Physiological Aspect and Biotechnology of Trigonelline

Roles of glycine betaine and proline in improving plant abiotic stress resistance

Ashraf, M., & Foolad, M. R. (2006) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2005.12.006 · Cited by 4,827 · see citing works

Environment and plant metabolism: flexibility and acclimation

(1995) · Choice Reviews Online · doi:10.5860/choice.33-0308 · Cited by 435 · see citing works

The enzymes of detoxication.

Jakoby, W. B., & Ziegler, D. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45272-0 · Cited by 415 · see citing works

The interface between the cell cycle and plant growth regulators: a mini review

Francis, D. A., & Sorrell, D. A. (2001) · Plant Growth Regulation · doi:10.1023/a:1010762111585 · Cited by 157 · see citing works

Synthesis of organic osmolytes and salt tolerance mechanisms in Paspalum vaginatum

Lee, G., Carrow, R. N., Duncan, R. R., Eiteman, M. A., & Rieger, M. W. (2007) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2007.10.009 · Cited by 155 · see citing works

HPLC/diode-array applied to the thermal degradation of trigonelline, nicotinic acid and caffeine in coffee

Casal, S. I. P., Oliveira, M. B. P. P., & Ferreira, M. A. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00228-9 · Cited by 123 · see citing works

Trigonelline Is a Novel Phytoestrogen in Coffee Beans ,

Allred, K. F., Yackley, K. M., Vanamala, J. K. P., & Allred, C. D. (2009) · Journal of Nutrition · doi:10.3945/jn.109.108001 · Cited by 117 · see citing works

Rhizobium meliloti Genes Encoding Catabolism of Trigonelline Are Induced under Symbiotic Conditions

Masson‐Boivin, C., Camut, S., Malpica, C. A., Truchet, G. L., & Rosenberg, C. (1990) · The Plant Cell · doi:10.2307/3869336 · Cited by 116 · see citing works

Distribution, biosynthesis and function of purine and pyridine alkaloids in Coffea arabica seedlings

Zheng, X., & Ashihara, H. (2003) · Plant Science · doi:10.1016/j.plantsci.2003.11.024 · Cited by 114 · see citing works

Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits

Koshiro, Y., Zheng, X., Wang, M.-L., Nagai, C., & Ashihara, H. (2006) · Plant Science · doi:10.1016/j.plantsci.2006.03.017 · Cited by 102 · see citing works

Trigonelline accumulation in salt-stressed legumes and the role of other osmoregulators as cell cycle control agents

Tramontano, W. A., & Jouve, D. (1997) · Phytochemistry · doi:10.1016/s0031-9422(96)00715-7 · Cited by 95 · see citing works

Nicotinamide, a missing link in the early stress response in eukaryotic cells: A hypothesis with special reference to oxidative stress in plants

Berglund, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00850-7 · Cited by 83 · see citing works

Betaine Use by Rhizosphere Bacteria: Genes Essential for Trigonelline, Stachydrine, and Carnitine Catabolism inRhizobium melilotiAre Located on pSym in the Symbiotic Region

Goldmann, A. (1991) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-4-571 · Cited by 81 · see citing works

Ultraviolet‐B‐Radiation‐Induced Changes in Nicotinamide and Glutathione Metabolism and Gene Expression in Plants

Kalbin, G., Ohlsson, A. B., Berglund, T., Rydström, J., & Strid, Å. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00465.x · Cited by 78 · see citing works

UV‐B‐ and oxidative stress‐induced increase in nicotinamide and trigonelline and inhibition of defensive metabolism induction by poly(ADP‐ribose)polymerase inhibitor in plant tissue

Berglund, T., Kalbin, G., Strid, Å., Rydström, J., & Ohlsson, A. B. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00027-0 · Cited by 68 · see citing works

Metabolic fate of nicotinamide in higher plants

Matsui, A., Yin, Y., Yamanaka, K., Iwasaki, M., & Ashihara, H. (2007) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2007.00959.x · Cited by 66 · see citing works

Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds

Zheng, X., Hayashibe, E., & Ashihara, H. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri156 · Cited by 63 · see citing works

Chemical Characterization of a Hormone That Promotes Cell Arrest in G 2 in Complex Tissues

Evans, L. S., Almeida, M. S., Lynn, D. G., & Nakanishi, K. (1979) · Science · doi:10.1126/science.203.4385.1122 · Cited by 62 · see citing works

