Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis

Prospective identification of tumorigenic breast cancer cells

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The basics of epithelial-mesenchymal transition

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Epithelial-Mesenchymal Transitions in Development and Disease

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Stem cells, cancer, and cancer stem cells

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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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Identification of human brain tumour initiating cells

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Epithelial–mesenchymal transitions in tumour progression

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The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.

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Involvement of chemokine receptors in breast cancer metastasis

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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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A Perspective on Cancer Cell Metastasis

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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EMT: 2016

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Cancer Metastasis: Building a Framework

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Identification and expansion of human colon-cancer-initiating cells

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Dissemination and growth of cancer cells in metastatic sites

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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

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Wnt signalling in stem cells and cancer

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Emerging Biological Principles of Metastasis

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Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer

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EMT Transition States during Tumor Progression and Metastasis

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Cancer stem cells revisited

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The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

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Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

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An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

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A molecular signature of metastasis in primary solid tumors

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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

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Breast cancer metastasis: markers and models

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Evolution of the Cancer Stem Cell Model

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Phenotypic characterization of human colorectal cancer stem cells

Dalerba, P. D., Dylla, S. J., Park, I.-K., Liu, R., Wang, X., Cho, R. W., Hoey, T., Gurney, A. L., Huang, E. H., Simeone, D. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703478104 · Cited by 2,187 · see citing works

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Malta, T. M., Sokolov, A., Gentles, A. J., Burzykowski, T., Poisson, L., Weinstein, J. N., Kamińska, B., Huelsken, J., Omberg, L., Gevaert, O., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.034 · Cited by 2,180 · see citing works

A restricted cell population propagates glioblastoma growth after chemotherapy

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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works

The epithelial–mesenchymal transition: new insights in signaling, development, and disease

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The cancer stem cell: premises, promises and challenges

Clevers, H. (2011) · Nature Medicine · doi:10.1038/nm.2304 · Cited by 1,915 · see citing works

Metastasis: a question of life or death

Mehlen, P., & Puisieux, A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1886 · Cited by 1,854 · see citing works

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

van Dijk, D., Sharma, R., Nainys, J., Yim, K., Kathail, P., Carr, A. J., Burdziak, C., Moon, K. R., Chaffer, C. L., Pattabiraman, D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.061 · Cited by 1,829 · see citing works

Efficient tumour formation by single human melanoma cells

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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works

Identification of the tumour transition states occurring during EMT

Pastushenko, I., Brisebarre, A., Sifrim, A., Fioramonti, M., Revenco, T., Boumahdi, S., Keymeulen, A. V., Brown, D. V., Moers, V., Lemaire, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0040-3 · Cited by 1,488 · see citing works

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

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Targeting metastasis-initiating cells through the fatty acid receptor CD36

Pascual, G., Avgustinova, A., Mejetta, S., Martı́n, M., Castellanos‐Martín, A., Attolini, C. S., Berenguer, A., Prats, N., Toll, A., Hueto-Madrid, J. A., et al. (2016) · Nature · doi:10.1038/nature20791 · Cited by 1,430 · see citing works

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

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Identification of cells initiating human melanomas

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Molecular Definition of Breast Tumor Heterogeneity

Shipitsin, M. V., Campbell, L. L., Argani, P., Weremowicz, S., Bloushtain-Qimron, N., Yao, J., Nikolskaya, T., Serebryiskaya, T., Beroukhim, R., Hu, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.013 · Cited by 1,358 · see citing works

Interactions between cancer stem cells and their niche govern metastatic colonization

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Cancer stem cells: current status and evolving complexities.

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Coexistence of Quiescent and Active Adult Stem Cells in Mammals

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Multistep Nature of Metastatic Inefficiency

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

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Senescence-associated reprogramming promotes cancer stemness

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Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., & Yang, J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.022 · Cited by 1,073 · see citing works

Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas

Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,072 · see citing works

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

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Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

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Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With 125I-5-Iodo-2′ -deoxyuridine 2 3

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Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

Ocaña, O. H., Córcoles, R. C., Fabra, À., Moreno‐Bueno, G., Acloque, H., Vega, S., Barrallo‐Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973 · see citing works

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

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Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

Nieto, M. A. (2013) · Science · doi:10.1126/science.1234850 · Cited by 962 · see citing works

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

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Biological Diversity in Metastatic Neoplasms: Origins and Implications

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Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Lawson, D. A., Bhakta, N. R., Kessenbrock, K., Prummel, K. D., Yu, Y., Takai, K., Zhou, A. Y., Eyob, H., Balakrishnan, S., Wang, C., et al. (2015) · Nature · doi:10.1038/nature15260 · Cited by 894 · see citing works

Gene expression profiles of human breast cancer progression

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Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

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Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

Kudo‐Saito, C., Shirako, H., Takeuchi, T., & Kawakami, Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.023 · Cited by 872 · see citing works

Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding

Gkountela, S., Castro-Giner, F., Szczerba, B. M., Vetter, M. H. F., Landin, J., Scherrer, R., Krol, I., Scheidmann, M. C., Beisel, C., Stirnimann, C. U., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.046 · Cited by 801 · see citing works

Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

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Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

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A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

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MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.

