Hypothalamic sensing of fatty acids

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Environmental Contributions to the Obesity Epidemic

Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,206 · see citing works

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Cholecystokinin decreases food intake in rats.

Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,498 · see citing works

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works

The role of depot fat in the hypothalamic control of food intake in the rat

Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432 · see citing works

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317 · see citing works

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works

Obesity Wars

Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works

Transient increase in obese gene expression after food intake or insulin administration

Saladin, R., Vos, P. D., Guerre-Millo, M., Leturque, A., Girard, J. R., Staels, B., & Auwerx, J. H. (1995) · Nature · doi:10.1038/377527a0 · Cited by 1,093 · see citing works

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033 · see citing works

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004 · see citing works

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works

Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis.

Mayer, J. (1955) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1955.tb36543.x · Cited by 858 · see citing works

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823 · see citing works

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736 · see citing works

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719 · see citing works

Obesity in the new millennium

Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 701 · see citing works

Mechanisms of nutritional and hormonal regulation of lipogenesis

Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700 · see citing works

Glucostatic Mechanism of Regulation of Food Intake

Mayer, J. (1953) · New England Journal of Medicine · doi:10.1056/nejm195307022490104 · Cited by 668 · see citing works

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654 · see citing works

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G. B., et al. (2002) · Nature Neuroscience · doi:10.1038/nn861 · Cited by 572 · see citing works

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works

Dealing with energy demand: the AMP-activated protein kinase

Kemp, B. E., Mitchelhill, K. I., Stapleton, D., Michell, B. J., Chen, Z., & Witters, L. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01340-1 · Cited by 521 · see citing works

Increased feeding in response to decreased glucose utilization in the rat and monkey

Smith, G., & Epstein, A. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.4.1083 · Cited by 457 · see citing works

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N., & Prentki, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1344 · Cited by 451 · see citing works

Mechanism of glucose-induced insulin secretion.

Hedeskov, C. J. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.2.442 · Cited by 435 · see citing works

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works

Genetic, Traumatic and Environmental Factors in the Etiology of Obesity

Mayer, J. (1953) · Physiological Reviews · doi:10.1152/physrev.1953.33.4.472 · Cited by 377 · see citing works

A war on obesity, not the obese.

Friedman, J. M. (2003) · Science · doi:10.1126/science.1079856 · Cited by 375 · see citing works

Central melanocortin receptors regulate insulin action

Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G. B., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12954 · Cited by 370 · see citing works

Central melanocortin receptors regulate insulin action

Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112954 · Cited by 370 · see citing works

Overfeeding Rapidly Induces Leptin and Insulin Resistance

Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., & Rossetti, L. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2786 · Cited by 355 · see citing works

The "thrifty genotype" in 1998.

Neel, J. V. (2009) · Nutrition reviews · doi:10.1111/j.1753-4887.1999.tb01782.x · Cited by 330 · see citing works

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase*

Kim, E.-K., Miller, I., Aja, S., Landree, L. E., Pinn, M., Mcfadden, J., Kuhajda, F., Moran, T., & Ronnett, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 302 · see citing works

Hypothalamic malonyl-CoA as a mediator of feeding behavior

Hu, Z., Cha, S. H., Chohnan, S., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834402100 · Cited by 272 · see citing works

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

Thupari, J. N., Landree, L. E., Ronnett, G. V., & Kuhajda, F. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132128899 · Cited by 262 · see citing works

Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.