Trigonelline concentrations in salt stressed leaves of cultivated Glycine max

Cho, Y., Lightfoot, D. A., & Wood, A. J. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00410-0 · Cited by 56 · see citing works

Enhancement of the NAD(P)(H) Pool in Escherichia coli for Biotransformation

Heuser, F., Schroer, K., Lütz, S., Bringer‐Meyer, S., & Sahm, H. (2007) · Engineering in Life Sciences · doi:10.1002/elsc.200720203 · Cited by 51 · see citing works

Trigonelline, a leaf-closing factor of the nyctinastic plant, Aeschynomene indica

Ueda, M., Niwa, M., & Yamamura, S. (1995) · Phytochemistry · doi:10.1016/0031-9422(95)00064-e · Cited by 49 · see citing works

A Role for Trigonelline During Imbibition and Germination of Coffee Seeds

Shimizu, M. M., & Mazzafera, P. (2000) · Plant Biology · doi:10.1055/s-2000-16645 · Cited by 48 · see citing works

Genetic analysis of a region of the Rhizobium meliloti pSym plasmid specifying catabolism of trigonelline, a secondary metabolite present in legumes

Masson‐Boivin, C., Barran, L. R., Malpica, C. A., & Rosenberg, C. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.9.2809-2817.1991 · Cited by 46 · see citing works

Stress metabolism. IX. Effect of salt stress on trigonelline accumulation in tomato

Rajasekaran, L. R., Aspinall, D., Jones, G. P., & Paleg, L. G. (2001) · Canadian Journal of Plant Science · doi:10.4141/p00-079 · Cited by 42 · see citing works

Biosynthesis of NAD and Its Manipulation in Plants☆

Noctor, G., Hager, J., & Li, S. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-386479-6.00002-0 · Cited by 38 · see citing works

Relationship between trigonelline concentration and promotion of cell arrest in G2 in cultured roots of Pisum sativum

Tramontano, W. A., Hartnett, C. M., Lynn, D. G., & Evans, L. S. (1982) · Phytochemistry · doi:10.1016/0031-9422(82)80111-8 · Cited by 38 · see citing works

The diversity of chemical substances controlling the nyctinastic leaf-movement in plants

Ueda, M., Shigemori, H., Sata, N., & Yamamura, S. (2000) · Phytochemistry · doi:10.1016/s0031-9422(99)00467-7 · Cited by 37 · see citing works

Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B′ methyltransferase family in Coffea arabica

Mizuno, K., Matsuzaki, M., Kanazawa, S., Tokiwano, T., Yoshizawa, Y., & Kato, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.043 · Cited by 37 · see citing works

Effect of nicotinic acid, nicotinamide and trigonelline on the proliferation of lettuce cells derived from protoplasts

Sasamoto, H., & Ashihara, H. (2013) · Phytochemistry Letters · doi:10.1016/j.phytol.2013.09.008 · Cited by 36 · see citing works

Inactivation of DNA replication origins by the cell cycle regulator, trigonelline, in root meristems of Lactuca sativa

Mazzuca, S., Bitonti, M. B., Innocenti, A. M., & Francis, D. A. (2000) · Planta · doi:10.1007/s004250000272 · Cited by 36 · see citing works

Effect of short‐term salt stress on the metabolic profiles of pyrimidine, purine and pyridine nucleotides in cultured cells of the mangrove tree, Bruguiera sexangula

Suzuki‐Yamamoto, M., Mimura, T., & Ashihara, H. (2006) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2006.00753.x · Cited by 34 · see citing works

Synthesis and Availability of Niacin in Roasted Coffee

Adrian, J., & Frangne, R. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2626-5_4 · Cited by 33 · see citing works

Nicotinic acid-N-glucoside in heterotrophic parsley cell suspension cultures

Upmeier, B., Thomzik, J. E., & Barz, W. (1988) · Phytochemistry · doi:10.1016/0031-9422(88)80754-4 · Cited by 31 · see citing works

Trigonelline content in coffee beans and the thermal conversion of trigonelline into nicotinic acid during the roasting of coffee beans.

