Cited by 139Gut microbiota and healthMenopause: Health Impacts and TreatmentsOral microbiology and periodontitis research

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Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

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Zhao, Hui, Chen, Juanjuan, Li, Xiaoping, Sun, Qiang, Qin, Panpan, Wang, Qi·2019·FEBS Letters

DOI 10.1002/1873-3468.13527

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Abstract

Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp . are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.

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Authors: Zhao, H., Chen, J., Li, X., Sun, Q., Qin, P., & Wang, Q.
Affiliations: BGI Group (China) (CN)
University of Toronto (CA)
Corresponding author: Wang, Qi
ORCID: Zhao, Hui
Chen, Juanjuan
Li, Xiaoping
Sun, Qiang
Qin, Panpan
Wang, Qi
Venue: FEBS Letters
Publisher: Wiley
Published: 2019-07-17
Volume: 593
Issue: 18
Pages: 2655-2664
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1002/1873-3468.13527
OpenAlex: W2956063300
Cited by: 138
References: 50
Citations by year: 2026: 20 · 2025: 27 · 2024: 23 · 2023: 17 · 2022: 28 · 2021: 19 · 2020: 3
FWCI: 4.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Shenzhen Government
Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20160229172757249, JCYJ20170817145523036)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, menopause, postmenopausal women, premenopausal women, estrogen deficiency, Firmicutes, Roseburia, Bacteroidetes, pentose phosphate pathway, microbial metabolites, metagenome-wide association study
MeSH terms: Gastrointestinal Microbiome, Female, Humans, Middle Aged, Phenotype, Quality of Life, Premenopause, Postmenopause

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Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

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