Witters, L. A., & Kemp, B. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50663-9 · Cited by 228 · see citing works

Immunohistochemical Localization of Leptin and Uncoupling Protein in White and Brown Adipose Tissue1

Cinti, S., Frederich, R. C., Zingaretti, M. C., Matteis, R. D., Flier, J. S., & Lowell, B. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.4908 · Cited by 221 · see citing works

In Vivo Fatty Acid Incorporation into Brain Phosholipids in Relation to Plasma Availability, Signal Transduction and Membrane Remodeling

Rapoport, S. I. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:243 · Cited by 215 · see citing works

Reduction of food intake and body weight by chronic intraventricular insulin infusion

Brief, D. J., & Davis, J. D. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90174-6 · Cited by 212 · see citing works

Inhibition of Food Response to Intracerebroventricular Injection of Leptin Is Attenuated in Rats With Diet-Induced Obesity

Widdowson, P. S., Upton, R., Buckingham, R. E., Arch, J. R. S., & Williams, G. (1997) · Diabetes · doi:10.2337/diab.46.11.1782 · Cited by 210 · see citing works

Role of reversible phosphorylation of acetyl‐CoA carboxylase in long‐chain fatty acid synthesis 1

Kim, K., López‐Casillas, F., Bai, D.-H., Luo, X., & Pape, M. E. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.11.2570725 · Cited by 201 · see citing works

The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans

Matzinger, D., Degen, L., Drewe, J., Meuli, J., Duebendorfer, R., Ruckstuhl, N., D'Amato, M., Rovati, L., & Beglinger, C. (2000) · Gut · doi:10.1136/gut.46.5.689 · Cited by 198 · see citing works

Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated

Morgan, K., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400458200 · Cited by 187 · see citing works

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

Shimokawa, T., Kumar, M. V., & Lane, M. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012606199 · Cited by 187 · see citing works

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

Air, E. L., Strowski, M. Z., Benoit, S. C., Conarello, S., Salituro, G., Guan, X.-M., Liu, K., Woods, S. C., & Zhang, B. B. (2002) · Nature Medicine · doi:10.1038/nm0202-179 · Cited by 169 · see citing works

Sustained Intracerebroventricular Infusion of Brain Fuels Reduces Body Weight and Food Intake in Rats

Davis, J. D., Wirtshafter, D., Asin, K. E., & Brief, D. J. (1981) · Science · doi:10.1126/science.7193909 · Cited by 152 · see citing works

Elusive Proximal Signals of β-Cells for Insulin Secretion

MacDonald, M. J. (1990) · Diabetes · doi:10.2337/diab.39.12.1461 · Cited by 152 · see citing works

Metabolic predictors of weight gain

Ravussin, É., & Gautier, J. F. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800793 · Cited by 139 · see citing works

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment

Kim, E. K., Miller, I., Landree, L. E., Borisy-Rudin, F. F., Brown, P., Tihan, T., Townsend, C. A., Witters, L. A., Moran, T. H., Kuhajda, F. P., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00178.2002 · Cited by 131 · see citing works

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C. A., Witters, L. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310991200 · Cited by 131 · see citing works

Suppression of food intake by intravenous nutrients and insulin in the baboon

Woods, S. C., Stein, L. J., McKay, L. D., & Porte, D. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.247.2.r393 · Cited by 130 · see citing works

Obesity Genes: Beneficial Effects in Heterozygous Mice

Coleman, D. L. (1979) · Science · doi:10.1126/science.760211 · Cited by 123 · see citing works

Neurobiology of cholecystokinin.

Moran, T. H., & Schwartz, G. J. (1994) · PubMed · Cited by 118 · see citing works

Pathways of Fos expression in locus ceruleus, dorsal vagal complex, and PVN in response to intestinal lipid

Mönnikes, H., Lauer, G., Bauer, C., Tebbe, J. J., Zittel, T. T., & Arnold, R. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r2059 · Cited by 113 · see citing works

Utilization of Plasma Fatty Acid in Rat Brain: Distribution of [ 14 C]Palmitate Between Oxidative and Synthetic Pathways

Miller, J. C., Gnaedinger, J. M., & Rapoport, S. I. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb01021.x · Cited by 111 · see citing works

Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem

Gao, S., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031698100 · Cited by 106 · see citing works

Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors

Schwartz, G. J., Whitney, A. C., Skoglund, C., Castonguay, T. W., & Moran, T. H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1144 · Cited by 101 · see citing works

Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion

Clegg, D. J., Wortman, M. D., Benoit, S. C., McOsker, C. C., & Seeley, R. J. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3196 · Cited by 92 · see citing works

Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting

Makimura, H., Mizuno, T. M., Yang, X.-J., Silverstein, J. H., Beasley, J., & Mobbs, C. V. (2001) · Diabetes · doi:10.2337/diabetes.50.4.733 · Cited by 80 · see citing works

The effect of leptin on Lep expression is tissue-specific and nutritionally regulated

Wang, J., Liu, R., Liu, L., Chowdhury, R., Barzilai, N., Tan, J., & Rossetti, L. (1999) · Nature Medicine · doi:10.1038/11335 · Cited by 78 · see citing works

Long-chain polyunsaturated fatty acid accretion in brain

Qi, K., Hall, M., & Deckelbaum, R. J. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200203000-00003 · Cited by 78 · see citing works

Arleriovenous Glucose Differences , METABOLIC HYPOGLYCEMIA AND FOOD INTAKE in Man

Itallie, T. B. V., Beaudoin, R., & Mayer, J. (1953) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/1.3.208 · Cited by 75 · see citing works

Δ 9 -Tetrahydrocannabinol enhancement of Lordosis Behavior in estrogen treated female rats

Gordon, J. H., Bromley, B. L., Gorski, R. A., & Zimmermann, E. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90395-7 · Cited by 65 · see citing works

In vivo labeling of brain phospholipids by long‐chain fatty acids: Relation to turnover and function

Rapoport, S. I. (1996) · Lipids · doi:10.1007/bf02637059 · Cited by 43 · see citing works

Behavioral effects of chronic oral administration of levo -alpha-acetylmethadol in the rat

Aigner, T. G., & Balster, R. L. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90393-3 · Cited by 43 · see citing works

The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is a Nonspecific Neuronal Activator

Takahashi, K. A., Smart, J. L., Liu, H., & Cone, R. D. (2003) · Endocrinology · doi:10.1210/en.2003-0337 · Cited by 42 · see citing works

Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes

Lavrentyev, E. N., Matta, S. G., & Cook, G. A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.040 · Cited by 32 · see citing works

Lipid Abnormalities in Muscle of Insulin‐resistant Rodents The Malonyl CoA Hypothesisa

Ruderman, N. B., Saha, A. K., Vavvas, D. G., Heydrick, S. J., & Kurowski, T. G. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51837.x · Cited by 32 · see citing works

2-deoxy-D-glucose induced feeding: Relation to diet palatability

Kanarek, R. B., & Mayer, J. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90397-0 · Cited by 31 · see citing works

Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei

Miller, I., Ronnett, G. V., Moran, T. H., & Aja, S. M. (2004) · Neuroreport · doi:10.1097/00001756-200404090-00038 · Cited by 26 · see citing works

Effect of intravenous nutrient infusions on food intake in rats

Walls, E. K., & Koopmans, H. S. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90113-3 · Cited by 21 · see citing works

Influence of fatty acid oxidation in lateral hypothalamus on food intake and body composition

Beverly, J. L., & Martin, R. J. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.2.r339 · Cited by 11 · see citing works

Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid

Goto, M., & Spitzer, J. J. (1971) · Experimental Biology and Medicine · doi:10.3181/00379727-136-35478 · Cited by 11 · see citing works

Polyunsaturated fatty acids and their metabolites in brain function and disease

Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,613 · see citing works

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

Circadian rhythms, sleep, and metabolism

Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 726 · see citing works

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710 · see citing works

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

López, M., Varela, L., Vazquez, M. J., Rodríguez‐Cuenca, S., González, C. R., Velagapudi, V., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2207 · Cited by 682 · see citing works

BOARD-INVITED REVIEW: The hepatic oxidation theory of the control of feed intake and its application to ruminants

