Cell biology of BDNF and its relevance to schizophrenia

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works

Cortical inhibitory neurons and schizophrenia

Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

Regulation of Cell Survival by Secreted Proneurotrophins

Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent <i>Bdnf</i> Gene Regulation

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works

The yin and yang of neurotrophin action

Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356 · see citing works

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136 · see citing works

Calcium regulation of neuronal gene expression

West, A. E., Chen, W. G., Dalva, M., Dolmetsch, R., Kornhauser, J., Shaywitz, A. J., Takasu, M., Tao, X., & Greenberg, M. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191352298 · Cited by 1,115 · see citing works

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works

Brain-Derived Neurotrophic Factor val ⁶⁶ met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F., & Weinberger, D. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06690.2003 · Cited by 1,045 · see citing works

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013 · see citing works

Sortilin is essential for proNGF-induced neuronal cell death

Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature · doi:10.1038/nature02319 · Cited by 962 · see citing works

BDNF and Activity-Dependent Synaptic Modulation: Figure 1.

Lu, B. (2003) · Learning &amp; Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works

The brain-derived neurotrophic factor Val66Met polymorphism and variation in human cortical morphology

Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890 · see citing works

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874 · see citing works

Multiple promoters direct tissue-specific expression of the rat BDNF gene

Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

Patterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555 · see citing works

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533 · see citing works

Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation

Minichiello, L., Calella, A. M., Medina, D. L., Bonhoeffer, T., Klein, R., & Korte, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00942-x · Cited by 506 · see citing works

Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology

Craddock, N. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj033 · Cited by 496 · see citing works

Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing <i>N</i> -methyl- <scp>d</scp> -aspartic acid receptor activity

Levine, E. S., Crozier, R. A., Black, I. B., & Plummer, M. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10235 · Cited by 412 · see citing works

Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway

Baranes, D., Lederfein, D., Huang, Y.-Y., Chen, M., Bailey, C. H., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80597-8 · Cited by 405 · see citing works

Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

Chen, Z.-Y., Ieraci, A., Teng, H. K., Dall, H., Meng, C.-X., Herrera, D. G., Nykjær, A., Hempstead, B. L., & Lee, F. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1017-05.2005 · Cited by 401 · see citing works

Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia

Hashimoto, T., Bergen, S. E., Nguyen, Q. L., Xu, B., Monteggia, L. M., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4035-04.2005 · Cited by 384 · see citing works

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., & Murphy, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02069.1999 · Cited by 350 · see citing works

Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients

Takahashi, M., Shirakawa, O., Toyooka, K., Kitamura, N., Hashimoto, T., Maeda, K., Koizumi, S., Wakabayashi, K., Takahashi, H., Someya, T., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000718 · Cited by 340 · see citing works

Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C., & Kandel, E. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00443-3 · Cited by 334 · see citing works

Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture

Barco, Á., Patterson, S., Alarcón, J. M., Gromova, P., Mata, M., Morozov, A., & Kandel, E. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.005 · Cited by 332 · see citing works

Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons

Ji, Y., Pang, P. T., Feng, L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1381 · Cited by 326 · see citing works

Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients

Toyooka, K., Asama, K., Watanabe, Y., Muratake, T., Takahashi, M., Someya, T., & Nawa, H. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00127-0 · Cited by 292 · see citing works

The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons

Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y.-A., Bonhoeffer, T., & Korte, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2492-05.2005 · Cited by 286 · see citing works

A role for BDNF in the late-phase of hippocampal long-term potentiation

Körte, M., Kang, H., Bonhoeffer, T., & Schuman, E. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00035-5 · Cited by 268 · see citing works

Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease

Liu, Q., Walther, D. M., Drgon, T., Polesskaya, O. O., Lesnick, T. G., Strain, K. J., de Andrade, M., Bower, J. H., Maraganore, D. M., & Uhl, G. R. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30109 · Cited by 227 · see citing works

BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs

Lipska, B. K., Khaing, Z. Z., Weickert, C. S., & Weinberger, D. R. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01633.x · Cited by 195 · see citing works

Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E

Lou, H., Kim, S., Zaitsev, E. N., SNELL, C. R., Lu, B., & Loh, Y. P. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.037 · Cited by 185 · see citing works

The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills

Harris, S. E., Fox, H. C., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., & Deary, I. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001799 · Cited by 169 · see citing works

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Yano, H., Ninan, I., Zhang, H., Milner, T. A., Arancio, O., & Chao, M. V. (2006) · Nature Neuroscience · doi:10.1038/nn1730 · Cited by 134 · see citing works

Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration

Chlan‐Fourney, J., Ashe, P. C., Nylen, K., Juorio, A. V., & Li, X. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03215-8 · Cited by 129 · see citing works

Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia

Angelucci, F., Mathé, A. A., & Aloe, L. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46011-1 · Cited by 127 · see citing works

Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young Females

Tsai, S., Hong, C., Yu, Y. W. ‐., & Chen, T. (2004) · Neuropsychobiology · doi:10.1159/000075333 · Cited by 104 · see citing works

The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia

Szekeres, G., Juhász, A., Rimanóczy, Á., Kéri, S., & Janka, Z. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00505-4 · Cited by 104 · see citing works

Brain-derived neurotrophic factor serum concentrations are increased in drug-naïve schizophrenic patients with chronic cannabis abuse and multiple substance abuse

Jockers-Scherübl, M. C., Danker‐Hopfe, H., Mahlberg, R., Selig, F., Rentzsch, J., Schürer, F., Lang, U. E., & Hellweg, R. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.045 · Cited by 98 · see citing works

Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia

Molteni, R., Lipska, B. K., Weinberger, D. R., Racagni, G., & Riva, M. A. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000865 · Cited by 75 · see citing works

Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus

Ashe, P. C., Chlan‐Fourney, J., Juorio, A. V., & Li, X. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03176-1 · Cited by 53 · see citing works

Untitled work

Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology

Pillai, A., Kale, A. A., Joshi, S., Naphade, N. M., Raju, M. S. V. K., Nasrallah, H. A., & Mahadik, S. P. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991015 · Cited by 273 · see citing works

Epigenetic mechanisms in schizophrenia

Roth, T. L., Lubin, F. D., Sodhi, M., & Kleinman, J. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.009 · Cited by 168 · see citing works

Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders

Ray, M. T., Shannon Weickert, C., & Webster, M. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.26 · Cited by 161 · see citing works

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

Neto, F. L. M., Borges, G., Torres-Sánchez, S., Micó, J. A., & Berrocoso, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376262 · Cited by 150 · see citing works

Progesterone–estrogen interactions in synaptic plasticity and neuroprotection

Baudry, M., Bi, X., & Aguirre, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.051 · Cited by 127 · see citing works

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

Kabir, Z. D., Martínez-Rivera, A., & Rajadhyaksha, A. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0532-0 · Cited by 125 · see citing works

Regulation of brain-derived neurotrophic factor expression in neurons.

Zheng, F., Zhou, X., Moon, C., & Wang, H. (2012) · PubMed Central · Cited by 121 · see citing works

Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair

Fletcher, J. L., Murray, S. S., & Xiao, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124131 · Cited by 122 · see citing works

Pharmacological activation of group-ii metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice

Matrisciano, F., Tueting, P., Maccari, S., Nicoletti, F., & Guidotti, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.274 · Cited by 110 · see citing works

Brain-derived neurotrophic factor and schizophrenia

Di Carlo, P., Punzi, G., & Ursini, G. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000237 · Cited by 110 · see citing works

BDNF–TrkB signaling and neuroprotection in schizophrenia

Pandya, C. D., Kutiyanawalla, A., & Pillai, A. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.08.010 · Cited by 110 · see citing works

Sex-specific disruptions in spatial memory and anhedonia in a “two hit” rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling

Hill, R. A., Klug, M., Kiss Von Soly, S., Binder, M. D., Hannan, A. J., & van den Buuse, M. (2014) · Hippocampus · doi:10.1002/hipo.22302 · Cited by 99 · see citing works

