Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
Open accessAbstract
Objective: Dementia with Lewy bodies (DLB) is associated with the accumulation of wild‐type human α‐synuclein (SYN) in neurons and with prominent slowing of brain oscillations on electroencephalography (EEG). However, it remains uncertain whether the EEG abnormalities are actually caused by SYN. Methods: To determine whether SYN can cause neural network abnormalities, we performed EEG recordings and analyzed the expression of neuronal activity‐dependent gene products in SYN transgenic mice. We also carried out comparative analyses in humans with DLB. Results: We demonstrate that neuronal expression of SYN in transgenic mice causes a left shift in spectral power that closely resembles the EEG slowing observed in DLB patients. Surprisingly,SYN mice also had seizures and showed molecular hippocampal alterations indicative of aberrant network excitability, including calbindin depletion in the dentate gyrus. In postmortem brain tissues from DLB patients, we found reduced levels of calbindin mRNA in the dentate gyrus. Furthermore, nearly one quarter of DLB patients showed myoclonus, a clinical sign of aberrant network excitability that was associated with an earlier age of onset of cognitive impairments. In SYN mice, partial suppression of epileptiform activity did not alter their shift in spectral power. Furthermore, epileptiform activity in human amyloid precursor protein transgenic mice was not associated with a left shift in spectral power. Interpretation: We conclude that neuronal accumulation of SYN slows brain oscillations and, in parallel, causes aberrant network excitability that can escalate into seizure activity. The potential role of aberrant network excitability in DLB merits further investigation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An EEG study with transgenic mice demonstrated a close correlation between neuronal accumulation of α-synuclein and slowing of brain oscillations and changes in network excitability.
“An EEG study with transgenic mice demonstrated a close correlation between neuronal accumulation of α-synuclein and slowing of brain oscillations and changes in network excitability [22, 41].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
Rockenstein, E., Nuber, S., Overk, C., Ubhi, K., Mante, M., Patrick, C., Adame, A., Trejo-Morales, M., Gerez, J., Picotti, P., et al. (2014) · Brain : a journal of neurology · doi:10.1093/brain/awu057 · Cited by 228 · see citing works
RetractedAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Fisher, R. S., Boas, W. V. E., Blume, W. T., Elger, C. E., Genton, P., Lee, P., & Engel, J. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.66104.x · Cited by 3,678 · see citing works
Beghi, E., Berg, A. T., Carpio, A., Forsgren, L., Hesdorffer, D. C., Hauser, W. A., Malmgren, K., Shinnar, S., Temkin, N. R., Thurman, D. J., et al. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00273_1.x · Cited by 2,301 · see citing works
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works
Self-citationMucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Self-citationDendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821 · see citing works
Modern Epidemiology 3rd edition
Rothman, K. J., Lash, T. L., & Greenland, S. (1986) · Cited by 1,736 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216 · see citing works
Self-citationNemani, V. M., Lü, W., Berge‐Seidl, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.023 · Cited by 1,051 · see citing works
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
Buzsáki, G., Bickford, R. G., Ponomareff, G., Thal, L. J., Mandel, R. J., & Gage, F. H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04007.1988 · Cited by 1,039 · see citing works
Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment
Bakker, A., Krauss, G. L., Albert, M., Speck, C. L., Jones, L. R., Stark, C. E. L., Yassa, M. A., Bassett, S. S., Shelton, A. L., & Gallagher, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.023 · Cited by 905 · see citing works
Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825 · see citing works
Hamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754 · see citing works
Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease
Vossel, K. A., Beagle, A. J., Rabinovici, G. D., Shu, H., Lee, S. E., Naasan, G., Hegde, M., Cornes, S. B., Henry, M. L., Nelson, A., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.136 · Cited by 730 · see citing works
Self-citationRoberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654 · see citing works
Self-citationSanchez, P. E., Zhu, L., Verret, L., Vossel, K. A., Orr, A. G., Cirrito, J. R., Devidze, N., Ho, K., Yu, G.-Q., Palop, J. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121081109 · Cited by 638 · see citing works
Self-citationMasliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works
Self-citationInhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
Dawson, H. N., Ferreira, A., Eyster, M. V., Ghoshal, N., Binder, L. I., & Vitek, M. P. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1179 · Cited by 527 · see citing works
Rockenstein, E., Mallory, M., Hashimoto, M., Song, D., Shults, C. W., Lang, I., & Masliah, E. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10231 · Cited by 502 · see citing works
Systematic Review and Meta‐analysis of Incidence Studies of Epilepsy and Unprovoked Seizures
Kotsopoulos, I. A. W., Merode, T. V., Kessels, F., de Krom, M. C. T. F. M., & Knottnerus, J. A. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.t01-1-26901.x · Cited by 436 · see citing works
Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402 · see citing works
Self-citationBonanni, L., Thomas, A., Tiraboschi, P., Perfetti, B., Varanese, S., & ONOFRJ, M. C. (2008) · Brain · doi:10.1093/brain/awm322 · Cited by 392 · see citing works
Forsgren, L., Bucht, G., Eriksson, S., & Bergmark, L. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb00017.x · Cited by 360 · see citing works
Fisher, R. S., Boas, W. V. E., Blume, W. T., Elger, C. E., Genton, P., Lee, P., & Engel, J. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00273_4.x · Cited by 349 · see citing works
A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice
Chesselet, M.-F., Richter, F., Zhu, C., Magen, I., Watson, M. B., & Subramaniam, S. R. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0104-2 · Cited by 346 · see citing works
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
Merdes, A., Hansen, L. A., Jeste, D. V., Galasko, D. R., Hofstetter, C. R., Ho, G. J., Thal, L. J., & Corey‐Bloom, J. (2003) · Neurology · doi:10.1212/01.wnl.0000065889.42856.f2 · Cited by 320 · see citing works
Interictal EEG and the Diagnosis of Epilepsy
Pillai, J., & Sperling, M. R. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00654.x · Cited by 318 · see citing works
Antisense Reduction of Tau in Adult Mice Protects against Seizures
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., Schuler, D. R., Maloney, S. E., Wozniak, D. F., Rigo, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-13.2013 · Cited by 311 · see citing works
Holth, J. K., Bomben, V. C., Reed, J. G., Inoue, T., Younkin, L., Younkin, S. G., Pautler, R. G., Botas, J., & Noebels, J. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3191-12.2013 · Cited by 238 · see citing works
Cholinergic Transmitter and Neurotrophic Activities in Lewy Body Dementia
Perry, E. K., Irving, D., Kerwin, J. M., McKeith, I. G., Thompson, P., Collerton, D., FAIRBAIRN, A. F., Ince, P. G., Morris, C. M., Cheng, A. V., et al. (1993) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199307020-00002 · Cited by 213 · see citing works
Myoclonic disorders: a practical approach for diagnosis and treatment
Kojović, M., Cordivari, C., & Bhatia, K. P. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285610395653 · Cited by 209 · see citing works
SPECTRUM OF PARKINSON'S DISEASE, PARKINSON'S DEMENTIA, AND LEWY BODY DEMENTIA
McKeith, I. G., & Burn, D. J. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70230-9 · Cited by 169 · see citing works
Louis, E. D., Klatka, L. A., Liu, Y., & Fahn, S. (1997) · Neurology · doi:10.1212/wnl.48.2.376 · Cited by 168 · see citing works
Marksteiner, J., Ortler, M., Bellmann, R., & Sperk, G. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90193-d · Cited by 162 · see citing works
EEG findings in dementia with Lewy bodies and Alzheimer’s disease
Briel, R., Mckeith, I., Barker, W., Hewitt, Y., Perry, R., Ince, P., & Fairbairn, A. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.3.401 · Cited by 160 · see citing works