TAGUCHI, H., SAKAGUCHI, M., & Shimabayashi, Y. (1985) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.49.3467 · Cited by 31 · see citing works

Chemical basis for differential acceptance of two sympatric rutaceous plants by ovipositing females of a swallowtail butterfly, Papilio polytes (Lepidoptera, Papilionidae)

Nakayama, T., & Honda, K. (2004) · Chemoecology · doi:10.1007/s00049-004-0272-6 · Cited by 29 · see citing works

Betaines and free amino acids in salt stressed vitroplants and winter resting buds of Populus trichocarpa X deltoides

Bray, L., Chriqui, D., Gloux, K., Rudulier, D. L., Meyer, M., & Péduzzi, J. (1991) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1991.tb01292.x · Cited by 25 · see citing works

Findings of trigonelline demethylating enzyme activity in various organisms and some properties of the enzyme from hog liver

Taguchi, H., & Shimabayashi, Y. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91763-1 · Cited by 22 · see citing works

Trigonelline, nicotinic acid and nicotinamide in seedlings of Pisum sativum

Tramontano, W. A., Lynn, D. G., & Evans, L. S. (1983) · Phytochemistry · doi:10.1016/s0031-9422(00)86960-5 · Cited by 19 · see citing works

Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos

Ashihara, H., Luit, B., Belmonte, M. F., & Stasolla, C. (2008) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2008.04.013 · Cited by 18 · see citing works

Changes in pyridine metabolism profile during growth of trigonelline-forming Lotus japonicus cell cultures

Yin, Y., Matsui, A., Sakuta, M., & Ashihara, H. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.10.002 · Cited by 15 · see citing works

Pyridine salvage and nicotinic acid conjugate synthesis in leaves of mangrove species

Ashihara, H., Yin, Y., Deng, W., & Watanabe, S. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.09.033 · Cited by 13 · see citing works

Effects of cytokinins on promotion of cell arrest in G2 by trigonelline and trigonelline concentrations in cultured roots of Pisum sativum and glycine max

Tramontano, W. A., Evans, L. S., & McGinley, P. A. (1985) · Environmental and Experimental Botany · doi:10.1016/0098-8472(85)90051-6 · Cited by 13 · see citing works

Trigonelline biosynthesis and the pyridine nucleotide cycle in Coffea arabica fruits: Metabolic fate of [carboxyl-14C]nicotinic acid riboside

Ashihara, H., Deng, W., & Nagai, C. (2011) · Phytochemistry Letters · doi:10.1016/j.phytol.2011.04.005 · Cited by 11 · see citing works

Biosynthesis of trigonelline in the coffee plant.

TAGUCHI, H., SAKAGUCHI, M., YAMAKI, K., & Shimabayashi, Y. (1987) · Nippon Nōgeikagaku Kaishi · doi:10.1271/nogeikagaku1924.61.183 · Cited by 11 · see citing works

Identification ofN-(beta- D -Glucopyranosyl)nicotinic Acid as a Major Metabolite from Niacin in Cultured Tobacco Cells

Nishitani, H., Yamada, Y., Ohshima, N., Okumura, K., & Taguchi, H. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.1336 · Cited by 10 · see citing works

Pyridine Metabolism and Trigonelline Synthesis in Leaves of the Mangrove Legume trees Derris indica (Millettia pinnata ) and Caesalpinia crista

Yin, Y., Sasamoto, H., & Ashihara, H. (2011) · Natural Product Communications · doi:10.1177/1934578x1100601212 · Cited by 9 · see citing works

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia

Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00997-x · Cited by 148 · see citing works

Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health

Ashihara, H., Ludwig, I. A., Katahira, R., Yokota, T., Fujimura, T., & Crozier, A. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-014-9375-z · Cited by 110 · see citing works

Pyridine nucleotide cycle and trigonelline (N‐methylnicotinic acid) synthesis in developing leaves and fruits of Coffea arabica

Zheng, X., Nagai, C., & Ashihara, H. (2004) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2004.00422.x · Cited by 62 · see citing works

Trigonelline (Nicotinic Acid Betaine) biosynthesis in plants: NaCl- & drought-stress induced accumulation in cultivated soybean (Glycine max).

Wood, A. J., Cho, Y., & Xin-bo, C. (2000) · Cited by 5 · see citing works

Biosynthesis of trigonelline in the coffee plant.

TAGUCHI, H., SAKAGUCHI, M., YAMAKI, K., & Shimabayashi, Y. (1987) · Nippon Nōgeikagaku Kaishi · doi:10.1271/nogeikagaku1924.61.183 · Cited by 11 · see citing works

Accumulation and Function of Trigonelline in Non-leguminous Plants

Ashihara, H., & Watanabe, S. (2014) · Natural Product Communications · doi:10.1177/1934578x1400900616 · Cited by 20 · see citing works