The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Compositional and functional features of the female premenopausal and postmenopausal gut microbiota
Open accessAbstract
Endogenous estrogen deficiency accelerates many diseases in postmenopausal women, and gut microbes contribute to estrogen level modulation. However, the compositional alterations and influences of the gut microbiota in postmenopausal women remain uncertain. A metagenome‐wide association study was performed to compare the gut microbiota of 24 premenopausal and 24 postmenopausal women. Firmicutes and Roseburia spp . are depleted, while Bacteroidetes and the toluene‐producing genus Tolumonas are overrepresented in fecal samples from postmenopausal women. The pentose phosphate pathway is enriched in premenopausal women. Homocysteine synthesis‐related processes are enriched in postmenopausal women. The gut microbiomes of premenopausal and postmenopausal women differ and produce different metabolites. The gut microbiome may be a therapeutic target to reduce risks and improve the quality of life in postmenopausal women.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Menopause further reshapes the community: premenopausal women display higher Firmicutes-to-Bacteroidetes ratios and higher levels of Roseburia, whereas the post-menopausal decline in estrogen is accompanied by lower diversity and expansions of taxa linked to cardiometabolic risk.48–50”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Self-citationRichness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., Andrews, E., Ajami, N. J., Bonham, K. S., Brislawn, C. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1237-9 · Cited by 3,143
Metagenomic microbial community profiling using unique clade-specific marker genes
Segata, N., Waldron, L., Ballarini, A., Narasimhan, V., Jousson, O., & Huttenhower, C. (2012) · Nature Methods · doi:10.1038/nmeth.2066 · Cited by 1,776
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755
Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690
Estrogen–gut microbiome axis: Physiological and clinical implications
Baker, J. M., Al‐Nakkash, L., & Herbst‐Kralovetz, M. M. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.025 · Cited by 1,056
Role of homocysteine in the development of cardiovascular disease
Ganguly, P. K., & Alam, S. F. (2015) · Nutrition Journal · doi:10.1186/1475-2891-14-6 · Cited by 1,030
Roseburia Spp.: A Marker of Health?
Tamanai‐Shacoori, Z., Smida, I., Bousarghin, L., Loréal, O., Meuric, V., Fong, S. B., Bonnaure‐Mallet, M., & Jolivet‐Gougeon, A. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0130 · Cited by 767
Atsma, F., Bartelink, M.-L. E. L., Grobbee, D. E., & van der Schouw, Y. T. (2006) · Menopause · doi:10.1097/01.gme.0000218683.97338.ea · Cited by 744
Research works printed but not linked: 1
- 10.1080/19490976.2019.1619440 · DOI
Cited by
Sorted by citations
How biological sex of the host shapes its gut microbiota
Valeri, F., & Endres, K. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100912 · Cited by 278
The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis
Seely, K. D., Kotelko, C. A., Douglas, H. E., Bealer, B., & Brooks, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179452 · Cited by 209
Lv, W., Xu, L., Shen, H., Liu, H., Qiu, X., Li, B., Shen, W., Ge, C.-L., Lv, F.-Y., Shen, J., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12788 · Cited by 161
Peters, B. A., Lin, J., Qi, Q., Usyk, M., Isasi, C. R., Mossavar-Rahmani, Y., Derby, C. A., Santoro, N., Perreira, K. M., Daviglus, M. L., et al. (2022) · mSystems · doi:10.1128/msystems.00273-22 · Cited by 130
Costa, D. A., Nobre, J. G., Batista, M. V., Ribeiro, C., Callé, C., Cortés, A., Marhold, M., Negreiros, I., Borralho, P., Brito, M., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.584332 · Cited by 125
Metadata
- Authors
- Zhao, H., Chen, J., Li, X., Sun, Q., Qin, P., & Wang, Q.
- Affiliations
- BGI Group (China) (CN)
- University of Toronto (CA)
- Corresponding author
- Wang, Qi
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2019-07-17
- Volume
- 593
- Issue
- 18
- Pages
- 2655-2664
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2956063300
- Cited by
- 138
- References
- 50
- Citations by year
- 2026: 20 · 2025: 27 · 2024: 23 · 2023: 17 · 2022: 28 · 2021: 19 · 2020: 3
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shenzhen Government
- Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20160229172757249, JCYJ20170817145523036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, menopause, postmenopausal women, premenopausal women, estrogen deficiency, Firmicutes, Roseburia, Bacteroidetes, pentose phosphate pathway, microbial metabolites, metagenome-wide association study
- MeSH terms
- Gastrointestinal Microbiome, Female, Humans, Middle Aged, Phenotype, Quality of Life, Premenopause, Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