Allen, M. S., Bradford, B. J., & Oba, M. (2009) · Journal of Animal Science · doi:10.2527/jas.2009-1779 · Cited by 633 · see citing works

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Valdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629 · see citing works

Molecular and anatomical determinants of central leptin resistance

Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550 · see citing works

Regulation of lipid stores and metabolism by lipophagy

Liu, K., & Czaja, M. J. (2013) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2012.63 · Cited by 542 · see citing works

Lipophagy: Connecting Autophagy and Lipid Metabolism

Singh, R., & Cuervo, A. M. (2012) · International Journal of Cell Biology · doi:10.1155/2012/282041 · Cited by 497 · see citing works

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

Muriach, M., Flores‐Bellver, M., Romero, F. J., & Barcia, J. M. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/102158 · Cited by 488 · see citing works

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 421 · see citing works

The central melanocortin system directly controls peripheral lipid metabolism

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31743 · Cited by 396 · see citing works

An evolutionary perspective on immunometabolism

Wang, A., Luan, H. H., & Medzhitov, R. M. (2019) · Science · doi:10.1126/science.aar3932 · Cited by 394 · see citing works

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

Kaushik, S., Rodriguez-Navarro, J. A., Arias, E., Kiffin, R., Sahu, S., Schwartz, G. J., Cuervo, A. M., & Singh, R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.008 · Cited by 382 · see citing works

Neurobiology of Feeding and Energy Expenditure

Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346 · see citing works

Glycerolipid Metabolism and Signaling in Health and Disease

Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 322 · see citing works

The Homeostatic Force of Ghrelin.

Yanagi, S., Sato, T., Kangawa, K., & Nakazato, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.008 · Cited by 293 · see citing works

AMPK: Lessons from transgenic and knockout animals

Viollet, B. (2009) · Frontiers in bioscience · doi:10.2741/3229 · Cited by 314 · see citing works

Hyperleptinemia Is Required for the Development of Leptin Resistance

Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311 · see citing works

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

Ishimoto, T., Lanaspa, M. A., Le, M. T., García, G., Diggle, C. P., MacLean, P. S., Jackman, M. R., Asipu, A., Roncal-Jiménez, C. A., Kosugi, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119908109 · Cited by 304 · see citing works

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

Xu, J., Ji, J., & Yan, X. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.500245 · Cited by 303 · see citing works

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 293 · see citing works

The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_9 · Cited by 291 · see citing works

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding

Dietrich, M. O., Zimmer, M. R., Bober, J., & Horváth, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.02.024 · Cited by 271 · see citing works

Pancreatic signals controlling food intake; insulin, glucagon and amylin

Woods, S. C., Lutz, T. A., Geary, N., & Langhans, W. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1858 · Cited by 286 · see citing works

Mechanisms Regulating Feed Intake, Energy Expenditure, and Body Weight in Poultry

Richards, M. P., & Proszkowiec‐Weglarz, M. (2007) · Poultry Science · doi:10.1093/ps/86.7.1478 · Cited by 269 · see citing works

Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism

Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 264 · see citing works

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1

Rizki, G., Arnaboldi, L., Gabrielli, B., Yan, J. S., Lee, G. S., Ng, R. K., Turner, S., Badger, T. M., Pitas, R. E., & Maher, J. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600198-jlr200 · Cited by 260 · see citing works

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256 · see citing works

Taste of Fat: A Sixth Taste Modality?

