Cited by 175Anesthesia and Pain ManagementPain Management and Opioid UseNausea and vomiting management

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Non-prescription (OTC) oral analgesics for acute pain - an overview of Cochrane reviews

Open access

Moore, R Andrew, Wiffen, Philip J, Derry, Sheena, Maguire, Terry, Roy, Yvonne M, Tyrrell, Laila·2015·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd010794.pub2PMC PMC6485506

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Non-prescription (over-the-counter, or OTC) analgesics (painkillers) are used frequently. They are available in various brands, package sizes, formulations, and dose. They can be used for a range of different types of pain, but this overview reports on how well they work for acute pain (pain of short duration, usually with rapid onset). Thirty-nine Cochrane reviews of randomised trials have examined the analgesic efficacy of individual drug interventions in acute postoperative pain. OBJECTIVES: To examine published Cochrane reviews for information about the efficacy of pain medicines available without prescription using data from acute postoperative pain. METHODS: We identified OTC analgesics available in the UK, Australia, Canada, and the USA by examining online pharmacy websites. We also included some analgesics (diclofenac potassium, dexketoprofen, dipyrone) of importance in parts of the world, but not currently available in these jurisdictions.We identified systematic reviews by searching the Cochrane Database of Systematic Reviews (CDSR) on The Cochrane Library through a simple search strategy. All reviews were overseen by a single review group, had a standard title, and had as their primary outcome numbers of participants with at least 50% pain relief over four to six hours compared with placebo. From individual reviews we extracted the number needed to treat for an additional beneficial outcome (NNT) for this outcome for each drug/dose combination, and also calculated the success rate to achieve at least 50% of maximum pain relief. We also examined the number of participants experiencing any adverse event, and whether the incidence was different from placebo. MAIN RESULTS: We found information on 21 different OTC analgesic drugs, doses, and formulations, using information from 10 Cochrane reviews, supplemented by information from one non-Cochrane review with additional information on ibuprofen formulations (high quality evidence). The lowest (best) NNT values were for combinations of ibuprofen plus paracetamol, with NNT values below 2. Analgesics with values close to 2 included fast acting formulations of ibuprofen 200 mg and 400 mg, ibuprofen 200 mg plus caffeine 100 mg, and diclofenac potassium 50 mg. Combinations of ibuprofen plus paracetamol had success rates of almost 70%, with dipyrone 500 mg, fast acting ibuprofen formulations 200 mg and 400 mg, ibuprofen 200 mg plus caffeine 100 mg, and diclofenac potassium 50 mg having success rates above 50%. Paracetamol and aspirin at various doses had NNT values of 3 or above, and success rates of 11% to 43%. We found no information on many of the commonly available low dose codeine combinations.The proportion of participants experiencing an adverse event were generally not different from placebo, except for aspirin 1000 mg and (barely) ibuprofen 200 mg plus caffeine 100 mg. For ibuprofen plus paracetamol, adverse event rates were lower than with placebo. AUTHORS' CONCLUSIONS: There is a body of reliable evidence about the efficacy of some of the most commonly available drugs and doses widely available without prescription. The postoperative pain model is predominantly pain after third molar extraction, which is used as the industry model for everyday pain. The proportion of people with acute pain who get good pain relief with any of them ranges from around 70% at best to less than 20% at worst; low doses of some drugs in fast acting formulations were among the best. Adverse events were generally no different from placebo. Consumers can make an informed choice based on this knowledge, together with availability and price. Headache and migraine were not included in this overview.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/14651858.cd010794.pub2

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

Single dose dipyrone for acute postoperative pain
Rees, J., Meseguer, F., Faura, C. C., Moore, R. A., & McQuay, H. J. (2001) · doi:10.1002/14651858.cd003227 · Cited by 107
Self-citation
Retracted
Single dose dipyrone for acute postoperative pain
Derry, S., Faura, C. C., Edwards, J. E., McQuay, H. J., & Moore, R. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003227.pub2 · Cited by 52
Self-citation
Retracted
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291
Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews
Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Porter, A. C., Tugwell, P., Moher, D., & Bouter, L. M. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-10 · Cited by 4,374
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
Chandrasekharan, N. V., Dai, H., Roos, K. L. T., Evanson, N. K., Tomsik, J., Elton, T. S., & Simmons, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162468699 · Cited by 1,989
The Coxibs, Selective Inhibitors of Cyclooxygenase-2
FitzGerald, G. A., & Patrono, C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108093450607 · Cited by 1,572
The visual analogue pain intensity scale: what is moderate pain in millimetres?
