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Fluorescence Spectroscopy In Vivo
Abstract
Diagnostic techniques based on optical spectroscopy have the potential to link the biochemical and morphological properties of tissues to individual patient care. In particular, these techniques are fast, noninvasive and quantitative. Furthermore, they can be used to elucidate key tissue features, such as the cellular metabolic rate, vascularity, intravascular oxygenation and alterations in tissue morphology. These tissue features can be interpreted to shed light on a variety of clinical problems, such as precancerous and cancerous growth and atherosclerosis. The goal of this report is to review the development and application of optical spectroscopy in the ultraviolet (UV) and visible (VIS) spectral regions, as a diagnostic tool in clinical applications. A particular emphasis is placed on steady‐state, UV/VIS fluorescence spectroscopy for the detection of precancers and cancers, in vivo.
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A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
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Wolfbeis, O. S. (2006) · Analytical Chemistry · doi:10.1021/ac060490z · Cited by 1,627
Diffuse optics for tissue monitoring and tomography
Durduran, T., Choe, R., Baker, W. B., & Yodh, A. G. (2010) · Reports on Progress in Physics · doi:10.1088/0034-4885/73/7/076701 · Cited by 1,161
Stability engineering of antibody single-chain Fv fragments
Wörn, A., & Plückthun, A. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4265 · Cited by 616
Fluorescence Spectroscopy Measurement for Quality Assessment of Food Systems—a Review
Karoui, R., & Blecker, C. (2011) · Food and Bioprocess Technology · doi:10.1007/s11947-010-0370-0 · Cited by 395
Autofluorescence of atmospheric bioaerosols – fluorescent biomolecules and potential interferences
Pöhlker, C., Huffman, J. A., & Pöschl, U. (2012) · Atmospheric Measurement Techniques · doi:10.5194/amt-5-37-2012 · Cited by 394
Metadata
- Authors
- Ramanujam, N.
- Venue
- Encyclopedia of Analytical Chemistry
- Publisher
- Wiley
- Published
- 2000-10-30
- OpenAlex
- W1479838483
- Cited by
- 508
- References
- 2
- Type
- reference entry
- Language
- en
- Open access
- closed
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