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Cited by 41

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial

Wilkinson, Thomas J., Lemmey, Andrew B., Jones, Jeremy G., Sheikh, Fazal, Ahmad, Yasmeen A., Chitale, Sarang, Maddison, Peter J., O'brien, Thomas D.·2016·Arthritis Care & Research
DOI 10.1002/acr.22747
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Abstract

Objective: Rheumatoid cachexia (muscle wasting) in rheumatoid arthritis (RA) patients contributes to substantial reductions in strength and impaired physical function. The objective of this randomized controlled trial was to investigate the effectiveness of oral creatine (Cr) supplementation in increasing lean mass and improving strength and physical function in RA patients. Methods: In a double‐blind design, 40 RA patients were randomized to either 12 weeks’ supplementation of Cr or placebo. Body composition (dual x‐ray absorptiometry and bioelectrical impedance spectroscopy [BIS]), strength, and objectively assessed physical function were measured at baseline, day 6, week 12, and week 24. Data analysis was performed by analysis of covariance. Results: Cr supplementation increased appendicular lean mass (ALM; a surrogate measure of muscle mass) by mean ± SE 0.52 ± 0.13 kg (P = 0.004 versus placebo), and total LM by 0.60 ± 0.37 kg (P = 0.158). The change in LM concurred with the gain in intracellular water (0.64 ± 0.22 liters; P = 0.035) measured by BIS. Despite increasing ALM, Cr supplementation, relative to placebo, failed to improve isometric knee extensor strength (P = 0.408), handgrip strength (P = 0.833), or objectively assessed physical function (P = 0.335–0.764). Conclusion: In patients with RA, Cr supplementation increased muscle mass, but not strength or objective physical function. No treatment‐related adverse effects were reported, suggesting that Cr supplementation may offer a safe and acceptable adjunct treatment for attenuating muscle loss; this treatment may be beneficial for patients experiencing severe rheumatoid cachexia.

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Research works printed but not linked: 37

  1. Roubenoff R, 1992, Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor, J Rheumatol, 19, 1505
  2. 10.1093/rheumatology/ken146 · DOI
  3. 10.1016/j.clnu.2012.05.012 · DOI
  4. 10.1002/art.23719 · DOI
  5. 10.1002/art.24891 · DOI · Paper page
  6. 10.1002/acr.22433 · DOI
  7. Lemmey AB, 2015, Treat‐to‐target treatment fails to restore either body composition or objectively assessed physical function in rheumatoid arthritis patients [abstract], Rheumatology (Oxford), 54, i78
  8. 10.1093/ajcn/84.6.1463 · DOI
  9. 10.1093/rheumatology/kem291 · DOI
  10. 10.1007/s00394-013-0599-2 · DOI
  11. Marcora SM, 2005, Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot study, J Rheumatol, 32, 1031
  12. 10.1002/acr.20523 · DOI
  13. 10.1016/j.clnu.2005.01.006 · DOI
  14. 10.1249/01.mss.0000247002.32589.ef · DOI · Paper page
  15. 10.1152/ajpendo.1994.266.5.E725 · DOI · Paper page
  16. Ziegenfuss TN, 1998, Acute fluid volume changes in men during three days of creatine supplementation, J Exerc Physiol, 1, 1
  17. 10.1083/jcb.62.1.145 · DOI
  18. Powers ME, 2003, Creatine supplementation increases total body water without altering fluid distribution, J Athl Train, 38, 44
  19. 10.5499/wjr.v4.i3.22 · DOI
  20. 10.1093/rheumatology/39.3.293 · DOI
  21. 10.1002/art.27584 · DOI · Paper page
  22. Eston R, 2009, Kinanthropometry and exercise physiology laboratory manual: anthropometry
  23. Rikli RE, 2012, Senior fitness test manual
  24. 10.3899/jrheum.090584 · DOI
  25. 10.1093/oxfordjournals.aje.a114010 · DOI
  26. 10.1016/j.berh.2007.02.005 · DOI
  27. 10.1097/00005768-200203000-00023 · DOI · Paper page
  28. 10.1016/j.exger.2014.02.003 · DOI · Paper page
  29. 10.1002/art.1780390309 · DOI
  30. Stout J, 2007, Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–86 years), J Nutr Health Aging, 11, 459
  31. 10.1002/mus.10527 · DOI · Paper page
  32. 10.1007/s00415-002-0923-x · DOI · Paper page
  33. 10.1212/01.WNL.0000044405.29988.E1 · DOI · Paper page
  34. 10.1371/journal.pone.0004605 · DOI
  35. 10.1055/s-2000-8859 · DOI · Paper page
  36. 10.1007/s004210000373 · DOI
  37. Syrotuik DG, 2004, Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders, J Strength Cond Res, 18, 610

Cited by

Metadata

Authors
Wilkinson, T. J., Lemmey, A. B., Jones, J. G., Sheikh, F., Ahmad, Y. A., Chitale, S., Maddison, P. J., & O'brien, T. D.
Affiliations
  • Bangor University Bangor UK
  • Peter Maddison Rheumatology Centre, Llandudno Hospital, Llandudno, North Wales, UK, and Bangor University Bangor UK
  • Research Institute for Sports and Exercise Sciences, Liverpool John Moores University Liverpool UK
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2016-05-26
Volume
68
Issue
6
Pages
729-737
ISSN
  • 2151-464X
  • 2151-4658
DOI
10.1002/acr.22747
Cited by
41
References
13
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Betsi Cadwaladr University Health Board Small Grants Committee (CF17-11)

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