Besnard, P., Passilly‐Degrace, P., & Khan, N. A. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2015 · Cited by 249 · see citing works

Mitochondrial fatty acid oxidation in obesity

Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works

Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit

Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works

Obesity and adipokines: effects on sympathetic overactivity

Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 237 · see citing works

Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Suzuki, T., Kudo, H., Uno, K., Hasegawa, Y., Gao, J., Kaneko, K., et al. (2008) · Science · doi:10.1126/science.1163971 · Cited by 236 · see citing works

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Contreras, C., González‐García, I., Martínez‐Sánchez, N., Seoane‐Collazo, P., Jacas, J., Morgan, D. A., Serra, D., Gallego, R., González, F., Casals, N., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.057 · Cited by 236 · see citing works

Molecular disruption of hypothalamic nutrient sensing induces obesity

He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226 · see citing works

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

Dietrich, M. O., & Horvath, T. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.005 · Cited by 227 · see citing works

Fatty Acids in Energy Metabolism of the Central Nervous System

Panov, A., Orynbayeva, Z., Vavilin, V., & Lyakhovich, V. (2014) · BioMed Research International · doi:10.1155/2014/472459 · Cited by 227 · see citing works

Protein-Mediated Fatty Acid Uptake: Novel Insights from In Vivo Models

Doege, H., & Stahl, A. (2006) · Physiology · doi:10.1152/physiol.00014.2006 · Cited by 220 · see citing works

Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity

Canale, M. P., di Villahermosa, S. M., Martino, G., Rovella, V., Noce, A., LORENZO, A. D., & Daniele, N. D. (2013) · International Journal of Endocrinology · doi:10.1155/2013/865965 · Cited by 219 · see citing works

Ghrelin: a hormone regulating food intake and energy homeostasis

Gil‐Campos, M., Aguilera, C. M., Cañete, R., & Gil, Á. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061787 · Cited by 218 · see citing works

Metabolic syndrome as a risk factor for neurological disorders

Farooqui, A. A., Farooqui, T., Panza, F., & Frisardi, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0840-1 · Cited by 206 · see citing works

Differential Accessibility of Circulating Leptin to Individual Hypothalamic Sites

Faouzi, M., Leshan, R. L., Björnholm, M., Hennessey, T., Jones, J. C., & Münzberg, H. (2007) · Endocrinology · doi:10.1210/en.2007-0655 · Cited by 205 · see citing works

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 205 · see citing works

Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms

Srinivasan, S., Sadegh, L., Elle, I. C., Christensen, A. G. L., Færgeman, N. J., & Ashrafi, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.012 · Cited by 205 · see citing works

Obesity and the regulation of fat metabolism

Ashrafi, K. (2007) · WormBook · doi:10.1895/wormbook.1.130.1 · Cited by 204 · see citing works

Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies

Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 197 · see citing works

The regulation of food intake by the gut-brain axis: implications for obesity

Hussain, S., & Bloom, S. R. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.93 · Cited by 195 · see citing works

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

Rojas-Gutierrez, E., Muñoz‐Arenas, G., Treviño, S., Espinosa, B., Chávez, R., Rojas, K., Flores, G., Díaz, A., & Guevara, J. (2017) · Synapse · doi:10.1002/syn.21990 · Cited by 193 · see citing works

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 189 · see citing works

Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K., Lombès, M., & Hayashi, Y. (2007) · Diabetes · doi:10.2337/db07-0698 · Cited by 187 · see citing works

A Model for Fatty Acid Transport into the Brain

Hamilton, J. A., & Brunaldi, K. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0050-3 · Cited by 176 · see citing works

Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T. A., Xu, H., Ortegon, A. M., Kazantzis, M., Kay, M. A., & Stahl, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803510200 · Cited by 170 · see citing works

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

Karnani, M., Apergis‐Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L. H., & Burdakov, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.027 · Cited by 166 · see citing works

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Jauch‐Chara, K., Friedrich, A., Rezmer, M., Melchert, U. H., Scholand-Engler, H. G., Hallschmid, M., & Oltmanns, K. M. (2012) · Diabetes · doi:10.2337/db12-0025 · Cited by 164 · see citing works

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

Jordan, S. D., Könner, A. C., & Brüning, J. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0414-7 · Cited by 163 · see citing works

Hypothalamic inflammation: a double‐edged sword to nutritional diseases

Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 159 · see citing works

Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing

Le Foll, C., Irani, B. G., Magnan, C., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2009 · Cited by 159 · see citing works

Fuel utilization by hypothalamic neurons: roles for ROS.

