Cited by 890Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyCognitive Abilities and Testing

The brain-derived neurotrophic factor Val66Met polymorphism and variation in human cortical morphology

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Pezawas, Lukas, Verchinski, Beth A., Mattay, Venkata S., Callicott, Joseph H., Kolachana, Bhaskar S., Straub, Richard E., Egan, Michael F., Meyer-Lindenberg, Andreas +1 more·2004·The Journal of Neuroscience

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

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Crossref · 10.1523/jneurosci.2680-04.2004

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Authors
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R.
Affiliations
National Institutes of Health (US)
Venue
The Journal of Neuroscience
Published
2004-11-10
Volume
24
Issue
45
Pages
10099-10102
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2013373204
Cited by
890
References
27
Citations by year
2026: 9 · 2025: 19 · 2024: 12 · 2023: 18 · 2022: 23 · 2021: 22 · 2020: 30 · 2019: 29 · 2018: 20 · 2017: 32 · 2016: 42 · 2015: 47 · 2014: 71 · 2013: 58 · 2012: 76
FWCI
11.51
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
brain-derived neurotrophic factor, BDNF Val66Met polymorphism, cortical morphology, hippocampus, prefrontal cortex, brain structure, learning and memory
MeSH terms
Adolescent, Adult, Alleles, Female, Hippocampus, Humans, Learning, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuronal Plasticity, Organ Size, Polymorphism, Genetic, Genetic Variation, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Imaging, Three-Dimensional

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