Pharmacotherapies for cannabis dependence
Open accessAbstract
Anticonvulsants and mood stabilisers versus placebo, Outcome 3 Completion of scheduled treatment.........
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There are no approved pharmacotherapies for the treatment of CUD.
“There are no approved pharmacotherapies for the treatment of CUD [61].”
From Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits (2025) · cites this paper as [61]
Cites
Young adult sequelae of adolescent cannabis use: an integrative analysis.
Silins, E., Horwood, L. J., Patton, G. C., Fergusson, D. M., Olsson, C. A., Hutchinson, D. M., Spry, E., Toumbourou, J. W., Degenhardt, L., Swift, W., et al. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70307-4 · Cited by 443 · see citing works
Gray, K. M., Carpenter, M. J., Baker, N. L., DeSantis, S. M., Kryway, E., Hartwell, K. J., McRae-Clark, A. L., & Brady, K. T. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010055 · Cited by 306 · see citing works
Psychosocial interventions for cannabis use disorder
Gates, P. J., Sabioni, P., Copeland, J., Le Foll, B., & Gowing, L. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005336.pub4 · Cited by 282 · see citing works
Self-citationMason, B. J., Crean, R., Goodell, V., Light, J. M., Quello, S., Shadan, F., Buffkins, K., Kyle, M., Adusumalli, M., Begovic, A., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.14 · Cited by 242 · see citing works
Levin, F. R., Mariani, J. J., Brooks, D. J., Pavlicova, M., Cheng, W., & Nunes, E. V. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.010 · Cited by 232 · see citing works
Haney, M., Malcolm, R. J., Babalonis, S., Nuzzo, P. A., Cooper, Z. D., Bedi, G., Gray, K. M., McRae-Clark, A., Lofwall, M. R., Sparenborg, S., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.367 · Cited by 206 · see citing works
Oral delta-9-tetrahydrocannabinol suppresses cannabis withdrawal symptoms
Budney, A. J., Vandrey, R. G., Hughes, J. R., Moore, B. A., & Bahrenburg, B. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.04.014 · Cited by 180 · see citing works
A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults.
Gray, K. M., Sonne, S. C., McClure, E. A., Ghitza, U. E., Matthews, A. G., McRae-Clark, A. L., Carroll, K. M., Potter, J. S., Wiest, K., Mooney, L. J., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.04.020 · Cited by 157 · see citing works
Levin, F. R., Mariani, J. J., Pavlicova, M., Brooks, D., Glass, A., Mahony, A., Nunes, E. V., Bisaga, A., Dakwar, E., Carpenter, K. M., et al. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.11.025 · Cited by 109 · see citing works
Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults.
Cornelius, J. R., Bukstein, O. G., Douaihy, A. B., Clark, D. B., Chung, T. A., Daley, D. C., Wood, D. S., & Brown, S. J. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.05.010 · Cited by 105 · see citing works
Haney, M., Ramesh, D., Glass, A., Pavlicova, M., Bedi, G., & Cooper, Z. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.108 · Cited by 73 · see citing works
Weinstein, A. M., Miller, H., Bluvstein, I., Rapoport, E., Schreiber, S., Bar-Hamburger, R., & Bloch, M. (2014) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.819362 · Cited by 53 · see citing works
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Cannabis use and cannabis use disorder
Connor, J. P., Stjepanović, D., Le Foll, B., Hoch, E., Budney, A. J., & Hall, W. D. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00247-4 · Cited by 552 · see citing works
Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits
Hoch, E., Volkow, N. D., Friemel, C. M., Lorenzetti, V., Freeman, T. P., & Hall, W. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01880-2 · Cited by 139 · see citing works
- Authors
- Nielsen, S., Gowing, L., Sabioni, P., & Le Foll, B.
- Affiliations
- Monash University (AU)
- The University of Adelaide (AU)
- Centre for Addiction and Mental Health (CA)
- Centre for Addiction and Mental Health; University of Toronto; Translational Addiction Research Laboratory; 33 Russell Street Toronto ON Canada
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2019-01-28
- Volume
- 2020
- Issue
- 3
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W4211088954
- Cited by
- 96
- References
- 12
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 16 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 9 · 2019: 9 · 2017: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Update notices
- new_version (2025-09-30)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- Funders
- U.S. Department of Health and Human Services
- American Academy of Child and Adolescent Psychiatry
- Substance Abuse and Mental Health Services Administration
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- cannabis use disorder, pharmacotherapy, antiepileptic drugs, mood stabilizers, treatment completion
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