Tau reduction prevents disease in a mouse model of <scp>D</scp> ravet syndrome
Gheyara, A. L., Ponnusamy, R., Djukic, B., Craft, R. J., Ho, K., Guo, W., Finucane, M. M., Sanchez, P. E., & Mucke, L. (2014) · Annals of Neurology · doi:10.1002/ana.24230 · Cited by 138 · see citing works
Self-citationLoss of Calbindin-D28K immunoreactivity from dentate granule cells in human temporal lobe epilepsy
Maglóczky, Z., Halász, P., Vajda, J., Czirják, S., & Freund, T. F. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00440-x · Cited by 119 · see citing works
Winston, S. M., Hayward, M. D., Nestler, E. J., & Duman, R. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04892.x · Cited by 119 · see citing works
del Ser, T., Hachinski, V., Merskey, H., & Muñoz, D. G. (2001) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200101000-00005 · Cited by 116 · see citing works
A pilot tolerability and efficacy study of levetiracetam in patients with chronic myoclonus
Frucht, S. J., Louis, E. D., Chuang, C., & Fahn, S. (2001) · Neurology · doi:10.1212/wnl.57.6.1112 · Cited by 115 · see citing works
Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology
Lippa, C. F., Smith, T. W., & Perry, E. K. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050176 · Cited by 114 · see citing works
Cognitive deficits in a mouse model of pre‐manifest Parkinson’s disease
Magen, I., Fleming, S. M., Zhu, C., Garcia, E. C., Cardiff, K. M., Dinh, D., Rosa, K. D. L., Sánchez, M. Á., Torres, E. R. S., Masliah, E., et al. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08012.x · Cited by 106 · see citing works
Dong, H., Yuede, C. M., Coughlan, C. A., Murphy, K. M., & Csernansky, J. G. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.097 · Cited by 105 · see citing works
Palop, J. J., Mucke, L., & Roberson, E. D. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-744-0_17 · Cited by 104 · see citing works
Self-citationMiller, J. J., & Baimbridge, K. G. (1983) · Brain Research · doi:10.1016/0006-8993(83)90264-0 · Cited by 94 · see citing works
Effectiveness of piracetam in cortical myoclonus
Brown, P., Steiger, M. J., Thompson, P. D., Rothwell, J. C., Day, B. L., Salama, M., Waegemans, T., & MARSDEN, C. D. (1993) · Movement Disorders · doi:10.1002/mds.870080112 · Cited by 93 · see citing works
Almkvist, O., Jelić, V., Amberla, K., Hellström‐Lindahl, E., Meurling, L., & Nordberg, A. K. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051232 · Cited by 89 · see citing works
Can Alzheimer’s Disease and Dementias with Lewy Bodies be Distinguished Clinically?
Weiner, M., Hynan, L. S., Parikh, B., Zaki, N., White, C. L., Bigio, E. H., Lipton, A. M., Martin‐Cook, K., Svetlik, D. A., Cullum, C. M., et al. (2003) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988703258671 · Cited by 84 · see citing works
The Incidence and Prevalence of Myoclonus in Olmsted County, Minnesota
Caviness, J. N., Alving, L. I., Maraganore, D. M., Black, R. A., McDonnell, S. K., & Rocca, W. A. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.6.565 · Cited by 78 · see citing works
Prediction of treatment response to rivastigmine in Alzheimer's dementia.
Adler, G., Brassen, S., Chwalek, K., Dieter, B., & Teufel, M. (2004) · PubMed Central · Cited by 77 · see citing works
Electroencephalogram Variability in Dementia with Lewy Bodies, Alzheimer’s Disease and Controls
Andersson, M. A., Hansson, O., Minthon, L., Rosén, I., & Londos, E. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000160962 · Cited by 77 · see citing works
Clinical trial of piracetam in patients with myoclonus: Nationwide multiinstitution study in Japan
Ikeda, A., Shibasaki, H., Tasgiro, K., et al. (1996) · Movement Disorders · doi:10.1002/mds.870110615 · Cited by 76 · see citing works
Carbonell, C. S., Rueda‐Orozco, P. E., Gómez, E. S., Buzsáki, G., Marsicano, G., & Robbe, D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217144110 · Cited by 72 · see citing works
Kinney, G. G., Patiño, P., Mermet-Bouvier, Y., Starrett, J. E., & Gribkoff, V. K. (1999) · PubMed · Cited by 64 · see citing works
Sleep Dysfunction and EEG Alterations in Mice Overexpressing Alpha-Synuclein
McDowell, K. A., Shin, D., Roos, K. P., & Chesselet, M. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-140374 · Cited by 62 · see citing works