Horvath, T., Andrews, Z., & Diano, S. (2009) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2008.10.003 · Cited by 159 · see citing works

Neuronal control of energy homeostasis

Gao, Q., & Horváth, T. L. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.063 · Cited by 153 · see citing works

Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins

Lam, T. K. T., Juárez, R. G., Pocai, A., Bhanot, S., Tso, P., Schwartz, G. J., & Rossetti, L. (2007) · Nature Medicine · doi:10.1038/nm1540 · Cited by 152 · see citing works

Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA

López, M., Lelliott, C. J., Tovar, S. A., Kimber, W. L., Gallego, R., Virtue, S., Blount, M., Vazquez, M. J., Finer, N., Powles, T. J., et al. (2006) · Diabetes · doi:10.2337/db05-1356 · Cited by 151 · see citing works

Hypothalamic dysfunction in obesity

Williams, L. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s002966511200078x · Cited by 145 · see citing works

Neuroinflammatory basis of metabolic syndrome

Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 146 · see citing works

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

Pinkosky, S. L., Scott, J. W., Desjardins, E. M., Smith, B. K., Day, E. A., Ford, R. J., Langendorf, C. G., Ling, N. X. Y., Nero, T. L., Loh, K., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0245-2 · Cited by 145 · see citing works

Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake

López, M., Lelliott, C. J., & Vidal‐Puig, A. (2007) · BioEssays · doi:10.1002/bies.20539 · Cited by 145 · see citing works

Dietary Omega-3 Fatty Acid Deficiency and High Fructose Intake in the Development of Metabolic Syndrome, Brain Metabolic Abnormalities, and Non-Alcoholic Fatty Liver Disease

Simopoulos, A. P. (2013) · Nutrients · doi:10.3390/nu5082901 · Cited by 141 · see citing works

Molecular physiology of weight regulation in mice and humans

Leibel, R. L. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.245 · Cited by 138 · see citing works

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

Stoll, E. A., Makin, R., Sweet, I. R., Trevelyan, A. J., Miwa, S., Horner, P. J., & Turnbull, D. M. (2015) · Stem Cells · doi:10.1002/stem.2042 · Cited by 139 · see citing works

Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics

Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 136 · see citing works

Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system

Nakamoto, K., Nishinaka, T., Matsumoto, K., Kasuya, F., Mankura, M., Kōyama, Y., & Tokuyama, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.012 · Cited by 134 · see citing works

A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C. A., Day, J. P., Houslay, M. D., & Baillie, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0470-1 · Cited by 134 · see citing works

Genetic and epigenetic control of metabolic health

Schwenk, R. W., Vogel, H., & Schürmann, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.002 · Cited by 132 · see citing works

Regulation of hypothalamic malonyl-CoA by central glucose and leptin

Wolfgang, M. J., Cha, S. H., Sidhaye, A., Chohnan, S., Cline, G., Shulman, G. I., & Lane, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709778104 · Cited by 127 · see citing works

Role for Mitochondrial Reactive Oxygen Species in Brain Lipid Sensing

Bénani, A., Troy, S., Carmona, M. C., Fioramonti, X., Lorsignol, A., Leloup, C., Casteilla, L., & Pénicaud, L. (2006) · Diabetes · doi:10.2337/db06-0440 · Cited by 127 · see citing works

Appetite Regulation: An Overview

Dhillo, W. S. (2007) · Thyroid · doi:10.1089/thy.2007.0018 · Cited by 126 · see citing works

Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice

Cardinal, P., Bellocchio, L., Clark, S., Cannich, A., Klugmann, M., Lutz, B., Marsicano, G., & Cota, D. (2012) · Endocrinology · doi:10.1210/en.2012-1405 · Cited by 123 · see citing works