Collins, S. L., Moore, A. R., & McQuay, H. J. (1997) · Pain · doi:10.1016/s0304-3959(97)00005-5 · Cited by 1,543
COX-2 inhibitors
Hawkey, C. J. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12154-2 · Cited by 1,180
Published by John Wiley & Sons Ltd
Modarresi, O. A. F., & Shakibaie, M. M. M. R. (2015) · Cited by 1,111
Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses
Song, F., Altman, D. G., Glenny, A., & Deeks, J. J. (2003) · BMJ · doi:10.1136/bmj.326.7387.472 · Cited by 947

Show all 94 references

Sorted by citations

Paracetamol: A Review of Guideline Recommendations
Freo, U., Ruocco, C., Valerio, A., Scagnol, I., & Nisoli, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153420 · Cited by 208
“A systematic review of the peer-reviewed literature confirmed that the combined use of paracetamol and NSAIDs could significantly enhance the analgesic effects of either drug alone [75,76].”
Background
Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials
Stiller, C., & Hjemdahl, P. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13505 · Cited by 207
International Olympic Committee consensus statement on pain management in elite athletes
Hainline, B. W., Derman, W. E., Vernec, A. R., Budgett, R., Deie, M., Dvořák, J., Harle, C. A., Herring, S. A., McNamee, M., Meeuwisse, W. H., et al. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097884 · Cited by 198
Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review
Varrassi, G., Pergolizzi, J. V., Dowling, P., & Paladini, A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01144-9 · Cited by 191
Pain-resolving immune mechanisms in neuropathic pain
Fiore, N. T., Debs, S. R., Hayes, J. P., Duffy, S. S., & Moalem‐Taylor, G. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00777-3 · Cited by 182
Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence
Cho, H., Lynham, A. J., & Hsu, E. (2017) · Australian Dental Journal · doi:10.1111/adj.12526 · Cited by 168
Benefits and harms associated with analgesic medications used in the management of acute dental pain
Moore, P. A., Ziegler, K. M., Lipman, R. D., Aminoshariae, A., Carrasco‐Labra, A., & Mariotti, A. J. (2018) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2018.02.012 · Cited by 162
Self‐medication in pain management: The state of the art of pharmacists’ role for optimal Over‐The‐Counter analgesic use
Perrot, S., Cittée, J., Louis, P., Quentin, B., Robert, C., Milon, J., Bismut, H., & Baumelou, A. (2019) · European Journal of Pain · doi:10.1002/ejp.1459 · Cited by 113
The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews
Abdel Shaheed, C., Ferreira, G. E., Dmitritchenko, A., McLachlan, A. J., Day, R. O., Saragiotto, B., Lin, C., Langendyk, V., Stanaway, F., Latimer, J., et al. (2021) · Medical Journal of Australia · doi:10.5694/mja2.50992 · Cited by 110
Single dose dipyrone for acute postoperative pain
Rees, J., Meseguer, F., Faura, C. C., Moore, R. A., & McQuay, H. J. (2001) · doi:10.1002/14651858.cd003227 · Cited by 107
Self-citation
Retracted
Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults
Derry, S., Wiffen, P. J., & Moore, R. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011509.pub2 · Cited by 88
Self-citation
Opioid prescribing practices from 2010 through 2015 among dentists in the United States
Gupta, N., Vujicic, M., & Blatz, A. (2018) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2018.01.005 · Cited by 86
An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact
Mallet, C., Desmeules, J., Pegahi, R., & Eschalier, A. (2023) · Journal of Pain Research · doi:10.2147/jpr.s393809 · Cited by 83
“In terms of safety, a Cochrane review concluded that the rate of adverse events was similar between the higher and lower single doses of paracetamol.(84) This was in line with another clinical trial showing similar rates of treatment-related adverse events between the higher and lower single doses of paracetamol.”
