Hypothalamic lipid‐laden astrocytes induce microglia migration and activation
Open accessAbstract
Obesity‐induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid‐rich conditions, such as obese environment, and that the lipid‐laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNF α, IL‐1β, IL‐6, MCP‐1) at the transcript and/or protein level. Medium conditioned by the lipid‐laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba‐1 and inflammatory cytokines. These findings indicate that the lipid‐laden astrocytes formed in free fatty acid‐rich obese condition may participate in obesity‐induced hypothalamic inflammation through promoting microglia migration and activation.
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Mice fed a high-fat diet experienced lipid droplet formation in astrocytes, which subsequently signaled microglia to augment inflammatory response.
“For example, mice fed to a high-fat diet experienced lipid droplet formation in their astrocytes, which subsequently signaled microglia to augment the inflammatory response.110”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [110]
Cites
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“For example, mice fed to a high-fat diet experienced lipid droplet formation in their astrocytes, which subsequently signaled microglia to augment the inflammatory response.(110) Diabetes is another disease that increases the risk of neurodegeneration, and higher blood glucose levels are considered a major contributin…”
BackgroundLipid droplets in the nervous system
Ralhan, I., Chang, C.-L., Lippincott-Schwartz, J., & Ioannou, M. S. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102136 · Cited by 281 · see citing works
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Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia
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- Authors
- Kwon, Y., Kim, J., Kim, C., Tu, T. H., Kim, M., Suk, K., Kim, D. H., Lee, B. J., Choi, H., Park, T., Choi, M., Goto, T., Kawada, T., Ha, T. Y., & Yu, R.
- Affiliations
- University of Ulsan (KR)
- Kyungpook National University (KR)
- Yonsei University (KR)
- Kyoto University (JP)
- Korea Food Research Institute (KR)
- Corresponding author
- Yu, Rina
- ORCID
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2017-06
- Volume
- 591
- Issue
- 12
- Pages
- 1742-1751
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2618719927
- Cited by
- 87
- References
- 7
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology
- Korea Food Research Institute (E0160500-02)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- hypothalamic astrocytes, lipid droplets, obesity, hypothalamic inflammation, microglial migration, microglial activation, astrocyte activation, saturated fatty acids, inflammatory cytokines, Iba1, neuroinflammation
- MeSH terms
- Animals, Animals, Newborn, Astrocytes, Cell Line, Cell Movement, Cells, Cultured, Chemotaxis, Fatty Acids, Nonesterified, Gene Expression Regulation, Hypothalamus, Mice, Inbred C57BL, Nerve Tissue Proteins, Obesity, RNA, Messenger, Biomarkers, Cytokines, Microglia, Palmitic Acid, Lipid Metabolism, Lipid Droplets
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