DNA-encoded chemistry: enabling the deeper sampling of chemical space

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Encoded self-assembling chemical libraries

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Chemical Space of DNA-Encoded Libraries

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Radiofrequency Encoded Combinatorial Chemistry

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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A Portable Albumin Binder from a DNA‐Encoded Chemical Library

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SureChEMBL: a large-scale, chemically annotated patent document database

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High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

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Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

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Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides:

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DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries

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Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

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Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

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A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

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Scaffold composition and biological relevance of screening libraries

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DNA Display I. Sequence-Encoded Routing of DNA Populations

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In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

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Synthetic Ligands Discovered by in Vitro Selection

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Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection

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Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

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Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

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Automated screening for small organic ligands using DNA-encoded chemical libraries

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Isolation of High‐Affinity Trypsin Inhibitors from a DNA‐Encoded Chemical Library

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Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

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Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library

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Encoding methods for combinatorial chemistry

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An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries

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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

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DNA‐Encoded Dynamic Combinatorial Chemical Libraries

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Nucleic Acid Chemistry in the Organic Phase: From Functionalized Oligonucleotides to DNA Side Chain Polymers

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Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

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DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

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DNA-Encoded Chemical Libraries for the Discovery of MMP-3 Inhibitors

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Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

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Selecting chemicals: the emerging utility of DNA-encoded libraries

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Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

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Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

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Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

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The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

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From haystack to needle: finding value with DNA encoded library technology at GSK

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Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library

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Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

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Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

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Design, preparation, and selection of DNA-encoded dynamic libraries

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DNA‐Templated Synthesis in Organic Solvents

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DNA Encoded Library Selections and Insights Provided by Computational Simulations

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Design and Application of a DNA-Encoded Macrocyclic Peptide Library

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Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery

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On-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water

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The Time and Place for Nature in Drug Discovery

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Strategies for targeting undruggable targets

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Stimuli-responsive DNA-based hydrogels for biosensing applications

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A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4

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gem ‐Difluoromethylene Alkyne‐Enabled Diverse C−H Functionalization and Application to the on‐DNA Synthesis of Difluorinated Isocoumarins

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Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection

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The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery

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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

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DDR1 role in fibrosis and its pharmacological targeting

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A Chemistry for Incorporation of Selenium into DNA‐Encoded Libraries

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Future challenges with DNA-encoded chemical libraries in the drug discovery domain

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Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries

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Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections

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Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

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Activity-Based DNA-Encoded Library Screening

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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor

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Prioritization of Molecular Targets for Antimalarial Drug Discovery

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Micellar Brønsted Acid Mediated Synthesis of DNA-Tagged Heterocycles

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Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media

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Evolving a Peptide: Library Platforms and Diversification Strategies

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Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction

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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

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Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis

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In-solution enrichment identifies peptide inhibitors of protein–protein interactions

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Functionality‐Independent DNA Encoding of Complex Natural Products

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Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells

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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library

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Use of artificial intelligence to enhance phenotypic drug discovery

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Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores

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Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries

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Evolution of commercially available compounds for HTS

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Structural Pharmacology of Voltage-Gated Sodium Channels

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Randomness in DNA Encoded Library Selection Data Can Be Modeled for More Reliable Enrichment Calculation

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What Do You Get from DNA-Encoded Libraries?

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DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences

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Ruthenium-Promoted C–H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids

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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

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Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications

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On-DNA Pd and Cu promoted C–N cross-coupling reactions

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Isocyanide Multicomponent Reactions on Solid-Phase-Coupled DNA Oligonucleotides for Encoded Library Synthesis

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An overview of DNA-encoded libraries: A versatile tool for drug discovery

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Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

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DNA-encoded chemical libraries: foundations and applications in lead discovery

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Chemical composition of DNA-encoded libraries, past present and future

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