Result
NSAIDs and COVID-19: A Systematic Review and Meta-analysis
Moore, N. D., Bosco‐Lévy, P., Thurin, N. H., Blin, P., & Droz‐Perroteau, C. (2021) · Drug Safety · doi:10.1007/s40264-021-01089-5 · Cited by 84
Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics
Moore, N. D., & Scheiman, J. M. (2018) · Postgraduate Medicine · doi:10.1080/00325481.2018.1429793 · Cited by 67
Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis
Miroshnychenko, A., Ibrahim, S., Azab, M., Roldán, Y., Martinez, J. P. D., Tamilselvan, D., He, L., Little, J. W., Urquhart, O., Tampi, M. P., et al. (2023) · Journal of Dental Research · doi:10.1177/00220345221139230 · Cited by 57
Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis
Alberti, F. F., Becker, M. W., Blatt, C. R., Ziegelmann, P. K., Pizzol, T. D. S. D., & Pilger, D. A. (2022) · Clinical Rheumatology · doi:10.1007/s10067-022-06129-8 · Cited by 50
Dental Emergencies Management in COVID-19 Pandemic Peak: A Cohort Study
Beauquis, J., Petit, A. E., Michaux, V., Sagué, V., Henrard, S., & Leprince, J. G. (2021) · Journal of Dental Research · doi:10.1177/0022034521990314 · Cited by 43
Overview of systematic reviews - a new type of study. Part II
Silva, V., Grande, A. J., de Carvalho, A. P. V., Martimbianco, A. L. C., & Riera, R. (2014) · Sao Paulo Medical Journal · doi:10.1590/1516-3180.2013.8150015 · Cited by 42
Analgesic use among the Brazilian population: Results from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM)
Pizzol, T. D. S. D., Fontanella, A. T., Ferreira, M. B. C., Bertoldi, A. D., Borges, R. B., & Mengue, S. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214329 · Cited by 41
Pain management following dental trauma and surgical procedures
Malamed, S. F. (2023) · Dental Traumatology · doi:10.1111/edt.12840 · Cited by 37
Benign Headache Management in the Emergency Department
Long, B., & Koyfman, A. (2018) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2017.12.023 · Cited by 36
Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting
Matji, A., Donato, N., Gagol, A., Morales, E., Carvajal, L., Serrano, D. R., Worku, Z. A., Healy, A. M., & Torrado, J. J. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.05.011 · Cited by 36
Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial
Ridderikhof, M. L., Lirk, P. B., Goddijn, H., Vandewalle, E., Schinkel, E., van Dieren, S., Kemper, E. M., Hollmann, M. W., & Goslings, J. C. (2017) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2017.08.041 · Cited by 33
Medical professionals' perspectives on prescribed and over-the-counter medicines containing codeine: a cross-sectional study
Foley, M., Carney, T., Rich, E. P., Parry, C. D. H., Hout, M. C. V., & Deluca, P. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011725 · Cited by 30
Evaluation of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in the Treatment of Postsurgical Dental Pain: A Pilot, Dose-Ranging, Randomized Study
Kellstein, D. E., & Leyva, R. (2020) · Drugs in R&D · doi:10.1007/s40268-020-00310-7 · Cited by 29
A new taxonomy was developed for overlap across 'overviews of systematic reviews': A meta‐research study of research waste
Lunny, C., Reid, E. K., Neelakant, T., Chen, A., Zhang, J. H., Shinger, G., Stevens, A., Tasnim, S., Sadeghipouya, S., Adams, S., et al. (2021) · Research Synthesis Methods · doi:10.1002/jrsm.1542 · Cited by 29
Why do we prescribe Vicodin?
