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Cited by 105Treatment of Major DepressionSubstance Abuse Treatment and OutcomesCannabis and Cannabinoid Research

Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults.

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Cornelius, Jack R., Bukstein, Oscar G., Douaihy, Antoine B., Clark, Duncan B., Chung, Tammy A., Daley, Dennis C., Wood, D. Scott, Brown, Sandra J.·2010·Drug and Alcohol Dependence
DOI 10.1016/j.drugalcdep.2010.05.010PMC PMC2946416
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Abstract

Objective This study compared the acute phase (12-week) efficacy of fluoxetine versus placebo for the treatment of the depressive symptoms and the cannabis use of adolescents and young adults with comorbid major depression (MDD) and a cannabis use disorder (CUD) (cannabis dependence or cannabis abuse). We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of the depressive symptoms and the cannabis use of adolescents and young adults with comorbid MDD/CUD.Methods We conducted the first double-blind placebo-controlled study of fluoxetine in adolescents and young adults with comorbid MDD/CUD. All participants in both treatment groups also received manual-based cognitive behavioral therapy (CBT) and motivation enhancement therapy (MET) during the 12-week course of the study.Results Fluoxetine was well tolerated in this treatment population. No significant group-by-time interactions were noted for any depression-related or cannabis-use related outcome variable over the 12-week study. Subjects in both the fluoxetine group and the placebo group showed significant within-group improvement in depressive symptoms and in number of DSM diagnostic criteria for a CUD. Large magnitude decreases in depressive symptoms were noted in both treatment groups, and end-of-study levels of depressive symptoms were low in both treatment groups.Conclusions Fluoxetine did not demonstrate greater efficacy than placebo for treating either the depressive symptoms or the cannabis-related symptoms of our study sample of comorbid adolescents and young adults. The lack of a significant between-group difference in these symptoms may reflect limited medication efficacy, or may result from efficacy of the CBT/MET psychotherapy or from limited sample size.

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Authors
Cornelius, J. R., Bukstein, O. G., Douaihy, A. B., Clark, D. B., Chung, T. A., Daley, D. C., Wood, D. S., & Brown, S. J.
Affiliations
  • University of Pittsburgh (US)
  • University of California San Diego (US)
Corresponding author
Cornelius, Jack R.
ORCID
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2010-11
Volume
112
Issue
1-2
Pages
39-45
ISSN
0376-8716 (ISSN-L)
DOI
10.1016/j.drugalcdep.2010.05.010
PMC
PMC2946416
OpenAlex
W2046264373
Cited by
105
References
57
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 11 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 4
FWCI
4.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders
  • National Institute on Drug Abuse (P50 DA05605, R01 DA019142, R01 DA14635, K02 DA017822)
  • National Institute on Alcohol Abuse and Alcoholism (R01 AA013370, R01 AA13397, R01 AA14357, R21 AA016272, R01 AA015173, K24 AA15320, U01 AA016482, K02 AA000291)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Keywords
fluoxetine, major depressive disorder, cannabis use disorder, comorbidities, adolescents, young adults, depressive symptoms, cognitive behavioral therapy, antidepressant efficacy, placebo comparison
MeSH terms
Adolescent, Adult, Marijuana Abuse, Combined Modality Therapy, Major Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Male, Placebos, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome, Antidepressive Agents, Second-Generation, Young Adult

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