The regulation of food intake in mammalian hibernators: a review

Florant, G., & Healy, J. E. (2012) · Journal of Comparative Physiology □ B · doi:10.1007/s00360-011-0630-y · Cited by 108 · see citing works

Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators

Sánchez-Lasheras, C., Könner, A. C., & Brüning, J. C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.08.002 · Cited by 120 · see citing works

From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants

Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 120 · see citing works

Hypothalamic resistin induces hepatic insulin resistance

Muse, E. D., Lam, T. K. T., Scherer, P. E., & Rossetti, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30440 · Cited by 119 · see citing works

The Role of CNS Fuel Sensing in Energy and Glucose Regulation

Cota, D., Proulx, K., & Seeley, R. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.049 · Cited by 117 · see citing works

The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

Bermúdez‐Silva, F. J., Cardinal, P., & Cota, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408458 · Cited by 117 · see citing works

Hypothalamic Microglial Activation in Obesity: A Mini-Review

Mendes, N. F., Kim, Y., Velloso, L. A., & ARAUJO, E. P. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00846 · Cited by 117 · see citing works

Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion

Vazquez, M. J., González, C. R., Varela, L., Lage, R., Tovar, S. A., Sangiao‐Alvarellos, S., Williams, L. M., Vidal‐Puig, A., Nogueiras, R., López, M., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1708 · Cited by 116 · see citing works

The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis

Wolfgang, M. J., & Lane, M. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600016200 · Cited by 114 · see citing works

Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain

Morita, S., & Miyata, S. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1421-9 · Cited by 112 · see citing works

Glucokinase activators in diabetes management

Coghlan, M. P., & Leighton, B. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.145 · Cited by 112 · see citing works

Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus

Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111 · see citing works

Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome

Aguilera, C. M., Gil‐Campos, M., Cañete, R., & Gil, Á. (2008) · Clinical Science · doi:10.1042/cs20070115 · Cited by 110 · see citing works

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 109 · see citing works

Cannabinoids and the Brain

Köfalvi, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3 · Cited by 110 · see citing works

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

Mountjoy, K. G. (2010) · Biochemical Journal · doi:10.1042/bj20091957 · Cited by 108 · see citing works

Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance

Lindén, J., Lensu, S., Tuomisto, J., & Pohjanvirta, R. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.002 · Cited by 107 · see citing works

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

Jo, Y., Su, Y., Juárez, R. G., & Chua, S. C. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91294.2008 · Cited by 106 · see citing works

Hypothalamic Control of Lipid Metabolism: Focus on Leptin, Ghrelin and Melanocortins

Diéguez, C., Vazquez, M. J., Romero, A., López, M., & Nogueiras, R. (2011) · Neuroendocrinology · doi:10.1159/000328122 · Cited by 105 · see citing works

Modulation of Fatty Acid Metabolism as a Potential Approach to the Treatment of Obesity and the Metabolic Syndrome

Kusunoki, J., Kanatani, A., & Moller, D. E. (2006) · Endocrine · doi:10.1385/endo:29:1:91 · Cited by 103 · see citing works

MONITORING ENERGY BALANCE: Metabolites of Fatty Acid Synthesis as Hypothalamic Sensors

Dowell, P., Hu, Z., & Lane, M. D. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074027 · Cited by 82 · see citing works

Hypothalamic nutrient sensing in the control of energy homeostasis

Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 323 · see citing works

Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake

López, M., Lelliott, C. J., & Vidal‐Puig, A. (2007) · BioEssays · doi:10.1002/bies.20539 · Cited by 145 · see citing works

[Hypothalamic nuclei sense metabolic signals and regulate feeding].

Kohno, D., Toriya, M., Yada, T., Kurita, H., & Kuramochi, M. (2006) · PubMed · Cited by 1 · see citing works

Hypothalamic Lipid Nutritional Sensing and Mechanisms in Appetite Regulation

Jiang, Q. (2013) · Dongwu yingyang xuebao