Moore, P. A., Dionne, R. A., Cooper, S. A., & Hersh, E. V. (2016) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2016.05.005 · Cited by 28
Therapie der Migräneattacke und Prophylaxe der Migräne
Gaul, C., Kropp, P., & Diener, H. (2018) · Nervenheilkunde · doi:10.1055/s-0038-1673598 · Cited by 29
Counting the cost of over‐the‐counter codeine containing analgesic misuse: A retrospective review of hospital admissions over a 5 year period
Mill, D. N., Johnson, J. L., Cock, V., Monaghan, E., & Hotham, E. D. (2017) · Drug and Alcohol Review · doi:10.1111/dar.12595 · Cited by 28
Acupuncture/Electroacupuncture as an Alternative in Current Opioid Crisis
Ali, U., Apryani, E., Ahsan, M. Z., Shoaib, R. M., Ahmad, K. A., & Wang, Y. (2019) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-019-3175-7 · Cited by 28
Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery
Xiong, X., Tao, M., Zhao, W., Tan, W., Jiang, Y., Sun, Z., Wang, Y., Lin, Y., Li, C., Yang, J., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.29127 · Cited by 27
Pharmacological Management of Acute Endodontic Pain
khan, A. W. A., & Diogenes, A. R. (2021) · Drugs · doi:10.1007/s40265-021-01564-4 · Cited by 27
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies
Abril, L., Zamora, C., Cordero, M., Williams, A. R., & Friedman, B. W. (2022) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2021.09.025 · Cited by 23
Sales of Over-the-Counter Products Containing Codeine in 31 Countries, 2013–2019: A Retrospective Observational Study
Richards, G. C., Aronson, J. K., MacKenna, B., Goldacre, B. M., Hobbs, R. F., & Heneghan, C. J. (2022) · Drug Safety · doi:10.1007/s40264-021-01143-2 · Cited by 23
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
(2017) · Springer eBooks · doi:10.1007/978-3-319-56637-5 · Cited by 22
Factors that influence how adults select oral over-the-counter analgesics: A systematic review
Kim, J., Kinney, K., Nyquist, M., Capellari, E. C., & Vordenberg, S. E. (2022) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2022.03.007 · Cited by 23
Ibuprofen Arginate for Rapid-Onset Pain Relief in Daily Practice: A Review of Its Use in Different Pain Conditions
Cajaraville, J. P. (2021) · Journal of Pain Research · doi:10.2147/jpr.s280571 · Cited by 22
Best Practices and Innovations for Managing Codeine Misuse and Dependence
Norman, I. J., Bergin, M., Parry, C. D. H., & Hout, M. C. V. (2016) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3t89k · Cited by 22
Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics
Moore, A., Crossley, A., Ng, B., Phillips, L. D., Sancak, Ö., & Rainsford, K. D. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12770 · Cited by 21
Current advances in the pain treatment and mechanisms of Traditional Chinese Medicine
Zhu, X., Jia, Z., Zhou, Y., Wu, J., Cao, M., Hu, C.-J., Yu, L., & Chen, Z. (2024) · Phytotherapy Research · doi:10.1002/ptr.8259 · Cited by 20
Anesthesia for Same-Day Total Joint Replacement
Amundson, A. W., Panchamia, J. K., & Jacob, A. K. (2019) · Anesthesiology Clinics · doi:10.1016/j.anclin.2019.01.006 · Cited by 20
Analgesia (mis)usage on a dental emergency service: a patient survey
Hommez, G. M. G., Ongena, B., Cauwels, R. G. E. C., Paepe, P. D., Christiaens, V., & Jacquet, W. (2017) · Clinical Oral Investigations · doi:10.1007/s00784-017-2228-6 · Cited by 19
Analgesics for Dental Implants: A Systematic Review
Melini, M., Forni, A., Cavallin, F., Parotto, M., & Zanette, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.634963 · Cited by 18
A computational model of liver tissue damage and repair
Adhyapok, P., Fu, X., Sluka, J. P., Clendenon, S. G., Sluka, V. D., Wang, Z., Dunn, K. W., Klaunig, J. E., & Glazier, J. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243451 · Cited by 18
