The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
EMT and MET : necessary or permissive for metastasis?
Open accessAbstract
Epithelial‐to‐mesenchymal transition ( EMT ) and its reverse mesenchymal‐to‐epithelial transition ( MET ) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT / MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.
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Maloney, S., Spring, C., Morejon-Lasso, L., & Prosperi, J. (2020) · Cancers · doi:10.3390/cancers12113323 · Cited by 198
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Celià-Terrassa, T., & Jolly, M. K. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036905 · Cited by 163
Self-citationEpithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β
Tsubakihara, Y., & Moustakas, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113672 · Cited by 160
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Metadata
- Authors
- Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A., & Levine, H.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2017-06-12
- Volume
- 11
- Issue
- 7
- Pages
- 755-769
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2603666401
- Cited by
- 371
- References
- 147
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A., & Levine, H. (2017). EMT and MET : necessary or permissive for metastasis? Molecular Oncology. https://doi.org/10.1002/1878-0261.12083
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
