The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas
Abstract
Gliomas are the most common primary malignant tumours of the central nervous system, and new molecular biomarkers are urgently needed for diagnosis and targeted therapy. Here, we report that increased beta‐site APP‐cleaving enzyme 2 (BACE2) expression is associated with increases in the grade of human glioma, the incidence of the mesenchymal molecular glioblastoma multiforme subtype and the likelihood of poor prognoses for patients. BACE2 knockdown suppressed cell invasion, cell migration and tumour growth both in vitro and in vivo, while BACE2 overexpression promoted the mesenchymal transition and cell proliferation. Furthermore, TGFβ1 stimulated BACE2 expression through Smad‐dependent signalling, which modulated TNF‐α‐induced NF‐κB activity through the PP1A/IKK pathway to promote tumorigenesis in both U87MG and U251 cells. Our study indicated that BACE2 plays a significant role in glioma development. Therefore, BACE2 is a potential therapeutic target for human gliomas due to its function and ability to be regulated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BACE2 regulates signalling pathways including Yap, STAT3, NF-κB, and Ca2+ influx, rather than performing its classical cleavage enzyme function, in these studies.
“BACE2 regulates signalling pathways including Yap (Matafora et al., 2020), STAT3 (Chen et al., 2021b), NF-κB (Wang et al., 2020), and Ca2+ influx (He et al., 2021), rather than performing its classical cleavage enzyme function, in these studies”
From ENO1–BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism (2025) · cites this paper as Wang et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Flagged first, then by citations
Research works printed but not linked: 33
- 10.1002/jcp.27955 · DOI
- 10.1371/journal.pone.0062042 · DOI
- 10.1016/j.cell.2013.09.034 · DOI · Paper page
- 10.1016/j.ccr.2006.11.023 · DOI
- 10.3390/jcm8040439 · DOI
- 10.1006/scbi.2000.0363 · DOI
- 10.1126/science.1064638 · DOI · Paper page
- 10.1016/j.cmet.2011.06.018 · DOI · Paper page
- 10.1016/j.biopha.2017.07.081 · DOI
- 10.1186/s13046-017-0619-9 · DOI
- 10.1016/j.cell.2011.02.013 · DOI · Paper page
- 10.1002/med.21408 · DOI
- 10.1002/ijc.2910490124 · DOI
- 10.1016/j.canlet.2016.01.024 · DOI
- 10.1016/j.canlet.2016.03.033 · DOI
- 10.1023/A:1022149226430 · DOI
- 10.1038/ni.1600 · DOI
- 10.3390/ijms19041115 · DOI
- 10.1515/hsz-2011-0254 · DOI
- 10.18632/oncotarget.322 · DOI
- 10.1016/j.tcb.2018.12.001 · DOI
- 10.1038/s41388-019-0996-y · DOI · Paper page
- 10.1093/jmcb/mjv041 · DOI
- 10.1038/s41419-018-0657-z · DOI
- 10.1042/CS20190145 · DOI
- 10.1038/nri.2017.142 · DOI · Paper page
- 10.1023/A:1011953118186 · DOI
- 10.3322/caac.21262 · DOI
- 10.1007/s00384-003-0510-3 · DOI
- 10.1016/j.ccr.2009.12.020 · DOI · Paper page
- 10.1056/NEJMra0708126 · DOI · Paper page
- 10.1080/15548627.2016.1178446 · DOI
- 10.1056/NEJMoa0808710 · DOI · Paper page
Cited by
Sorted by citations
Li, Z., Fan, K., Suo, C., Gu, X., Zhu, C., Wei, H., Chen, L., Gao, P., & Sun, L. (2025) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaf001 · Cited by 13
Metadata
- Authors
- Wang, H., Chen, Z., Wang, S., Gao, X., Qian, M., Qiu, W., Zhang, Z., Zhang, S., Qi, Y., Sun, X., Xue, H., Guo, X., Zhao, R., & Li, G.
- Affiliations
- Department of Neurosurgery Qilu Hospital of Shandong University Jinan Shandong Province China
- Institute of Brain and Brain‐Inspired Science Shandong University Jinan Shandong Province China
- ORCID
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2020-01-07
- Volume
- 14
- Issue
- 2
- Pages
- 407-425
- ISSN
- 1574-7891
- 1878-0261
- PMC
- PMC6998390
- Cited by
- 20
- References
- 1
- Language
- en
- Funders
- National Natural Science Foundation of China (81571284, 81702468, 81802966, 81874083, 91542115)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