Survey of opioid prescribing among dentists indicates need for more effective education regarding pain management
Heron, M. J., Nwokorie, N. A., O'Connor, B. B., Brown, R. S., & Fugh‐Berman, A. (2021) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2021.07.018 · Cited by 17
Nonopioid vs opioid analgesics after impacted third-molar extractions
Feldman, C. A., Fredericks-Younger, J., Desjardins, P. J., Malmström, H., Miloro, M., Warburton, G., Ward, B. B., Ziccardi, V. B., Greenberg, P. J., Andrews, T., et al. (2025) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2024.10.014 · Cited by 17
Efficacy and Safety of Single and Multiple Doses of a Fixed-dose Combination of Ibuprofen and Acetaminophen in the Treatment of Postsurgical Dental Pain
Searle, S. L., Muse, D. D., Paluch, E., Leyva, R., DePadova, E., Cruz‐Rivera, M., & Kellstein, D. E. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000828 · Cited by 17
The Opioid Analgesic Reduction Study (OARS)—a comparison of opioid vs. non-opioid combination analgesics for management of post-surgical pain: a double-blind randomized clinical trial
Feldman, C. A., Fredericks-Younger, J., Lu, S., Desjardins, P. J., Malmström, H., Miloro, M., Warburton, G., Ward, B. B., Ziccardi, V. B., & Fine, D. H. (2022) · Trials · doi:10.1186/s13063-022-06064-8 · Cited by 17
Pain Relief with Combination Acetaminophen/Codeine or Ibuprofen following Third-Molar Extraction: A Systematic Review and Meta-Analysis
Watson, H., Hildebolt, C. F., & Rowland, K. C. (2021) · Pain Medicine · doi:10.1093/pm/pnab334 · Cited by 16
Update on pain management in acute pancreatitis
Pandanaboyana, S., Huang, W., Windsor, J. A., & Drewes, A. M. (2022) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000861 · Cited by 16
Safety of metamizole (dipyrone) for the treatment of mild to moderate pain—an overview of systematic reviews
Eleutério, O. H. P., Veronezi, R. N., Martinez-Sobalvarro, J. V., Marrafon, D. A. F. D. O., Eleutério, L. P., Rascado, R. R., dos Reis, T. M., Podestá, M. H. M. C., & Torres, L. H. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03240-2 · Cited by 16
Emergency department pain management in older patients
Tyler, K. R., Hullick, C., Newton, B. A., Adams, C. B., & Arendts, G. (2020) · Emergency Medicine Australasia · doi:10.1111/1742-6723.13562 · Cited by 15
The Quality of Counseling for Headache OTC Medications in German Community Pharmacies Using a Simulated Patient Approach: Are There Differences between Self-Purchase and Purchase for a Third Party?
Langer, B., & Kunow, C. (2022) · The Scientific World JOURNAL · doi:10.1155/2022/5851117 · Cited by 15
A study of medical professionals’ perspectives on medicines containing codeine in South Africa
Foley, M., Carney, T., Rich, E. P., Dada, S., Mburu, C., & Parry, C. D. H. (2018) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v24.i0.1162 · Cited by 15
Acute Tolerance to the Analgesic Effects of Alcohol
Williams, M. K., Vitus, D., Ferguson, E. G., Stennett, B., Robinson, M., & Boissoneault, J. (2021) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2021.82.422 · Cited by 14
Prescribing patterns of opioid analgesics in a dental setting: 2013–2018
Miller, C. S., Ke, C., Witty, J. T., & Nagarajan, R. (2020) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2020.06.015 · Cited by 14
Effect of the characteristics of raw material ibuprofen on roller compaction and dissolution
Matji, A., Carvajal, L., Conde, F., Peña, M. D. L. Á., Donato, N., Serrano, D. R., & Torrado, J. J. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.03.020 · Cited by 13
