The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
DNA‐encoded chemical libraries – achievements and remaining challenges
Open accessAbstract
DNA‐encoded chemical libraries (DECL s) are collections of compounds, individually coupled to DNA tags serving as amplifiable identification barcodes. Since individual compounds can be identified by the associated DNA tag, they can be stored as a mixture, allowing the synthesis and screening of combinatorial libraries of unprecedented size, facilitated by the implementation of split‐and‐pool synthetic procedures or other experimental methodologies. In this review, we briefly present relevant concepts and technologies, which are required for the implementation and interpretation of screening procedures with DNA‐encoded chemical libraries. Moreover, we illustrate some success stories, detailing how novel ligands were discovered from encoded libraries. Finally, we critically review what can realistically be achieved with the technology at the present time, highlighting challenges and opportunities for the future.
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Cites
Encoded combinatorial chemistry.
Brenner, S., & Lerner, R. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5381 · Cited by 1,014
DNA-encoded chemistry: enabling the deeper sampling of chemical space
Goodnow, R. A., Dumelin, C. E., & Keefe, A. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.213 · Cited by 621
Neri, D., & Lerner, R. A. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012550 · Cited by 364
Self-citation
Cited by
Rethinking drug design in the artificial intelligence era
Schneider, P., Walters, W. P., Plowright, A. T., Sieroka, N., Listgarten, J., Goodnow, R. A., Fisher, J., Jansen, J. M., Duca, J. S., Rush, T. S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0050-3 · Cited by 894
DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges
Gironda-Martínez, A., Donckele, E. J., Samain, F., & Neri, D. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00118 · Cited by 344
Self-citationNovel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Guilinger, J. P., Archna, A., Augustin, M., Bergmann, A., Centrella, P. A., Clark, M. A., Cuozzo, J. W., Däther, M., Guié, M.-A., Habeshian, S., et al. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116223 · Cited by 49
Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries
Mata, J. M., van der Nol, E., & Pomplun, S. J. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04899 · Cited by 27
Metadata
- Authors
- Favalli, N., Bassi, G., Scheuermann, J., & Neri, D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2018-05-10
- Volume
- 592
- Issue
- 12
- Pages
- 2168-2180
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2803083648
- Cited by
- 171
- References
- 3
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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