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Cited by 135

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Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

Esterházy, Daria, Stützer, Ina, Wang, Haiyan, Rechsteiner, Markus P., Beauchamp, Jeremy, Döbeli, Heinz, Hilpert, Hans, Matile, Hugues, Prummer, Michael, Schmidt, Alexander, Lieske, Nora, Boehm, Bernhard, Marselli, Lorella, Bosco, Domenico, Kerr-Conte, Julie, Aebersold, Ruedi, Spinas, Giatgen Andreia, Moch, Holger, Migliorini, Cristiano, Stoffel, Markus·2011·Cell Metabolism
DOI 10.1016/j.cmet.2011.06.018
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  • Therapeutic inhibition of BACE2 in mice has been linked to increased pancreatic β-cell function and mass, enhanced insulin production and improved glucose homeostasis, likely via its role in the cleavage of Tmem27.

    “Furthermore, therapeutic inhibition of BACE2 in mice, has been linked to increased pancreatic β‐cell function and mass, enhanced insulin production and improved glucose homeostasis, likely via its role in the cleavage of Tmem27.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [89]

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Research works printed but not linked: 39

  1. Akpinar, 2005, Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation, Cell Metab., 2, 385, 10.1016/j.cmet.2005.11.001 · DOI
  2. Altirriba, 2010, The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker, Diabetologia, 53, 1406, 10.1007/s00125-010-1728-6 · DOI
  3. Bennett, 2000, Expression analysis of BACE2 in brain and peripheral tissues, J. Biol. Chem., 275, 20647, 10.1074/jbc.M002688200 · DOI · Paper page
  4. Bettegazzi, 2010, beta-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression, Eur. J. Neurosci., 33, 236, 10.1111/j.1460-9568.2010.07482.x · DOI
  5. Cavallaro, 2011, Adhesion molecule signalling: not always a sticky business, Nat. Rev. Mol. Cell Biol., 12, 189, 10.1038/nrm3068 · DOI
  6. Danilczyk, 2006, Essential role for collectrin in renal amino acid transport, Nature, 444, 1088, 10.1038/nature05475 · DOI
  7. Dominguez, 2005, Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice, J. Biol. Chem., 280, 30797, 10.1074/jbc.M505249200 · DOI
  8. Donath, 2004, Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications, Diabetologia, 47, 581, 10.1007/s00125-004-1336-4 · DOI
  9. Efrat, 2008, Ex-vivo expansion of adult human pancreatic beta-cells, Rev. Diabet. Stud., 5, 116, 10.1900/RDS.2008.5.116 · DOI
  10. Farzan, 2000, BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein, Proc. Natl. Acad. Sci. USA, 97, 9712, 10.1073/pnas.160115697 · DOI · Paper page
  11. Finzi, 2008, BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells, Ultrastruct. Pathol., 32, 246, 10.1080/01913120802486217 · DOI
  12. Fluhrer, 2002, A non-amyloidogenic function of BACE-2 in the secretory pathway, J. Neurochem., 81, 1011, 10.1046/j.1471-4159.2002.00908.x · DOI · Paper page
  13. Francis, 2002, aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation, Dev. Cell, 3, 85, 10.1016/S1534-5807(02)00189-2 · DOI
  14. Fukui, 2005, The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation, Cell Metab., 2, 373, 10.1016/j.cmet.2005.11.003 · DOI
  15. Gandhi, 2004, Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization, J. Mol. Neurosci., 24, 137, 10.1385/JMN:24:1:137 · DOI
  16. Gruninger-Leitch, 2002, Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases, J. Biol. Chem., 277, 4687, 10.1074/jbc.M109266200 · DOI · Paper page
  17. Han, 2007, Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice, J. Agric. Food Chem., 55, 10641, 10.1021/jf0722598 · DOI
  18. Hemming, 2009, Identification of beta-secretase (BACE1) substrates using quantitative proteomics, PLoS ONE, 4, e8477, 10.1371/journal.pone.0008477 · DOI
  19. Hussain, 2000, ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site, Mol. Cell. Neurosci., 16, 609, 10.1006/mcne.2000.0884 · DOI
  20. Kahn, 2006, Mechanisms linking obesity to insulin resistance and type 2 diabetes, Nature, 444, 840, 10.1038/nature05482 · DOI · Paper page
  21. Kim, 2002, Enzymic properties of recombinant BACE2, Eur. J. Biochem., 269, 5668, 10.1046/j.1432-1033.2002.03277.x · DOI
  22. Kuhn, 2007, Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase, J. Biol. Chem., 282, 11982, 10.1074/jbc.M700356200 · DOI · Paper page
  23. Maechler, 2002, Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas, Diabetes, 51, S99, 10.2337/diabetes.51.2007.S99 · DOI
  24. Malakauskas, 2009, Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha, Mol. Endocrinol., 23, 881, 10.1210/me.2008-0274 · DOI
  25. Malakauskas, 2007, Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin, Am. J. Physiol. Renal Physiol., 292, F533, 10.1152/ajprenal.00325.2006 · DOI
  26. Park, 2011, A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models, J. Clin. Neurol., 7, 10, 10.3988/jcn.2011.7.1.10 · DOI
  27. Parnaud, 2008, Proliferation of sorted human and rat beta cells, Diabetologia, 51, 91, 10.1007/s00125-007-0855-1 · DOI · Paper page
  28. Roe, 1994, Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans, J. Biol. Chem., 269, 18279, 10.1016/S0021-9258(17)32299-8 · DOI
  29. Shih, 2001, Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism, Diabetes, 50, 2472, 10.2337/diabetes.50.11.2472 · DOI
  30. Sun, 2006, BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome, FASEB J., 20, 1369, 10.1096/fj.05-5632com · DOI
  31. Turner, 2001, Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design, Biochemistry, 40, 10001, 10.1021/bi015546s · DOI
  32. Turner, 2002, Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity, Biochemistry, 41, 8742, 10.1021/bi025926t · DOI
  33. Walter, 2006, Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase, Neurodegener. Dis., 3, 247, 10.1159/000095263 · DOI
  34. Winzell, 2009, Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice, Eur. J. Pharmacol., 626, 297, 10.1016/j.ejphar.2009.09.053 · DOI
  35. Wollscheid, 2009, Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins, Nat. Biotechnol., 27, 378, 10.1038/nbt.1532 · DOI · Paper page
  36. Yan, 2001, BACE2 functions as an alternative alpha-secretase in cells, J. Biol. Chem., 276, 34019, 10.1074/jbc.M105583200 · DOI
  37. Zhang, 2001, Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys, J. Biol. Chem., 276, 17132, 10.1074/jbc.M006723200 · DOI
  38. Zhang, 2007, The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells, PLoS ONE, 2, e414, 10.1371/journal.pone.0000414 · DOI
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Metadata

Authors
Esterházy, D., Stützer, I., Wang, H., Rechsteiner, M. P., Beauchamp, J., Döbeli, H., Hilpert, H., Matile, H., Prummer, M., Schmidt, A., Lieske, N., Boehm, B., Marselli, L., Bosco, D., Kerr-Conte, J., Aebersold, R., Spinas, G. A., Moch, H., Migliorini, C., & Stoffel, M.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2011-09
Volume
14
Issue
3
Pages
365-377
ISSN
1550-4131
DOI
10.1016/j.cmet.2011.06.018
Cited by
135
References
1
Language
en
Licence

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