Applying Loop-mediated Isothermal Amplification (LAMP) in the Diagnosis of Malaria, Leishmaniasis and Trypanosomiasis as Point-of-Care Tests (POCTs)
Dea‐Ayuela, M. A., Galiana‐Roselló, C., Lalatsa, A., & Serrano, D. R. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666181025095735 · Cited by 13
Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations
Tarabar, S., Kelsh, D., Vince, B. D., Leyva, R., Song, D., Matschke, K. T., Kellstein, D. E., Meeves, S. G., & Cruz‐Rivera, M. (2020) · Drugs in R&D · doi:10.1007/s40268-020-00293-5 · Cited by 13
De-Implementing Opioid Use and Implementing Optimal Pain Management Following Dental Extractions (DIODE): Protocol for a Cluster Randomized Trial
Rindal, D. B., Asche, S. E., Gryczynski, J., Kane, S. M., Truitt, A. R., Shea, T. L., Ziegenfuss, J. Y., Schwartz, R. P., Worley, D. C., & Mitchell, S. G. (2021) · JMIR Research Protocols · doi:10.2196/24342 · Cited by 12
Oligoanalgesia in the emergency setting – An Indian review
Vijayvargiya, M., Panchal, S., Asawale, K., & Desai, A. S. (2021) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2021.03.025 · Cited by 12
In-vivo disintegration and absorption of two fast acting aspirin tablet formulations compared to ibuprofen tablets using pharmacoscintigraphy
Stevens, H. N. E., Voelker, M., Gow, L., MacDougall, F., & Bieri, G. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.02.027 · Cited by 12
Paracetamol Use and COVID-19 Clinical Outcomes: A Meta-Analysis
Bianconi, A., Zauli, E., Biagiotti, C., Calò, G. L., Cioni, G., Imperiali, G., Orazi, V., Martellucci, C. A., Rosso, A., & Fiore, M. (2024) · Healthcare · doi:10.3390/healthcare12222309 · Cited by 11
Just‐in‐case opioid prescribing
Moore, P. A., & Hersh, E. V. (2020) · Journal of Dental Education · doi:10.1002/jdd.12500 · Cited by 11
Highlighting the hidden dangers of a ‘weak’ opioid: Deaths following use of dihydrocodeine in England (2001–2020)
Rock, K. L., Reynolds, L. M., Rees, P. J., & Copeland, C. S. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109376 · Cited by 11
Development and validation of machine learning based prediction model for postoperative pain risk after extraction of impacted mandibular third molars
Yu, D., Liu, Z., Zhuang, W., Li, K., & Lu, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23052 · Cited by 10
Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample
Duong, M., Abouelfath, A., Lassalle, R., Droz‐Perroteau, C., Blin, P., & Moore, N. D. (2018) · Drug Safety · doi:10.1007/s40264-018-0686-7 · Cited by 10
Clinical Decision Support to Reduce Opioid Prescriptions for Dental Extractions using SMART on FHIR: Implementation Report
Rindal, D. B., Pasumarthi, D. P., Thirumalai, V., Truitt, A. R., Asche, S. E., Worley, D. C., Kane, S. M., Gryczynski, J., & Mitchell, S. G. (2023) · JMIR Medical Informatics · doi:10.2196/45636 · Cited by 10
Pain Management for Orthopedic Injuries
Nischal, N., Arulraja, E., & Shaheen, S. P. (2019) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2019.09.013 · Cited by 10
Frequency, Nature and Management of Patient-Reported Severe Acute Pain Episodes in the Over-The-Counter Setting: Results of an Online Survey
Hersch, C., Denis, C., & Sugár, D. (2019) · Pain Management · doi:10.2217/pmt-2018-0092 · Cited by 9
Preoperative Preparation and Planning of the Oral and Maxillofacial Surgery Patient
Bennett, J. (2017) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2016.12.005 · Cited by 9
Dose Can Help to Achieve Effective Pain Relief for Acute Mild to Moderate Pain with Over-the-Counter Paracetamol
Gaul, C., & Eschalier, A. (2018) · The Open Pain Journal · doi:10.2174/1876386301811010012 · Cited by 8
Occurrence of emerging and persistent organic pollutants in the rivers Cam, Ouse and Thames, UK
