Peptides: Chemistry and Biology

Abstract

INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and Main Conformational Features of the Peptide Bond Building Blocks, Classification, and Nomenclature Analysis of the Covalent Structure of Peptides and Proteins Three-Dimensional Structure Methods of Structural Analysis BIOLOGY OF PEPTIDES Historical Aspects and Biological Functions Biosynthesis Selected Biologically Active Peptides PEPTIDE SYNTHESIS Principles and Objectives Protection of Functional Groups Peptide Bond Formation Racemization During Synthesis Solid-Phase Peptide Synthesis (SPPS) Biochemical Synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and Tactics Solution Phase Synthesis (SPS) NEW: Solution Phase/Solid Phase-Hybrid Approaches Optimized Strategies on Polymeric Support Chemical Ligation Strategies SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine Peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated Peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS Peptide Design Modified Peptides Peptidomimetics Pseudobiopolymers Macropeptides and De-Novo Design of Peptides and Proteins COMBINATORIAL PEPTIDE SYNTHESIS Parallel Synthesis Synthesis of Mixtures APPLICATION OF PEPTIDES AND PROTEINS NEW: General Production Strategies NEW: Improvement of the Therapeutic Potential Protein Pharmaceuticals Peptide Pharmaceuticals PEPTIDES IN PROTEOMICS NEW: Genome and Proteome NEW: Separation Methods NEW: Peptide and Protein Analysis in Proteomics NEW: Activity-Based Proteomics