The DOI matches its Crossref record; 77 of the 78 references it cites were found in a registry or an index.
Psychological therapies for the management of chronic neuropathic pain in adults
Open accessAbstract
BACKGROUND: Neuropathic pain is thought to arise from damage to the somatosensory nervous system. Its prevalence is increasing in line with many chronic disorders such as diabetes. All treatments have limited effectiveness. Given the evidence regarding psychological treatment for distress and disability in people with various chronic pain conditions, we were interested to investigate whether psychological treatments have any effects for those with chronic neuropathic pain. OBJECTIVES: To assess the effects of psychological treatments on pain experience, disability, mood, and health-care use in adults with chronic neuropathic pain. SEARCH METHODS: We searched for randomised controlled trials (RCTs) published in any language in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and PsycINFO, from database inception to March 2015. SELECTION CRITERIA: Full publications of RCTs on psychological interventions for neuropathic pain. Trials had to have lasted at least three months, had at least 20 participants in each arm at the end of treatment, and compared a psychological intervention with any active or inactive intervention. DATA COLLECTION AND ANALYSIS: We used the standard methodological procedures expected by Cochrane. MAIN RESULTS: Two small studies (enrolling a total of 105 participants) met the inclusion criteria. One was a standard cognitive behavioural treatment (CBT) programme for 61 people with pain from spinal cord injury, followed up for three months, and compared with a waiting list. The other was weekly group psychotherapy for 44 people with burning mouth syndrome, compared with a daily placebo tablet. The overall risk of bias was high in both trials.The CBT study assessed participants for pain, disability, mood, and quality of life, with improvement in treatment and control groups. However, there was no more improvement in the treatment group than in the control for any outcome, either post-treatment or at follow-up. The group psychotherapy study only assessed pain, classifying participants by pain severity. There is a lack of evidence on the efficacy and safety of psychological interventions for people with neuropathic pain. AUTHORS' CONCLUSIONS: There is insufficient evidence of the efficacy and safety of psychological interventions for chronic neuropathic pain. The two available studies show no benefit of treatment over either waiting list or placebo control groups.
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Metadata
- Authors
- Eccleston, C., Hearn, L., & Williams, A. C. D. C.
- Affiliations
- University of Bath (GB)
- Churchill Hospital (GB)
- University College London (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2015-10-29
- Issue
- 10
- Pages
- CD011259-CD011259
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC6485637
- OpenAlex
- W1853576970
- Cited by
- 102
- References
- 78
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 17 · 2019: 14 · 2018: 12 · 2017: 13 · 2016: 2
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (13/89/29)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- chronic neuropathic pain, psychological intervention, cognitive behavioral therapy, group therapy, spinal cord injury pain, burning mouth syndrome, pain-related disability, mood, quality of life, health care utilization, treatment efficacy
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Neuralgia, Psychotherapy, Group, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Chronic Pain
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