Folorunsho, O., Bogush, A., & Kourtchev, I. (2025) · Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178436 · Cited by 8
Complementary Instrumental Techniques Applied to Pain Relieving Tablets in an Undergraduate Laboratory Experiment
Adels, K., Thönnessen, V., & Monakhova, Y. B. (2024) · Journal of Chemical Education · doi:10.1021/acs.jchemed.4c00681 · Cited by 8
Ibuprofen/acetaminophen fixed-dose combination as an alternative to opioids in management of common pain types
Kushner, P. R., McCarberg, B. H., Wright, W. L., Aldoori, W. H., Gao, P., Iqbal, A., & Petruschke, R. A. (2024) · Postgraduate Medicine · doi:10.1080/00325481.2024.2382671 · Cited by 8
Advances in Migraine Treatment: A Comprehensive Clinical Review
Rushendran, R., & Vellapandian, C. (2025) · Current Protein and Peptide Science · doi:10.2174/0113892037329429241123095325 · Cited by 8
Caution with the forthcoming rescheduling of over‐the‐counter codeine‐containing analgesics
Schug, S. A., Dobbin, M., & Schumann, J. (2018) · The Medical Journal of Australia · doi:10.5694/mja16.00881 · Cited by 8
Medikamentöse Therapie bei akuten und chronischen lumbalen Rückenschmerzen
Wertli, M. M., & Steurer, J. (2018) · Der Internist · doi:10.1007/s00108-018-0475-5 · Cited by 8
The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical Federation
BaniHani, H., Lampl, C., MaassenVanDenBrink, A., Amin, F. M., Carlsen, L. N., Coppola, G., Deligianni, C. I., Gil‐Gouveia, R., Holland, P. R., Husøy, A. K., et al. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02021-3 · Cited by 7
Dentists' Current and Optimal Opioid Prescribing Practices: A Proactive Review.
Reynolds, W. R., & Schwarz, E. S. (2019) · Europe PMC (PubMed Central) · Cited by 7
Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users
Rauschert, C., Seitz, N., Olderbak, S. G., Pogarell, O. M., Dreischulte, T., & Kraus, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864389 · Cited by 7
Metamizole: A comprehensive approach to its benefit-risk profile
Stromer, W., & Palladini, M. C. (2022) · Evidence for Self-Medication · doi:10.52778/efsm.22.0153 · Cited by 6
Exploring Australian pharmacists’ perceptions and attitudes toward codeine up-scheduling from over-the-counter to prescription only
Mckenzie, M., Johnson, J. L., Anderson, K., Summers, R. J., & Wood, P. (2020) · Pharmacy Practice · doi:10.18549/pharmpract.2020.2.1904 · Cited by 6
Perioperative Schmerztherapie mit Nichtopioidanalgetika
Stamer, U. M., Erlenwein, J., Freys, S. M., Stammschulte, T., Stichtenoth, D. O., & Wirz, S. (2021) · Der Schmerz · doi:10.1007/s00482-021-00566-1 · Cited by 6
Schmerztherapie bei Kindern und Jugendlichen mit Hämophilie
Stromer, W., Messerer, B., Crevenna, R., Hemberger, S. H., Jauk, B., Schwarz, R., Streif, W., Thom, K., Wagner, B. R., Zwiauer, K., et al. (2018) · Der Schmerz · doi:10.1007/s00482-018-0321-7 · Cited by 6
Comparative Analgesia Between Acupuncture and Dipyrone in Odontalgia
de Almeida, T. B., Zotelli, V. L. R., Wada, R. S., & Sousa, M. L. R. (2019) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2019.07.005 · Cited by 6
Neural Mechanisms of Hypnotic Analgesia
Benedittis, G. D. (2020) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2002023 · Cited by 6
Safety and tolerability of fixed-dose combinations of ibuprofen and acetaminophen: pooled analysis of phase 1–3 clinical trials
Su, J., Leyva, R., Kellstein, D. E., Cruz‐Rivera, M., & Meeves, S. G. (2021) · Postgraduate Medicine · doi:10.1080/00325481.2021.1912466 · Cited by 6
Perioperative Schmerztherapie mit Nichtopioidanalgetika
Stamer, U. M., Erlenwein, J., Freys, S. M., Stammschulte, T., Stichtenoth, D. O., & Wirz, S. (2021) · Der Chirurg · doi:10.1007/s00104-021-01421-w · Cited by 8