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Cancer stem cells: The challenges ahead

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Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

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Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer

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Defining the mode of tumour growth by clonal analysis

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A microfluidic device for label-free, physical capture of circulating tumor cell clusters

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EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

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Metastatic Stem Cells: Sources, Niches, and Vital Pathways

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Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

Ye, X., Tam, W. L., Shibue, T., Kaygusuz, Y., Reinhardt, F., Eaton, E. N., & Weinberg, R. A. (2015) · Nature · doi:10.1038/nature14897 · Cited by 697 · see citing works

Single-cell dissection of transcriptional heterogeneity in human colon tumors

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Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

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Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

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Tumour heterogeneity and metastasis at single-cell resolution

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Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

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Emerging Role of E2F Family in Cancer Stem Cells

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Signaling pathways in the regulation of cancer stem cells and associated targeted therapy

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Cancer-associated fibroblasts in non-small cell lung cancer: Recent advances and future perspectives

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Deciphering the Role of Cancer Stem Cells: Drivers of Tumor Evolution, Therapeutic Resistance, and Precision Medicine Strategies

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Linking Tumor Microenvironment to Plasticity of Cancer Stem Cells: Mechanisms and Application in Cancer Therapy

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Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity

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The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes

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The Roles of Stroma-Derived Chemokine in Different Stages of Cancer Metastases

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Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT)

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Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology

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Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells

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BMI1 Silencing Liposomes Suppress Postradiotherapy Cancer Stemness against Radioresistant Hepatocellular Carcinoma

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PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

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PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c‐Myc‐mediated positive feedback loop

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Tumor Hybrid Cells: Nature and Biological Significance

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KLF4 Induces Mesenchymal–Epithelial Transition (MET) by Suppressing Multiple EMT-Inducing Transcription Factors

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Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor

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Chronic Oxidative Stress Promotes Molecular Changes Associated with Epithelial Mesenchymal Transition, NRF2, and Breast Cancer Stem Cell Phenotype

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Circulating tumor cell-derived preclinical models: current status and future perspectives

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Antimetastatic defense by CD8+ T cells

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Regulation of epithelial-mesenchymal transition by protein lysine acetylation

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Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis

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Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

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Clinical Relevancy of Circulating Tumor Cells in Breast Cancer: Epithelial or Mesenchymal Characteristics, Single Cells or Clusters?

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Reporters of Cancer Stem Cells as a Tool for Drug Discovery

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Regulatory roles of RNA modifications in breast cancer

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Quantifying the Patterns of Metabolic Plasticity and Heterogeneity along the Epithelial–Hybrid–Mesenchymal Spectrum in Cancer

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Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool

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Association of Preoperative NANOG-Positive Circulating Tumor Cell Levels With Recurrence of Hepatocellular Carcinoma

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HMMR is a downstream target of FOXM1 in enhancing proliferation and partial epithelial-to-mesenchymal transition of bladder cancer cells

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Prognostic Role of Immune Checkpoint Regulators in Cholangiocarcinoma: A Pilot Study

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Dual cancer stem cell manipulation to enhance phototherapy against tumor progression and metastasis

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TGFβ family signaling in human stem cell self-renewal and differentiation

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Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells

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Unravelling the Mysteries of the Sonic Hedgehog Pathway in Cancer Stem Cells: Activity, Crosstalk and Regulation

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Circulating tumor cell markers for early detection and drug resistance assessment through liquid biopsy

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Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs

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Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3β/β-catenin signaling pathway.

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Single-Cell RNA-Seq Analysis Reveals the Acquisition of Cancer Stem Cell Traits and Increase of Cell–Cell Signaling during EMT Progression

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Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis

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DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma

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KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner

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Integrins as Key Mediators of Metastasis

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Chemokines network in bone metastasis: Vital regulators of seeding and soiling

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Proteases Regulate Cancer Stem Cell Properties and Remodel Their Microenvironment

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Intermittent Hypoxia Mediates Paraspeckle Protein-1 Upregulation in Sleep Apnea

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Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs

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Small cell lung cancer with liver metastases: from underlying mechanisms to treatment strategies

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Epithelial-to-Mesenchymal Transition and Phenotypic Marker Evaluation in Human, Canine, and Feline Mammary Gland Tumors

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Development of a novel, clinically relevant anoikis-related gene signature to forecast prognosis in patients with prostate cancer

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LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression

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BIRC5: A novel therapeutic target for lung cancer stem cells and glioma stem cells

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Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway

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Characteristics of Cancer Stem Cells and Their Potential Role in Endometrial Cancer

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Loss of Krüppel‐like factor 9 facilitates stemness in ovarian cancer ascites‐derived multicellular spheroids via Notch1/slug signaling

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Hypoxia enhances motility and EMT through the Na+/H+ exchanger NHE-1 in MDA-MB-231 breast cancer cells

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The Role of Epithelial-to-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma

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Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments

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Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL-6/JAK–induced cancer cell plasticity

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Impact of Epithelial–Mesenchymal Transition on the Immune Landscape in Breast Cancer

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The Impact of Epithelial–Mesenchymal Transition and Metformin on Pancreatic Cancer Chemoresistance: A Pathway towards Individualized Therapy

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CSRP2 promotes cell stemness in head and neck squamous cell carcinoma

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Multi-Stability and Consequent Phenotypic Plasticity in AMPK-Akt Double Negative Feedback Loop in Cancer Cells

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Integrins and the Metastasis-like Dissemination of Acute Lymphoblastic Leukemia to the Central Nervous System

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Photodynamic therapy in cancer stem cells — state of the art

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Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

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Interaction between prostate cancer stem cells and bone microenvironment regulates prostate cancer bone metastasis and treatment resistance

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Immune evasion by cancer stem cells ensures tumor initiation and failure of immunotherapy

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ALDH1A1 as a marker for metastasis initiating cells: A mechanistic insight

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Dual-phase nanoscissors disrupt vasculature-breast cancer stem cell crosstalk for breast cancer treatment

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Core Molecular Clock Factors Regulate Osteosarcoma Stem Cell Survival and Behavior via CSC/EMT Pathways and Lipid Droplet Biogenesis

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Plexin-B3 Regulates Cellular Motility, Invasiveness, and Metastasis in Pancreatic Cancer

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Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness

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Sorafenib targets and inhibits the oncogenic properties of endometrial cancer stem cells via the RAF/ERK pathway

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Role of Epiregulin in Lung Tumorigenesis and Therapeutic Resistance

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Cancer stem cells: Masters of all traits

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Therapeutic Approaches of Dual-targeted Nanomedicines for Tumor Multidrug Resistance

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FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness

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Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3

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GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance

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Utility of CD44/CD24 in the Outcome and Prognosis of Oral Squamous Cell Carcinoma: A Systematic Review

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From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies

Алексеенко, И. В., Kondratyeva, L. G., Чернов, И. П., & Sverdlov, E. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032796 · Cited by 8 · see citing works

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

Mannion, A. J., Odell, A. F., Baker, S. M., Matthews, L. C., Jones, P. F., & Cook, G. P. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1129015 · Cited by 7 · see citing works

Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers

Lan, H., Wu, B., Jin, K., & Chen, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1260491 · Cited by 6 · see citing works

Tn antigen promotes breast cancer metastasis via impairment of CASC4

Li, R., Dong, X., Chen, S., Tan, J.-Y. B., Chen, X., Liu, J., Wen, T., & Ru, X. (2023) · Cell Biology International · doi:10.1002/cbin.12077 · Cited by 7 · see citing works

siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression

Chaudhary, P., Yadav, K., Lee, H. J., Kang, K. W., Mo, J., & Kim, J. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01827-4 · Cited by 7 · see citing works

Clinical significance of epithelial-mesenchymal transition and cancer stem cells.

Topçul, M., & Çeti̇n, İ. (2016) · PubMed · Cited by 4 · see citing works

The effect and related mechanism of cancer stem cell in tumor metastasis:new perspective and progress

Fu, D. (2012) · Basic & Clinical Medicine

The Significance of Cancer Stem Cells and Epithelial–Mesenchymal Transition in Metastasis and Anti-Cancer Therapy

Liang, L., & Kaufmann, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032555 · Cited by 66 · see citing works

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?

Kong, D., Li, Y., Wang, Z. P., & Sarkar, F. H. (2011) · Cancers · doi:10.3390/cancers30100716 · Cited by 346 · see citing works

The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links

Liu, X., & Fan, D. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666141211115611 · Cited by 149 · see citing works