Modulatory effects of sex steroid hormones on brain-derived neurotrophic factor-tyrosine kinase B expression during adolescent development in C57Bl/6 mice

Hill, R. A., Wu, Y. W. C., Kwek, P., & Buuse, M. V. D. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02277.x · Cited by 96 · see citing works

Advantages and Limitations of Animal Schizophrenia Models

Białoń, M., & Wąsik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115968 · Cited by 97 · see citing works

Increased Oxidative Stress and Imbalance in Antioxidant Enzymes in the Brains of Alloxan-Induced Diabetic Rats

Ceretta, L. B., Réus, G. Z., Abelaira, H. M., Ribeiro, K. F., Zappellini, G., Felisbino, F. F., Steckert, A. V., Dal‐Pizzol, F., & Quevedo, J. (2012) · Experimental Diabetes Research · doi:10.1155/2012/302682 · Cited by 94 · see citing works

Lack of Brain-Derived Neurotrophic Factor Hampers Inner Hair Cell Synapse Physiology, But Protects against Noise-Induced Hearing Loss

Zuccotti, A., Kuhn, S. A. C., Johnson, S. L., Franz, C., Singer, W., Hecker, D., Geisler, H.-S., Köpschall, I., Rohbock, K., Gutsche, K., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1247-12.2012 · Cited by 82 · see citing works

Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Zuo, W., Pang, Q., Yao, L.-P., Zhang, Y., Peng, C. Y., Huang, W., & Han, B. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.05.011 · Cited by 81 · see citing works

BDNF pro-peptide regulates dendritic spines via caspase-3

Guo, J., Ji, Y., Ding, Y., Jiang, W., Sun, Y., Lu, B., & Nagappan, G. (2016) · Cell Death &amp; Disease · doi:10.1038/cddis.2016.166 · Cited by 76 · see citing works

Episodic Memory in Schizophrenia

Leavitt, V. M., & Goldberg, T. E. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9107-0 · Cited by 76 · see citing works

A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia

Nurjono, M., Lee, J., & Chong, S. A. (2012) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2012.10.2.61 · Cited by 75 · see citing works

BDNF/MAPK/ERK–Induced BMP7 Expression in the Developing Cerebral Cortex Induces Premature Radial Glia Differentiation and Impairs Neuronal Migration

Ortega, J. A., & Alcántara, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp275 · Cited by 73 · see citing works

The function of BDNF in the adult auditory system

Singer, W., Panford-Walsh, R., & Knipper, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.008 · Cited by 67 · see citing works

Metabolic adverse effects of olanzapine on cognitive dysfunction: A possible relationship between BDNF and TNF-alpha

Zhang, C., Fang, X., Yao, P., Mao, Y., Cai, J., Zhang, Y., Chen, M., Fan, W., Tang, W., & Song, L. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.014 · Cited by 67 · see citing works

Lifestyle modification and behavior therapy effectively reduce body weight and increase serum level of brain-derived neurotrophic factor in obese non-diabetic patients with schizophrenia

Kuo, F.-C., Lee, C.-H., Hsieh, C., Kuo, P., Chen, Y.-C., & Hung, Y. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.11.020 · Cited by 59 · see citing works

Hyperactivity and Enhanced Curiosity of Mice Expressing PKB/SGK-resistant Glycogen Synthase Kinase-3 (GSK-3)

Ackermann, T. F., Kempe, D. S., Lang, F. J. W., & Lang, U. E. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000315097 · Cited by 58 · see citing works

Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence

Sabb, F. W., Burggren, A. C., Higier, R. G., Fox, J., He, J., Parker, D. S., Poldrack, R. A., Chu, W. W., Cannon, T. D., Freimer, N. B., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.013 · Cited by 58 · see citing works

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Sangiovanni, E., Brivio, P., Dell’Agli, M., & Calabrese, F. (2017) · Neural Plasticity · doi:10.1155/2017/5965371 · Cited by 57 · see citing works

The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression

Tatham, E. L., Hall, G. B. C., Clark, D., Foster, J. A., & Ramasubbu, R. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0702-9 · Cited by 56 · see citing works

Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior

Martinowich, K., Schloesser, R. J., Jimenez, D. V., Weinberger, D. R., & Lu, B. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-11 · Cited by 56 · see citing works

Novel implications of Lingo-1 and its signaling partners in schizophrenia

Fernandez, F., Andrews, J. L., Newell, K. A., Pantelis, C., & Huang, X. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.121 · Cited by 54 · see citing works

May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? Critical Review and Synthesis of Evidence

Papathanassoglou, E. D. E., Miltiadous, P., & Karanikola, M. N. K. (2014) · Biological Research For Nursing · doi:10.1177/1099800414555411 · Cited by 53 · see citing works

Biological substrates underpinning diagnosis of major depression

Sibille, E. L., & French, B. J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000436 · Cited by 50 · see citing works

Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases

Yanev, S. G. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i4.92 · Cited by 50 · see citing works

Effect of BDNF Val66Met Polymorphism on Digital Working Memory and Spatial Localization in a Healthy Chinese Han Population

Gong, P., Zheng, A., Chen, D., Ge, W., Lv, C., Zhang, K., Gao, X., & Zhang, F. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9205-8 · Cited by 47 · see citing works

Epigenetic and Pharmacoepigenomic Studies of Major Psychoses and Potentials for Therapeutics

Abdolmaleky, H. M., Zhou, J., Thiagalingam, S., & Smith, C. L. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.12.1809 · Cited by 45 · see citing works

Sugars, exercise and health

Codella, R., Terruzzi, I., & Luzi, L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.035 · Cited by 38 · see citing works

Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

You, H., & Lu, B. (2023) · Biomolecules · doi:10.3390/biom13040655 · Cited by 37 · see citing works

Brain-Derived Neurotrophic Factor: The Neurotrophin Hypothesis of Psychopathology

Stein, D. J., Daniels, W. M. U., Savitz, J. B., & Harvey, B. H. (2008) · CNS Spectrums · doi:10.1017/s1092852900013997 · Cited by 37 · see citing works

Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

Chen, Y., Xiao, N., Chen, Y., Chen, X., Zhong, C., Cheng, Y., Du, B., & Li, P. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110808 · Cited by 36 · see citing works

Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice

Thomas, J., Garg, M. L., & Smith, D. W. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9418-y · Cited by 30 · see citing works

MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice

Akol, I., Kalogeraki, E., Pielecka-Fortuna, J., Fricke, M., & Löwel, S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0902-21.2021 · Cited by 28 · see citing works

Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways

Rodrígues-Amorím, D., Baltanás, T. R., Vallejo-Curto, M. D. C., Rodríguez-Jamardo, C., Heras, M. E. D. L., Barreiro-Villar, C., Blanco-Formoso, M., Fernández-Palleiro, P., Álvarez-Ariza, M., López, M., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00885 · Cited by 27 · see citing works

Molecular mechanisms underlying synergistic effects of SSRI–antipsychotic augmentation in treatment of negative symptoms in schizophrenia

Chertkow, Y., Weinreb, O., Youdim, M. B. H., & Silver, H. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0255-4 · Cited by 26 · see citing works

Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801

Yu, W., Zhu, H., Wang, Y., Li, G., Wang, L., & Li, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145651 · Cited by 26 · see citing works

The impact of antidepressant treatment on brain-derived neurotrophic factor level: An evidence-based approach through systematic review and meta-analysis

Arumugam, V., John, V., Augustine, N., Jacob, T., Joy, S., Sen, S., & Sen, T. (2017) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_700_16 · Cited by 26 · see citing works

Risperidone Reverses the Downregulation of BDNF in Hippocampal Neurons and MK801-Induced Cognitive Impairment in Rats

Yu, W., Zhu, M., Fang, H., Zhou, J., Ye, L., Bian, W., Wang, Y., Zhu, H., Xiao, J., Zhu, H., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00163 · Cited by 26 · see citing works

Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

de Castro-Català, M., van Nierop, M. M., Barrantes‐Vidal, N., Cristóbal-Narváez, P., Sheinbaum, T., Kwapil, T. R., Peña, E., Jacobs, N., Derom, C. A., Thiery, E. W., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.014 · Cited by 25 · see citing works

The BDNF Val66Met polymorphism impacts victim's moral emotions following interpersonal transgression

Quan, R., Wu, Z., Guo, W., He, L., Fang, P., & Gong, P. (2020) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12678 · Cited by 26 · see citing works

The Impact of Chronic Early Administration of Psychostimulants on Brain Expression of BDNF and Other Neuroplasticity-Relevant Proteins

Tenenbaum, Y. S., Weizman, A., & Rehavi, M. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0611-9 · Cited by 24 · see citing works

Imaging genetics of structural brain connectivity and neural integrity markers

Marenco, S., & Radulescu, E. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.030 · Cited by 22 · see citing works

Altered BDNF is correlated to cognition impairment in schizophrenia patients with tardive dyskinesia

Wu, J. Q., Chen, D. C., Tan, Y., Tan, S., Hui, L., Lv, M., Soares, J. C., & Zhang, X. Y. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3660-9 · Cited by 22 · see citing works

DNA Methylation of BDNF Gene in Schizophrenia

Çöpoğlu, Ü. S., İğci, M., Bozgeyi̇k, E., Kokaçya, M. H., İğci, Y. Z., Dokuyucu, R., Arı, M., & SAVAS, H. A. (2016) · Medical Science Monitor · doi:10.12659/msm.895896 · Cited by 22 · see citing works

BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children

Armbruster, D., Mueller‐Alcazar, A., Strobel, A., Lesch, K., Kirschbaum, C., & Brocke, B. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.020 · Cited by 21 · see citing works

Genetic association of the Phosphoinositide‐3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism

Carrard, A., Salzmann, A., Perroud, N. A., Gafner, J., Malafosse, A., & Karege, F. (2011) · Brain and Behavior · doi:10.1002/brb3.23 · Cited by 21 · see citing works

Expression and methylation of BDNF in the human brain in schizophrenia

Cheah, S.-Y., McLeay, R. C., Wockner, L. F., Lawford, B. R., Young, R. M., Morris, C. P., & Voisey, J. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1245443 · Cited by 20 · see citing works

An Association Study of the Genetic Polymorphisms in 13 Neural Plasticity-Related Genes with Semantic and Episodic Memories

Gong, P., Zheng, Z., Chi, W., Xu, L., Wu, X., Chen, D., Zhang, K., Zheng, A., Gao, X., & Zhang, F. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9592-5 · Cited by 19 · see citing works

Further evidence supporting the influence of brain-derived neurotrophic factor on the outcome of bipolar depression: independent effect of brain-derived neurotrophic factor and harm avoidance

Mandelli, L., Mazza, M., Martinotti, G., Tavian, D., Colombo, E., Missaglia, S., Nicola, M. D., Ronchi, D. D., Negri, G., Colombo, R., et al. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109353463 · Cited by 17 · see citing works

Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling

Yu, W., Fang, H., Zhang, L., Hu, M., He, S., Li, H., & Zhu, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.672136 · Cited by 18 · see citing works

Ibotenic acid induced lesions impair the modulation of dendritic spine plasticity in the prefrontal cortex and amygdala, a phenomenon that underlies working memory and social behavior

Martínez-Torres, N. I., Vázquez-Hernández, N., Martín-Amaya-Barajas, F. L., Flores-Soto, M. E., & González‐Burgos, I. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173883 · Cited by 15 · see citing works

Nicotine Restores Wt-Like Levels of Reelin and GAD67 Gene Expression in Brain of Heterozygous Reeler Mice

Romano, E., Fuso, A., & Giovanni Laviola, A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9378-3 · Cited by 15 · see citing works

5-HT2A Receptors and BDNF Regulation: Implications for Psychopathology

Jaggar, M., & Vaidya, V. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-70474-6_17 · Cited by 15 · see citing works

Does metabolic status affect serum levels of BDNF and MMP-9 in patients with schizophrenia?

Arabska, J., Margulska, A., Strzelecki, D., & Wysokiński, A. (2019) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2019.1658126 · Cited by 15 · see citing works

Clozapine blockade of MK-801-induced learning/memory impairment in the mEPM: Role of 5-HT1A receptors and hippocampal BDNF levels

López‐Hill, X., Richeri, A., & Scorza, C. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.07.016 · Cited by 15 · see citing works

BDNF gene Val66Met polymorphisms as a predictor for clinical presentation in schizophrenia – recent findings

Farcas, A., Hindmarch, C. C. T., & Iftene, F. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1234220 · Cited by 12 · see citing works

Disclosing common biological signatures and predicting new therapeutic targets in schizophrenia and obsessive–compulsive disorder by integrated bioinformatics analysis

Ghanbarzehi, A., Sepehrinezhad, A., Hashemi, N., Karimi, M., & Shahbazi, A. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04543-z · Cited by 12 · see citing works

Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice

Romano, E., Angelis, F. D., Ulbrich, L., Jaco, A. D., Fuso, A., & Giovanni Laviola, A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3388-y · Cited by 12 · see citing works

Functional and structural specific roles of activity-driven BDNF within circuits formed by single spiny stellate neurons of the barrel cortex

Sun, Q., Zhang, Z., Sun, J., Nair, A. S., Petrus, D. P., & Zhang, C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00372 · Cited by 8 · see citing works

Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia

Pan, L., Cao, Z., Chen, L., Qian, M., & Yan, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.941973 · Cited by 8 · see citing works

Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder

Zelena, D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3345-3_10 · Cited by 7 · see citing works

Association Study of BDNF, SLC6A4, and FTO Genetic Variants with Schizophrenia Spectrum Disorders

Bednářová, A., Habalová, V., Krivosova, M., Marcatili, M., & Tkáč, I. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13040658 · Cited by 6 · see citing works

Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats

Andrews, J. L., Newell, K. A., Matosin, N., Huang, X., & Fernandez, F. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.003 · Cited by 6 · see citing works

The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry

Montel Hayes, R., Mason, C. E., & Miller, J. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671122 · Cited by 5 · see citing works

The Effect of Valproic Acid on the Transcriptional Activity of Ngf and Bdnf Genes of in Vitro Cultured Neurons Under Oxidative Stress Conditions

Filev, A. D., Ershova, E. S., Savinova, E. A., Кalakov, A. M., Вейко, Н. Н., Umriukhin, P. E., & Kostyuk, S. V. (2021) · International Journal of Biology and Biomedical Engineering · doi:10.46300/91011.2021.15.45 · Cited by 4 · see citing works

Epigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders

Boulle, F. (2013) · doi:10.26481/dis.20131129fb · Cited by 4 · see citing works

Molecular aspects of regeneration and neuroprotection in neuropsychiatric diseases

Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00008-5 · Cited by 2 · see citing works

Alterations in the plasma concentrations of BDNF, proBDNF, and MMP-9 in patients with schizophrenia

Liang, Y., Pan, H., Yang, Z., Yu, C., Jiang, T., Li, Y., Yu, H., Qiu, M., & Zhang, S. (2025) · European journal of medical research · doi:10.1186/s40001-025-03153-7 · Cited by 3 · see citing works

Sub-region expression of brain-derived neurotrophic factor in the dorsal hippocampus and amygdala is Affected by mild traumatic brain injury and stress in male rats

Fleischer, A. W., Fox, L. C., Davies, D. R., Vinzant, N. J., Scholl, J. L., & Forster, G. L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23339 · Cited by 3 · see citing works

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortexPreprint

Kwon, S. H., Guo, B., Fang, C., Tippani, M., Bach, S. V., Pertea, G. M., Miller, R. A., Maguire, S. E., Iatrou, A., Eagles, N. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.16.706214 · Cited by 5 · see citing works

Neuroprotective factors in schizophrenia: BDNF, NGF, NT3, GDNF and their connection to the pathogenesis of schizophrenia. A narrative review

Sikorski, P., Sikorska, E., Michalska, M. N., Stec, A., Kasarełło, K., & Fudalej, S. (2023) · Current Problems of Psychiatry · doi:10.12923/2353-8627/2023-0010 · Cited by 2 · see citing works