Prevalence of over-the-counter drug abuse among adults in Jeddah, Saudi Arabia
Safdar, O. Y., Albaz, G. F., Mannan, S. M., Alshehri, W. A., Altumaihi, R. M., Bakhashwain, W. J., Khayyat, S. T., & Almehmadi, W. M. (2021) · Journal of Contemporary Medical Sciences · doi:10.22317/jcms.v7i6.1098 · Cited by 6
Select Issues in Pain Management for the Youth and Adolescent Athlete
(2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002333 · Cited by 5
Pain Management - From Acute to Chronic and Beyond
Aslanidis, T., & Nouris, C. (2023) · Pharmaceutical science. · doi:10.5772/intechopen.107760 · Cited by 5
Comparative study of the effects of ibuprofen, acetaminophen, and codeine in a model of orofacial postoperative pain in male and female rats
Zortea, J. M., Baggio, D. F., da Luz, F. M. R., Lejeune, V. B. P., Spagnol, F. J., & Chichorro, J. G. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03254-w · Cited by 5
Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review
Mobasheri, A., Morlion, B. J., Sethi, V. S., Cardosa, M. S., Pasqua, O. E. D., & Kalita, P. (2025) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70180 · Cited by 5
Systematic review of self-medication in students of medical and biological sciences careers
Azócar, P., Valdés, M., Garrido‐Suárez, B. B., Fernández‐Alfonso, M. S., & Garrido, G. (2023) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres23.1671_11.6.1079 · Cited by 5
Employment Shocks and Demand for Pain Medication
Musse, I. (2020) · Health Economics · doi:10.1002/hec.4901 · Cited by 5
Sex differences in the consumption of over-the-counter analgesics among amateur volleyball players
Hager, L., Averbeck, B., Voelcker‐Rehage, C., & Kutz, D. F. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00273-5 · Cited by 5
Symptom management in Chinese adults with end stage renal disease (ESRD)
Levy, N. A., Cheung, W., McDonald, H., Banez, M. C., Shang, J., Stone, P. W., & Sun, C. (2021) · Applied Nursing Research · doi:10.1016/j.apnr.2021.151549 · Cited by 5
Pain management after third molar extractions in adolescents: a qualitative study
Mitchell, S. G., Truitt, A. R., Davin, L. M., & Rindal, D. B. (2022) · BMC Pediatrics · doi:10.1186/s12887-022-03261-x · Cited by 5

Authors: Moore, R. A., Wiffen, P. J., Derry, S., Maguire, T., Roy, Y. M., & Tyrrell, L.
Affiliations: Plymouth UK
Thame UK
Oxford Oxfordshire UK
Queen's University Belfast (GB)
Churchill Hospital (GB)
ORCID: Moore, R Andrew
Wiffen, Philip J
Derry, Sheena
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2015-11-04
Issue: 11
Pages: CD010794-CD010794
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd010794.pub2
PMC: PMC6485506
OpenAlex: W2142451706
Cited by: 174
References: 94
Citations by year: 2026: 4 · 2025: 16 · 2024: 13 · 2023: 17 · 2022: 25 · 2021: 36 · 2020: 13 · 2019: 12 · 2018: 18 · 2017: 10 · 2016: 6 · 2015: 1
FWCI: 2.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
National Institutes of Health
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Surgery › Nausea and vomiting management
Keywords: over-the-counter analgesics, acute pain, postoperative pain, ibuprofen, paracetamol, diclofenac potassium, dipyrone, caffeine, analgesic efficacy, adverse events, number needed to treat, analgesic combination, placebo comparison, diclofenac sodium, dexketoprofen
MeSH terms: Administration, Oral, Analgesics, Nonprescription Drugs, Humans, Review Literature as Topic, Randomized Controlled Trials as Topic, Acute Pain, Numbers Needed To Treat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Non-prescription (OTC) oral analgesics for acute pain - an overview of Cochrane reviews

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks