The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Emerging functions of the EGFR in cancer
Open accessAbstract
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigenesis. Inappropriate activation of the EGFR in cancer mainly results from amplification and point mutations at the genomic locus, but transcriptional upregulation or ligand overproduction due to autocrine/paracrine mechanisms has also been described. Moreover, the EGFR is increasingly recognized as a biomarker of resistance in tumors, as its amplification or secondary mutations have been found to arise under drug pressure. This evidence, in addition to the prominent function that this receptor plays in normal epithelia, has prompted intense investigations into the role of the EGFR both at physiological and at pathological level. Despite the large body of knowledge obtained over the last two decades, previously unrecognized (herein defined as ‘noncanonical’) functions of the EGFR are currently emerging. Here, we will initially review the canonical ligand‐induced EGFR signaling pathway, with particular emphasis to its regulation by endocytosis and subversion in human tumors. We will then focus on the most recent advances in uncovering noncanonical EGFR functions in stress‐induced trafficking, autophagy, and energy metabolism, with a perspective on future therapeutic applications.
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Cites
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ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
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Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
Subhan, M. A., Parveen, F., Filipczak, N., Yalamarty, S. S. K., & Torchilin, V. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030389 · Cited by 98
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BackgroundOncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges
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Metadata
- Authors
- Sigismund, S., Avanzato, D., & Lanzetti, L.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2017-11-27
- Volume
- 12
- Issue
- 1
- Pages
- 3-20
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W2767336741
- Cited by
- 1,469
- References
- 14
- FWCI
- 26.71
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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