Small‐Amplitude cortical myoclonus in Parkinson's disease: Physiology and clinical observations
Caviness, J. N., Adler, C. H., Beach, T. G., Wetjen, K. L., & Caselli, R. J. (2002) · Movement Disorders · doi:10.1002/mds.10177 · Cited by 53 · see citing works
Riekkinen, P. J., Riekkinen, M., Sirviö, J., Miettinen, R. A., & Riekkinen, P. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90032-w · Cited by 48 · see citing works
Rivastigmine is associated with restoration of left frontal brain activity in Parkinson's disease
Possin, K. L., Kang, G. A., Guo, C. C., Fine, E. M., Trujillo, A. J., Racine, C. A., Wilheim, R., Johnson, E. T., Witt, J. L., Seeley, W. W., et al. (2013) · Movement Disorders · doi:10.1002/mds.25575 · Cited by 41 · see citing works
A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia
Bandopadhyay, R., Liu, J. Y. W., Sisodiya, S. M., & Thom, M. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12087 · Cited by 33 · see citing works
Electrophysiology of the myoclonus in dementia with Lewy bodies
Caviness, J. N., Adler, C. H., Caselli, R. J., et al. (2003) · Neurology · doi:10.1212/wnl.60.3.523 · Cited by 27 · see citing works
Parkinson's disease, cortical dysfunction, and alpha‐synuclein
Caviness, J. N., Lue, L., Beach, T. G., Hentz, J. G., Adler, C. H., Sue, L. I., Sadeghi, R., Driver‐Dunckley, E. D., Evidente, V. G. H., Sabbagh, M. N., et al. (2011) · Movement Disorders · doi:10.1002/mds.23697 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [16]Rothman K, Greenland S. Modern epidemiology. 3rd ed Philadelphia: Lippincott Williams & Wilkins, 2008.
Cited by
Sorted by citations
Network abnormalities and interneuron dysfunction in Alzheimer disease
Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022 · see citing works
Self-citationProtein misfolding in neurodegenerative diseases: Implications and strategies
Sweeney, P., Park, H., Baumann, M., Dunlop, J., Frydman, J., Kopito, R., McCampbell, A., Leblanc, G., Venkateswaran, A., Nurmi, A., et al. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0077-5 · Cited by 675 · see citing works
The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
Rey, N. L., Wesson, D. W., & Brundin, P. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.013 · Cited by 257 · see citing works
Scheiblich, H., Eikens, F., Wischhof, L., Opitz, S., Jüngling, K., Cserép, C., Schmidt, S. V., Lambertz, J., Bellande, T., Pósfai, B., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.029 · Cited by 207 · see citing works
Beagle, A. J., Darwish, S. M., Ranasinghe, K. G., La, A. L., Karageorgiou, E., & Vossel, K. A. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170031 · Cited by 173 · see citing works
Self-citationDiagnostic and prognostic value of EEG in prodromal dementia with Lewy bodies
van der Zande, J. J., Gouw, A. A., van Steenoven, I., van de Beek, M., Scheltens, P., Stam, C. J., & Lemstra, A. W. (2020) · Neurology · doi:10.1212/wnl.0000000000009977 · Cited by 43 · see citing works
Liu, H., Huang, Z., Deng, B., Chang, Z., Yang, X., Guo, X., Yuan, F., Yang, Q., Wang, L., Zou, H., et al. (2023) · Aging and disease · doi:10.14336/ad.2022.0514 · Cited by 20 · see citing works
- Authors
- Morris, M., Sanchez, P. E., Verret, L., Beagle, A. J., Guo, W., Dubal, D., Ranasinghe, K. G., Koyama, A., Ho, K., Yu, G., Vossel, K. A., & Mucke, L.
- Affiliations
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Corresponding author
- Mucke, Lennart
- ORCID
- Venue
- Annals of Clinical and Translational Neurology
- Publisher
- Wiley
- Published
- 2015-10-16
- Volume
- 2
- Issue
- 11
- Pages
- 1012-1028
- ISSN
- 2328-9503 (ISSN-L)
- PMC
- PMC4693622
- OpenAlex
- W2128212150
- Cited by
- 61
- References
- 66
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 2 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Annals of Clinical and Translational Neurology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (K23 AG038357, P30 NS065780)
- University of California, San Francisco
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dementia with Lewy bodies, alpha-synuclein, EEG slowing, neural oscillations, network dysfunction, network excitability, seizures, calbindin, dentate gyrus, myoclonus, epileptiform activity, amyloid precursor protein transgenic mice, age of onset
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