Altered GABA function in Major Depression

French, B. J., Seney, M. L., & Sibille, E. L. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1056-4_13 · Cited by 1 · see citing works

Development of Genetic Engineering Tools for p75ngfr Methylation and Expression Modulation

Lanshakov, D. A., & Sukhareva, E. V. (2020) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2020.811018 · Cited by 1 · see citing works

Evolution of Molecular Function in Mammalian Neurons

Francis, C. (2011) · ScholarlyCommons (University of Pennsylvania)

Flavonoids as regulators of amyloid precursor protein processing

Cox, C. J. (2014) · The University of Bath Online Publications Store (The University of Bath)

Histone Methyltransferases (GLP, G9a, SETDB1) and H3K9me2; Regulation in Psychiatric Disorders

Chase, K. A. (2012) · Figshare

One more view of neurotrophin-netrotrasmitter signaling in neurons: BDNF-AMPAR crosstalk

Chaldakov, G. N. (2008) · Biomedical Reviews · doi:10.14748/bmr.v19.58

RELATIONSHIPS AMONG SYMPTOMS, BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF), DAILY ACTIVITIES, SELF-CARE, AND QUALITY OF LIFE IN BREAST CANCER SURVIVORS

Heinze, S. (2012) · KU ScholarWorks (The University of Kansas)

Protein levels of brain-derived neurotrophic factor in the hippocampus of low/high aerobic capacity rats

Mertikas, G. G. (2010) · Jyväskylä University Digital Archive (University of Jyväskylä)

Tools for Analyzing the Role of Local Protein Synthesis in Synaptic Plasticity

Orefice, L. L., & Xu, B. (2015) · Neuromethods · doi:10.1007/978-1-4939-2754-8_12

Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety

Oliveira, K. S., Hounie, A. G., Cappi, C., & Diniz, J. B. (2016) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000132

Mecanismos moleculares de la esquizofrenia

Laverde-Sudupe, N., Serna, A. L. G., & Becerra-Hernández, L. V. (2023) · Medicina UPB · doi:10.18566/medupb.v42n2.a06

Epigenetic regulation of BDNF-TRKB signaling in the pathophysiology and treatment of mood disorders

Boulle, F. (2013) · theses.fr (ABES) · doi:10.70675/7796cc83z9f91z48c6zadb1zb6a90897b5d5

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus

Bach, S. V., Punzi, G., Smith, N. E., Mukherjee, S., Shin, J. H., Chen, Q., Pertea, G. M., Collado‐Torres, L., Maynard, K. R., Page, S. C., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03695-0

BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

Hao, R., Qi, Y., Hou, D., Ji, Y., Zheng, C., Li, C., Yung, W., Lu, B., & Huang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00306 · Cited by 32 · see citing works

Brain-derived neurotrophic factor and schizophrenia

Di Carlo, P., Punzi, G., & Ursini, G. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000237 · Cited by 110 · see citing works

BDNF and Schizophrenia: From Neurodevelopment to Neuronal Plasticity, Learning, and Memory

Nieto, R. R., Manuel Kukuljan, P., & Silva, H. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00045 · Cited by 213 · see citing works

THE SINGLE NUCLEOTIDE POLYMORPHISM (SNP) rs1018381 IN SCHIZOPHRENIA-RISK-GENE DYSBINDIN 1 MODULATES BRAIN ACTIVATION DURING LANGUAGE PRODUCTION

Markov, V., Krug, A., Krach, S., Stöcker, T., Shah, N. J., Skowronek, M. H., Eggermann, T., Zerres, K., Schneider, F. W., Rietschel, M., et al. (2008) · Schizophrenia Research · doi:10.1016/s0920-9964(08)70570-x

Role of Brain-Derived Neurotrophic Factor as a Modulator of Synaptic Plasticity

Ishikawa, Y., & Kojima, M. (2012) · Springer eBooks · doi:10.1007/978-94-007-5237-5_3 · Cited by 2 · see citing works