The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
An updated structural classification of substrate-binding proteins.
Open accessAbstract
Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins.
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Metadata
- Authors
- Scheepers, G. H., Lycklama a Nijeholt, J. A., & Poolman, B.
- Affiliations
- University of Groningen (NL)
- Department of Biochemistry Groningen Biomolecular Sciences and Biotechnology Institute Zernike Institute for Advanced Materials University of Groningen The Netherlands
- Corresponding author
- Poolman, Bert
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2016-10-23
- Volume
- 590
- Issue
- 23
- Pages
- 4393-4401
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2528162531
- Cited by
- 260
- References
- 47
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 26 · 2023: 29 · 2022: 31 · 2021: 51 · 2020: 28 · 2019: 28 · 2018: 22 · 2017: 13 · 2016: 1
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- European Research Council (670578)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- substrate-binding protein, structural classification, protein clusters, solute uptake, signal transduction, protein structure, Protein Data Bank
- MeSH terms
- Protein Conformation, alpha-Helical, Models, Molecular, Protein Binding, Proteins, Computational Biology, Databases, Protein
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