Mairesse, S., Iaria, P., et al. (2007) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(07)91997-5 · Cited by 1
Flagged first, then by citations
Research works printed but not linked: 7
- Baker, 2002, Blinded comparison of folic acid and placebo in patients with ischaemic heart disease: an outcome trial, Circulation, 106, 741
- Redbeg, 2006, A randomized trial of folic acid and B-vitamins in the secondary prevention of cardiovascular events in women: Results from the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), ACC Cardiosource Review Journal., 16, 52
- Gaziano, 2006, Cardiovascular Disease
- 1997, Code of Federal Regulations & International Conference on Harmonisation Guidelines
- Spence, 2005, Vitamin Intervention For Stroke Prevention trial: an efficacy analysis, Stroke, 36, 2404, 10.1161/01.STR.0000185929.38534.f3 · DOI
- Ueland, 1992, Plasma homocysteine and cardiovascular disease
- Wang, 2007, Efficacy of folic acid supplementation in stroke prevention: a meta-analysis, The Lancet, 369, 1876, 10.1016/S0140-6736(07)60854-X · DOI
Cited by
Sorted by citations
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
Kennedy, D. (2016) · Nutrients · doi:10.3390/nu8020068 · Cited by 1,055
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813
Nussbaumer-Streit, B., Klerings, I., Dobrescu, A. I., Persad, E., Stevens, A., Garritty, C., Kamel, C., Affengruber, L., King, V. J., & Gartlehner, G. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.10.011 · Cited by 440
Metadata
- Authors
- Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Salanti, G.
- Affiliations
- G. Papanikolaou General Hospital (GR)
- University of Ioannina (GR)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2009-10-07
- Volume
- 8
- Issue
- 4
- Pages
- CD006612-CD006612
- ISSN
- 1361-6137 (ISSN-L)
- PMC
- PMC4164174
- OpenAlex
- W2144717748
- Cited by
- 520
- References
- 311
- Citations by year
- 2025: 16 · 2024: 18 · 2023: 32 · 2022: 30 · 2021: 48 · 2020: 47 · 2019: 41 · 2018: 31 · 2017: 33 · 2016: 45 · 2015: 42 · 2014: 34 · 2013: 31 · 2012: 26
- Type
- reference entry
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- total homocysteine, cardiovascular disease prevention, myocardial infarction, stroke, vitamin B12, folic acid, pyridoxine, cardiovascular risk factors, cardiovascular mortality, congestive heart failure, coronary artery disease, stroke prevention, myocardial infarction prevention, vitamin supplementation, randomized controlled trials, meta-analysis of trials
- MeSH terms
- Angina Pectoris, Cardiovascular Diseases, Humans, Myocardial Infarction, Vitamin B Complex, Randomized Controlled Trials as Topic, Hyperhomocysteinemia, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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